metronidazole has been researched along with MODS in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "After receiving different broad-spectrum antibiotics over seven weeks the patient developed Clostridium difficile toxin-positive diarrhea that resolved after administration of oral metronidazole and Saccharomyces boulardii (Perenterol ((R)))." | 3.72 | [Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities]. ( Lestin, F; Pertschy, A; Rimek, D, 2003) |
| "Necrotizing fasciitis is a potentially fatal, acute bacterial infection characterized by extensive fascial and subcutaneous tissue necrosis." | 1.28 | Fatal necrotizing fasciitis of dental origin. ( Beecroft, WA; Cogan, AG; Stoykewych, AA, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 3 (37.50) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Torrijo Gómez, I | 1 |
| Uribe Quintana, N | 1 |
| Catalá Llosa, J | 1 |
| Raga Vázquez, J | 1 |
| Sellés Dechent, R | 1 |
| Martín Dieguez, MC | 1 |
| Báguena Requena, G | 1 |
| Asencio Arana, F | 1 |
| Montes, MI | 1 |
| Hernández Ortiz, OH | 1 |
| Guerra Palacio, A | 1 |
| Hariri, S | 1 |
| Gouin, P | 1 |
| Tuech, JJ | 1 |
| Veber, B | 1 |
| Dureuil, B | 1 |
| Evans, SM | 1 |
| Whittle, BJ | 1 |
| Lestin, F | 1 |
| Pertschy, A | 1 |
| Rimek, D | 1 |
| Rózsai, B | 1 |
| Szász, M | 1 |
| Ottóffy, G | 1 |
| Mohay, G | 1 |
| Major, A | 1 |
| Németh, G | 1 |
| Adamovich, K | 1 |
| Zeitoun, IM | 1 |
| Dhanarajani, PJ | 1 |
| Stoykewych, AA | 1 |
| Beecroft, WA | 1 |
| Cogan, AG | 1 |
1 review available for metronidazole and MODS
| Article | Year |
|---|---|
Cervical cellulitis and mediastinitis caused by odontogenic infections: report of two cases and review of literature.
Topics: Adult; Amikacin; Fatal Outcome; Focal Infection, Dental; Humans; Ludwig's Angina; Male; Mediastinal | 1995 |
7 other studies available for metronidazole and MODS
| Article | Year |
|---|---|
[Fulminant Clostridium difficile colitis].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Clostridioides difficile; Colectomy; Enterocol | 2016 |
[Electroencephalographic burst-suppression pattern due to baclofen intoxication].
Topics: Baclofen; Coma; Drug Overdose; Electroencephalography; Emergencies; Fatal Outcome; Female; Humans; I | 2011 |
Clostridium difficile infection causing multiple organ failure and small-bowel enteritis.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Clostridioides difficile; Clostridium Infections; Drug | 2011 |
Role of bacteria and inducible nitric oxide synthase activity in the systemic inflammatory microvascular response provoked by indomethacin in the rat.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non- | 2003 |
[Fungemia after oral treatment with Saccharomyces boulardii in a patient with multiple comorbidities].
Topics: Administration, Oral; Amputation, Surgical; Clostridioides difficile; Diabetes Mellitus, Type 2; Dia | 2003 |
[Different clinical forms of adrenal abscess in two newborns].
Topics: Abscess; Adrenal Gland Diseases; Anti-Infective Agents; Bacteroides fragilis; Diagnosis, Differentia | 2006 |
Fatal necrotizing fasciitis of dental origin.
Topics: Adult; Bacteroides Infections; Candidiasis; Cefotaxime; Clindamycin; Cloxacillin; Fasciitis; Female; | 1992 |