Candidiasis, Invasive

An important nosocomial fungal infection with species of the genus CANDIDA, most frequently CANDIDA ALBICANS. Invasive candidiasis occurs when candidiasis goes beyond a superficial infection and manifests as CANDIDEMIA, deep tissue infection, or disseminated disease with deep organ involvement.

Synonym
Candidiasis, Invasive

Excerpt	Reference
"Invasive candidiasis is rare in children after the neonatal period, but can occur in children with (secondary) immunodeficiency with a damaged gastrointestinal or skin barrier, or when receiving antibiotics."	( Abele-Horn, M; Beer, M; Hebestreit, H; Kunzmann, S; Radike, K, 2011)
"Invasive candidiasis is a leading cause of mortality and morbidity in neonatal intensive care units."	( Ascher, SB; Benjamin, DK; Clark, RH; Cohen-Wolkowiez, M; Moran, C; Smith, PB; Watt, K, 2012)
"Invasive candidiasis is the third most common bloodstream infection in the intensive care unit (ICU) and is associated with morbidity and mortality."	( Barron, MA; Bedimo, R; Betts, R; Caeiro, JP; Deerman, JB; Dismukes, WE; Freifeld, A; Judson, MA; Kauffman, CA; Mangino, JE; Mushatt, D; Nguyen, MH; Ostrosky-Zeichner, L; Pappas, PG; Reboli, A; Revankar, SG; Schuster, M; Shoham, S; Sobel, JD; Vazquez, J; Westfall, AO; Wood, C, 2014)
"Invasive candidiasis is a serious infection in hospitalized infants that results in significant mortality and morbidity."	( Benjamin, DK; Ericson, JE, 2014)
"Invasive candidiasis is responsible for ∼ 10% of nosocomial sepsis in very-low-birth-weight infants and is associated with substantial morbidity and mortality."	( Benjamin, DK; Botero-Calderon, L; Cohen-Wolkowiez, M, 2015)
"Invasive candidiasis is an important cause of sepsis in extremely low birth weight infants (ELBW, < 1000 g), is often fatal, and frequently results in neurodevelopmental impairment (NDI) among survivors."	( Adams-Chapman, I; Autmizguine, J; Benjamin, DK; Cohen-Wolkowiez, M; Cotten, CM; Goldberg, RN; Smith, PB; Stoll, BJ; Tan, S; Wiederhold, N, 2018)
"Invasive candidiasis is an important health-care-associated fungal infection that can be caused by several Candida spp."	( Arendrup, MC; Kullberg, BJ; Lionakis, MS; Ostrosky-Zeichner, L; Pappas, PG, 2018)
"Invasive candidiasis is the most common fungal infection affecting critically ill adults."	( Geoghegan, P; Keane, S; Martin-Loeches, I; Nseir, S; Povoa, P; Rodriguez, A, 2018)
"Invasive candidiasis is a healthcare-associated fungal infection with a high mortality rate."	( Besemer, M; Bothe, AK; Dandekar, T; Dittrich, M; Durotin, A; Klaile, E; Klassert, TE; Luther, CH; Müller, MM; Prada Salcedo, JP; Schmitt, V; Singer, BB; Slevogt, H, 2022)
"Invasive candidiasis is a serious, progressive, and potentially deadly infection that can affect the brain, heart, bones, eyes, and other parts of the body."	( Ibe, C; Nweze, E; Okoye, CA, 2022)
"Invasive candidiasis is the most common fungal infection in patients attending health services and is associated with high mortality rates and prolonged hospital stay."	( Adam, LM; Böger, B; Domingos, EL; Fachi, MM; Pontarolo, R; Santos, JMMF; Tonin, FS; Vilhena, RO, 2022)

Excerpt	Reference
"Invasive candidiasis has emerged over the last few decades as an increasingly important nosocomial problem for the critically ill, affecting around 2% of intensive care unit patients."	( Lipman, J; Peake, SL; Playford, EG; Roberts, JA; Roberts, MS; Sinnollareddy, M, 2011)
"Recent studies on invasive candidiasis have documented the emergence of non albicans Candida (NAC) species as major pathogens."	( Deorukhkar, SC; Saini, S, 2016)
"The treatment of invasive candidiasis has changed greatly in the past decade and must continue to evolve if we are to improve outcomes in this serious infection."	( Bassetti, M; Cornely, OA; Montravers, P; Righi, E, 2018)
"Neonatal invasive candidiasis has worse outcomes than non-neonatal pediatric candidiasis."	( Chiang, MC; Chu, SM; Fu, RH; Hsu, JF; Huang, HR; Lai, MY; Lee, CW; Lee, IT; Tsai, MH; Wu, IH, 2018)

Excerpt	Reference
"This drug is approved for use in the treatment of invasive candidiasis and Candida esophagitis, as well as in the prophylaxis of Candida infections in hematopoietic stem cell transplant recipients or those at risk of prolonged neutropenia."	( Montejo, M; Quindós, G, 2011)
"As an example, in the treatment of invasive candidiasis, antifungal therapy with intravenous micafungin is dosed daily."	( Gumbo, T, 2015)
"The current standard of treatment of invasive candidiasis with echinocandins requires once-daily therapy."	( Hope, WW; Petraitiene, R; Petraitis, V; Walsh, TJ, 2015)
"Early initiation of antifungal treatment for invasive candidiasis is associated with change in mortality."	( Ip, M; Pang, YK; You, JHS, 2017)
"Guidelines on treating invasive candidiasis recommend initial treatment with a broad-spectrum echinocandin (e."	( Chen, C; Chen, D; Kruger, E; Wan, X; Wang, L; Wu, J; Yue, X, 2018)
"Echinocandins are the first-line treatment of invasive candidiasis caused by C."	( Ding, H; Hou, X; Ji, P; Kang, W; Kong, H; Li, J; Li, R; Li, Y; Liao, K; Ma, L; Wang, X; Xia, Y; Xiao, M; Xu, Y; Zhang, G, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	267 (72.75)	28.8240
2020's	100 (27.25)	9.53

Drug	Relationship Strength	Studies	Trials
lactic acid	low	1	0
berberine	low	1	0
cefuroxime	medium	1	1
ciprofloxacin	medium	1	1
flucytosine	low	6	0
metronidazole	low	1	0
potassium chloride	low	1	0
prednisone	low	1	0
lysine	low	1	0
galactose	medium	8	1
cytarabine	low	1	0
penicillanic acid	medium	2	1
trehalose	low	1	0
dimethyldioctadecylammonium	low	1	0
quinazolines	low	1	0
isoxazoles	low	1	0
thiazoles	low	1	0
1,2,4-triazole	low	1	0
fusarium	low	2	0
alpha-aminopyridine	low	1	0
vancomycin	low	2	0
daunorubicin	low	1	0
amikacin	low	1	0
piperacillin	medium	2	1
itraconazole	medium	7	1
glucose, (beta-d)-isomer	low	2	0
cephalosporin c	low	1	0
triazoles	medium	33	5
fluorodeoxyglucose f18	low	1	0
oxazolidin-2-one	low	1	0
arabitol	low	1	0
clofarabine	low	1	0
ertapenem	low	1	0
albaconazole	low	1	0
deoxycholic acid	medium	7	2
epiglucan	medium	59	7
laminaran	low	1	0
meropenem	medium	1	1
terconazole	low	1	0
linezolid	low	1	0
ergosterol	low	1	0
farnesol	low	1	0
tacrolimus	low	1	0
ravuconazole	low	1	0
posaconazole	low	3	0
l 743,872	medium	56	11
glycosides	medium	5	1
galactomannan	medium	8	1
1-monooleoyl-rac-glycerol	low	1	0
isavuconazole	medium	13	1
chlorhexidine	low	1	0
nystatin a1	medium	2	1
aminocandin	low	1	0
empagliflozin	low	1	0
nad	low	1	0
liraglutide	low	1	0
insulin detemir	low	1	0
3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine	low	1	0
cilastatin, imipenem drug combination	low	1	0
amphotericin b, deoxycholate drug combination	medium	7	2
ro13-9904	low	1	0
piperacillin, tazobactam drug combination	medium	4	1
mannans	medium	22	2
glycolipids	low	1	0
interleukin-8	low	2	0
calca protein, human	low	1	0
fsl-1 lipoprotein, synthetic	low	1	0
cyclosporine	low	1	0
lactoferrin	low	1	0
exudates	low	1	0
acyclovir	low	1	0
ganciclovir	low	1	0
valganciclovir	low	1	0
concanavalin a	low	1	0

Protein Targets (564)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Diacylglycerol kinase alpha	0	1	0	1
retinoid X nuclear receptor alpha	7	0	0	7
activating transcription factor 6	5	0	0	5
Histone H2A.x	7	0	0	7
Chain E, Purine nucleoside phosphorylase	0	1	0	1
Chain A, HADH2 protein	5	0	0	5
Chain B, HADH2 protein	5	0	0	5
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
Chain A, Ferritin light chain	4	0	0	4
Thymidine kinase	0	2	0	2
thioredoxin reductase	3	0	0	3
phosphopantetheinyl transferase	6	0	0	6
GLS protein	4	0	0	4
TDP1 protein	15	0	0	15
Smad3	2	0	0	2
thyroid stimulating hormone receptor	4	0	0	4
EWS/FLI fusion protein	10	0	0	10
arylsulfatase A	2	0	0	2
euchromatic histone-lysine N-methyltransferase 2	7	0	0	7
Bloom syndrome protein isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
ubiquitin carboxyl-terminal hydrolase 2 isoform a	1	0	0	1
lamin isoform A-delta10	11	0	0	11
Solute carrier family 22 member 1	0	1	0	3
ATP-binding cassette sub-family C member 3	0	14	0	14
Multidrug resistance-associated protein 4	0	14	0	14
Solute carrier family 22 member 6	0	0	0	1
Bile salt export pump	0	1	0	1
Bile salt export pump	0	15	0	15
Purine nucleoside phosphorylase	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	2
POU domain, class 2, transcription factor 2	0	0	0	2
Cytochrome P450 2C9	0	8	0	9
Cytochrome P450 2J2	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
Purine nucleoside phosphorylase	0	0	2	2
Solute carrier family 22 member 6	0	0	0	2
Thymidine kinase	0	1	0	1
Solute carrier family 22 member 8	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	15	0	15
Thymidine kinase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	7	0	8
Sterol 14-alpha demethylase	0	3	2	5
AR protein	13	0	0	13
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
estrogen nuclear receptor alpha	16	0	0	16
thyroid stimulating hormone receptor	5	0	0	5
thyroid hormone receptor beta isoform 2	11	0	0	11
Voltage-dependent calcium channel gamma-2 subunit	7	0	0	7
Heat shock protein HSP 90-alpha	0	0	1	1
Botulinum neurotoxin type A	0	1	0	1
Neutrophil cytosol factor 1	0	1	0	1
Glutamate receptor 2	7	0	0	7
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, brain	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Kappa-type opioid receptor	0	0	1	2
Phosphatidylinositol 4-kinase alpha	0	1	0	1
Mu-type opioid receptor	0	0	1	1
Tyrosine-protein kinase	0	0	1	1
Phosphatidylinositol 4-kinase type 2-beta	0	1	0	1
Phosphatidylinositol 4-kinase type 2-alpha	0	1	0	1
Phosphatidylinositol 4-kinase beta	0	1	0	1
peripheral myelin protein 22	7	0	0	7
histone acetyltransferase KAT2A isoform 1	3	0	0	3
Aminoglycoside 3'-phosphotransferase	0	0	0	1
ATP-dependent phosphofructokinase	3	0	0	3
Chain A, Cruzipain	3	0	0	3
interleukin 8	2	0	0	2
glucocorticoid receptor [Homo sapiens]	11	0	0	11
farnesoid X nuclear receptor	6	0	0	6
peroxisome proliferator-activated receptor delta	6	0	0	6
vitamin D (1,25- dihydroxyvitamin D3) receptor	4	0	0	4
tumor necrosis factor	1	0	0	1
vitamin D3 receptor isoform VDRA	5	0	0	5
nuclear factor erythroid 2-related factor 2 isoform 1	9	0	0	9
Cytochrome P450 1A2	0	4	0	5
Cytochrome P450 3A4	0	10	0	11
Cytochrome P450 2D6	0	4	0	5
Cytochrome P450 2C19	0	5	0	6
Nuclear receptor ROR-gamma	3	0	0	3
Aurora kinase B	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	5	0	6
Replicase polyprotein 1ab	0	1	1	2
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2B6	0	2	0	2
pregnane X nuclear receptor	11	0	0	11
Chain A, Putative fructose-1,6-bisphosphate aldolase	2	0	0	2
Fumarate hydratase	5	0	0	5
PPM1D protein	2	0	0	2
Microtubule-associated protein tau	3	0	0	3
aldehyde dehydrogenase 1 family, member A1	6	0	0	6
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	4	0	0	4
polyprotein	5	0	0	5
cytochrome P450 2D6 isoform 1	2	0	0	2
survival motor neuron protein isoform d	2	0	0	2
cytochrome P450 3A4 isoform 1	6	0	0	6
Gamma-aminobutyric acid receptor subunit pi	6	1	0	7
Telomerase reverse transcriptase	0	1	0	1
Acetylcholinesterase	0	1	0	1
Lysine-specific histone demethylase 1A	0	1	0	1
Interferon beta	11	0	0	11
Neuraminidase	0	2	0	2
Neuraminidase	0	1	0	1
Cholinesterase	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	6	1	0	7
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-5	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	6	1	0	7
Acetylcholinesterase	0	2	0	2
Gamma-aminobutyric acid receptor subunit gamma-1	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	6	1	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	6	1	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	6	1	0	7
Aldo-keto reductase family 1 member C3	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	6	1	0	7
Gamma-aminobutyric acid receptor subunit beta-3	6	1	0	7
Gamma-aminobutyric acid receptor subunit beta-2	6	1	0	7
Cholinesterase	0	1	0	1
Inositol monophosphatase 1	2	0	0	2
Cytochrome P450 1B1	0	2	0	2
GABA theta subunit	6	1	0	7
Gamma-aminobutyric acid receptor subunit epsilon	6	1	0	7
Chain A, JmjC domain-containing histone demethylation protein 3A	2	0	0	2
Chain A, BCL-2-RELATED PROTEIN A1	0	0	2	2
Luciferase	2	0	0	2
acid sphingomyelinase	1	0	0	1
acetylcholinesterase	4	0	0	4
PAX8	0	0	0	1
glp-1 receptor, partial	2	0	0	2
15-lipoxygenase, partial	2	0	0	2
pregnane X receptor	2	0	0	2
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
RAR-related orphan receptor gamma	7	0	0	7
SMAD family member 2	2	0	0	2
USP1 protein, partial	6	0	0	6
SMAD family member 3	2	0	0	2
GLI family zinc finger 3	8	0	0	8
caspase 7, apoptosis-related cysteine protease	3	0	0	3
PINK1	1	0	0	1
estrogen receptor 2 (ER beta)	7	0	0	7
nuclear receptor subfamily 1, group I, member 3	9	0	0	9
progesterone receptor	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	10	0	0	10
estrogen-related nuclear receptor alpha	9	0	0	9
G	9	0	0	9
cytochrome P450 2D6	5	0	0	5
67.9K protein	2	0	0	2
glucocerebrosidase	1	0	0	1
Parkin	1	0	0	1
peroxisome proliferator activated receptor gamma	6	0	0	6
heat shock protein 90	0	0	2	2
caspase-3	3	0	0	3
IDH1	3	0	0	3
calcineurin A1, putative	0	0	2	2
aryl hydrocarbon receptor	4	0	0	4
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	2	0	0	2
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
cytochrome P450 2C19 precursor	1	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
perilipin-5	0	1	0	1
thyroid hormone receptor beta isoform a	4	0	0	4
perilipin-1	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	4	0	0	4
potassium voltage-gated channel subfamily H member 2 isoform d	4	0	0	4
transcriptional regulator ERG isoform 3	2	0	0	2
heat shock protein beta-1	3	0	0	3
huntingtin isoform 2	2	0	0	2
importin subunit beta-1 isoform 1	2	0	0	2
mitogen-activated protein kinase 1	4	0	0	4
ubiquitin-conjugating enzyme E2 N	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
flap endonuclease 1	1	0	0	1
protein AF-9 isoform a	0	0	0	1
snurportin-1	2	0	0	2
melanocortin receptor 4	0	1	0	1
CAAX prenyl protease	0	0	0	1
urokinase-type plasminogen activator precursor	1	0	0	1
plasminogen precursor	1	0	0	1
bcl-2-related protein A1	0	1	0	1
urokinase plasminogen activator surface receptor precursor	1	0	0	1
nuclear receptor ROR-gamma isoform 1	4	0	0	4
geminin	11	0	0	11
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
DNA polymerase kappa isoform 1	4	0	0	4
glycogen synthase kinase-3 alpha	0	0	0	1
hexokinase HKDC1	0	1	0	1
DNA repair protein RAD52 homolog isoform a	0	0	0	1
bcl-2-like protein 11 isoform 1	0	0	2	2
lethal factor (plasmid)	3	0	0	3
Synaptojanin-2	0	1	0	1
Solute carrier family 22 member 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	2	0	0	2
Synaptojanin-1	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Glutathione reductase, mitochondrial	0	3	0	4
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
Cellular tumor antigen p53	12	0	0	12
Integrin beta-3	3	0	0	3
72 kDa type IV collagenase	0	2	0	2
Integrin alpha-IIb	3	0	0	3
Matrix metalloproteinase-9	0	1	0	1
Trypanothione reductase	0	1	0	1
Alpha-synuclein	1	0	0	1
Histamine H2 receptor	3	0	0	3
Spike glycoprotein	8	0	1	9
TAR DNA-binding protein 43	5	0	0	5
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase	0	1	0	1
Multidrug and toxin extrusion protein 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	2	0	0	2
Inositol hexakisphosphate kinase 1	9	0	0	9
Multidrug and toxin extrusion protein 1	0	1	0	1
ATPase family AAA domain-containing protein 5	5	0	0	5
Ataxin-2	6	0	0	6
Spermine oxidase	0	1	0	1
cytochrome P450 2C9, partial	9	0	0	9
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	1	0	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	2	0	4
DNA gyrase subunit B	0	2	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	1	0	5
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	1
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	1	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
endonuclease IV	2	0	0	2
LMP1 [Human herpesvirus 4]	0	0	0	2
chromobox protein homolog 1	4	0	0	4
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	1	0	1
serine/threonine-protein kinase mTOR isoform 1	1	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase iota isoform a (long)	5	0	0	5
transactivating tegument protein VP16 [Human herpesvirus 1]	0	1	0	1
nuclear receptor coactivator 3 isoform a	0	1	0	1
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	0	0	1
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
D(1A) dopamine receptor	1	0	0	1
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	2	0	0	2
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Caspase-7	1	0	0	1
runt-related transcription factor 1 isoform AML1b	1	0	0	1
caspase-3	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
Transthyretin	0	1	0	1
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
ATP-dependent translocase ABCB1	0	2	0	3
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	2	0	3
Histone deacetylase 1	0	2	0	2
Reverse transcriptase/RNaseH	0	1	0	1
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Ileal sodium/bile acid cotransporter	0	1	0	1
G-protein coupled bile acid receptor 1	0	0	1	1
Bile acid receptor	0	0	1	1
Sodium/glucose cotransporter 1	0	0	1	1
Sodium/glucose cotransporter 2	0	1	1	2
Nitric oxide synthase, inducible	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	3
Beta-lactamase	0	0	0	3
Metallo-b-lactamase	0	0	0	3
Beta-lactamase class B VIM-2	0	0	1	4
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] A	0	3	0	3
UDP-glucuronosyltransferase 1A1	0	1	0	1
Amine oxidase [flavin-containing] B	0	2	0	2
Amine oxidase [flavin-containing] B	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
apical membrane antigen 1, AMA1	1	0	0	1
unnamed protein product	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	2
Histone deacetylase 3	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Chymotrypsinogen A	0	1	0	1
Beta-lactamase	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	2	0	2
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	3	4
Aromatase	0	2	0	2
Cytochrome P450 11B1, mitochondrial	0	2	0	2
Cytochrome P450 11B2, mitochondrial	0	2	0	2
ATP-dependent translocase ABCB1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	1	0	1
Histone deacetylase 4	0	1	0	1
Cytochrome P450 144	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Steroid C26-monooxygenase	0	0	3	3
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	3	1	4
Sterol 14-alpha demethylase	0	0	3	3
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
14-alpha sterol demethylase	0	0	3	3
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	1	0	0	1
serine/threonine-protein kinase PLK1	1	0	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	2
Beta-galactosidase	0	1	0	1
Lipopolysaccharide heptosyltransferase 1	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Jacalin	0	0	1	1
ClpP	1	0	0	1
NFKB1 protein, partial	1	0	0	1
Transitional endoplasmic reticulum ATPase	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Asialoglycoprotein receptor 1	0	1	1	2
GALC protein	1	0	0	1
streptokinase A precursor	0	0	2	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	4	0	4
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Estrogen receptor	0	0	1	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
50S ribosomal protein L36 2	0	1	0	1
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	1	0	1
Estrogen receptor beta	0	0	1	1
Renin	0	1	0	1
Glucagon-like peptide 1 receptor	0	2	2	4
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Chain A, Ribulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplast	0	1	0	1
Cationic amino acid transporter 3	0	1	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	1	3
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	1	2
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Histamine H3 receptor	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	2
Thioredoxin reductase	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Flavodoxin	0	0	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Vpr	1	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase OXA-7	0	0	0	1
Solute carrier family 15 member 1	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Sterol 14-alpha-demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
14-alpha sterol demethylase	0	0	2	2
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Carbonic anhydrase 9	0	1	0	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
thioredoxin glutathione reductase	1	0	0	1
Glucocorticoid receptor	0	2	1	3
Glycine receptor subunit alpha-1	0	2	0	2
Glycine receptor subunit beta	0	2	0	2
Glycine receptor subunit alpha-2	0	2	0	2
Glycine receptor subunit alpha-3	0	2	0	2
Epidermal growth factor receptor	0	1	0	1
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Solute carrier organic anion transporter family member 1B1	0	1	0	1
Chain A, Beta-lactamase	1	0	0	1
P53	1	0	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
5-hydroxytryptamine receptor 4	0	2	0	2
Tyrosine-protein kinase Fyn	0	1	0	1
Procathepsin L	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	0	2
Alpha-2A adrenergic receptor	0	3	0	3
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Muscarinic acetylcholine receptor M1	0	2	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Alpha-2B adrenergic receptor	0	2	0	2
Alpha-2C adrenergic receptor	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Sodium-dependent noradrenaline transporter	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Sodium-dependent dopamine transporter	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Angiotensin-converting enzyme 2	0	0	1	1
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with trehalose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with cellobiose	0	1	0	1
Chain A, X-ray structure of the sucrose-phosphatase (SPP) from Synechocystis sp.PCC6803 in complex with maltose	0	1	0	1
Trehalose-phosphatase	0	1	0	1
Albumin	0	0	1	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	1	0	1
Alpha-2A adrenergic receptor	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	1	0	1
Alpha-1A adrenergic receptor	0	1	0	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Transporter	0	1	0	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (367)

Protein Targets (564)

Candidiasis, Invasive

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (367)

Drugs Studied (89)

Protein Targets (564)