An idiopathic, rapidly evolving, and severely debilitating disease occurring most commonly in association with chronic ulcerative colitis. It is characterized by the presence of boggy, purplish ulcers with undermined borders, appearing mostly on the legs. The majority of cases are in people between 40 and 60 years old. Its etiology is unknown.
| Excerpt | Reference |
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| "Pyoderma gangrenosum is strongly associated with inflammatory bowel disease and exhibits pathergy, occurring at sites of previous minor trauma." | ( Brookes, C; Dwarakanath, AD; Pryce, D; Rhodes, JM; Yu, LG, 1995) |
| "Pyoderma gangrenosum is an uncommon chronic skin disease characterized by rapidly enlarging cutaneous ulcers." | ( Límová, M; Mauro, T, 1994) |
| "Pyoderma gangrenosum is a chronic ulceronecrotic inflammatory cutaneous disorder that can be associated with diseases such as rheumatoid arthritis (RA)." | ( Jiménez-Balderas, FJ; Martínez-Osuna, P; Mintz, G; Zonana-Nacach, A, 1994) |
| "Parastomal pyoderma gangrenosum is uncommon and its association with inflammatory bowel disease is unclear." | ( Hughes, LE; Tjandra, JJ, 1994) |
| "Pyoderma gangrenosum is an uncommon ulcerative skin disorder that occurs in all age groups." | ( Esterly, NB; Graham, JA; Hansen, KK; Rabinowitz, LG, 1994) |
| "Pyoderma gangrenosum is rare, and treatment is non-surgical." | ( Brown, RE; Graham, D; Lay, L, 1993) |
| "Pyoderma gangrenosum is a rare cutaneous disorder that may complicate recovery after a cardiac operation." | ( Olerud, JE; Rand, RP; Verrier, ED, 1993) |
| "Pyoderma gangrenosum is a dermatological disease of unknown origin." | ( Arpurt, JP; Bartel, HR; Bodock, I; Caroli-Bosc, FX; Delmont, JP; Dumas, R; Harris, AG; Hastier, P; Maes, B; Taillan, B, 1996) |
| "Pyoderma gangrenosum is an uncommon skin disease usually treated with systemic drugs, most frequently corticosteroids." | ( Brenner, S; Landau, M; Tamir, A, 1996) |
| "Pyoderma gangrenosum is an ulcerative skin condition of unknown cause." | ( Teitel, AD, 1996) |
| "Pyoderma gangrenosum is a chronic inflammatory ulcerative skin disease of unknown etiology, often associated with various systemic disorders such as inflammatory bowel disease, rheumatoid arthritis, chronic active hepatitis, diabetes mellitus and hematologic malignancies." | ( De Dobbeleer, G; Heenen, M; Vereecken, P; Wautrecht, JC, 1997) |
| "Pyoderma gangrenosum is a destructive, ulcerative skin condition often associated with systemic illnesses such as inflammatory bowel disease, myeloproliferative disorders, and the inflammatory arthritides." | ( Carp, JM; Das, K; Gottlieb, AB; Onuma, E, 1997) |
| "Pyoderma gangrenosum is a rare ulcerating inflammatory skin disease." | ( Alli, N; Artüz, F; Güngör, E; Karakayali, G; Lenk, N, 1999) |
| "Pyoderma gangrenosum is an unusual neutrophilic dermatosis associated to different rheumatologic, haematologic and inflammatory bowel diseases which generally responds to the therapy of the underlying disease." | ( Carrasco, FJ; Domínguez Macías, A; Ferrer Ríos, T; Garrido Mora, M; Pallarés Manrique, H; Pérez Gómez, MB; Ramos Lora, M, 1999) |
| "Pyoderma gangrenosum is a neutrophilic dermatosis of unknown aetiology." | ( Domingo, A; Jucgla, A; Podzamczer, D; Rufi, G; Vadillo, M, 1999) |
| "Pyoderma gangrenosum is a destructive cutaneous disease characterised by progressive painful ulceration." | ( Bunker, C; Jain, A; Nanchahal, J, 2000) |
| "Pyoderma gangrenosum is an unusual cause of skin necrosis following surgery, particularly in those without an associated systemic condition." | ( Frame, JD; MacKenzie, D; Moiemen, N, 2000) |
| "Pyoderma gangrenosum is a painful, noninfectious, ulcerating skin disorder often associated with systemic disease." | ( Federman, DG; Federman, GL, 2000) |
| "Pyoderma gangrenosum is a rare, destructive, neutrophilic dermatosis, the origin of which remains largely obscure." | ( de Imus, G; Falanga, V; Golomb, C; Nowak, M; Tsoukas, M; Wilkel, C, 2001) |
| "Pyoderma gangrenosum is an uncommon ulcerative condition associated with inflammatory bowel disease, arthritis, and hematologic disease." | ( King , KW; Murray , A, 2000) |
| "Pyoderma gangrenosum is a potential life-threatening complication that must be considered in patients with severely impaired wound healing after cardiac operation." | ( Rothenburger, M; Scheld, HH; Schmid, C; Schmidt, C; Schwarz, T; Tjan, TD, 2001) |
| "Pyoderma gangrenosum is a distinct clinical entity characterized by chronic, recurring, destructive ulcerations." | ( Breuer, C; Kapp, A; Kiehl, P; Petering, H; Werfel, T, 2001) |
| "Pyoderma gangrenosum is a rapidly developing cutaneous ulcer that is rare in the hand and may mimic a fulminating infection." | ( de La Paz, EM; Ellis, PR; Huish, SB; Stern, PJ, 2001) |
| "Post-traumatic pyoderma gangrenosum is an ulceronecrotizing dermatosis that is rare and therefore often misinterpreted." | ( Born, S; Marsch, WC, 2001) |
| "Pyoderma gangrenosum is an ulcerative disease of the skin of unknown cause and generally associated to systemic illnesses." | ( Amaro, P; Aranibar, L; López de Maturana, D; Segovia, L, 2001) |
| "Pyoderma gangrenosum is used as the basis for applying the new pain standards." | ( Dunwoody, CJ; McCann, SA; Zumbo, M, 2000) |
| "Pyoderma gangrenosum is a noninfectious neutrophilic dermatosis that usually starts with sterile pustules which rapidly progress to painful ulcers of variable depth and size with undermined violaceous borders." | ( Wollina, U, 2002) |
| "Although pyoderma gangrenosum is a disorder known since over 70 years, it still remains a diagnostic and therapeutic problem." | ( Brzezińska-Wcisło, L; Kamińska-Budzińska, G; Krauze, E; Lis, A; Pierzchała, E; Wygledowska-Kania, M, 2002) |
| "Pyoderma gangrenosum is potentially a devastating and destructive disorder." | ( Evans, B; Holt, PJ; Patel, GK; Rhodes, JR, 2004) |
| "Pyoderma gangrenosum is a rare idiopathic skin disorder associated with other diseases, including inflammatory bowel disease." | ( Khurrum Baig, M; Marquez, H; Nogueras, JJ; Weiss, EG; Wexner, SD, 2004) |
| "Pyoderma gangrenosum is a difficult problem to manage and its early resolution is important." | ( Khurrum Baig, M; Marquez, H; Nogueras, JJ; Weiss, EG; Wexner, SD, 2004) |
| "Pyoderma gangrenosum is a rare ulcerative skin disorder mainly occurring in adults." | ( Desnoes, R; East-Innis, A; Gilbert, D; Shirley, S; Thame, K, 2005) |
| "Pyoderma gangrenosum is a chronic, noninfectious, ulcerating cutaneous disease of unknown etiology usually presenting with multiple lesions on the legs and trunk." | ( Glorer, E; Goerdt, S; Klemke, CD; Poenitz, N; Tadler, D, 2005) |
| "Pyoderma gangrenosum is a reactive inflammatory dermatosis which belongs to the spectrum of neutrophilic dermatoses." | ( Alomar, A; Busquets, D; Corella, F; Dalmau, J; Delgado, E; García-Navarro, X; Monfort, D; Ribé, A; Roé, E, 2006) |
| "Pyoderma gangrenosum is a rare autoimmune disorder that can affect the eye." | ( Baltatzis, S; Foster, CS; Teasley, LA, 2007) |
| "Pyoderma gangrenosum is an uncommon ulcerative cutaneous disorder." | ( Chahine, B; Chenivesse, C; Delaporte, E; Grignet, JP; Scherpereel, A; Tillie-Leblond, I; Tonnel, AB, 2007) |
| "Pyoderma gangrenosum is a rare, chronic, progressive and noninfectious necrosis of skin with an unclear etiology." | ( Dziankowska-Bartkowiak, B; Jurałowicz, P; Kondras, K; Kondras, M; Modzelewski, B; Torzecka, JD; Waszczykowska, E, 2008) |
| "Pyoderma gangrenosum is a dermatologic manifestation of systemic disease such as inflammatory bowel disease, monoclonal gammopathy, arthritis, malignancies, and Behçet's disease." | ( Kim, DW; Lee, BI; Park, SH, 2008) |
| "Pyoderma gangrenosum is an ulcerative skin disease with variable clinical outcomes." | ( Frank, J; Henquet, CJ; Nellen, RG; Parren, LJ; Poblete-Gutiérrez, P; van Marion, AM, 2008) |
| "Pyoderma gangrenosum is a neutrophilic dermatosis in which systemic involvement is rare." | ( Boccara, O; Brahimi, N; Crickx, B; Descamps, V; Hersent, B; Lecaille, C; Marinho, E; Maubec, E; Picard-Dahan, C; Sebban, V; Valeyrie-Allanore, L, 2009) |
| "Pyoderma gangrenosum is an ulcerative condition that may be associated with inflammatory bowel disease or inflammatory arthritis." | ( Callen, JP; Eaton, PA, 2009) |
| "The treatment of pyoderma gangrenosum is challenging as there is often only partial response to systemic glucocorticosteroids and immunosuppressive therapies." | ( Brenner, M; Herzer, P; Plewig, G; Ruzicka, T; Thomas, P, 2009) |
| "Pyoderma gangrenosum is a rare but significant cutaneous disease that can lead to skin ulceration and necrosis." | ( Bunker, CB; Ghattaura, A; Harris, PA; Henton, J; Jallali, N; James, SE; Rajapakse, Y; Searle, AE, 2010) |
| "Pyoderma gangrenosum is a rare disease characterized by chronic, nonhealing, noninfectious ulcers that can become exacerbated by trauma or manipulation, including surgical treatment." | ( Ferris, LK; Hawryluk, EB; Johnson, JT; Penn, SK; Wasko, MC, 2010) |
| "Pyoderma gangrenosum is a rare ulcerative disorder of the skin of unknown etiology." | ( Ikeuchi, M; Izumi, M; Kuriyama, M; Nakajima, H; Nakajima, N; Tani, T, 2011) |
| "Pyoderma gangrenosum is an inflammatory disease that has been found to be associated with many systemic illnesses." | ( Alegre-de-Miquel, V; Esteve-Martínez, A; García-Rabasco, AE; Sánchez-Carazo, JL; Zaragoza-Ninet, V, 2010) |
| "Pyoderma gangrenosum is a severe neutrophilic dermatosis that may occur as a complication following any kind of surgery." | ( Caux, I; de Thomasson, E, 2010) |
| "Pyoderma gangrenosum is a non-infectious neutro?philic skin disease commonly associated with underlying systemic diseases." | ( Akanay-Diesel, S; Bölke, E; Budach, W; Erhardt, A; Gerber, PA; Haes, J; Häussinger, D; Hoff, NP; Homey, B; Kürle, S; Matuschek, C; Schulte, KW, 2011) |
| "Pyoderma gangrenosum is a rare neutrophilic dermatosis that affects 4% of children." | ( Benchikhi, H; Bouayad, K; Chiheb, S; Hali, F; Khadir, K; Mikou, N, 2011) |
| "Pyoderma gangrenosum is a rarely diagnosed autoimmune disease which often occurs after physical trauma such as surgical interventions." | ( Al Ghazal, P; Dissemond, J, 2012) |
| "Atypical pyoderma gangrenosum is a rare variant of pyoderma gangrenosum that occurs on the upper extremities, presenting as a cutaneous ulcer." | ( Baniahmad, O; Cognetta, AB; Green, WH; Hatfield, HK; Wolfe, CM, 2012) |
| "Pyoderma gangrenosum is a rare dermatologic disorder that can occur on the vulva." | ( Belin, E; Kremp, A; Reed, BG; Shippey, S, 2013) |
| "Pyoderma gangrenosum is a rare disease distinguished by rapid progression of painful, necrolytic, cutaneous ulcers with irregular, violaceous undermined borders." | ( Burton, GG; Hambrook, LE; Simpson, DL, 2013) |
| "Pyoderma gangrenosum is a rare condition with few cases of eyelid involvement reported in the literature." | ( Al-Niaimi, F; Duff, CG; Leatherbarrow, B; Lyon, C; Thampy, RS, 2014) |
| "Pyoderma gangrenosum is a rare neutrophilic dermatosis, often associated with underlying systemic diseases." | ( Furlan, C; Mascarin, M; Minatel, E; Rumeileh, IA, 2014) |
| "Pyoderma gangrenosum is a rare inflammatory, ulcerative skin disease that mainly involves the lower extremities." | ( Ohtsuka, M; Yamamoto, T, 2014) |
| "Malignant pyoderma gangrenosum is a rare ulcerative variant of pyoderma gangrenosum (PG) involving the head and neck." | ( Ambooken, B; Khader, A; Muhammed, K; Rajan, U; Snigdha, O, 2014) |
| "Pyoderma gangrenosum is a chronic sterile skin disorder that is frequently seen in association with systemic disorders such as inflammatory bowel disease." | ( Colby, TV; Gotway, MB; Penupolu, S; Sakata, KK; Wesselius, LJ, 2016) |
| "Pyoderma gangrenosum is a non-infectious neutrophilic dermatosis that may be either idiopathic or associated with some underlying diseases like inflammatory bowel diseases, SLE, sarcoidosis, vasculitis etc." | ( Baloch, BK; Baloch, SK; Jawad, A; Kumar, S; Mansoor, F, 2014) |
| "Pyoderma gangrenosum is usually diagnosed in the third to sixth decade, but early debut in childhood is also described." | ( Andersen, AK; Bendstrup, E; Fogh, C; Gade, M; Hilberg, O; Studstrup, F, 2015) |
| "Pyoderma gangrenosum is associated with a concomitant systemic disease in 50 to 70 % of cases, including inflammatory bowel disease (IBD), rheumatoid arthritis, and lymphoproliferative disorders." | ( Androutsakos, T; Aroni, K; Hatzis, G; Stamopoulos, P, 2015) |
| "Pyoderma gangrenosum is an unusual cause of skin ulcerations that wound specialists must be prepared to recognize." | ( Pompeo, MQ, 2016) |
| "Pyoderma gangrenosum is a rare, ulcerative cutaneous condition that was first described by Brocq in 1916." | ( Al-Tarawneh, M; Bader, G; Cook, E; Pourmorteza, M; Shams, W; Tawadros, F; Young, M, 2016) |
| "Pyoderma gangrenosum is an inflammatory process of unknown etiology, and establishing the correct diagnosis can be a difficult task." | ( Al-Tarawneh, M; Bader, G; Cook, E; Pourmorteza, M; Shams, W; Tawadros, F; Young, M, 2016) |
| "Pyoderma gangrenosum is an unusual wounding disease that makes the diagnosis and manage- ment challenging." | ( Agarwal, P; Agarwal, US; Prakash, C; Sharma, P, 2017) |
| "Pyoderma gangrenosum is an intractable disease of unknown cause involving recurrent ulcerative lesions on the skin, and may accompany ulcerative colitis, rheumatoid arthritis, leukemia, systemic lupus erythematosus, and other conditions." | ( Akamatsu, T; Imagawa, K; Kumaki, N; Morioka, T; Niikura, N; Okamura, T; Suzuki, Y; Terao, M; Tokuda, Y; Tsuda, B; Yamada, E; Yokoyama, K, 2017) |
| "Pyoderma gangrenosum is an inflammatory, ulcerative, neutrophilic dermatosis that is clinically characterized by rapidly evolving, painful, necrotic skin lesions." | ( Anderl, W; Domej, MA; Heuberer, PR; Pauzenberger, L, 2017) |
| "Pyoderma gangrenosum is a chronic non-infectious neutrophilic dermatosis that causes undermining ulcers." | ( Hirata, Y; Natsuga, K; Nishimura, M; Sato, K; Shiiya, C; Shimizu, H; Tsukinaga, I; Ujiie, I; Yamaguchi, Y; Yanagi, T; Yoshimoto, N, 2018) |
| "Pyoderma gangrenosum is an inflammatory neutrophilic dermatosis." | ( Ashchyan, HJ; Butler, DC; James, WD; Lockwood, SJ; Micheletti, RG; Mostaghimi, A; Nelson, CA; Noe, MH; Rosenbach, M; Tsiaras, WG, 2018) |
| "Pyoderma gangrenosum is a neutrophilic dermatosis that is rare in infancy, with only 20 cases reported in the literature." | ( Crouse, L; McShane, D; Morrell, DS; Wu, EY, 2018) |
| "Pyoderma gangrenosum is most commonly treated with immunosuppressants or anti-inflammatory agents and is often worsened by surgical procedures due to the presence of pathergy." | ( Gordon, C; Hizon, BJ; Mota, JA; Nahm, WJ; Rojas, S, 2018) |
| "Generally, pyoderma gangrenosum is known to be common among patients with systemic diseases such as inflammatory bowel diseases, polyarthritis, diverticulosis, paraproteinaemia, myeloma, leukaemia, active chronic hepatitis, and Behcet syndrome." | ( Alajlan, A; AlTaleb, R, 2018) |
| "Treatment of pyoderma gangrenosum is often challenging with no standardized treatment protocols." | ( Cohen, GF; Om, A; Shaath, TS; Wolfe, CM, 2019) |
| "Pyoderma gangrenosum is a rare inflammatory skin condition and rarely presents as lesions of the eyelid." | ( Bromeo, AJ; Suller, A, 2019) |
| "Pyoderma gangrenosum is clinically diagnosed when subcutaneous chronic inflammatory findings are present without concurrent bacterial infection." | ( Habuchi, T; Honma, N; Inoue, T; Kanda, S; Kubo, K; Matsuda, Y; Nara, T; Narita, S; Numakura, K; Saito, M; Satoh, S; Takahashi, S; Yamamoto, R, 2019) |
| "Pyoderma gangrenosum is a rare autoinflammatory skin disease." | ( Cline, A; Feldman, SR; Glines, KR; Huang, WW; Jorizzo, JL; Muse, ME; Stiff, KM, 2020) |
| "Pyoderma gangrenosum is often misdiagnosed and can have deleterious consequences to the patient, as there is no gold standard treatment and it can be difficult to manage." | ( Bar-David, T; Fridman, R; Larsen, J; Olson, AR, 2020) |
| "Pyoderma gangrenosum is an uncommon ulcerative neutrophilic dermatosis." | ( Bech, R; Fogh, K; Schøsler, L, 2021) |
| "Pyoderma gangrenosum is a rare neutrophilic dermatosis that is commonly treated with systemic corticosteroids; however, their potent side effects may warrant tapering, and non-steroidal systemic immunosuppressants may help maintain or bolster disease clearance during weaning." | ( Bashyam, AM; Feldman, SR; Hrin, ML; Huang, WW, 2021) |
| "Pyoderma gangrenosum is characteristically associated with inflammatory bowel disease." | ( Álvarez-Salafranca, M; Bularca, EA; Espuelas-Monge, M; Lapeña-Casado, A; Rivera-Fuertes, I; Soria-Navarro, J, 2021) |
| "Posttraumatic pyoderma gangrenosum is a rare diagnosis." | ( Babst, R; Beeres, FJP; Bertschy, S; Hartmann, A; Link, BC, 2023) |
| "Pyoderma gangrenosum is a rare neutrophilic inflammatory skin disorder commonly seen over lower limbs." | ( A, S; Bhat, RM; Dandakeri, S; Fernandes, MS; Jayaraman, J, 2022) |
| "Pyoderma gangrenosum is a rare neutrophilic dermatosis that leads to exceedingly painful ulcerations of the skin." | ( Dissemond, J; Hampton, PJ; Marzano, AV; Ortega-Loayza, AG, 2023) |