metronidazole has been researched along with Thrombocytopenia in 7 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Thrombocytopenia: A subnormal level of BLOOD PLATELETS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neutropenia was ameliorated with use of granulocyte colony-stimulating factor." | 5.37 | Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease. ( Alkim, C; Alkim, H; Altinkaya, E; Boğa, S; Buğdaci, MS; Köksal, AR; Özdoğan, O; Sökmen, M, 2011) |
| "Malaria has been associated with acute acalculous cholecystitis, a very uncommon complication in children." | 2.58 | Acalculous Cholecystitis in a Pediatric Patient With Plasmodium Falciparum Infection: A Case Report and Literature Review. ( Aguilera-Alonso, D; Del Rosal, T; Escosa-García, L; García-Hortelano, M; López Medina, EM; Villota Arrieta, J, 2018) |
| "Metronidazole is known to cause hematologic adverse effects, including a reversible mild neutropenia; in rare circumstances, thrombocytopenia has been associated with metronidazole treatment." | 1.56 | A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use. ( Koura, D; Sam, AM; Saunders, IM; Taplitz, R, 2020) |
| "Neutropenia was ameliorated with use of granulocyte colony-stimulating factor." | 1.37 | Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease. ( Alkim, C; Alkim, H; Altinkaya, E; Boğa, S; Buğdaci, MS; Köksal, AR; Özdoğan, O; Sökmen, M, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Aguilera-Alonso, D | 1 |
| López Medina, EM | 1 |
| Del Rosal, T | 1 |
| Villota Arrieta, J | 1 |
| Escosa-García, L | 1 |
| García-Hortelano, M | 1 |
| Sam, AM | 1 |
| Saunders, IM | 1 |
| Taplitz, R | 1 |
| Koura, D | 1 |
| Köksal, AR | 1 |
| Alkim, C | 1 |
| Altinkaya, E | 1 |
| Buğdaci, MS | 1 |
| Özdoğan, O | 1 |
| Boğa, S | 1 |
| Alkim, H | 1 |
| Sökmen, M | 1 |
| Stewart, DJ | 1 |
| Benoit, B | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Dennery, J | 1 |
| Russell, N | 1 |
| Peterson, E | 1 |
| Grahovac, Z | 1 |
| Belanger, G | 1 |
| Maroun, JA | 1 |
| Sucak, GT | 1 |
| Yagoci, M | 1 |
| Karakan, T | 1 |
| Haznedar, R | 1 |
| Ambroise-Thomas, P | 1 |
| Meyer, HA | 1 |
| Dobrzańska, A | 1 |
| Ordyński, J | 1 |
1 review available for metronidazole and Thrombocytopenia
| Article | Year |
|---|---|
Acalculous Cholecystitis in a Pediatric Patient With Plasmodium Falciparum Infection: A Case Report and Literature Review.
Topics: Acalculous Cholecystitis; Acute Kidney Injury; Administration, Intravenous; Anti-Bacterial Agents; A | 2018 |
6 other studies available for metronidazole and Thrombocytopenia
| Article | Year |
|---|---|
A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use.
Topics: Anemia, Aplastic; Anti-Bacterial Agents; Humans; Metronidazole; Thrombocytopenia | 2020 |
Infliximab- and azathioprine-related severe neutropenia and thrombocytopenia in a case with Crohn's disease.
Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Antibodies, Monoclonal; Azathioprine; Crohn | 2011 |
Treatment of malignant gliomas in adults with BCNU plus metronidazole.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Carmustine; Female; Gliobl | 1984 |
Unusual presentation of amebic liver abscess with thrombocytopenia and splenomegaly.
Topics: Adolescent; Animals; Anti-Bacterial Agents; Drainage; Entamoeba histolytica; Humans; Liver Abscess, | 2001 |
[Hepatic amebiasis in the Kilimanjaro region. Serodiagnosis on micro-specimens of dried blood and attempts at treatment with tinidazole (fasigyn)].
Topics: Adult; Aged; Alkaline Phosphatase; Emetine; Female; Fluorescent Antibody Technique; Hand; Humans; Li | 1975 |
[Thrombocytopenia associated with lambliasis].
Topics: Child; Giardiasis; Humans; Male; Metronidazole; Thrombocytopenia | 1965 |