Page last updated: 2024-10-31

metronidazole and Atrophy

metronidazole has been researched along with Atrophy in 12 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.

Research Excerpts

ExcerptRelevanceReference
"Treated with metronidazole, 500 mg twice daily for 6 days the patient reduced diarrhea after few days."1.48Improving basic skills in celiac-like disease diagnosis: a case report. ( Annibale, B; Antonelli, G; Coluccio, C; Corleto, VD; Di Cerbo, A; Di Marino, VP; Galli, G; Uccini, S, 2018)
"The cumulative 5-year incidences of gastric cancer were 3."1.43Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication. ( Fukayama, M; Hayakawa, Y; Hirata, Y; Koike, K; Niikura, R; Shichijo, S; Ushiku, T; Yamada, A, 2016)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19904 (33.33)18.7374
1990's3 (25.00)18.2507
2000's1 (8.33)29.6817
2010's3 (25.00)24.3611
2020's1 (8.33)2.80

Authors

AuthorsStudies
Kodama, M1
Okimoto, T1
Mizukami, K1
Hirashita, Y1
Wada, Y1
Fukuda, M1
Matsunari, O1
Okamoto, K1
Ogawa, R1
Fukuda, K1
Kudo, Y1
Kawahara, Y1
Murakami, K1
Corleto, VD1
Di Marino, VP1
Galli, G1
Antonelli, G1
Coluccio, C1
Di Cerbo, A1
Uccini, S1
Annibale, B1
Kusunoki, M1
Yuki, M1
Ishitobi, H1
Kobayashi, Y1
Nagaoka, M1
Takahashi, Y1
Fukuba, N1
Komazawa, Y1
Shizuku, T1
Kinoshita, Y1
Shichijo, S1
Hirata, Y1
Niikura, R1
Hayakawa, Y1
Yamada, A1
Ushiku, T1
Fukayama, M1
Koike, K1
Salih, BA1
Abasiyanik, MF1
Saribasak, H1
Huten, O1
Sander, E1
Fleury, FJ1
Prokopova, IV1
Makarenko, IuI1
Osin, AIa1
Ovchar, GV1
Kopyt'ko, TA1
Orth, T1
Protzer, U1
Mayet, WJ1
Meyer zum Büschenfelde, KH1
Espinal, JB1
Ruibal, M1
Martí-Massó, JF1
Poza, JJ1
Tucci, A1
Poli, L1
Tosetti, C1
Biasco, G1
Grigioni, W1
Varoli, O1
Mazzoni, C1
Paparo, GF1
Stanghellini, V1
Caletti, G1
Longy, M1
Delmas, M1
Costa, JM1
Roussy, P1
Sarrat, P1
Le Bras, M1
Veyret, V1
Moretti, G1
Levinson, JD1
Nastro, LJ1

Trials

2 trials available for metronidazole and Atrophy

ArticleYear
A follow-up study on the effect of Helicobacter pylori eradication on the severity of gastric histology.
    Digestive diseases and sciences, 2005, Volume: 50, Issue:8

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer

2005
Reversal of fundic atrophy after eradication of Helicobacter pylori.
    The American journal of gastroenterology, 1998, Volume: 93, Issue:9

    Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Ulcer Agents; Atrophy; Female; Follow-Up Studies; Gastric A

1998

Other Studies

10 other studies available for metronidazole and Atrophy

ArticleYear
Gastric mucosal changes, and sex differences therein, after Helicobacter pylori eradication: A long-term prospective follow-up study.
    Journal of gastroenterology and hepatology, 2021, Volume: 36, Issue:8

    Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Clarithromycin; Female; Follow-Up Studies;

2021
Improving basic skills in celiac-like disease diagnosis: a case report.
    BMC gastroenterology, 2018, Nov-03, Volume: 18, Issue:1

    Topics: Adult; Antiprotozoal Agents; Atrophy; Celiac Disease; Diagnosis, Differential; Duodenum; Female; Gia

2018
Effect of Age on Effectiveness of Vonoprazan in Triple Therapy for Helicobacter pylori Eradication.
    Internal medicine (Tokyo, Japan), 2019, Jun-01, Volume: 58, Issue:11

    Topics: Adult; Age Factors; Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Clarithromycin; Drug Therapy,

2019
Histologic intestinal metaplasia and endoscopic atrophy are predictors of gastric cancer development after Helicobacter pylori eradication.
    Gastrointestinal endoscopy, 2016, Volume: 84, Issue:4

    Topics: Aged; Amoxicillin; Anti-Bacterial Agents; Atrophy; Breath Tests; Clarithromycin; Cohort Studies; Fem

2016
Adult vaginitis.
    Clinical obstetrics and gynecology, 1981, Volume: 24, Issue:2

    Topics: Atrophy; Female; Haemophilus Infections; Humans; Metronidazole; Trichomonas Vaginitis; Uterine Cervi

1981
[Use of metronidazole in chronic atrophic gastritis in children].
    Pediatriia, 1980, Issue:3

    Topics: Atrophy; Chronic Disease; Gastric Mucosa; Gastritis; Humans; Metronidazole

1980
[Long-term damage to duodenal mucosa in malabsorption syndrome as a sequela of Giardia lamblia infection].
    Zeitschrift fur Gastroenterologie, 1995, Volume: 33, Issue:3

    Topics: Adult; Animals; Antiprotozoal Agents; Atrophy; Dose-Response Relationship, Drug; Drug Administration

1995
[Motor polyneuropathy due to massive ingestion of metronidazole].
    Neurologia (Barcelona, Spain), 1998, Volume: 13, Issue:5

    Topics: Adult; Antitrichomonal Agents; Atrophy; Female; Humans; Metronidazole; Muscle, Skeletal; Psychomotor

1998
[Total atrophy of the villi during primary agammaglobulinemia in adults. Therapeutic problems (author's transl)].
    Annales de medecine interne, 1979, Volume: 130, Issue:12

    Topics: Adjuvants, Immunologic; Adult; Agammaglobulinemia; Atrophy; Diarrhea; Giardiasis; Humans; Intestine,

1979
Giardiasis with total villous atrophy.
    Gastroenterology, 1978, Volume: 74, Issue:2 Pt 1

    Topics: Atrophy; Biopsy; Female; Giardiasis; Humans; Intestinal Diseases, Parasitic; Intestinal Mucosa; Inte

1978