metronidazole has been researched along with Marasmus in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Hepatic encephalopathy is characterized by neuropsychiatric abnormalities in patients with liver failure." | 2.45 | Hepatic encephalopathy: pathophysiology and emerging therapies. ( Shaikh, OS; Sundaram, V, 2009) |
| "Cancrum oris (noma) is a gangrenous infection that develops in the mouth and spreads rapidly to other parts of the face." | 1.31 | Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child. ( Chikte, UM; Naidoo, S, 2000) |
| " The results indicate that a predicted drug cumulation would occur in malnourished children with the ordinary dosage regimen (30 mg/kg/day)." | 1.29 | A new dosing regimen for metronidazole in malnourished children. ( Cravioto, J; Lares-Asseff, I; Pérez-Ortíz, B; Santiago, P, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sundaram, V | 1 |
| Shaikh, OS | 1 |
| Oji, C | 1 |
| Naidoo, S | 1 |
| Chikte, UM | 1 |
| Drenick, EJ | 1 |
| Fisler, J | 1 |
| Johnson, D | 1 |
| Lares-Asseff, I | 1 |
| Cravioto, J | 1 |
| Santiago, P | 1 |
| Pérez-Ortíz, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition[NCT02746276] | Phase 2 | 81 participants (Actual) | Interventional | 2016-04-01 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for metronidazole and Marasmus
| Article | Year |
|---|---|
Hepatic encephalopathy: pathophysiology and emerging therapies.
Topics: Ammonia; Anti-Infective Agents; Drug Therapy, Combination; Dyskinesias; Gastrointestinal Agents; Hep | 2009 |
4 other studies available for metronidazole and Marasmus
| Article | Year |
|---|---|
Cancrum oris: its incidence and treatment in Enugu, Nigeria.
Topics: Adolescent; Adult; Anti-Infective Agents; Child, Preschool; Female; Humans; Incidence; Male; Metroni | 2002 |
Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child.
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Child, Preschool; Female; HIV Seroposi | 2000 |
Hepatic steatosis after intestinal bypass--prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition.
Topics: Adult; Amino Acids; Body Weight; Fatty Liver; Female; Humans; Ileum; Jejunum; Liver; Male; Metronida | 1982 |
A new dosing regimen for metronidazole in malnourished children.
Topics: Biotransformation; Child, Preschool; Computer Simulation; Female; Humans; Infant; Male; Metabolic Cl | 1993 |