metronidazole has been researched along with Bronchitis in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Bronchitis: Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have evaluated the absorption and the penetration of metronidazole into the bronchial secretions and saliva in acute infective exacerbations of chronic bronchitis." | 7.66 | Serum, saliva, and sputum levels of metronidazole in acute exacerbations of chronic bronchitis. ( Kaye, CM; Reilly, S; Sankey, MG; Siegler, D; Willis, AT, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (75.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Siegler, D | 1 |
| Kaye, CM | 1 |
| Reilly, S | 1 |
| Willis, AT | 1 |
| Sankey, MG | 1 |
| Dammann, HG | 1 |
| Fölsch, UR | 1 |
| Hahn, EG | 1 |
| von Kleist, DH | 1 |
| Klör, HU | 1 |
| Kirchner, T | 1 |
| Strobel, S | 1 |
| Kist, M | 1 |
| Gray, JA | 1 |
| Schwigon, CD | 1 |
| Hulla, FW | 1 |
| Schulze, B | 1 |
| Maslak, A | 1 |
1 review available for metronidazole and Bronchitis
| Article | Year |
|---|---|
Antibacterial prophylaxis--a clinician's view.
Topics: Adult; Anti-Bacterial Agents; Bacterial Infections; Bronchitis; Child; Child, Preschool; Female; Hum | 1979 |
1 trial available for metronidazole and Bronchitis
| Article | Year |
|---|---|
Eradication of H. pylori with pantoprazole, clarithromycin, and metronidazole in duodenal ulcer patients: a head-to-head comparison between two regimens of different duration.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Abdominal Pain; Adult; Aged; Anti-Bacterial Agents; Anti-Ul | 2000 |
2 other studies available for metronidazole and Bronchitis
| Article | Year |
|---|---|
Serum, saliva, and sputum levels of metronidazole in acute exacerbations of chronic bronchitis.
Topics: Absorption; Adult; Aged; Bronchitis; Female; Humans; Male; Metronidazole; Middle Aged; Saliva; Sputu | 1981 |
Timentin in the treatment of nosocomial bronchopulmonary infections in intensive care units.
Topics: Adult; Aged; Aminoglycosides; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Bronchitis; Cla | 1986 |