Page last updated: 2024-10-31

metronidazole and Leukemia, Myeloid, Acute

metronidazole has been researched along with Leukemia, Myeloid, Acute in 9 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.

Research Excerpts

ExcerptRelevanceReference
"Busulfan is a bifunctional alkylating agent widely used in pretransplant conditioning regimens in patients undergoing stem cell transplantation for hematologic malignancies."1.37Busulfan and metronidazole: an often forgotten but significant drug interaction. ( Andersson, BS; Culotta, KS; Gulbis, AM; Jones, RB, 2011)
"Bacteremia was associated with a abscess of the anal margin."1.31[Clostridium difficile bacteremia]. ( Blanckaert, K; Cattoen, C; Duthilly, A; Simon, M; Thielemans, B, 2001)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's1 (11.11)18.2507
2000's2 (22.22)29.6817
2010's3 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Magréault, S1
Leroux, S1
Touati, J1
Storme, T1
Jacqz-Aigrain, E1
Gupta, NK1
Masia, R1
Gulbis, AM1
Culotta, KS1
Jones, RB1
Andersson, BS1
Levenga, H1
Donnelly, P1
Blijlevens, N1
Verweij, P1
Shirango, H1
de Pauw, B1
Galal, O1
Osse, G1
Weigel, W1
Gahr, M1
Bavaro, P1
Di Girolamo, G1
Di Bartolomeo, P1
Angrilli, F1
Olioso, P1
Papalinetti, G1
Del Vecchio, A1
Torlontano, G1
Duthilly, A1
Blanckaert, K1
Thielemans, B1
Simon, M1
Cattoen, C1
Storring, RA1
Gerken, ME1
Wienbren, M1
Perinpanayagam, RM1
Camba, L1
Lee, CA1

Reviews

1 review available for metronidazole and Leukemia, Myeloid, Acute

ArticleYear
Fatal hemorrhagic pneumonia caused by infection due to Kytococcus sedentarius--a pathogen or passenger?
    Annals of hematology, 2004, Volume: 83, Issue:7

    Topics: Actinomycetales; Actinomycetales Infections; Acyclovir; Antineoplastic Combined Chemotherapy Protoco

2004

Other Studies

8 other studies available for metronidazole and Leukemia, Myeloid, Acute

ArticleYear
UPLC/MS/MS assay for the simultaneous determination of seven antibiotics in human serum-Application to pediatric studies.
    Journal of pharmaceutical and biomedical analysis, 2019, Sep-10, Volume: 174

    Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Azithromycin; Blood Chemical Analysis; Calibration;

2019
Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract.
    The American journal of surgical pathology, 2013, Volume: 37, Issue:7

    Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Colitis; Cord Blood Stem Cell Transplantation; Crohn Di

2013
Busulfan and metronidazole: an often forgotten but significant drug interaction.
    The Annals of pharmacotherapy, 2011, Volume: 45, Issue:7-8

    Topics: Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Busulfan; Child; Clostridioides difficile;

2011
Pneumatosis intestinalis in children with leukaemia; report of three cases.
    European journal of pediatrics, 1981, Volume: 137, Issue:1

    Topics: Adolescent; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Metronid

1981
Amebiasis after bone marrow transplantation.
    Bone marrow transplantation, 1994, Volume: 13, Issue:2

    Topics: Adult; Animals; Bone Marrow Transplantation; Dysentery, Amebic; Humans; Leukemia, Myeloid, Acute; Ma

1994
[Clostridium difficile bacteremia].
    Presse medicale (Paris, France : 1983), 2001, Dec-08, Volume: 30, Issue:37

    Topics: Aged; Anti-Bacterial Agents; Antineoplastic Agents; Bacteremia; Clostridioides difficile; Enterocoli

2001
Letter: Mucosal ulcers and anaerobic organisms.
    Lancet (London, England), 1975, May-17, Volume: 1, Issue:7916

    Topics: Adult; Anaerobiosis; Bacteria; Clindamycin; Humans; Leukemia, Myeloid, Acute; Metronidazole; Mouth M

1975
Convulsions and encephalopathy in a patient with leukemia after treatment with metronidazole.
    Journal of clinical pathology, 1985, Volume: 38, Issue:9

    Topics: Adult; Brain Diseases; Epilepsy; Female; Humans; Leukemia, Myeloid, Acute; Metronidazole

1985