Page last updated: 2024-10-31

metronidazole and Marasmus

metronidazole has been researched along with Marasmus in 5 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Hepatic encephalopathy is characterized by neuropsychiatric abnormalities in patients with liver failure."2.45Hepatic encephalopathy: pathophysiology and emerging therapies. ( Shaikh, OS; Sundaram, V, 2009)
"Cancrum oris (noma) is a gangrenous infection that develops in the mouth and spreads rapidly to other parts of the face."1.31Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child. ( Chikte, UM; Naidoo, S, 2000)
" The results indicate that a predicted drug cumulation would occur in malnourished children with the ordinary dosage regimen (30 mg/kg/day)."1.29A new dosing regimen for metronidazole in malnourished children. ( Cravioto, J; Lares-Asseff, I; Pérez-Ortíz, B; Santiago, P, 1993)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sundaram, V1
Shaikh, OS1
Oji, C1
Naidoo, S1
Chikte, UM1
Drenick, EJ1
Fisler, J1
Johnson, D1
Lares-Asseff, I1
Cravioto, J1
Santiago, P1
Pérez-Ortíz, B1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacokinetics of Antimicrobials and Carriage of Antimicrobial Resistance Amongst Hospitalised Children With Severe Acute Malnutrition[NCT02746276]Phase 281 participants (Actual)Interventional2016-04-01Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for metronidazole and Marasmus

ArticleYear
Hepatic encephalopathy: pathophysiology and emerging therapies.
    The Medical clinics of North America, 2009, Volume: 93, Issue:4

    Topics: Ammonia; Anti-Infective Agents; Drug Therapy, Combination; Dyskinesias; Gastrointestinal Agents; Hep

2009

Other Studies

4 other studies available for metronidazole and Marasmus

ArticleYear
Cancrum oris: its incidence and treatment in Enugu, Nigeria.
    The British journal of oral & maxillofacial surgery, 2002, Volume: 40, Issue:5

    Topics: Adolescent; Adult; Anti-Infective Agents; Child, Preschool; Female; Humans; Incidence; Male; Metroni

2002
Noma (cancrum oris): case report in a 4-year-old HIV-positive South African child.
    SADJ : journal of the South African Dental Association = tydskrif van die Suid-Afrikaanse Tandheelkundige Vereniging, 2000, Volume: 55, Issue:12

    Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Child, Preschool; Female; HIV Seroposi

2000
Hepatic steatosis after intestinal bypass--prevention and reversal by metronidazole, irrespective of protein-calorie malnutrition.
    Gastroenterology, 1982, Volume: 82, Issue:3

    Topics: Adult; Amino Acids; Body Weight; Fatty Liver; Female; Humans; Ileum; Jejunum; Liver; Male; Metronida

1982
A new dosing regimen for metronidazole in malnourished children.
    Scandinavian journal of infectious diseases, 1993, Volume: 25, Issue:1

    Topics: Biotransformation; Child, Preschool; Computer Simulation; Female; Humans; Infant; Male; Metabolic Cl

1993