metronidazole has been researched along with Leukemia, Myeloid, Acute in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Leukemia, Myeloid, Acute: Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Busulfan is a bifunctional alkylating agent widely used in pretransplant conditioning regimens in patients undergoing stem cell transplantation for hematologic malignancies." | 1.37 | Busulfan and metronidazole: an often forgotten but significant drug interaction. ( Andersson, BS; Culotta, KS; Gulbis, AM; Jones, RB, 2011) |
| "Bacteremia was associated with a abscess of the anal margin." | 1.31 | [Clostridium difficile bacteremia]. ( Blanckaert, K; Cattoen, C; Duthilly, A; Simon, M; Thielemans, B, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (33.33) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Magréault, S | 1 |
| Leroux, S | 1 |
| Touati, J | 1 |
| Storme, T | 1 |
| Jacqz-Aigrain, E | 1 |
| Gupta, NK | 1 |
| Masia, R | 1 |
| Gulbis, AM | 1 |
| Culotta, KS | 1 |
| Jones, RB | 1 |
| Andersson, BS | 1 |
| Levenga, H | 1 |
| Donnelly, P | 1 |
| Blijlevens, N | 1 |
| Verweij, P | 1 |
| Shirango, H | 1 |
| de Pauw, B | 1 |
| Galal, O | 1 |
| Osse, G | 1 |
| Weigel, W | 1 |
| Gahr, M | 1 |
| Bavaro, P | 1 |
| Di Girolamo, G | 1 |
| Di Bartolomeo, P | 1 |
| Angrilli, F | 1 |
| Olioso, P | 1 |
| Papalinetti, G | 1 |
| Del Vecchio, A | 1 |
| Torlontano, G | 1 |
| Duthilly, A | 1 |
| Blanckaert, K | 1 |
| Thielemans, B | 1 |
| Simon, M | 1 |
| Cattoen, C | 1 |
| Storring, RA | 1 |
| Gerken, ME | 1 |
| Wienbren, M | 1 |
| Perinpanayagam, RM | 1 |
| Camba, L | 1 |
| Lee, CA | 1 |
1 review available for metronidazole and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
Fatal hemorrhagic pneumonia caused by infection due to Kytococcus sedentarius--a pathogen or passenger?
Topics: Actinomycetales; Actinomycetales Infections; Acyclovir; Antineoplastic Combined Chemotherapy Protoco | 2004 |
8 other studies available for metronidazole and Leukemia, Myeloid, Acute
| Article | Year |
|---|---|
UPLC/MS/MS assay for the simultaneous determination of seven antibiotics in human serum-Application to pediatric studies.
Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; Azithromycin; Blood Chemical Analysis; Calibration; | 2019 |
Cord colitis syndrome: a cause of granulomatous inflammation in the upper and lower gastrointestinal tract.
Topics: Adult; Anti-Bacterial Agents; Ciprofloxacin; Colitis; Cord Blood Stem Cell Transplantation; Crohn Di | 2013 |
Busulfan and metronidazole: an often forgotten but significant drug interaction.
Topics: Anti-Bacterial Agents; Antineoplastic Agents, Alkylating; Busulfan; Child; Clostridioides difficile; | 2011 |
Pneumatosis intestinalis in children with leukaemia; report of three cases.
Topics: Adolescent; Child, Preschool; Female; Humans; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Metronid | 1981 |
Amebiasis after bone marrow transplantation.
Topics: Adult; Animals; Bone Marrow Transplantation; Dysentery, Amebic; Humans; Leukemia, Myeloid, Acute; Ma | 1994 |
[Clostridium difficile bacteremia].
Topics: Aged; Anti-Bacterial Agents; Antineoplastic Agents; Bacteremia; Clostridioides difficile; Enterocoli | 2001 |
Letter: Mucosal ulcers and anaerobic organisms.
Topics: Adult; Anaerobiosis; Bacteria; Clindamycin; Humans; Leukemia, Myeloid, Acute; Metronidazole; Mouth M | 1975 |
Convulsions and encephalopathy in a patient with leukemia after treatment with metronidazole.
Topics: Adult; Brain Diseases; Epilepsy; Female; Humans; Leukemia, Myeloid, Acute; Metronidazole | 1985 |