metronidazole has been researched along with Kidney Diseases in 11 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Necrobacillosis is a potentially life-threatening septicaemic illness occurring in the previously fit and healthy." | 1.29 | Necrobacillosis--an unusual case of pharyngotonsillitis. ( Carrie, S; Fenton, PA, 1994) |
| " The metronidazole half-life ranged between 4." | 1.27 | The pharmacokinetics of metronidazole and its metabolites in critically ill patients. ( Nightingale, CH; Plaisance, KI; Quintiliani, R, 1988) |
| " The serum half-life of metronidazole was 7." | 1.27 | Pharmacokinetics of metronidazole and its metabolites in reduced renal function. ( Bergan, T; Thorsteinsson, SB, 1986) |
| " The pharmacokinetic parameters of metronidazole elimination half-life, area under the metronidazole concentration against time curve, apparent volume of distribution, metronidazole clearance and predicted degree of accumulation of metronidazole on repeated dosing were not statistically significantly affected by renal inadequacy of any degree." | 1.27 | Pharmacokinetics of metronidazole in patients with varying degrees of renal failure. ( Dennis, MJ; Gabriel, R; Houghton, GW, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wan, X | 1 |
| Lee, MS | 1 |
| Zhou, W | 1 |
| Calvert, LD | 1 |
| Collins, M | 1 |
| Bateman, JR | 1 |
| Al-Ebous, AD | 1 |
| Hiasat, B | 1 |
| Sarayrah, M | 1 |
| Al-Jahmi, M | 1 |
| Al-Zuriqat, AN | 1 |
| Wunderlich, HF | 1 |
| Bailen, JL | 1 |
| Raff, MJ | 1 |
| Melo, JC | 1 |
| Carrie, S | 1 |
| Fenton, PA | 1 |
| Stallworth, JR | 1 |
| Carroll, JM | 1 |
| Matuchansky, C | 1 |
| Malhotra, OP | 1 |
| Bhatla, B | 1 |
| Karak, PK | 1 |
| Sawhney, S | 1 |
| Berry, M | 1 |
| Gupta, R | 1 |
| Plaisance, KI | 1 |
| Quintiliani, R | 1 |
| Nightingale, CH | 1 |
| Bergan, T | 1 |
| Thorsteinsson, SB | 1 |
| Houghton, GW | 1 |
| Dennis, MJ | 1 |
| Gabriel, R | 1 |
1 trial available for metronidazole and Kidney Diseases
| Article | Year |
|---|---|
Management of diabetic foot in a Jordanian hospital.
Topics: Amikacin; Amputation, Surgical; Anti-Bacterial Agents; Ceftazidime; Chemotherapy, Adjuvant; Debridem | 2005 |
10 other studies available for metronidazole and Kidney Diseases
| Article | Year |
|---|---|
Dosage-dependent role of Rac1 in podocyte injury.
Topics: Animals; Animals, Genetically Modified; Disease Models, Animal; Down-Regulation; Glomerular Filtrati | 2016 |
Multiple abscesses caused by Gardnerella vaginalis in an immunocompetent man.
Topics: Abdominal Abscess; Bacterial Infections; Cefuroxime; Empyema, Pleural; Gardnerella vaginalis; Humans | 2005 |
Bacteroides fragilis perinephric abscess.
Topics: Abscess; Bacteroides fragilis; Bacteroides Infections; Female; Humans; Kidney Diseases; Metronidazol | 1980 |
Necrobacillosis--an unusual case of pharyngotonsillitis.
Topics: Adult; Drug Therapy, Combination; Fusobacterium Infections; Fusobacterium necrophorum; Humans; Kidne | 1994 |
Lemierre's syndrome: new insights into an old disease.
Topics: Adolescent; Anti-Bacterial Agents; Ceftriaxone; Cephalosporins; Drug Therapy, Combination; Female; F | 1997 |
Inflammatory bowel diseases 1977.
Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Diet; Eye Diseases; Humans; Joint | 1977 |
Amoebic liver abscess--an unusual presentation report of a case.
Topics: Adolescent; Humans; Kidney Diseases; Liver Abscess, Amebic; Male; Metronidazole; Tomography, X-Ray C | 1992 |
The pharmacokinetics of metronidazole and its metabolites in critically ill patients.
Topics: Adult; Aged; Aged, 80 and over; Critical Care; Half-Life; Humans; Kidney Diseases; Liver Diseases; M | 1988 |
Pharmacokinetics of metronidazole and its metabolites in reduced renal function.
Topics: Adult; Aged; Biotransformation; Female; Humans; Kidney Diseases; Kinetics; Male; Metronidazole; Midd | 1986 |
Pharmacokinetics of metronidazole in patients with varying degrees of renal failure.
Topics: Adolescent; Adult; Female; Half-Life; Humans; Kidney; Kidney Diseases; Kinetics; Male; Metabolic Cle | 1985 |