metronidazole has been researched along with Genital Diseases, Female in 44 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Genital Diseases, Female: Pathological processes involving the female reproductive tract (GENITALIA, FEMALE).
| Excerpt | Relevance | Reference |
|---|---|---|
| " Cephalosporins of the second generation in combination with metronidazole can, therefore, be considered effective and safe drugs in the prevention of postsurgical infections." | 2.69 | [Efficacy and safety of two cephalosporins in the perioperative prophylaxis in patients undergoing abdominal or vaginal hysterectomies or gynaecological laparotomies: a prospective randomized study]. ( Bier, UW; Eickhoff, C; Hillger, H; Kienle, E; Preuss, MJ; Regidor, PA; Schindler, AE, 2000) |
| "As metronidazole has excellent in vitro activity against almost all clinically significant anaerobes, the newly available parenteral form of the drug was evaluated in a comparative study with clindamycin." | 2.65 | Intravenous metronidazole or clindamycin with tobramycin for therapy of pelvic infections. ( Addison, WA; Ayers, OM; Gall, SA; Hill, GB; Hughes, CE; Kohan, AP, 1981) |
| "Metronidazole prophylaxis was associated with a dramatic reduction from 18 percent to 1 percent of major postoperative wound and pelvic infections." | 2.65 | Single dose metronidazole prophylaxis in gynaecological surgery. ( Jackson, P; Pattison, NS; Ridley, WJ, 1979) |
| "Metronidazole has proven to be a useful and inexpensive antibiotic for the treatment of T." | 2.38 | Metronidazole. ( Hager, WD; Rapp, RP, 1992) |
| "The latter category includes pelvic inflammatory disease, pelvic thrombophlebitis, septic abortion, and premature rupture of the membranes." | 2.36 | Infections in the female genital tract. ( Gall, SA, 1983) |
| "mulieris in Turkish women with bacterial vaginosis, vulvo-vaginal abscesses, endometritis or salpingitis." | 1.33 | Mobiluncus species in gynaecological and obstetric infections: antimicrobial resistance and prevalence in a Turkish population. ( Bahar, H; Kocazeybek, B; Oçer, F; Torun, MM, 2005) |
| "Bacterial vaginosis was present in 32% of the women screened, Chlamydia trachomatis was identified in 8%, none tested positive for Neisseria gonorrhoeae." | 1.32 | Should we offer antibiotic prophylaxis post sexual assault? ( Forster, GE; Gibb, AM; McManus, T, 2003) |
| "Metronidazole also has been used either alone or in combination, most frequently with amoxicillin, to treat many other anaerobic infections: head and neck, pleuropulmonary, genital tract, bone and joint, skin and soft tissue, and cases of fusobacterial septicemia (necrobacillosis)." | 1.27 | The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital. ( Eykyn, SJ, 1983) |
| "Metronidazole was the only antimicrobial agent given to 4 patients." | 1.27 | Treatment of anaerobic female genital tract infections with metronidazole. ( Aravantinos, D; Creatsa, O; Creatsas, G; Loutradis, D, 1985) |
| "Anaerobic infections are reviewed with emphasis on management." | 1.25 | Management of anaerobic infections. ( Bartlett, JG; Chow, AW; Finegold, SM; Flora, DJ; Gorbach, SL; Harder, EJ; Tally, FP, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (84.09) | 18.7374 |
| 1990's | 3 (6.82) | 18.2507 |
| 2000's | 4 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gibb, AM | 1 |
| McManus, T | 1 |
| Forster, GE | 1 |
| Bahar, H | 1 |
| Torun, MM | 1 |
| Oçer, F | 1 |
| Kocazeybek, B | 1 |
| Sen, A | 1 |
| Mahalanabis, D | 1 |
| Mukhopadhyay, S | 1 |
| Chakrabarty, K | 1 |
| Singh, AK | 1 |
| Bisai, S | 1 |
| Chakrabarty, M | 1 |
| Halder, D | 1 |
| Islam, MA | 1 |
| Stöckli, A | 1 |
| Houang, ET | 1 |
| Watson, C | 1 |
| Howell, R | 1 |
| Chapman, M | 1 |
| Sol'skiĭ, IaP | 1 |
| Ivchenko, VN | 1 |
| Robbie, MO | 2 |
| Sweet, RL | 2 |
| Göbel, G | 1 |
| Link, M | 1 |
| Hillmann, E | 1 |
| Gorbach, SL | 2 |
| Zrubek, H | 1 |
| Szymański, CZ | 1 |
| Czajka, R | 1 |
| Oleszczuk, J | 1 |
| Gall, SA | 2 |
| Eykyn, SJ | 1 |
| Khan, MS | 1 |
| Begg, HB | 1 |
| Frampton, J | 1 |
| Hughes, TB | 1 |
| Kohan, AP | 1 |
| Ayers, OM | 1 |
| Hughes, CE | 1 |
| Addison, WA | 1 |
| Hill, GB | 1 |
| Baines, EJ | 1 |
| McFadzean, JA | 1 |
| Lang, E | 1 |
| Brockmann, J | 1 |
| Höhne, C | 1 |
| Nopdonrattakoon, L | 1 |
| Regidor, PA | 1 |
| Bier, UW | 1 |
| Preuss, MJ | 1 |
| Eickhoff, C | 1 |
| Hillger, H | 1 |
| Kienle, E | 1 |
| Schindler, AE | 1 |
| McCormack, WM | 1 |
| Heginbotham, D | 1 |
| Rutherford, AM | 1 |
| Jackson, P | 1 |
| Ridley, WJ | 1 |
| Pattison, NS | 1 |
| Matsuda, S | 1 |
| Finegold, SM | 2 |
| Bartlett, JG | 1 |
| Chow, AW | 1 |
| Flora, DJ | 1 |
| Harder, EJ | 1 |
| Tally, FP | 1 |
| Hager, WD | 1 |
| Rapp, RP | 1 |
| Varga, A | 1 |
| Lovas, J | 1 |
| Hammill, HA | 1 |
| Crombleholme, WR | 1 |
| Ohm-Smith, M | 1 |
| DeKay, V | 1 |
| Schwiersch, U | 1 |
| Lang, N | 1 |
| Friese, S | 1 |
| Pricker, GJ | 1 |
| Willems, FT | 1 |
| Loriaux, SM | 1 |
| Magnin, G | 1 |
| Ledger, WJ | 1 |
| Gaudin, G | 1 |
| Gardó, S | 1 |
| Gacs, M | 1 |
| Briedigkeit, H | 1 |
| Creatsas, G | 1 |
| Loutradis, D | 1 |
| Creatsa, O | 1 |
| Aravantinos, D | 1 |
| Wilkowske, CJ | 1 |
| Hermans, PE | 1 |
| Breier, M | 1 |
| Pechar, A | 1 |
| Rosenblatt, JE | 1 |
| Horský, J | 1 |
| Brodskaia, LM | 1 |
| Deis, H | 1 |
9 reviews available for metronidazole and Genital Diseases, Female
| Article | Year |
|---|---|
[Use of metronidazole and its analogs in obstetrical and gynecological practice].
Topics: Bacteroides fragilis; Bacteroides Infections; Biological Availability; Clostridium Infections; Femal | 1983 |
Metronidazole use in obstetrics and gynecology: a review.
Topics: Abnormalities, Drug-Induced; Animals; Chemical Phenomena; Chemistry; Drug Resistance, Microbial; Fem | 1983 |
Current experience with clindamycin in the treatment of abdominal and female pelvic infections.
Topics: Abdomen; Animals; Bacterial Infections; Bacteroides Infections; Clindamycin; Clinical Trials as Topi | 1984 |
Infections in the female genital tract.
Topics: Abortion, Septic; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cephalosporins; En | 1983 |
The action of metronidazole on anaerobic bacilli and similar organisms.
Topics: Administration, Oral; Anaerobiosis; Animals; Bacteria; Bacterial Infections; Bacteroides Infections; | 1981 |
Management of sexually transmissible infections during pregnancy.
Topics: Anti-Bacterial Agents; Candidiasis; Chlamydia Infections; Coitus; Condylomata Acuminata; Corynebacte | 1975 |
Metronidazole.
Topics: Bacterial Infections; Costs and Cost Analysis; Drug Interactions; Drug Resistance, Microbial; Entero | 1992 |
Metronidazole, clindamycin, and quinolones.
Topics: 4-Quinolones; Anti-Infective Agents; Bacterial Infections; Clindamycin; Female; Genital Diseases, Fe | 1989 |
Antimicrobial agents in the treatment of obstetric and gynecologic infections.
Topics: Aminoglycosides; Anti-Bacterial Agents; Antifungal Agents; Cephalosporins; Chloramphenicol; Erythrom | 1974 |
14 trials available for metronidazole and Genital Diseases, Female
| Article | Year |
|---|---|
Routine use of antimicrobials by pregnant Indian women does not improve birth outcome: a randomized controlled trial.
Topics: Adult; Anti-Bacterial Agents; Birth Weight; Cephalexin; Female; Genital Diseases, Female; Gestationa | 2005 |
Ampicillin combined with sulbactam or metronidazole for single-dose chemoprophylaxis in major gynaecological surgery.
Topics: Adult; Ampicillin; beta-Lactamase Inhibitors; Double-Blind Method; Drug Therapy, Combination; Female | 1984 |
Current experience with clindamycin in the treatment of abdominal and female pelvic infections.
Topics: Abdomen; Animals; Bacterial Infections; Bacteroides Infections; Clindamycin; Clinical Trials as Topi | 1984 |
[Evaluation of the validity of the preventive use of metronidazole and tinidazole in surgery of the genital organs].
Topics: Adult; Bacterial Infections; Clinical Trials as Topic; Female; Genital Diseases, Female; Humans; Met | 1984 |
A comparative study of the prophylactic effect of one dose and two dose intravenous metronidazole therapy in gynaecological surgery.
Topics: Double-Blind Method; Drug Administration Schedule; Female; Genital Diseases, Female; Humans; Metroni | 1981 |
Intravenous metronidazole or clindamycin with tobramycin for therapy of pelvic infections.
Topics: Anti-Bacterial Agents; Bacterial Infections; Clindamycin; Clinical Trials as Topic; Dose-Response Re | 1981 |
[Efficacy and safety of two cephalosporins in the perioperative prophylaxis in patients undergoing abdominal or vaginal hysterectomies or gynaecological laparotomies: a prospective randomized study].
Topics: Antibiotic Prophylaxis; Cefotiam; Cefoxitin; Drug Therapy, Combination; Female; Genital Diseases, Fe | 2000 |
Metronidazole in the prophylaxis of anaerobic infections in gynaecological surgery: a trial.
Topics: Anaerobiosis; Bacterial Infections; Clinical Trials as Topic; Double-Blind Method; Female; Fever; Ge | 1979 |
Single dose metronidazole prophylaxis in gynaecological surgery.
Topics: Adult; Clinical Trials as Topic; Double-Blind Method; Female; Fever; Genital Diseases, Female; Human | 1979 |
Ampicillin/sulbactam versus metronidazole-gentamicin in the treatment of soft tissue pelvic infections.
Topics: Ampicillin; Bacterial Infections; Clinical Trials as Topic; Drug Combinations; Female; Genital Disea | 1987 |
A comparative study of cefotetan versus cefoxitin plus metronidazole in the treatment of gynecological infections.
Topics: Adult; Bacterial Infections; Cefotetan; Cefoxitin; Clinical Trials as Topic; Drug Therapy, Combinati | 1987 |
Single-dose prophylaxis in gynaecological surgery: amoxycillin/clavulanic acid versus the combination of cefuroxim and metronidazole in a randomized prospective comparison.
Topics: Adult; Aged; Amoxicillin; Cefuroxime; Cephalosporins; Clavulanic Acid; Clavulanic Acids; Drug Therap | 1988 |
[Comparative clinical study between Rocephin (Roche) and doxycycline, amoxycillin, erythromycin and amoxycillin + metronidazole combination in gynecology].
Topics: Abscess; Adult; Aged; Amoxicillin; Breast Diseases; Cefotaxime; Ceftriaxone; Clinical Trials as Topi | 1985 |
Treatment of urogenital trichomoniasis with klion.
Topics: Clinical Trials as Topic; Female; Genital Diseases, Female; Genital Diseases, Male; Humans; Male; Me | 1972 |
22 other studies available for metronidazole and Genital Diseases, Female
| Article | Year |
|---|---|
Should we offer antibiotic prophylaxis post sexual assault?
Topics: Adolescent; Adult; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Azithromycin; Chlamydia t | 2003 |
Mobiluncus species in gynaecological and obstetric infections: antimicrobial resistance and prevalence in a Turkish population.
Topics: Abscess; Actinomycetales Infections; Anaerobiosis; Anti-Bacterial Agents; Cross-Sectional Studies; C | 2005 |
[New therapeutic and diagnostic points of view in gynecology].
Topics: Female; Genital Diseases, Female; Humans; Metronidazole; Pregnancy; Trichomonas Vaginitis; Urinary I | 1967 |
[Prevention of preoperative infection with metronidazole].
Topics: Abscess; Bacteriological Techniques; Female; Genital Diseases, Female; Humans; Metronidazole; Pregna | 1983 |
The therapeutic use of metronidazole in anaerobic infection: six years' experience in a London hospital.
Topics: Adult; Aged; Bacterial Infections; Bone Diseases; Empyema; Female; Fusobacterium Infections; Gastroi | 1983 |
[Clinico-therapeutic aspects of anaerobic infections in gynecology and obstetrics].
Topics: Abortion, Septic; Abscess; Anaerobiosis; Azlocillin; Bacterial Infections; Cefoxitin; Cefuroxime; Ce | 1980 |
[Use of Vagimid (Metronidazol) for chemotherapy of bacterial genital infections (author's transl)].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Bacterial Infections; Drug Therapy, Combination; Female; G | 1981 |
Amoebiasis of the female genital tract: a case report.
Topics: Amebiasis; Antitrichomonal Agents; Female; Genital Diseases, Female; Humans; Metronidazole; Middle A | 1996 |
[Symposium on asporogenic anaerobic bacterial infections. 4. Asporogenic anaerobic bacterial infections in the field of obstetrics and gynecology].
Topics: Anti-Bacterial Agents; Bacterial Infections; Female; Genital Diseases, Female; Humans; Metronidazole | 1977 |
Management of anaerobic infections.
Topics: Anaerobiosis; Anti-Bacterial Agents; Bacterial Infections; Bacteroides Infections; Bone Diseases; Br | 1975 |
Klion infusion for controlling surgical and other bacterial gynaecological febrile complications.
Topics: Adult; Bacterial Infections; Female; Genital Diseases, Female; Humans; Hungary; Incidence; Infusions | 1991 |
[Flash antibiotic prophylaxis with cefuroxime-metronidazole combination in gynecologic surgery].
Topics: Adult; Bacterial Infections; Cefuroxime; Cephalosporins; Cesarean Section; Drug Therapy, Combination | 1987 |
Aminoglycosides in gynecologic infections.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Bacterial Infections; Cephalosporins; Clindamycin; | 1986 |
[Therapeutic and prophylactic use of metronidazole (Klion) in obstetric and gynecologic practice].
Topics: Cesarean Section; Female; Genital Diseases, Female; Humans; Hysterectomy; Metronidazole; Obstetric L | 1985 |
[Therapy and prevention with metronidazole].
Topics: Bacteria, Anaerobic; Bacterial Infections; Female; Genital Diseases, Female; Humans; Metronidazole; | 1985 |
Treatment of anaerobic female genital tract infections with metronidazole.
Topics: Bacteria, Anaerobic; Bacterial Infections; Cervix Mucus; Female; Genital Diseases, Female; Humans; K | 1985 |
Inadequate antibody response to HBAg or suppressor T-cell defect in development of active chronic hepatitis.
Topics: Administration, Oral; Bacteroides; Bacteroides Infections; Carrier State; Female; Follow-Up Studies; | 1974 |
[1st experiences in the follow-up of prescriptions by means of a computer technic].
Topics: Computers; Costs and Cost Analysis; Drug Prescriptions; Drug Utilization; Female; Genital Diseases, | 1972 |
Practical aspects of anaerobic sepsis.
Topics: Abscess; Anaerobiosis; Arthritis, Infectious; Bacterial Infections; Bacteroides; Bone Diseases; Brai | 1973 |
[New drugs for the improvement of gynaecological and obstetric treatment (author's transl)].
Topics: Female; Genital Diseases, Female; Humans; Isoproterenol; Metronidazole; Oxytocin; Pregnancy; Pregnan | 1973 |
[Treatment of trichomonas infections in women with the use of metronidazole].
Topics: Adult; Child; Female; Genital Diseases, Female; Humans; Metronidazole; Trichomonas Infections | 1967 |
[Observations on the versatile symptomatology of Trichomonas infections in women in gynecological practice].
Topics: Adult; Female; Genital Diseases, Female; Humans; Metronidazole; Middle Aged; Trichomonas Infections | 1968 |