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metronidazole and Hepatic Encephalopathy

metronidazole has been researched along with Hepatic Encephalopathy in 14 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Hepatic Encephalopathy: A syndrome characterized by central nervous system dysfunction in association with LIVER FAILURE, including portal-systemic shunts. Clinical features include lethargy and CONFUSION (frequently progressing to COMA); ASTERIXIS; NYSTAGMUS, PATHOLOGIC; brisk oculovestibular reflexes; decorticate and decerebrate posturing; MUSCLE SPASTICITY; and bilateral extensor plantar reflexes (see REFLEX, BABINSKI). ELECTROENCEPHALOGRAPHY may demonstrate triphasic waves. (From Adams et al., Principles of Neurology, 6th ed, pp1117-20; Plum & Posner, Diagnosis of Stupor and Coma, 3rd ed, p222-5)

Research Excerpts

ExcerptRelevanceReference
"Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes."5.37Metronidazole-induced encephalopathy in a patient with liver cirrhosis. ( Cheong, HC; Cho, EY; Cho, YB; Jeong, TG; Kim, HC; Kim, TH; Yang, BJ, 2011)
"001) and the elimination half-life prolonged (20 +/- 9 versus 7."5.27Metronidazole pharmacokinetics in patients with hepatic encephalopathy. ( Andreasen, PB; Døssing, M; Loft, S; Sonne, J, 1987)
"In cirrhotic patients with advanced hepatic encephalopathy treatment with LOLA was safe and associated with relatively rapid improvement and shorter hospital stay."2.76Efficacy of L-ornithine-L-aspartate as an adjuvant therapy in cirrhotic patients with hepatic encephalopathy. ( Abbas, Z; Abid, S; Hamid, S; Islam, M; Jafri, W; Mumtaz, K; Shah, HA, 2011)
"To review the management of hepatic encephalopathy (HE), including lifestyle modifying strategies and pharmacological interventions."2.53Management of Hepatic Encephalopathy: A Primer. ( Bridgeman, MB; Dixit, D; Jawaro, T; Yang, A, 2016)
"Hepatic encephalopathy is characterized by neuropsychiatric abnormalities in patients with liver failure."2.45Hepatic encephalopathy: pathophysiology and emerging therapies. ( Shaikh, OS; Sundaram, V, 2009)
"Encephalopathy is a disorder characterized by altered brain function, which can be attributed to various causes."1.37Metronidazole-induced encephalopathy in a patient with liver cirrhosis. ( Cheong, HC; Cho, EY; Cho, YB; Jeong, TG; Kim, HC; Kim, TH; Yang, BJ, 2011)
"001) and the elimination half-life prolonged (20 +/- 9 versus 7."1.27Metronidazole pharmacokinetics in patients with hepatic encephalopathy. ( Andreasen, PB; Døssing, M; Loft, S; Sonne, J, 1987)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19903 (21.43)18.7374
1990's2 (14.29)18.2507
2000's3 (21.43)29.6817
2010's6 (42.86)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mekky, MA1
Riad, AR1
Gaber, MA1
Abdel-Malek, MO1
Swifee, YM1
Leise, MD1
Poterucha, JJ1
Kamath, PS1
Kim, WR1
Jawaro, T1
Yang, A1
Dixit, D1
Bridgeman, MB1
Sundaram, V1
Shaikh, OS1
Sharma, P1
Eesa, M1
Scott, JN1
Cheong, HC1
Jeong, TG1
Cho, YB1
Yang, BJ1
Kim, TH1
Kim, HC1
Cho, EY1
Abid, S1
Jafri, W1
Mumtaz, K1
Islam, M1
Abbas, Z1
Shah, HA1
Hamid, S1
Fehérvári, I1
Nemes, B1
Görög, D1
Gerlei, Z1
Kóbori, L1
Deenadayalu, VP1
Orinion, EJ1
Chalasani, NP1
Yoo, HY1
Crossley, IR1
Williams, R1
Morgan, MH1
Read, AE1
Speller, DC1
Uhl, MD1
Riely, CA1
Alexander, T1
Thomas, K1
Cherian, AM1
Loft, S1
Sonne, J1
Døssing, M1
Andreasen, PB1

Reviews

6 reviews available for metronidazole and Hepatic Encephalopathy

ArticleYear
Management of hepatic encephalopathy in the hospital.
    Mayo Clinic proceedings, 2014, Volume: 89, Issue:2

    Topics: Disease Management; Drug Therapy, Combination; Gastrointestinal Agents; Hepatic Encephalopathy; Huma

2014
Management of Hepatic Encephalopathy: A Primer.
    The Annals of pharmacotherapy, 2016, Volume: 50, Issue:7

    Topics: Anti-Bacterial Agents; Disaccharides; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Metronidazole

2016
Hepatic encephalopathy: pathophysiology and emerging therapies.
    The Medical clinics of North America, 2009, Volume: 93, Issue:4

    Topics: Ammonia; Anti-Infective Agents; Drug Therapy, Combination; Dyskinesias; Gastrointestinal Agents; Hep

2009
Toxic and acquired metabolic encephalopathies: MRI appearance.
    AJR. American journal of roentgenology, 2009, Volume: 193, Issue:3

    Topics: Brain Diseases, Metabolic; Carbon Monoxide Poisoning; Cocaine; Cyclosporine; Diagnosis, Differential

2009
[Hepatic encephalopathy and liver transplantation].
    Magyar sebeszet, 2012, Volume: 65, Issue:2

    Topics: Ammonia; Anti-Infective Agents; Colon; Dipeptides; Disaccharides; End Stage Liver Disease; Evidence-

2012
Progress in the treatment of chronic portasystemic encephalopathy.
    Gut, 1984, Volume: 25, Issue:1

    Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Bromocriptine; Chronic Disease; Clinical Trials as To

1984

Trials

4 trials available for metronidazole and Hepatic Encephalopathy

ArticleYear
Rifaximin versus metronidazole in management of acute episode of hepatic encephalopathy: An open labeled randomized clinical trial.
    Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology, 2018, Volume: 19, Issue:2

    Topics: Acute Disease; Adult; Ammonia; Anti-Infective Agents; Female; Hepatic Encephalopathy; Humans; Length

2018
Efficacy of L-ornithine-L-aspartate as an adjuvant therapy in cirrhotic patients with hepatic encephalopathy.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2011, Volume: 21, Issue:11

    Topics: Anti-Infective Agents; Dipeptides; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up

2011
Progress in the treatment of chronic portasystemic encephalopathy.
    Gut, 1984, Volume: 25, Issue:1

    Topics: Amino Acids, Branched-Chain; Ammonia; Animals; Bromocriptine; Chronic Disease; Clinical Trials as To

1984
Treatment of hepatic encephalopathy with metronidazole.
    Gut, 1982, Volume: 23, Issue:1

    Topics: Aged; Ammonia; Clinical Trials as Topic; Double-Blind Method; Electroencephalography; Female; Hepati

1982

Other Studies

5 other studies available for metronidazole and Hepatic Encephalopathy

ArticleYear
Metronidazole-induced encephalopathy in a patient with liver cirrhosis.
    The Korean journal of hepatology, 2011, Volume: 17, Issue:2

    Topics: Anti-Infective Agents; Brain Diseases; Hepatic Encephalopathy; Humans; Liver Cirrhosis; Magnetic Res

2011
Abnormal enhancing lesion of dentate nuclei causing neurologic symptoms induced by metronidazole toxicity.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2005, Volume: 3, Issue:3

    Topics: Anti-Infective Agents; Cerebellar Nuclei; Hepatic Encephalopathy; Humans; Magnetic Resonance Imaging

2005
Metronidazole in treating portosystemic encephalopathy.
    Annals of internal medicine, 1996, Feb-15, Volume: 124, Issue:4

    Topics: Aged; Female; Hepatic Encephalopathy; Humans; Metronidazole; Substance-Related Disorders

1996
Effect of three antibacterial drugs in lowering blood & stool ammonia production in hepatic encephalopathy.
    The Indian journal of medical research, 1992, Volume: 96

    Topics: Administration, Oral; Ammonia; Ampicillin; Feces; Hepatic Encephalopathy; Humans; Hydrogen-Ion Conce

1992
Metronidazole pharmacokinetics in patients with hepatic encephalopathy.
    Scandinavian journal of gastroenterology, 1987, Volume: 22, Issue:1

    Topics: Aged; Female; Hepatic Encephalopathy; Humans; Infusions, Intravenous; Kinetics; Male; Metronidazole;

1987