metronidazole has been researched along with Benign Neoplasms in 111 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty cancer patients being treated with EGFRIs were included in the study." | 3.85 | Pimecrolimus cream 1% for the treatment of papulopustular eruption related to epidermal growth factor receptor inhibitors: a case series and a literature review of therapeutic approaches. ( Antoniou, C; Katsambas, A; Kiagia, M; Nikolaou, C; Nikolaou, V; Stratigos, A; Syrigos, K, 2010) |
| "When misonidazole (MISO) was introduced into clinical trials there were great expectations that the cure rate of many tumors would be dramatically increased." | 3.75 | Hypoxic cell radiosensitizers: expectations and progress in drug development. ( Coleman, CN, 1985) |
| "The authors conclude that although there was no increase in risk for all cancers associated with in utero exposure to metronidazole, the observed increased risk for neuroblastomas, although not significant, requires further evaluation." | 3.70 | Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years. ( Brockman Worrell, KG; Gideon, P; Mitchel, EF; Pais, R; Ray, WA; Roberson, P; Thapa, PB; Whitlock, JA, 1998) |
| " Teratogenicity tests in animals have given negative results in the case of metronidazole, ornidazole and tinidazole, and in the case of metronidazole no evidence of any adverse effect on the outcome of pregnancy was seen in women treated for trichomoniasis at various times during gestation, including the first trimester." | 3.67 | Safety of nitroimidazoles. ( Roe, FJ, 1985) |
| "Metronidazole was administered in 5/54 events (9." | 3.01 | Chemotherapy-induced diarrhoea in dogs and its management with smectite: Results of a monocentric open-label randomized clinical trial. ( Bavcar, S; Fournier, Q; Serra, JC; Williams, C, 2021) |
| "So a study was undertaken in various cancer patients to observe the role of metrnidazole as a selective radiosensitizer." | 2.67 | Role of metronidazole in radiation therapy (a review of 717 cancer cases). ( Acharya, DK, 1994) |
| "Metronidazole (MTZ) is a synthetic derivative of nitroimidazole that has been widely used for the treatment of several bacterial and parasitic infections including trichomoniasis, amoebiasis, giardiasis, liver abscess, gingivitis, syphilis and phagedena." | 2.58 | Association of Metronidazole with Cancer: A Potential Risk Factor or Inconsistent Deductions? ( Adil, M; Adnan, F; Ahmad, S; Ahmed, J; Iqbal, W; Kamal, MA; Khan, I; Khan, IN; Khayam, MU; Wazir, S, 2018) |
| "Malignant wounds are a devastating complication of cancer." | 2.55 | Systemic antibiotics for treating malignant wounds. ( Cronin, P; Hayden, F; Ramasubbu, DA; Smith, V, 2017) |
| "Some ulcerative colitis patients develop complications after IPAA and are subsequently diagnosed with Crohn's disease." | 2.41 | Complications after ileal pouch-anal anastomosis. ( Lichtenstein, GR; Stein, RB, 2000) |
| "Three drugs have been advocated for the treatment of giardiasis; furazolidone (Furoxone), metronidazole (Flagyl), and quinacrine (Atabrine)." | 2.36 | Treatment of giardiasis: literature review and recommendations. ( Lerman, SJ; Walker, RA, 1982) |
| " Nonetheless, there is a lack in pharmacokinetics information for this population, and dosing criteria may vary between healthcare centers." | 1.91 | Model-informed precision dosing of antimicrobial drugs in pediatrics: experiences from a pilot scale program. ( Arriaga-García, FJ; Medellín-Garibay, SE; Milán-Segovia, RDC; Pérez-González, LF; Rodríguez-Báez, AS; Romano-Moreno, S; Velarde-Salcedo, R, 2023) |
| "Epidemiology of Clostridioides difficile infection (CDI) in paediatric cancer patients is uncertain." | 1.72 | Clostridioides difficile infection in paediatric patients with cancer and haematopoietic stem cell transplant recipients. ( Aftandilian, CC; Agyeman, PKA; Castagnola, E; Chirra, KM; Dupuis, LL; Groll, AH; Haeusler, GM; Lehrnbecher, T; Loves, R; Phillips, B; Schneider, C; Sung, L; van de Wetering, M, 2022) |
| "To improve the efficiency of cancer treatment, the multifunctional nanocomposites MGO/FU-MI (MGO/FU-MI NCs) were used for combination chemotherapy and radiotherapy to verify its effectiveness in treating tumors." | 1.56 | Multifunctional nanocomposites MGO/FU-MI inhibit the proliferation of tumor cells and enhance the effect of chemoradiotherapy in vivo and in vitro. ( Dai, W; Kong, X; Peng, X; Quan, H; Xiang, Y; Yang, C, 2020) |
| "Forty-five (11%) experienced a recurrence." | 1.51 | Risk Factors for Recurrent Community-associated Clostridiodes Difficile Infection in Children. ( Alabaster, A; Dang, R; Greenhow, TL; Miranda-Katz, M; Parmar, D, 2019) |
| "Clostridium difficile infection is considered a major cause of nosocomial diarrhoea in developed countries and is increasingly becoming more important as an etiologic agent of community diarrhoea, also in patients without risk factors." | 1.40 | [Epidemiology of Clostridium difficile-associated disease (CDAD) in Salamanca]. ( Calvo-García, N; de Frutos-Serna, M; García-Sánchez, JE; Hernández-Egido, S; María-Blázquez, A; Siller-Ruiz, M, 2014) |
| "We studied the late incidence of cancer after metronidazole use among persons enrolled in the Group Health Cooperative of Puget Sound, Seattle, a health maintenance organization." | 1.30 | Late incidence of cancer after metronidazole use: a matched metronidazole user/nonuser study. ( Falagas, ME; Griffith, J; Jick, H; Ruthazer, R; Snydman, DR; Walker, AM, 1998) |
| "A reported excess of liver tumors in rats exposed to metronidazole can be explained by the fact that the authors failed to age standardize their data despite a big and highly significant beneficial effect of the drug on survival." | 1.27 | Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential. ( Roe, FJ, 1983) |
| "Metronidazole, 1." | 1.27 | Feasibility study of combining metronidazole with chemotherapy. ( Bélanger, R; Crook, AF; Heringer, R; Hopkins, HS; Hugenholtz, H; Maroun, JA; Richard, MT; Stewart, DJ; Yan, RC; Young, V, 1983) |
| "We assessed the risk of occurrence of cancer associated with exposure to metronidazole in the 771 female residents of Rochester, Minnesota, who were treated with metronidazole for vaginal trichomoniasis during the period 1960 through 1969 and were followed up for a total of 12,628 person-years." | 1.27 | Cancer after exposure to metronidazole. ( Beard, CM; Dahlin, DC; Kurland, LT; Noller, KL; O'Fallon, WM, 1988) |
| "Metronidazole was administered orally to 25 patients and its maximum concentration in blood and tumor tissues, its ability to cross the blood/brain barrier and concentrate in the cerebrospinal fluid and brain tumor tissue, its immediate and long-term toxicity, and its enhancement of irradiation in normal tissue were studied." | 1.25 | Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells. ( Band, P; Chapman, JD; Fryer, CG; Rabin, HR; Sturmwind, J; Urtasun, RC, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 71 (63.96) | 18.7374 |
| 1990's | 15 (13.51) | 18.2507 |
| 2000's | 4 (3.60) | 29.6817 |
| 2010's | 13 (11.71) | 24.3611 |
| 2020's | 8 (7.21) | 2.80 |
| Authors | Studies |
|---|---|
| Helguera, AM | 1 |
| Cordeiro, MN | 1 |
| Pérez, MA | 1 |
| Combes, RD | 1 |
| González, MP | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 2 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 2 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Ali, EMH | 1 |
| Abdel-Maksoud, MS | 1 |
| Oh, CH | 1 |
| Haeusler, GM | 1 |
| Lehrnbecher, T | 1 |
| Agyeman, PKA | 1 |
| Loves, R | 1 |
| Castagnola, E | 1 |
| Groll, AH | 1 |
| van de Wetering, M | 1 |
| Aftandilian, CC | 1 |
| Phillips, B | 1 |
| Chirra, KM | 1 |
| Schneider, C | 1 |
| Dupuis, LL | 1 |
| Sung, L | 1 |
| Edwards, PT | 1 |
| Thurm, CW | 1 |
| Hall, M | 1 |
| Busing, JD | 1 |
| Kahn, SA | 1 |
| Kellermayer, R | 1 |
| Kociolek, LK | 1 |
| Oliva-Hemker, MM | 1 |
| Sammons, JS | 1 |
| Weatherly, M | 1 |
| Edwards, KM | 1 |
| Nicholson, MR | 1 |
| Yang, L | 1 |
| Afshari, MJ | 1 |
| Ge, J | 1 |
| Kou, D | 1 |
| Chen, L | 1 |
| Zhou, D | 1 |
| Li, C | 1 |
| Zeng, J | 1 |
| Zhong, J | 1 |
| Stauber, RH | 1 |
| Gao, M | 1 |
| Gao, C | 1 |
| Wang, X | 1 |
| Yang, B | 1 |
| Yuan, W | 1 |
| Huang, W | 1 |
| Wu, G | 1 |
| Ma, J | 1 |
| Velarde-Salcedo, R | 1 |
| Pérez-González, LF | 1 |
| Rodríguez-Báez, AS | 1 |
| Arriaga-García, FJ | 1 |
| Milán-Segovia, RDC | 1 |
| Romano-Moreno, S | 1 |
| Medellín-Garibay, SE | 1 |
| Parmar, D | 1 |
| Dang, R | 1 |
| Miranda-Katz, M | 1 |
| Alabaster, A | 1 |
| Greenhow, TL | 1 |
| Al-Arjeh, G | 1 |
| Shamieh, O | 1 |
| Al-Ajarmeh, S | 1 |
| Salmany, S | 1 |
| Naberhuis, JK | 1 |
| Hui, D | 1 |
| Peng, X | 1 |
| Yang, C | 1 |
| Kong, X | 1 |
| Xiang, Y | 1 |
| Dai, W | 1 |
| Quan, H | 1 |
| Fournier, Q | 1 |
| Serra, JC | 1 |
| Williams, C | 1 |
| Bavcar, S | 1 |
| Ramasubbu, DA | 1 |
| Smith, V | 1 |
| Hayden, F | 1 |
| Cronin, P | 1 |
| Adil, M | 1 |
| Iqbal, W | 1 |
| Adnan, F | 1 |
| Wazir, S | 1 |
| Khan, I | 1 |
| Khayam, MU | 1 |
| Kamal, MA | 1 |
| Ahmad, S | 1 |
| Ahmed, J | 1 |
| Khan, IN | 1 |
| Siller-Ruiz, M | 1 |
| Calvo-García, N | 1 |
| Hernández-Egido, S | 1 |
| María-Blázquez, A | 1 |
| de Frutos-Serna, M | 1 |
| García-Sánchez, JE | 1 |
| García-Lozano, T | 1 |
| Aznar-Oroval, E | 1 |
| Martín-Utrilla, S | 1 |
| Copp, JN | 1 |
| Mowday, AM | 1 |
| Williams, EM | 1 |
| Guise, CP | 1 |
| Ashoorzadeh, A | 1 |
| Sharrock, AV | 1 |
| Flanagan, JU | 1 |
| Smaill, JB | 1 |
| Patterson, AV | 1 |
| Ackerley, DF | 1 |
| Nikolaou, V | 1 |
| Stratigos, A | 1 |
| Antoniou, C | 1 |
| Kiagia, M | 1 |
| Nikolaou, C | 1 |
| Katsambas, A | 1 |
| Syrigos, K | 1 |
| Giglio, J | 2 |
| Fernández, S | 2 |
| Rey, A | 1 |
| Cerecetto, H | 2 |
| Splith, K | 1 |
| Bergmann, R | 1 |
| Pietzsch, J | 1 |
| Neundorf, I | 1 |
| Rey, AM | 1 |
| McCormack, E | 1 |
| Silden, E | 1 |
| West, RM | 1 |
| Pavlin, T | 1 |
| Micklem, DR | 1 |
| Lorens, JB | 1 |
| Haug, BE | 1 |
| Cooper, ME | 1 |
| Gjertsen, BT | 1 |
| LOCK, FR | 1 |
| LYNG, J | 1 |
| WALL, JA | 1 |
| KAUFMAN, RH | 1 |
| CONNERS, JS | 1 |
| Pu, RT | 1 |
| Rosenthal, DL | 1 |
| Mekrut-Barrows, C | 1 |
| Nori, D | 1 |
| Kim, JH | 1 |
| Hilaris, BS | 1 |
| Chu, F | 1 |
| Setchell, KD | 1 |
| Lawson, AM | 1 |
| Borriello, SP | 1 |
| Harkness, R | 1 |
| Gordon, H | 1 |
| Morgan, DM | 1 |
| Kirk, DN | 1 |
| Adlercreatz, H | 1 |
| Anderson, LC | 1 |
| Axelson, M | 1 |
| Ashford, R | 1 |
| Plant, G | 1 |
| Maher, J | 1 |
| Teare, L | 1 |
| Moldenhauer, H | 1 |
| Rose, H | 1 |
| Saul, G | 1 |
| Wolf, G | 1 |
| Kehrberg, G | 1 |
| Roe, FJ | 2 |
| Tsyb, AF | 1 |
| Konopliannikov, AG | 2 |
| Kudriavtseva, GT | 2 |
| Goldobenko, GV | 2 |
| Kherkheulidze, ZSh | 1 |
| Shchebetenko, IuE | 1 |
| Polotskiĭ, BE | 1 |
| Kiseleva, ES | 3 |
| Dar'ialova, SL | 3 |
| Stewart, DJ | 2 |
| Maroun, JA | 1 |
| Young, V | 1 |
| Crook, AF | 1 |
| Hopkins, HS | 1 |
| Yan, RC | 1 |
| Richard, MT | 1 |
| Hugenholtz, H | 1 |
| Bélanger, R | 1 |
| Heringer, R | 1 |
| Pfeffer, MR | 1 |
| Sulkes, A | 1 |
| Peretz, TY | 1 |
| Fuks, Z | 1 |
| Catane, R | 1 |
| Konopljannikow, AG | 1 |
| Falk, RE | 1 |
| Moffat, FL | 1 |
| Calhoun, K | 1 |
| Dreznik, Z | 1 |
| Makowka, L | 1 |
| Ambus, U | 1 |
| Langer, J | 1 |
| Howard, V | 1 |
| Rotstein, L | 1 |
| Falk, JA | 1 |
| Baĭsogolov, GD | 1 |
| Berdov, BA | 1 |
| Haneke, E | 1 |
| Gebhart, E | 1 |
| Magdon, E | 1 |
| Lerman, SJ | 1 |
| Walker, RA | 1 |
| Danielson, DA | 1 |
| Hannan, MT | 1 |
| Jick, H | 2 |
| Volenec, K | 1 |
| Vrastilová, P | 1 |
| Vodicka, I | 1 |
| Chvojka, Z | 1 |
| Urtasun, RC | 3 |
| Band, P | 2 |
| Ferri, H | 1 |
| Singh, DR | 1 |
| Krishnan, D | 1 |
| Bostofte, E | 1 |
| Bak, JF | 1 |
| Høier, R | 1 |
| Andersen, M | 1 |
| Binderup, ML | 1 |
| Kiel, P | 1 |
| Larsen, H | 1 |
| Friedman, GD | 2 |
| Mirer, FE | 1 |
| Silverstein, MA | 1 |
| Haas, JF | 1 |
| Carmichael, DH | 1 |
| Melious, N | 1 |
| el Azzouni, MZ | 1 |
| el Badry, AM | 1 |
| Acharya, DK | 1 |
| Spikes, JD | 1 |
| Bommer, JC | 1 |
| Finlay, IG | 1 |
| Bowszyc, J | 1 |
| Ramlau, C | 1 |
| Gwiezdzinski, Z | 1 |
| Cripps, MC | 1 |
| Goel, R | 1 |
| Dahrouge, S | 1 |
| Yau, J | 1 |
| Tomiak, E | 1 |
| Huan, S | 1 |
| Soltys, K | 1 |
| Prosser, A | 1 |
| Davies, RA | 1 |
| Falagas, ME | 1 |
| Walker, AM | 1 |
| Ruthazer, R | 1 |
| Griffith, J | 1 |
| Snydman, DR | 1 |
| Thapa, PB | 1 |
| Whitlock, JA | 1 |
| Brockman Worrell, KG | 1 |
| Gideon, P | 1 |
| Mitchel, EF | 1 |
| Roberson, P | 1 |
| Pais, R | 1 |
| Ray, WA | 1 |
| Berbel-Tornero, O | 1 |
| López-Andreu, JA | 1 |
| Ferris-Tortajada, J | 1 |
| Stein, RB | 1 |
| Lichtenstein, GR | 1 |
| Matuchansky, C | 1 |
| Willson, RL | 5 |
| Karim, AB | 1 |
| Sutherland, RM | 1 |
| Durand, RE | 1 |
| Baines, EJ | 1 |
| Chapman, JD | 3 |
| Fowler, JF | 3 |
| Bahnemann, D | 1 |
| Basaga, H | 1 |
| Dunlop, JR | 1 |
| Searle, AJ | 2 |
| Phillips, TL | 1 |
| Arnott, SJ | 1 |
| Kaplan, HS | 1 |
| Munzenrider, JE | 1 |
| Beard, CM | 2 |
| Noller, KL | 2 |
| O'Fallon, WM | 2 |
| Kurland, LT | 2 |
| Dockerty, MB | 1 |
| Kimler, BF | 1 |
| McDonald, T | 1 |
| Cheng, CC | 1 |
| Podrebarac, EG | 1 |
| Mansfield, CM | 1 |
| Foster, JL | 2 |
| Stratford, IJ | 1 |
| Adams, GE | 2 |
| Coulter, JR | 1 |
| Turner, JV | 1 |
| Minnich, V | 1 |
| Smith, ME | 1 |
| Thompson, D | 1 |
| Kornfeld, S | 1 |
| Hofer, KG | 1 |
| Hofer, MG | 1 |
| Ieracitano, J | 1 |
| McLaughlin, WH | 1 |
| Voronina, SS | 1 |
| Pelevina, II | 1 |
| Denekamp, J | 1 |
| Deutsch, G | 1 |
| McFadzean, JA | 1 |
| Parnell, M | 1 |
| Rabin, HR | 1 |
| Fryer, CG | 1 |
| Sturmwind, J | 1 |
| Setekleiv, J | 1 |
| Borchgrevink, CH | 1 |
| Bower, M | 1 |
| Stein, R | 1 |
| Evans, TR | 1 |
| Hedley, A | 1 |
| Pert, P | 1 |
| Coombes, RC | 1 |
| Hentschel, M | 1 |
| Schmidt, W | 1 |
| Dean, MM | 1 |
| Selby, JV | 1 |
| Coleman, CN | 1 |
| Dische, S | 1 |
| Dahlin, DC | 1 |
| Poliakov, PIu | 1 |
| Zimina, ES | 1 |
| Zel'vin, BM | 1 |
| Wideröe, R | 1 |
| Kvasov, VA | 1 |
| Pitskhelauri, VG | 1 |
| Sukirko, VA | 1 |
| Cyb, AF | 1 |
| Chmelevskaja, ZI | 1 |
| Kudrjavceva, GT | 1 |
| Pittman, FE | 1 |
| Pittman, JC | 1 |
18 reviews available for metronidazole and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Thieno[2,3-d]pyrimidine as a promising scaffold in medicinal chemistry: Recent advances.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Chemistry, Ph | 2019 |
Systemic antibiotics for treating malignant wounds.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Double-Blind Method; Humans; Metronidazole; Neoplasms; | 2017 |
Association of Metronidazole with Cancer: A Potential Risk Factor or Inconsistent Deductions?
Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Humans; Metronidazole; Neoplasms | 2018 |
Pimecrolimus cream 1% for the treatment of papulopustular eruption related to epidermal growth factor receptor inhibitors: a case series and a literature review of therapeutic approaches.
Topics: Aged; Antineoplastic Agents; Dermatologic Agents; Drug Eruptions; ErbB Receptors; Female; Humans; Ma | 2010 |
[Modification of the radiation effects for overcoming radiation-resistant hypoxic tumor tissue].
Topics: Amifostine; Animals; Central Nervous System Diseases; Dogs; Humans; Hyperthermia, Induced; In Vitro | 1983 |
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
[Electron acceptor compounds as radiation sensitizers of hypoxic cells in human tumors].
Topics: Brain Neoplasms; Combined Modality Therapy; Esophageal Neoplasms; Female; Head and Neck Neoplasms; H | 1984 |
[On the present state of use of radiosensitizers in radiation therapy from the radiobiological point of view (author's transl)].
Topics: Animals; Cell Fractionation; HeLa Cells; Humans; Metronidazole; Mice; Mice, Inbred C3H; Neoplasms; R | 1980 |
Treatment of giardiasis: literature review and recommendations.
Topics: Animals; Child; Diarrhea; Drug Evaluation; Female; Fever; Furazolidone; Giardiasis; Humans; Metronid | 1982 |
Complications after ileal pouch-anal anastomosis.
Topics: Anastomosis, Surgical; Ciprofloxacin; Colitis, Ulcerative; Crohn Disease; Humans; Male; Metronidazol | 2000 |
Metronidazole: its past, present and future.
Topics: Anaerobiosis; Bacterial Infections; Crohn Disease; Dracunculiasis; Humans; Kinetics; Metronidazole; | 1978 |
Hypoxic sensitizers--implications for radiation therapy.
Topics: Animals; Female; Glioblastoma; Humans; Metronidazole; Misonidazole; Neoplasms; Oxygen Consumption; R | 1979 |
Chemical modification of radiation effects.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Cell Survival; Cysteamine; DNA; Drug Evaluation; | 1977 |
Advances in radiotherapy.
Topics: Fast Neutrons; Humans; Hyperbaric Oxygenation; Metronidazole; Misonidazole; Neoplasms; Neutrons; Par | 1978 |
Recent advances in radiotherapy.
Topics: Breast Neoplasms; Bromodeoxyuridine; Carcinoid Tumor; Elementary Particles; Fast Neutrons; Hot Tempe | 1977 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazol | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administra | 1985 |
14 trials available for metronidazole and Benign Neoplasms
| Article | Year |
|---|---|
Chemotherapy-induced diarrhoea in dogs and its management with smectite: Results of a monocentric open-label randomized clinical trial.
Topics: Animals; Anti-Infective Agents; Antidiarrheals; Antineoplastic Agents; Diarrhea; Dog Diseases; Dogs; | 2021 |
[Recurrences in Clostridium difficile infections in cancer patients].
Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Clostridioides difficile; Clostridium Infecti | 2016 |
Pimecrolimus cream 1% for the treatment of papulopustular eruption related to epidermal growth factor receptor inhibitors: a case series and a literature review of therapeutic approaches.
Topics: Aged; Antineoplastic Agents; Dermatologic Agents; Drug Eruptions; ErbB Receptors; Female; Humans; Ma | 2010 |
Radiosensitizers and protectors.
Topics: Amifostine; Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Human | 1984 |
Double-blind trial of metronidazole in malodorous ulcerating tumours.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Metronidazole; Neoplasms; Random Allocation; | 1984 |
[Use of electron acceptor compounds in radiotherapy].
Topics: Clinical Trials as Topic; Esophageal Neoplasms; Female; Humans; Laryngeal Neoplasms; Metronidazole; | 1983 |
[Analysis of clinical experience in the use of metronidazole as a radiosensitizer of tumors].
Topics: Brain Neoplasms; Clinical Trials as Topic; Esophageal Neoplasms; Female; Genital Neoplasms, Female; | 1983 |
Role of metronidazole in radiation therapy (a review of 717 cancer cases).
Topics: Female; Humans; Metronidazole; Mouth Neoplasms; Neoplasms; Uterine Cervical Neoplasms | 1994 |
The effect of topical 0.75% metronidazole gel on malodorous cutaneous ulcers.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Male | 1996 |
Hypoxic cell radiosensitizers.
Topics: Animals; Clinical Trials as Topic; Humans; Hyperbaric Oxygenation; Hypoxia; Metronidazole; Mice; Mis | 1978 |
A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours.
Topics: Administration, Topical; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Infections; Breast | 1992 |
Hypoxic cell radiosensitizers: expectations and progress in drug development.
Topics: Clinical Trials as Topic; Combined Modality Therapy; Etanidazole; Humans; Metronidazole; Misonidazol | 1985 |
Chemical sensitizers for hypoxic cells: a decade of experience in clinical radiotherapy.
Topics: Adrenal Cortex Hormones; Clinical Trials as Topic; Dose-Response Relationship, Drug; Drug Administra | 1985 |
[Metronidazole in the radiotherapy of malignant neoplasms].
Topics: Clinical Trials as Topic; Combined Modality Therapy; Humans; Metronidazole; Neoplasm Recurrence, Loc | 1986 |
83 other studies available for metronidazole and Benign Neoplasms
| Article | Year |
|---|---|
QSAR modeling of the rodent carcinogenicity of nitrocompounds.
Topics: Animals; Drug Evaluation, Preclinical; Female; Neoplasms; Nitro Compounds; Quantitative Structure-Ac | 2008 |
Clostridioides difficile infection in paediatric patients with cancer and haematopoietic stem cell transplant recipients.
Topics: Anti-Bacterial Agents; Child; Clostridioides difficile; Clostridium Infections; Hematopoietic Stem C | 2022 |
Clostridioides difficile Infection in Hospitalized Pediatric Patients: Comparisons of Epidemiology, Testing, and Treatment from 2013 to 2019.
Topics: Adolescent; Anti-Bacterial Agents; Child; Child, Preschool; Clostridioides difficile; Clostridium In | 2023 |
Functionalized Ultrasmall Iron Oxide Nanoparticles for
Topics: Contrast Media; Humans; Hypoxia; Magnetic Iron Oxide Nanoparticles; Magnetic Resonance Imaging; Magn | 2022 |
Synergistic Target of Intratumoral Microbiome and Tumor by Metronidazole-Fluorouridine Nanoparticles.
Topics: Animals; Anti-Bacterial Agents; Bacteria; Metronidazole; Microbiota; Nanoparticles; Neoplasms; Tumor | 2023 |
Model-informed precision dosing of antimicrobial drugs in pediatrics: experiences from a pilot scale program.
Topics: Anti-Bacterial Agents; Bayes Theorem; Child; Clindamycin; Critical Illness; Fluconazole; Humans; Lin | 2023 |
Risk Factors for Recurrent Community-associated Clostridiodes Difficile Infection in Children.
Topics: Adolescent; California; Child; Child, Preschool; Clostridioides difficile; Clostridium Infections; C | 2019 |
Crushed Metronidazole in Managing Chronic Nonsurgical Wound Malodor in Patients with Cancer: Preliminary Findings.
Topics: Humans; Metronidazole; Neoplasms | 2020 |
Multifunctional nanocomposites MGO/FU-MI inhibit the proliferation of tumor cells and enhance the effect of chemoradiotherapy in vivo and in vitro.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chemoradiotherapy; Fluorouracil; Humans; M | 2020 |
[Epidemiology of Clostridium difficile-associated disease (CDAD) in Salamanca].
Topics: Aged; Aged, 80 and over; Antacids; Anti-Bacterial Agents; Antineoplastic Agents; Clostridioides diff | 2014 |
Engineering a Multifunctional Nitroreductase for Improved Activation of Prodrugs and PET Probes for Cancer Gene Therapy.
Topics: Binding Sites; Cell Line, Tumor; Escherichia coli; Escherichia coli Proteins; Etanidazole; HCT116 Ce | 2017 |
Synthesis and biological characterisation of novel dithiocarbamate containing 5-nitroimidazole (99m)Tc-complexes as potential agents for targeting hypoxia.
Topics: Animals; Carbamates; Cell Hypoxia; Metronidazole; Mice; Neoplasms; Nitroimidazoles; Organotechnetium | 2011 |
Specific targeting of hypoxic tumor tissue with nitroimidazole-peptide conjugates.
Topics: Amino Acid Sequence; Animals; Cell-Penetrating Peptides; Drug Delivery Systems; Hypoxia; Metronidazo | 2012 |
Influence of ligand denticity on the properties of novel ⁹⁹mTc(I)-carbonyl complexes. Application to the development of radiopharmaceuticals for imaging hypoxic tissue.
Topics: Animals; Cell Line, Tumor; Click Chemistry; Contrast Media; Coordination Complexes; Diagnostic Imagi | 2012 |
Nitroreductase, a near-infrared reporter platform for in vivo time-domain optical imaging of metastatic cancer.
Topics: Animals; Anti-Infective Agents; Carbocyanines; Cell Line, Tumor; Cell Survival; Escherichia coli Pro | 2013 |
GYNECOLOGY AND OBSTETRICS.
Topics: Congenital Abnormalities; Endometriosis; Female; Fetal Diseases; Gynecology; Humans; Maternal-Fetal | 1964 |
[GLUCOSE-6-PHOSPHATE DEHYDROGENASE CONTENT OF THE VAGINAL SECRETION. ENZYMATIC COMPARISON OF CYTOLOGICAL AND PATHOLOGICAL CHANGES IN THE UTERUS].
Topics: Biomedical Research; Chemical Phenomena; Chemistry; Clinical Enzyme Tests; Denmark; Diagnosis, Diffe | 1964 |
CARCINOMA IN SITU OF THE CERVIX.
Topics: Carcinoma in Situ; Carcinoma, Squamous Cell; Cytodiagnosis; Female; Fluorescent Antibody Technique; | 1964 |
Incidental giardiasis diagnosed by fine-needle aspiration of a phantom cecal "mass".
Topics: Animals; Antiprotozoal Agents; Biopsy, Fine-Needle; Diagnosis, Differential; Endosonography; Giardia | 2005 |
Softening the pain of cancer-related wounds.
Topics: Aged; Female; Humans; Metronidazole; Neoplasms; Pain; Pain Management; Wounds and Injuries | 2006 |
Lignan formation in man--microbial involvement and possible roles in relation to cancer.
Topics: 4-Butyrolactone; Bacteria; Butylene Glycols; Clostridium; Depression, Chemical; Female; Humans; Inte | 1981 |
Toxicologic evaluation of metronidazole with particular reference to carcinogenic, mutagenic, and teratogenic potential.
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Crohn Disease; Female; Follow-Up Studies; Humans; | 1983 |
Feasibility study of combining metronidazole with chemotherapy.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Brain Neoplasms; Breast Neoplasms; Carcinoma, Sq | 1983 |
Phase I study of the combination of iv mitomycin and oral metronidazole.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; | 1984 |
[Current studies in the field of clinical radiobiology].
Topics: Animals; Fast Neutrons; Female; Hematopoietic Stem Cells; Humans; Hyperthermia, Induced; Male; Metro | 1983 |
The effect of radiofrequency hyperthermia and chemotherapy upon human neoplasms when used with adjuvant metronidazole.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Body Temperature; Combined Modality The | 1983 |
[Short-term results of radio- and combination therapy of malignant tumors using metronidazole].
Topics: Administration, Oral; Enema; Female; Humans; Metronidazole; Neoplasms | 1983 |
[Mutagenicity and carcinogenicity of metronidazole].
Topics: Animals; Dose-Response Relationship, Drug; Humans; Metronidazole; Mice; Mutation; Neoplasms; Neoplas | 1983 |
Metronidazole and cancer.
Topics: Adult; Aged; Humans; Metronidazole; Middle Aged; Neoplasms; Risk | 1982 |
[Radiosensitizers and their use in radiotherapy (author's transl)].
Topics: Chemical Phenomena; Chemistry; Humans; Metronidazole; Neoplasms | 1982 |
Tumor growth delay studies in patients with multiple metastatic nodules: practical difficulties.
Topics: Humans; Lung Neoplasms; Male; Metronidazole; Middle Aged; Neoplasm Metastasis; Neoplasms; Regression | 1980 |
Role of hypoxic sensitizers in radiotherapy.
Topics: Humans; Metronidazole; Misonidazole; Neoplasms; Oxygen; Radiation-Sensitizing Agents | 1981 |
[Metronidazole and its possible carcinogenic and mutagenic effect].
Topics: Animals; Humans; Metronidazole; Mutation; Neoplasms | 1981 |
[Mutagenic and carcinogenic effect of metronidazole].
Topics: Humans; Metronidazole; Mutagens; Neoplasms | 1981 |
Cancer after metronidazole.
Topics: Carcinogens; Female; Humans; Male; Metronidazole; Neoplasms | 1980 |
Cancer after metronidazole.
Topics: Carcinogens; Humans; Metronidazole; Neoplasms | 1980 |
Cancer after metronidazole.
Topics: Carcinogens; Female; Humans; Metronidazole; Neoplasms; Pregnancy; Teratogens | 1980 |
The draining malignant ulceration.
Topics: Humans; Metronidazole; Neoplasms; Odorants; Ulcer | 1981 |
Using metronidazole (Flagyl) for odor control.
Topics: Anti-Bacterial Agents; Antitrichomonal Agents; Humans; Metronidazole; Neoplasms; Odorants; Wound Inf | 1995 |
Frequency of Entamoeba gingivalis among periodontal and patients under chemotherapy.
Topics: Adult; Animals; Entamoeba; Entamoebiasis; Gingiva; Humans; Metronidazole; Neoplasms; Periodontitis | 1994 |
Drug watch providing essential information.
Topics: Buspirone; Humans; Lactation; Metronidazole; Neoplasms; Nicotine; Paclitaxel; Substance-Related Diso | 1994 |
Photobleaching of mono-L-aspartyl chlorin e6 (NPe6): a candidate sensitizer for the photodynamic therapy of tumors.
Topics: Animals; Antineoplastic Agents; Aspartic Acid; Azides; Deuterium; Humans; Mannitol; Metronidazole; M | 1993 |
Pilot study of multiple chemotherapy resistance modulators plus epirubicin in the treatment of resistant malignancies.
Topics: Adjuvants, Pharmaceutic; Administration, Oral; Adult; Aged; Antibiotics, Antineoplastic; Antifungal | 1997 |
Late incidence of cancer after metronidazole use: a matched metronidazole user/nonuser study.
Topics: Adolescent; Adult; Aged; Carcinogens; Child; Child, Preschool; Cohort Studies; Female; Follow-Up Stu | 1998 |
Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years.
Topics: Adolescent; Adult; Carcinogens; Child, Preschool; Cohort Studies; Databases, Factual; Female; Humans | 1998 |
Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years.
Topics: Carcinogens; Child, Preschool; Female; Humans; Metronidazole; Neoplasms; Pregnancy; Prenatal Exposur | 1999 |
IARC monographs on the evaluation of the carcinogenic risk of chemicals to man: some miscellaneous pharmaceutical substances.
Topics: Acriflavine; Animals; Anthralin; Aurothioglucose; Carcinogens; Chloroquine; Diazepam; Ethanolamines; | 1977 |
Inflammatory bowel diseases 1977.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Diet; Eye Diseases; Humans; Joint | 1977 |
Letter: Metronidazole and iron in cancer therapy.
Topics: Humans; Iron; Metronidazole; Neoplasms; Radiation-Sensitizing Agents; Radiotherapy Dosage | 1976 |
Letter: Metronidazole and tissue zinc/iron ratio in cancer therapy.
Topics: Humans; Iron; Metronidazole; Neoplasms; Nervous System Diseases; Skin Diseases; Zinc | 1976 |
Hypoxic-cell sensitisers.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Hypoxia; Metronidazole; Misonidazole; Neo | 1978 |
Radiation response of multicell spheroids--an in vitro tumour model.
Topics: Cell Line; Cell Survival; Cells, Cultured; Cyclic N-Oxides; Dinitrophenols; Dose-Response Relationsh | 1976 |
The application in radiation therapy of substances which modify cellular radiation response.
Topics: Amifostine; Animals; Drug Evaluation; Drug Therapy, Combination; Humans; Metronidazole; Neoplasms; N | 1977 |
Developments in radiotherapy other than heavy particle beams.
Topics: Animals; Brain Neoplasms; Energy Transfer; Fast Neutrons; Female; Glioblastoma; Hot Temperature; Hum | 1977 |
Metronidazole (Flagyl), misonidazole (Ro 07-0582), iron, zinc and sulphur compounds in cancer therapy.
Topics: Cysteamine; Cysteine; Ferrous Compounds; Glutathione; Kinetics; Metronidazole; Neoplasms; Nitroimida | 1978 |
Radiotherapeutic advances in the treatment of neoplastic disease.
Topics: DNA; Elementary Particles; Evaluation Studies as Topic; Fever; Hodgkin Disease; Humans; Metronidazol | 1977 |
Lack of evidence for cancer due to use of metronidazole.
Topics: Adolescent; Adult; Aged; Breast Neoplasms; Female; Humans; Lung Neoplasms; Metronidazole; Middle Age | 1979 |
Development and testing of new hypoxic cell radiosensitizers.
Topics: Animals; Cell Survival; Cricetinae; Dose-Response Relationship, Radiation; Fibroblasts; Lung; Metron | 1979 |
Metronidazole in cancer therapy: an alternate view.
Topics: Drug Therapy, Combination; Humans; Metronidazole; Neoplasms | 1978 |
Use of metronidazole and other nitroimidazole drugs in cancer therapy.
Topics: Animals; Humans; Metronidazole; Neoplasms; Nitroimidazoles | 1978 |
Treatment of amoebiasis and giardiasis.
Topics: Child; Dysentery, Amebic; Giardiasis; Humans; Metronidazole; Neoplasms; Nitroimidazoles; Research De | 1978 |
Detection of mutagenic activity in human urine using mutant strains of Salmonella typhimurium.
Topics: Antineoplastic Agents; Biological Assay; Cyclophosphamide; Ethylnitrosourea; Fluorouracil; Humans; M | 1976 |
Radiosensitization of hypoxic tumor cells by simultaneous administration of hyperthermia and nitroimidazoles.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Deoxyuridine; Female; Hyperthermia, Induced; Hypox | 1977 |
[Increasing the effectiveness of tumor radiotherapy with metronidazole].
Topics: Animals; Metronidazole; Mice; Neoplasm Transplantation; Neoplasms; Neoplasms, Experimental; Radiatio | 1977 |
Letter: Radiosensitization of tumor cells.
Topics: Humans; Metronidazole; Neoplasms; Radiation-Sensitizing Agents | 1976 |
Letter: Metronidazole as a radiosensitizer.
Topics: Metronidazole; Neoplasms; Nervous System Diseases; Radiation-Sensitizing Agents | 1976 |
Radiosensitizers of hypoxic cells in solid tumors.
Topics: Animals; Cells, Cultured; Cricetinae; Dose-Response Relationship, Drug; Fast Neutrons; Mammary Neopl | 1976 |
Metronidazole (Flagyl): iron catalysed reaction with sulphydryl groups and tumour radiosensitisation.
Topics: Animals; Catalysis; Cysteine; Iron; Kinetics; Metronidazole; Mice; Neoplasms; Radiation-Sensitizing | 1975 |
Human studies with "high dose" metronidazole: a non-toxic radiosensitizer of hypoxic cells.
Topics: Administration, Oral; Animals; Humans; Injections, Intraperitoneal; Male; Metronidazole; Mice; Neopl | 1975 |
Phase 1 study of high-dose metronidazole: a specific in vivo and in vitro radiosensitizer of hypoxic cells.
Topics: Brain Neoplasms; Carcinoma, Bronchogenic; Carcinoma, Squamous Cell; Humans; Lung Neoplasms; Mediasti | 1975 |
[Editorial: Metronidazole].
Topics: Abnormalities, Drug-Induced; Animals; Female; Humans; Metronidazole; Mutagens; Neoplasms; Pregnancy | 1975 |
Metronidazole gel for smelly tumours.
Topics: Administration, Topical; Gels; Humans; Metronidazole; Neoplasms; Odorants | 1992 |
Pharmacokinetics of isometronidazole. Basic model and estimation of the kinetic parameters from experimental data.
Topics: Animals; Humans; Mammary Neoplasms, Experimental; Metronidazole; Mice; Mice, Inbred C3H; Models, Bio | 1992 |
Management of smelly tumours.
Topics: Administration, Topical; Bacteroides Infections; Bandages; Breast Neoplasms; Fatty Acids, Volatile; | 1990 |
Metronidazole and fungating tumours.
Topics: Humans; Metronidazole; Neoplasms; Palliative Care | 1990 |
Metronidazole and cancer.
Topics: Female; Follow-Up Studies; Humans; Metronidazole; Neoplasms; Trichomonas Vaginitis | 1989 |
Cancer after exposure to metronidazole.
Topics: Carcinoma, Bronchogenic; Female; Follow-Up Studies; Humans; Lung Neoplasms; Metronidazole; Minnesota | 1988 |
Optimization of cancer radiotherapy with selective sensitizers.
Topics: Cells, Cultured; Chemical Phenomena; Chemistry; Combined Modality Therapy; Humans; Metronidazole; Mi | 1987 |
Safety of nitroimidazoles.
Topics: Abnormalities, Drug-Induced; Animals; Chromosome Aberrations; Cricetinae; Dose-Response Relationship | 1985 |
[Use of radiomodifiers during radiotherapy of patients with malignant tumors].
Topics: Combined Modality Therapy; Humans; Hyperbaric Oxygenation; Metronidazole; Neoplasms; Oxygen; Radioth | 1986 |
[Clinical experiences with the use of metronidazole in the radiotherapy of cancer patients].
Topics: Combined Modality Therapy; Follow-Up Studies; Humans; Metronidazole; Neoplasms; Radiation-Sensitizin | 1985 |
Letter: Acute drug administration and cancer control.
Topics: Animals; Bacteroides; Biotransformation; Carcinogens; Enterobacteriaceae; Metronidazole; Mice; Neopl | 1974 |
Amebic liver abscess following metronidazole therapy for amebic colitis.
Topics: Adult; Chloroquine; Dysentery, Amebic; Emetine; Entamoeba histolytica; Follow-Up Studies; Heart Dise | 1974 |