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metronidazole and Asthma

metronidazole has been researched along with Asthma in 5 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"Afebrile seizures associated with rotavirus gastroenteritis, respiratory syncytial virus bronchiolitis, influenza infection, asthma, blood transfusions, and intake of a number of drugs (including theophylline, cephalosporins, metronidazole, and acyclovir) with therapeutic drug levels are uncommonly encountered in clinical practice."4.85Common causes of uncommon seizures. ( Boustany, RM; El-Bitar, MK, 2009)
"Perturbation of commensal bacteria by antibiotic exposure aggravates ovalbumin (OVA)-induced allergic asthma in pre-weaning mice."3.88Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice. ( Chen, Y; Huang, C; Sun, R; Tian, Z; Wang, J; Wei, H; Zheng, X; Zhou, R, 2018)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Huang, C1
Wang, J1
Zheng, X1
Chen, Y1
Zhou, R1
Wei, H1
Sun, R1
Tian, Z1
El-Bitar, MK1
Boustany, RM1
Kumar, P1
Parashette, KR1
Noronha, P1
Selgrad, M1
Bornschein, J1
Malfertheiner, P1
Barbato, A1
Panizzolo, C1
Landi, L1
Semenzato, R1
Rugge, M1

Reviews

2 reviews available for metronidazole and Asthma

ArticleYear
Common causes of uncommon seizures.
    Pediatric neurology, 2009, Volume: 41, Issue:2

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antiviral Agents; Asthma; Brain; Bronchiolitis; Child;

2009
[Helicobacter pylori: an infection with local complications and systemic effects].
    Deutsche medizinische Wochenschrift (1946), 2011, Volume: 136, Issue:36

    Topics: Amoxicillin; Anemia, Iron-Deficiency; Anti-Bacterial Agents; Asthma; Clarithromycin; Cross-Sectional

2011

Other Studies

3 other studies available for metronidazole and Asthma

ArticleYear
Commensal bacteria aggravate allergic asthma via NLRP3/IL-1β signaling in post-weaning mice.
    Journal of autoimmunity, 2018, Volume: 93

    Topics: Animals; Animals, Newborn; Anti-Bacterial Agents; Asthma; Bronchoalveolar Lavage Fluid; Disease Mode

2018
Letter: Perioral dermatitis in a child associated with an inhalation steroid.
    Dermatology online journal, 2010, Apr-15, Volume: 16, Issue:4

    Topics: Administration, Inhalation; Adolescent; Albuterol; Androstadienes; Anti-Asthmatic Agents; Asthma; Cl

2010
Asthma-like syndrome in a teenager.
    Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology, 2003, Volume: 14, Issue:5

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adolescent; Albuterol; Amoxicillin; Androstadienes; Anti-Ba

2003