metronidazole has been researched along with Atrophy in 12 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treated with metronidazole, 500 mg twice daily for 6 days the patient reduced diarrhea after few days." | 1.48 | Improving basic skills in celiac-like disease diagnosis: a case report. ( Annibale, B; Antonelli, G; Coluccio, C; Corleto, VD; Di Cerbo, A; Di Marino, VP; Galli, G; Uccini, S, 2018) |
| "The cumulative 5-year incidences of gastric cancer were 3." | 1.43 | Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication. ( Fukayama, M; Hayakawa, Y; Hirata, Y; Koike, K; Niikura, R; Shichijo, S; Ushiku, T; Yamada, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kodama, M | 1 |
| Okimoto, T | 1 |
| Mizukami, K | 1 |
| Hirashita, Y | 1 |
| Wada, Y | 1 |
| Fukuda, M | 1 |
| Matsunari, O | 1 |
| Okamoto, K | 1 |
| Ogawa, R | 1 |
| Fukuda, K | 1 |
| Kudo, Y | 1 |
| Kawahara, Y | 1 |
| Murakami, K | 1 |
| Corleto, VD | 1 |
| Di Marino, VP | 1 |
| Galli, G | 1 |
| Antonelli, G | 1 |
| Coluccio, C | 1 |
| Di Cerbo, A | 1 |
| Uccini, S | 1 |
| Annibale, B | 1 |
| Kusunoki, M | 1 |
| Yuki, M | 1 |
| Ishitobi, H | 1 |
| Kobayashi, Y | 1 |
| Nagaoka, M | 1 |
| Takahashi, Y | 1 |
| Fukuba, N | 1 |
| Komazawa, Y | 1 |
| Shizuku, T | 1 |
| Kinoshita, Y | 1 |
| Shichijo, S | 1 |
| Hirata, Y | 1 |
| Niikura, R | 1 |
| Hayakawa, Y | 1 |
| Yamada, A | 1 |
| Ushiku, T | 1 |
| Fukayama, M | 1 |
| Koike, K | 1 |
| Salih, BA | 1 |
| Abasiyanik, MF | 1 |
| Saribasak, H | 1 |
| Huten, O | 1 |
| Sander, E | 1 |
| Fleury, FJ | 1 |
| Prokopova, IV | 1 |
| Makarenko, IuI | 1 |
| Osin, AIa | 1 |
| Ovchar, GV | 1 |
| Kopyt'ko, TA | 1 |
| Orth, T | 1 |
| Protzer, U | 1 |
| Mayet, WJ | 1 |
| Meyer zum Büschenfelde, KH | 1 |
| Espinal, JB | 1 |
| Ruibal, M | 1 |
| Martí-Massó, JF | 1 |
| Poza, JJ | 1 |
| Tucci, A | 1 |
| Poli, L | 1 |
| Tosetti, C | 1 |
| Biasco, G | 1 |
| Grigioni, W | 1 |
| Varoli, O | 1 |
| Mazzoni, C | 1 |
| Paparo, GF | 1 |
| Stanghellini, V | 1 |
| Caletti, G | 1 |
| Longy, M | 1 |
| Delmas, M | 1 |
| Costa, JM | 1 |
| Roussy, P | 1 |
| Sarrat, P | 1 |
| Le Bras, M | 1 |
| Veyret, V | 1 |
| Moretti, G | 1 |
| Levinson, JD | 1 |
| Nastro, LJ | 1 |
2 trials available for metronidazole and Atrophy
| Article | Year |
|---|---|
A follow-up study on the effect of Helicobacter pylori eradication on the severity of gastric histology.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer | 2005 |
Reversal of fundic atrophy after eradication of Helicobacter pylori.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Atrophy; Female; Follow-Up Studies; Gastric A | 1998 |
10 other studies available for metronidazole and Atrophy
| Article | Year |
|---|---|
Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Clarithromycin; Female; Follow-Up Studies; | 2021 |
Improving basic skills in celiac-like disease diagnosis: a case report.
Topics: Adult; Antiprotozoal Agents; Atrophy; Celiac Disease; Diagnosis, Differential; Duodenum; Female; Gia | 2018 |
Effect of Age on Effectiveness of Vonoprazan in Triple Therapy for Helicobacter pylori Eradication.
Topics: Adult; Age Factors; Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Clarithromycin; Drug Therapy, | 2019 |
Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication.
Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Breath Tests; Clarithromycin; Cohort Studies; Fem | 2016 |
Adult vaginitis.
Topics: Atrophy; Female; Haemophilus Infections; Humans; Metronidazole; Trichomonas Vaginitis; Uterine Cervi | 1981 |
[Use of metronidazole in chronic atrophic gastritis in children].
Topics: Atrophy; Chronic Disease; Gastric Mucosa; Gastritis; Humans; Metronidazole | 1980 |
[Long-term damage to duodenal mucosa in malabsorption syndrome as a sequela of Giardia lamblia infection].
Topics: Adult; Animals; Antiprotozoal Agents; Atrophy; Dose-Response Relationship, Drug; Drug Administration | 1995 |
[Motor polyneuropathy due to massive ingestion of metronidazole].
Topics: Adult; Antitrichomonal Agents; Atrophy; Female; Humans; Metronidazole; Muscle, Skeletal; Psychomotor | 1998 |
[Total atrophy of the villi during primary agammaglobulinemia in adults. Therapeutic problems (author's transl)].
Topics: Adjuvants, Immunologic; Adult; Agammaglobulinemia; Atrophy; Diarrhea; Giardiasis; Humans; Intestine, | 1979 |
Giardiasis with total villous atrophy.
Topics: Atrophy; Biopsy; Female; Giardiasis; Humans; Intestinal Diseases, Parasitic; Intestinal Mucosa; Inte | 1978 |