metronidazole has been researched along with Cellulitis, Orbital in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Orbital cellulitis is a serious sight threatening and potentially life threatening condition which can be complicated by orbital abscess formation." | 5.46 | Orbital abscess following posterior subtenon injection of triamcinolone acetonide. ( Connell, P; Fulcher, T; McAnena, L; McElnea, E; Rhatigan, M, 2017) |
| "Orbital cellulitis is a serious sight threatening and potentially life threatening condition which can be complicated by orbital abscess formation." | 1.46 | Orbital abscess following posterior subtenon injection of triamcinolone acetonide. ( Connell, P; Fulcher, T; McAnena, L; McElnea, E; Rhatigan, M, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Diouf, MS | 1 |
| Tall, A | 1 |
| Ndiaye, C | 1 |
| Thiam, A | 1 |
| Deguenonvo, R | 1 |
| Ndiaye, M | 1 |
| Rhatigan, M | 1 |
| McAnena, L | 1 |
| McElnea, E | 1 |
| Connell, P | 1 |
| Fulcher, T | 1 |
| Pushker, N | 1 |
| Tejwani, LK | 1 |
| Bajaj, MS | 1 |
| Khurana, S | 1 |
| Velpandian, T | 1 |
| Chandra, M | 1 |
| Pham Dang, N | 1 |
| Bouchet, A | 1 |
| Mondie, JM | 1 |
| Barthelemy, I | 1 |
| Parvizi, N | 1 |
| Choudhury, N | 1 |
| Singh, A | 1 |
| Kromberg, R | 1 |
| Mozet, C | 1 |
| Fritzsch, D | 1 |
| Dawczynski, J | 1 |
| Dietz, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of Corticosteroids in Children Hospitalized With Cellulitis: Randomized, Double Blind, Placebo Controlled Trial[NCT02087527] | 19 participants (Actual) | Interventional | 2014-06-30 | Terminated (stopped due to Calculated sample size not achieved) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for metronidazole and Cellulitis, Orbital
| Article | Year |
|---|---|
Role of oral corticosteroids in orbital cellulitis.
Topics: Administration, Oral; Adolescent; Adult; Anti-Bacterial Agents; Ceftriaxone; Child; Drug Therapy, Co | 2013 |
5 other studies available for metronidazole and Cellulitis, Orbital
| Article | Year |
|---|---|
Complications of sinusitis: An 80-case series from the ENT and neurosurgery departments of the Fann university hospital center of Dakar, Senegal.
Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Brain Abscess; Child; Child, Preschool; Cla | 2020 |
Orbital abscess following posterior subtenon injection of triamcinolone acetonide.
Topics: Abscess; Anti-Bacterial Agents; Ceftriaxone; Drug Therapy, Combination; Floxacillin; Glucocorticoids | 2017 |
[Frontal sinusitis, mucocele and subperiosteal superolateral orbit abscess].
Topics: Abscess; Anti-Bacterial Agents; Cefotaxime; Child; Drainage; Drug Combinations; Exophthalmos; Fronta | 2011 |
Complicated periorbital cellulitis: case report and literature review.
Topics: Abscess; Adolescent; Anti-Infective Agents; Cefuroxime; Contrast Media; Decompression, Surgical; Dra | 2012 |
[A rare complication of acute sinusitis].
Topics: Aged; Cavernous Sinus Thrombosis; Cefuroxime; Combined Modality Therapy; Decompression, Surgical; Di | 2012 |