Page last updated: 2024-10-31

metronidazole and Colitis Gravis

metronidazole has been researched along with Colitis Gravis in 142 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"The fecal flora obtained from 13 patients with ulcerative colitis was examined at the beginning of a pouchitis episode before treatment, during treatment with metronidazole or ciprofloxacin, and during pouchitis-free periods."9.11Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis. ( Gosselink, MP; Hop, WC; Laman, JD; Ruseler-van Embden, JG; Schouten, WR; van Lieshout, LM, 2004)
"Metronidazole is effective for the treatment of acute pouchitis after ileal pouch-anal anastomosis, but it has not been directly compared with other antibiotics."9.09A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. ( Achkar, JP; Bambrick, ML; Bevins, CL; Brzezinski, A; Fazio, VW; Lashner, BA; Ormsby, AH; Remzi, FH; Seidner, DL; Shen, B, 2001)
"In this retrospective cohort study, we demonstrated no significant difference in the real-world effectiveness of ciprofloxacin, metronidazole, or combination therapy for the initial episode of pouchitis."8.31The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study. ( Barnes, EL; Desai, A; Kochhar, GS, 2023)
"We present the first case of metronidazole-related acute pancreatitis during a relapse of ulcerative colitis."7.74Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis. ( Ekonomou, IA; Giannoulis, EK; Giannoulis, KE; Savopoulos, CG; Tsesmeli, NE; Vretou, EE, 2007)
"Pouch contents of patients with ongoing pouchitis or an episode within the previous year released significantly more hydrogen sulfide than did the contents of patients who never had an attack of pouchitis and those with longstanding inactive disease."7.73Association between fecal hydrogen sulfide production and pouchitis. ( Furne, JK; Levitt, MD; Madoff, RD; Ohge, H; Rothenberger, DA; Springfield, J, 2005)
" When compared to placebo, rifaximin was found to be the best antibiotic for acute pouchitis whereas ciprofloxacin ranked highest against metronidazole."5.22Network meta-analysis: efficacy of treatment for acute, chronic, and prevention of pouchitis in ulcerative colitis. ( Poo, S; Segal, JP; Sriranganathan, D, 2022)
"The fecal flora obtained from 13 patients with ulcerative colitis was examined at the beginning of a pouchitis episode before treatment, during treatment with metronidazole or ciprofloxacin, and during pouchitis-free periods."5.11Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis. ( Gosselink, MP; Hop, WC; Laman, JD; Ruseler-van Embden, JG; Schouten, WR; van Lieshout, LM, 2004)
"Metronidazole is effective for the treatment of acute pouchitis after ileal pouch-anal anastomosis, but it has not been directly compared with other antibiotics."5.09A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis. ( Achkar, JP; Bambrick, ML; Bevins, CL; Brzezinski, A; Fazio, VW; Lashner, BA; Ormsby, AH; Remzi, FH; Seidner, DL; Shen, B, 2001)
"For acute pouchitis, very low quality evidence suggests that ciprofloxacin may be more effective than metronidazole."4.91Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Pardi, DS; Sandborn, WJ; Singh, S; Stroud, AM, 2015)
" For the treatment of acute pouchitis (4 RCTS, 5 agents), ciprofloxacin was more effective at inducing remission than metronidazole."4.86Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Cima, RR; Holubar, SD; Pardi, DS; Sandborn, WJ, 2010)
"In this retrospective cohort study, we demonstrated no significant difference in the real-world effectiveness of ciprofloxacin, metronidazole, or combination therapy for the initial episode of pouchitis."4.31The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study. ( Barnes, EL; Desai, A; Kochhar, GS, 2023)
"5%) used antibiotics for pouchitis, predominantly ciprofloxacin."4.12Long-term Antibiotic Treatment in Pouchitis-Patterns of Use and Safety. ( Avraham, Y; Banon, L; Bar, N; Cohen, NA; Dotan, I; Dubinsky, V; Gophna, U; Maharshak, N; Tulchinsky, H; Weiss, GA, 2022)
"The concept that the gut microbiota plays a major role in the development of pouchitis in ulcerative colitis patients after restorative proctocolectomy with ileal pouch-anal anastomosis, is widely accepted and supported by a widespread use of some antibiotics (metronidazole and/or ciprofloxacin, rifaximin) to treat this condition."3.80Role of probiotics in the management of pouchitis. ( Guslandi, M, 2014)
"We present the first case of metronidazole-related acute pancreatitis during a relapse of ulcerative colitis."3.74Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis. ( Ekonomou, IA; Giannoulis, EK; Giannoulis, KE; Savopoulos, CG; Tsesmeli, NE; Vretou, EE, 2007)
"Pouch contents of patients with ongoing pouchitis or an episode within the previous year released significantly more hydrogen sulfide than did the contents of patients who never had an attack of pouchitis and those with longstanding inactive disease."3.73Association between fecal hydrogen sulfide production and pouchitis. ( Furne, JK; Levitt, MD; Madoff, RD; Ohge, H; Rothenberger, DA; Springfield, J, 2005)
"The observing of pouchitis at a patient with ulcerative colitis with onset 4 months after the closing of the ileostoma, protecting the reservoir and with good response to metronidazole, was the reason for performing a literature review of the modern problems of this complication."3.72[Pouchitis, on the basis of a single observation]. ( Aleksandrova, A; Nedin, D, 2004)
"To evaluate the potential for pharmacokinetic interactions between MMX mesalamine and amoxicillin, ciprofloxacin extended release (XR), metronidazole, or sulfamethoxazole in four open-label, randomized, placebo-controlled, two-period crossover studies."2.79Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials. ( Barrett, K; Corcoran, M; Inglis, S; Martin, P; Pierce, D; Preston, P; Thompson, TN; Willsie, SK, 2014)
"The incidence of overall surgical site infection was significantly lower in group A (6/97 patients, 6."2.78Preoperative oral antibiotics and intravenous antimicrobial prophylaxis reduce the incidence of surgical site infections in patients with ulcerative colitis undergoing IPAA. ( Ikeuchi, H; Matsuoka, H; Nakajima, K; Oshima, T; Sasako, M; Takesue, Y; Tomita, N; Uchino, M, 2013)
"Fusobacterium varium may contribute to ulcerative colitis (UC)."2.75Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial. ( Chiba, T; Kato, K; Mabe, K; Mizokami, Y; Murakami, K; Ohkusa, T; Okayasu, I; Sato, N; Sugiyama, T; Tajiri, H; Takeuchi, Y; Terao, S; Watanabe, S; Yamato, S; Yanaka, A; Yokoyama, T, 2010)
"Twenty patients with ulcerative colitis were randomly assigned into the antibiotic treatment group (amoxicillin, tetracycline and metronidazole for 2 weeks) and no-antibiotics group."2.71Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy. ( Benno, Y; Hayashi, H; Hirai, S; Hojo, M; Kobayashi, O; Miwa, H; Nomura, T; Ogihara, T; Ohkusa, T; Okayasu, I; Sakamoto, M; Sato, N; Takei, Y; Terai, T; Yoshida, T, 2005)
"Metronidazole has been used to treat pouchitis, but there are no controlled data that show it is effective."2.67Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis. ( Madden, MV; McIntyre, AS; Nicholls, RJ, 1994)
"Thirty nine patients with severe ulcerative colitis were randomised on admission to hospital to receive either intravenous metronidazole 500 mg eight hourly (19 patients) or an identical intravenous placebo (20 patients)."2.66Controlled trial of intravenous metronidazole as an adjunct to corticosteroids in severe ulcerative colitis. ( Chapman, RW; Jewell, DP; Selby, WS, 1986)
"Metronidazole was found to be slightly more effective than sulfasalazine, a difference statistically significant only at 12 months."2.66A comparison of metronidazole and sulfasalazine in the maintenance of remission in patients with ulcerative colitis. ( Bar Meir, S; Delpre, G; Eshchar, J; Fireman, Z; Gilat, T; Leichtman, G, 1989)
" Metronidazole and azathioprin are considered to be reserve drugs and can be used in the treatment of fistulae or in order to cut down the dosage of prednisolone during remission."2.66[Drug therapy of chronic inflammatory intestinal diseases--current status of 5-aminosalicylic acid]. ( Gerok, W; Schölmerich, J, 1986)
"Four studies assessed treatment of acute pouchitis."2.61Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Nguyen, N; Pardi, DS; Singh, S; Zhang, B, 2019)
"Patients with pouchitis have a wide range of symptoms, endoscopic and histologic features, disease course, and prognosis."2.61Prevention and Medical Treatment of Pouchitis In Ulcerative Colitis. ( Benlice, C; Shen, B; Steele, SR, 2019)
"Pouchitis is a common and long-term complication of ileal pouch-anal anastomosis in patients with underlying ulcerative colitis."2.43[Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis]. ( Fujii, T; Kawamata, S; Matsushita, M; Okazaki, K; Shimatani, M, 2005)
"One of them also had primary sclerosing cholangitis."2.42[Pancreatitis accompanying inflammatory bowel diseases, and our observations]. ( Aleksandrova, A; Nedin, D, 2004)
"In general, patients with Crohn's disease are not usually offered IPAA, because recurrence of disease, fistulas, abscesses, and strictures may lead to a higher incidence of pouch failure."2.41Complications after ileal pouch-anal anastomosis. ( Lichtenstein, GR; Stein, RB, 2000)
"Treatment of pouchitis is largely empirical and few controlled studies have been carried-out."2.41Review article: treatment of mild to moderate ulcerative colitis and pouchitis. ( Amadini, C; Campieri, M; Gionchetti, P; Rizzello, F; Venturi, A, 2002)
"In both ulcerative colitis and Crohn's disease 5-ASA has proved effective in the acute phase of the disease."2.39Medical management of patients with difficult-to-treat inflammatory bowel disease. ( van Hogezand, RA, 1994)
"Rectovaginal fistulas secondary to ulcerative colitis may be treated by ileoanal pouch anastomosis and primary repair."2.38Perianal inflammatory conditions in inflammatory bowel disease. ( Gordon, PH; Stein, BL, 1993)
"Basis treatment of severe ulcerative colitis and Crohn's disease comprises the systemic administration of corticosteroids."2.38[Conservative therapy of ulcerative colitis and Crohn disease]. ( Kreisel, W; Rasenack, J, 1991)
"The elective treatment for acute pouchitis is antibiotics."1.56Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment. ( Barreiro-de Acosta, M; Beltrán, B; Chaparro, M; Espín, E; Ferrer Bradley, I; Gisbert, JP; Guarner, F; Gutiérrez, A; Marín-Jimenez, I; Nos, P; Rodríguez-Lago, I, 2020)
"We identified 461 cases of ulcerative colitis (UC) and 683 cases of Crohn's disease (CD)."1.56Antibiotic Use in Childhood and Adolescence and Risk of Inflammatory Bowel Disease: A Case-Control Study in the UK Clinical Practice Research Datalink. ( Jick, S; Troelsen, FS, 2020)
"Four studies assessed treatment of acute pouchitis."1.51Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis. ( Holubar, SD; Nguyen, N; Pardi, DS; Singh, S; Zhang, B, 2019)
"A case of amoebic colitis and liver abscess is described in a previously fit 59-year old man who had been given the incorrect diagnosis of ulcerative colitis."1.46Learning points from a case of severe amoebic colitis. ( Al-Badri, A; Dryden, M; Dua, A; Petridou, C; Saeed, K, 2017)
"Reversible posterior leukoencephalopathy syndrome (RPLS) is a clinical syndrome of varying etiologies with similar neuroimaging findings."1.43Reversible Posterior Leukoencephalopathy Syndrome Associated with Treatment for Acute Exacerbation of Ulcerative Colitis. ( Ashida, T; Kikuchi, S; Maemoto, A; Orii, F, 2016)
"Pouchitis was classified as acute or chronic pouchitis."1.39Clinical features and management of pouchitis in Japanese ulcerative colitis patients. ( Bando, T; Ikeuchi, H; Matsuoka, H; Takesue, Y; Tomita, N; Uchino, M, 2013)
"Pouchitis is the most common long-term complication after restorative total proctocolectomy and IPAA for ulcerative colitis."1.38The long-term clinical course of pouchitis after total proctocolectomy and IPAA for ulcerative colitis. ( Funayama, Y; Haneda, S; Ogawa, H; Sasaki, I; Shibata, C; Suzuki, H; Takahashi, K; Watanabe, K, 2012)
"hominis in refractory ulcerative colitis."1.37Six ulcerative colitis patients with refractory symptoms co-infective with Blastocystis hominis in China. ( Hu, PJ; Lin, XC; Tai, WP; Wu, J, 2011)
"We describe a pediatric case of Sweet syndrome presenting 10 days after treatment with azathioprine."1.37Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis. ( Choe, YH; Jang, KT; Kim, MJ, 2011)
"However, the exact role of bacteria in ulcerative colitis (UC) has still to be elucidated."1.35Diversity of mucosa-associated microbiota in active and inactive ulcerative colitis. ( Benno, Y; Kudo, T; Nishikawa, J; Sakata, S; Sugiyama, T, 2009)
"The incidence of PPI in patients with ulcerative colitis/indeterminate colitis is 5."1.35Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis. ( Bell, AJ; Ciclitira, PJ; Clark, SK; McLaughlin, SD; Nicholls, RJ; Tekkis, PP, 2009)
"Treatment with metronidazole suppositories improved his symptoms and avoided further inappropriate intervention."1.33"Diversion" colitis caused by Clostridium difficile infection: report of a case. ( Feakins, RM; Irving, PM; Rampton, DS; Tsironi, E, 2006)
"The medical treatment of acute pouchitis was usually oral metronidazole (250 mg twice daily) for 2 weeks or oral ciprofloxacin (200 mg thrice daily) in patients who could not tolerate metronidazole."1.32Incidence and therapeutic outcome of pouchitis for ulcerative colitis in Japanese patients. ( Ikeuchi, H; Nakamura, M; Nakano, H; Noda, M; Uchino, M; Yamamura, T; Yanagi, H, 2004)
"A further 2 patients (4%) had treatment resistant pouchitis and required pouch excision."1.31Pouchitis following restorative proctocolectomy for ulcerative colitis: incidence and therapeutic outcome. ( Bartolo, DC; Madiba, TE, 2001)
"Episodic pouchitis is easily treated and causes minimum functional consequences, whereas chronic pouchitis increases defecation frequency and needs prolonged medication."1.30Functional results after restorative proctocolectomy complicated by pouchitis. ( Järvinen, H; Keränen, U; Luukkonen, P, 1997)
"Records of 217 patients with mucosal ulcerative colitis who underwent restorative proctocolectomy with a stapled ileal pouch-anal anastomosis without anal mucosectomy from 1987 through 1990 were retrospectively reviewed."1.29Anal canal inflammation after ileal pouch-anal anastomosis. The need for treatment. ( Fazio, VW; Lavery, IC; Sirimarco, MT; Ziv, Y, 1995)
"Bloody bowel movements were common with ulcerative colitis patients and watery diarrhea with Crohn's disease; other findings included abdominal pain, fever, nausea, and vomiting."1.29Blastocystis hominis in inflammatory bowel disease. ( Brown, M; Nagler, J; Soave, R, 1993)
"Three patients with ulcerative colitis in the active stage demonstrated reduced levels of F XIII activity and F XIII subunit A (61 and 80."1.28Substitution of factor XIII: a therapeutic approach to ulcerative colitis. ( Classen, M; Gain, T; Heinmüller, M; Lorenz, R; Tornieporth, N, 1991)
"In six of the nine Crohn's disease patients with an initial Best index of greater than 150, a definite fall by at least 100 points was observed after 2-10 weeks of treatment, but the van Hees index declined only in two patients."1.28Cyclosporin A treatment in inflammatory bowel disease. ( Ditschuneit, H; Fleig, WE; Rehklau, E; Stange, EF, 1989)
"A 43-year-old female suffering from ulcerative colitis did not improve under therapy with sulfasalazine."1.27Acute ulcerative colitis--a rare complication of sulfasalazine therapy. ( Domschke, S; Ruppin, H, 1984)
"A 28-year-old man with chronic ulcerative colitis had a proctocolectomy with creation of a continent ileostomy."1.27Pouch ileitis: report of a case with severe systemic manifestations. ( Katon, RM; Klein, K; Stenzel, P, 1983)
"The remission period of patients with ulcerative colitis was extended by long term treatment with 2-3 g sulphasalazine daily."1.26[Long-term therapy in ulcerative colitis and Crohn's disease]. ( Malchow, H, 1979)

Research

Studies (142)

TimeframeStudies, this research(%)All Research%
pre-199041 (28.87)18.7374
1990's29 (20.42)18.2507
2000's26 (18.31)29.6817
2010's37 (26.06)24.3611
2020's9 (6.34)2.80

Authors

AuthorsStudies
Bar, N1
Avraham, Y1
Dubinsky, V1
Cohen, NA1
Weiss, GA1
Banon, L1
Tulchinsky, H1
Maharshak, N1
Gophna, U1
Dotan, I1
Poo, S1
Sriranganathan, D1
Segal, JP1
Satka, S1
Frybortova, V1
Zapletalova, I1
Anzenbacher, P1
Anzenbacherova, E1
Kozakova, H1
Srutkova, D1
Hudcovic, T1
Jourova, L1
Barnes, EL1
Desai, A1
Kochhar, GS1
Emile, SH1
Horesh, N1
Freund, MR1
Garoufalia, Z1
Gefen, R1
Khan, SM1
Silva-Alvarenga, E1
Wexner, SD1
Nguyen, N2
Zhang, B2
Holubar, SD4
Pardi, DS5
Singh, S3
Barreiro-de Acosta, M1
Marín-Jimenez, I1
Rodríguez-Lago, I1
Guarner, F1
Espín, E1
Ferrer Bradley, I1
Gutiérrez, A1
Beltrán, B1
Chaparro, M1
Gisbert, JP1
Nos, P1
Mishra, S1
Mandavdhare, HS1
Singh, H1
Choudhury, A1
Shah, J1
Ram, S1
Kalsi, D1
Samanta, J1
Prasad, KK1
Sharma, AK1
Dutta, U1
Sharma, V1
Kayal, M1
Bhagya Rao, B1
Bhattacharya, A1
Ungaro, R1
Petridou, C1
Al-Badri, A1
Dua, A1
Dryden, M1
Saeed, K1
Theochari, NA1
Stefanopoulos, A1
Mylonas, KS1
Economopoulos, KP1
Nishii, S1
Higashiyama, M1
Ogata, S1
Komoto, S1
Ito, S2
Mizoguchi, A1
Terada, H1
Furuhashi, H1
Takajo, T1
Shirakabe, K1
Watanabe, C1
Tomita, K1
Nagao, S1
Miura, S1
Hokari, R1
Kordy, K1
Romeo, AC1
Lee, DJ1
Li, F1
Zabih, S1
Saavedra, M1
Cunningham, NJ1
Tobin, N1
Aldrovandi, GM1
Ishikawa, D2
Sasaki, T2
Takahashi, M1
Kuwahara-Arai, K2
Haga, K2
Okahara, K1
Nakajima, A1
Shibuya, T2
Osada, T2
Hiramatsu, K2
Watanabe, S3
Nagahara, A1
Little, K1
Argollo, M1
Kotze, PG1
Lamonaca, L1
Gilardi, D1
Furfaro, F1
Yamamoto, T1
Danese, S1
Troelsen, FS1
Jick, S1
Meyer, C1
Bowers, A1
Heavener, TE1
Checketts, JX1
Vassar, M1
Benlice, C1
Shen, B3
Steele, SR1
Samaha, M1
Moloney, M1
Oshima, T1
Takesue, Y2
Ikeuchi, H3
Matsuoka, H2
Nakajima, K1
Uchino, M3
Tomita, N2
Sasako, M1
Guslandi, M1
Koido, S1
Ohkusa, T9
Kajiura, T1
Shinozaki, J1
Suzuki, M1
Saito, K1
Takakura, K1
Tsukinaga, S1
Odahara, S1
Yukawa, T1
Mitobe, J1
Kajihara, M1
Uchiyama, K1
Arakawa, H1
Tajiri, H3
Kato, K4
Terao, S3
Chiba, T2
Murakami, K3
Yanaka, A2
Uehara, T2
Ishii, Y2
Soma, M1
Pierce, D1
Corcoran, M1
Martin, P1
Barrett, K1
Inglis, S1
Preston, P1
Thompson, TN1
Willsie, SK1
Turner, D1
Levine, A1
Kolho, KL1
Shaoul, R1
Ledder, O1
Stroud, AM1
Sandborn, WJ3
Den, Y1
Kinoshita, J1
Deshpande, GA1
Hiraoka, E1
Kikuchi, S1
Orii, F1
Maemoto, A1
Ashida, T1
Ozdemir, S1
Gulpinar, K1
Ozis, SE1
Sahli, Z1
Kesikli, SA1
Korkmaz, A1
Gecim, IE1
Peixoto, A1
Silva, M1
Vilas-Boas, F1
Macedo, G1
Nomura, K1
Fujimoto, Y1
Yamashita, M1
Morimoto, Y1
Ohshiro, M1
Sato, K1
Oyake, T1
Kowata, S1
Konishi, H1
Yoshikawa, T1
Ishida, Y1
Taniwaki, M1
Nishikawa, J1
Kudo, T1
Sakata, S1
Benno, Y2
Sugiyama, T2
McLaughlin, SD1
Clark, SK1
Bell, AJ1
Tekkis, PP1
Ciclitira, PJ1
Nicholls, RJ2
He, X1
Bennett, AE1
Lian, L1
Mabe, K1
Mizokami, Y1
Takeuchi, Y1
Yamato, S1
Yokoyama, T1
Okayasu, I4
Sato, N3
Cima, RR1
Sugitani, M1
Nemoto, N1
Moriyama, M1
Tai, WP1
Hu, PJ1
Wu, J1
Lin, XC1
Yamashiro, K1
Tamura, I1
Hirano, T1
Ott, C1
Girlich, C1
Klebl, F1
Plentz, A1
Iesalnieks, I1
Schölmerich, J2
Obermeier, F1
Na, DK1
Kim, JB1
Shin, YC1
Shin, SL1
Kim, HJ1
Baek, IH1
Park, SH1
Lee, MS1
Kim, MJ1
Jang, KT1
Choe, YH1
Suzuki, H1
Ogawa, H1
Shibata, C1
Haneda, S1
Watanabe, K1
Takahashi, K1
Funayama, Y1
Sasaki, I1
Tursi, A1
Elisei, W1
Brandimarte, G1
Giorgetti, GM1
Inchingolo, CD1
Nenna, R1
Picchio, M1
Giorgio, F1
Ierardi, E1
Bando, T1
Chiba, M1
Abe, T1
Tsuda, S1
Ono, I1
Nakano, H1
Nakamura, M1
Yanagi, H1
Noda, M1
Yamamura, T1
Gosselink, MP1
Schouten, WR1
van Lieshout, LM1
Hop, WC1
Laman, JD1
Ruseler-van Embden, JG1
Herrlinger, K1
Stange, EF2
Miner, J1
Gillan, MM1
Alex, P1
Centola, M1
Nedin, D2
Aleksandrova, A2
Ohge, H1
Furne, JK1
Springfield, J1
Rothenberger, DA1
Madoff, RD1
Levitt, MD1
Nomura, T2
Yoshida, T2
Sakamoto, M1
Hayashi, H1
Hirai, S2
Hojo, M2
Kobayashi, O2
Terai, T2
Miwa, H2
Takei, Y2
Ogihara, T2
Gionchetti, P2
Rizzello, F2
Morselli, C1
Romagnoli, R1
Campieri, M2
De Bleecker, JL1
Leroy, BP1
Meire, VI1
Okazaki, K1
Matsushita, M1
Kawamata, S1
Shimatani, M1
Fujii, T1
Tsironi, E1
Irving, PM1
Feakins, RM1
Rampton, DS2
Tremaine, WJ1
Tsesmeli, NE1
Giannoulis, KE1
Savopoulos, CG1
Vretou, EE1
Ekonomou, IA1
Giannoulis, EK1
Riis, P1
Singleton, JW1
Ewe, K1
Karbach, U1
Gilat, T3
Järnerot, G1
Goldstein, F1
Ruppin, H1
Domschke, S1
Malchow, H2
Ambrose, NS1
Alexander-Williams, J1
Keighley, MR2
Fukuda, H1
Ide, T1
Ichimura, T1
Haraguchi, M1
Mori, N1
Makiyama, K1
Saito, A1
Hara, K1
Klein, K1
Stenzel, P1
Katon, RM1
Hares, MM1
Bentley, S1
Allan, RN1
Burdon, DW1
Thiel, H1
Ecker, KW1
Kojima, T1
Nakamura, T1
Aoki, Y1
Tomita, E1
Stein, BL1
Gordon, PH1
Lavery, IC1
Sirimarco, MT1
Ziv, Y1
Fazio, VW2
Sachar, DB2
Mignon, M2
Stettler, C2
Phillips, SF2
van Hogezand, RA2
Lamers, CB1
Nygaard, K1
Bergan, T1
Bjørneklett, A1
Høverstad, T1
Lassen, J1
Aase, S1
Madden, MV1
McIntyre, AS1
Chaussade, S1
Mantzaris, GJ1
Hatzis, A1
Kontogiannis, P1
Triadaphyllou, G1
Menzel, J1
Bauer, J1
von Pritzbuer, E1
Klempa, I1
Nagler, J1
Brown, M1
Soave, R1
Hurst, RD1
Molinari, M1
Chung, TP1
Rubin, M1
Michelassi, F1
Bonner, GF1
Castro, M1
Rosati, P1
Lucidi, V1
Scotta, MS1
Papadatou, B1
Hadorn, HB1
McCaulley, ME1
Keränen, U1
Luukkonen, P1
Järvinen, H1
Wyllie, R1
Sarigol, S1
Arimura, Y1
Endo, T1
Imai, K1
Stein, RB1
Lichtenstein, GR1
Balbir-Gurman, A1
Schapira, D1
Nahir, M1
Parlak, E1
Dağli, U1
Ulker, A1
Alkim, C1
Sahin, B1
Achkar, JP1
Lashner, BA1
Ormsby, AH1
Remzi, FH1
Brzezinski, A1
Bevins, CL1
Bambrick, ML1
Seidner, DL1
Madiba, TE1
Bartolo, DC1
Amadini, C1
Venturi, A1
Matuchansky, C1
Cavell, B1
Hildebrand, H1
Meeuwisse, GW1
Lindquist, B1
Lennard-Jones, JE1
Powell-Tuck, J1
Hilmer, R1
Goulston, K1
Sunarwan, I1
Rosekrans, PC1
Onderdonk, AB1
Hermos, JA1
Dzink, JL1
Bartlett, JG1
Present, DH1
Yamada, M2
Lorenz, R1
Heinmüller, M1
Classen, M1
Tornieporth, N1
Gain, T1
McCarthy, DA1
Liu, YC1
Feurle, GE1
Jeddy, TA1
Farrington, GH1
Rasenack, J1
Kreisel, W1
Fellhauer, M1
Dubé, S1
Heyen, F1
Lloyd-Still, JD1
Takenaga, T1
Kitazume, C1
Yamamoto, N1
Sasabe, M1
Takashimizu, I1
Tamura, Y1
Sakamoto, E1
Kurosawa, H1
Gitnick, G1
Leichtman, G2
Delpre, G2
Eshchar, J1
Bar Meir, S1
Fireman, Z2
Fleig, WE1
Rehklau, E1
Ditschuneit, H1
Korelitz, BI1
Nagy, G1
Prónay, G1
Ujszászy, L1
Shaffer, JL1
Kershaw, A1
Houston, JB1
Gerok, W1
Ruderman, WB1
Farmer, RG1
Suissa, A1
Pavlotzky, M1
Grossman, A1
Sutherland, LR1
Dölle, W1
Daiss, W1
Okada, M1
Yao, T1
Chapman, RW1
Selby, WS1
Jewell, DP1
McCulloch, AJ1
McEvoy, A1
Jackson, JD1
Jarvis, EH1
Miller, B1
Martini, GA1
Pittman, FE1
el-Hashimi, WK1
Pittman, JC1
Balikian, JP1
Uthman, SM1
Khouri, NF1
Tanimoto-Weki, M1
Delgado-Carnica, R1
López-Mora, G1
Ramírez-Degollado, J1

Clinical Trials (12)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
"A Phase 1b/2 Study to Demonstrate the Safety and Efficacy of EXE-346 Live Biotherapeutic to Reduce High Bowel Movement Frequency in Subjects With an Ileal Pouch-Anal Anastomosis (PROF). The PROF Study."[NCT05938465]Phase 1/Phase 250 participants (Anticipated)Interventional2023-10-11Recruiting
Use of Antibiotics as an Adjuvant in Patients With Acute Severe Ulcerative Colitis: A Randomised Trial[NCT03794765]Phase 250 participants (Actual)Interventional2019-04-01Completed
Antimicrobial Therapy for Ulcerative Colitis : Evaluation of Two Antibiotic Combinations for Refractory Ulcerative Colitis[NCT03986996]Phase 220 participants (Actual)Interventional2019-07-25Terminated (stopped due to There is no feasibility to conduct the study)
A Phase 1, Randomized, Open-label, Crossover, Drug Interaction Study Evaluating the Pharmacokinetic Profiles of Amoxicillin Administered Alone and in Combination With MMX® Mesalazine/Mesalamine in Healthy Adult Subjects[NCT01442688]Phase 162 participants (Actual)Interventional2011-10-07Completed
A Phase 1, Randomized, Open-label, Crossover, Drug Interaction Study Evaluating the Pharmacokinetic Profiles of Sulfamethoxazole Administered Alone and in Combination With MMX® Mesalazine/Mesalamine in Healthy Adult Subjects[NCT01469637]Phase 144 participants (Actual)Interventional2011-11-07Completed
A Phase 1, Randomized, Open-label, Crossover, Drug Interaction Study Evaluating the Pharmacokinetic Profiles of Ciprofloxacin XR Administered Alone and in Combination With MMX® Mesalazine/Mesalamine in Healthy Adult Subjects[NCT01402947]Phase 130 participants (Actual)Interventional2011-07-25Completed
A Phase 1, Randomized, Open-label, Crossover, Drug Interaction Study Evaluating the Pharmacokinetic Profiles of Metronidazole Administered Alone and in Combination With MMX® Mesalazine/Mesalamine in Healthy Adult Subjects[NCT01418365]Phase 130 participants (Actual)Interventional2011-08-22Completed
Precision Medicine in Systemic Sclerosis Gastrointestinal Disease: Evaluating Imaging and Stool Biomarkers for Differentiating Disease Stages and Treatment Responses[NCT04630782]70 participants (Anticipated)Observational2020-04-09Recruiting
A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Antibiotic-Refractory Pouchitis[NCT00583531]Phase 22 participants (Actual)Interventional2007-03-31Terminated (stopped due to Lack of enrollment)
A Pilot Study of the Safety and Efficacy of AST-120 in the Treatment of Active Pouchitis[NCT00583076]Phase 219 participants (Actual)Interventional2007-02-28Completed
Fecal Microbiota Transplantation for the Treatment of Chronic Pouchitis[NCT03538366]10 participants (Actual)Interventional2018-05-15Completed
Randomized, Double-Blind, Placebo-Controlled Study of VSL#3 Versus Placebo in the Maintenance of Remission in Crohn's Disease[NCT00114465]Phase 438 participants (Actual)Interventional2005-06-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Area Under the Plasma Concentration Versus Time Curve From Time Zero to Infinity (AUC 0→∞) for Amoxicillin

AUC can be used as a measure of drug exposure. It is derived from drug concentration and time so it gives a measure how much and how long a drug stays in a body. (NCT01442688)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionh*ug/ml (Mean)
Amoxicillin + MMX Placebo27.8
Amoxicillin + MMX Mesalazine/Mesalamine28.3

Maximum Plasma Concentration (Cmax) for Amoxicillin

Cmax is a term that refers to the maximum (or peak) concentration that a drug achieves in the body after the drug has been administrated. (NCT01442688)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionug/ml (Mean)
Amoxicillin + MMX Placebo10.3
Amoxicillin + MMX Mesalazine/Mesalamine10.2

Area Under the Plasma Concentration Versus Time Curve Within a Dosing Interval at Steady-State (AUCss) for Sulfamethoxazole

AUC can be used as a measure of drug exposure. It is derived from drug concentration and time so it gives a measure of how much and how long a drug stays in a body. (NCT01469637)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionh*ug/ml (Mean)
Sulfamethoxazole + MMX Placebo786
Sulfamethoxazole + MMX Mesalazine/Mesalamine909

Maximum Plasma Concentration at Steady-State (Cmaxss) for Sulfamethoxazole

Cmax is a term that refers to the maximum (or peak) concentration that a drug achieves in the body after the drug has been administrated. (NCT01469637)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionug/ml (Mean)
Sulfamethoxazole + MMX Placebo89.1
Sulfamethoxazole + MMX Mesalazine/Mesalamine100

Area Under the Plasma Concentration Versus Time Curve From Time Zero to Infinity (AUC 0→∞) of Ciprofloxacin XR

AUC can be used as a measure of drug exposure. It is derived from drug concentration and time so it gives a measure how much and how long a drug stays in a body. (NCT01402947)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionng*h/ml (Mean)
MMX Placebo + Ciprofloxacin7805
MMX Mesalazine/Mesalamine + Ciprofloxacin7934

Maximum Plasma Concentration (Cmax) of Ciprofloxacin XR

Cmax is a term that refers to the maximum (or peak) concentration that a drug achieves in the body after the drug has been administrated. (NCT01402947)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionng/ml (Mean)
MMX Placebo + Ciprofloxacin1455
MMX Mesalazine/Mesalamine + Ciprofloxacin1433

Area Under the Plasma Concentration Curve (AUC) at Steady State for Metronidazole

AUC can be used as a measure of drug exposure. It is derived from drug concentration and time so it gives a measure how much and how long a drug stays in a body. (NCT01418365)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionng*h/ml (Mean)
Metronidazole + MMX Placebo217686
Metronidazole + MMX Mesalazine/Mesalamine215809

Maximum Plasma Concentration (Cmax) at Steady State for Metronidazole

Cmax is a term that refers to the maximum (or peak) concentration that a drug achieves in the body after the drug has been administrated. (NCT01418365)
Timeframe: Assessed over a 24-hour period starting post-dose on day 4

Interventionng/ml (Mean)
Metronidazole + MMX Placebo28193
Metronidazole + MMX Mesalazine/Mesalamine28057

Reviews

35 reviews available for metronidazole and Colitis Gravis

ArticleYear
Network meta-analysis: efficacy of treatment for acute, chronic, and prevention of pouchitis in ulcerative colitis.
    European journal of gastroenterology & hepatology, 2022, 05-01, Volume: 34, Issue:5

    Topics: Anti-Bacterial Agents; Colitis, Ulcerative; Humans; Metronidazole; Network Meta-Analysis; Pouchitis;

2022
A Systematic Review and Meta-analysis of Randomized Clinical Trials on the Prevention and Treatment of Pouchitis after Ileoanal Pouch Anastomosis.
    Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2023, Volume: 27, Issue:11

    Topics: Anastomosis, Surgical; Ciprofloxacin; Colitis, Ulcerative; Humans; Metronidazole; Pouchitis; Proctoc

2023
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
    The Cochrane database of systematic reviews, 2019, 11-30, Volume: 11

    Topics: Anastomosis, Surgical; Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema;

2019
Antibiotics exposure and risk of inflammatory bowel disease: a systematic review.
    Scandinavian journal of gastroenterology, 2018, Volume: 53, Issue:1

    Topics: Anti-Bacterial Agents; Colitis, Ulcerative; Crohn Disease; Fluoroquinolones; Humans; Metronidazole;

2018
Prevention of Postoperative Recurrence in CD: Tailoring Treatment to Patient Profile.
    Current drug targets, 2019, Volume: 20, Issue:13

    Topics: Ciprofloxacin; Colitis, Ulcerative; Humans; Metronidazole; Patient-Centered Care; Pouchitis; Practic

2019
Prevention and Medical Treatment of Pouchitis In Ulcerative Colitis.
    Current drug targets, 2019, Volume: 20, Issue:13

    Topics: Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Humans; Male; Metronidazole;

2019
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
    The Cochrane database of systematic reviews, 2015, Nov-23, Issue:11

    Topics: Adult; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema; Gastrointestinal Agents; Humans; Metro

2015
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
    The Cochrane database of systematic reviews, 2010, Jun-16, Issue:6

    Topics: Adult; Ciprofloxacin; Colitis, Ulcerative; Enema; Gastrointestinal Agents; Humans; Metronidazole; Po

2010
[Chronic inflammatory bowel diseases].
    Deutsche medizinische Wochenschrift (1946), 2004, Oct-15, Volume: 129, Issue:42

    Topics: Adrenal Cortex Hormones; Adult; Aminosalicylic Acids; Anti-Bacterial Agents; Anti-Infective Agents;

2004
[Pancreatitis accompanying inflammatory bowel diseases, and our observations].
    Khirurgiia, 2004, Volume: 60, Issue:1

    Topics: Acute Disease; Amylases; Anti-Infective Agents; Anti-Inflammatory Agents; Bulgaria; Cholangitis, Scl

2004
Management of inflammatory bowel disease: does rifaximin offer any promise?
    Chemotherapy, 2005, Volume: 51 Suppl 1

    Topics: Anti-Bacterial Agents; Bacteria; Ciprofloxacin; Clinical Trials as Topic; Colitis, Ulcerative; Crohn

2005
[Diagnosis and medical treatment of pouchitis in ileal pouch-anal anastomosis in patients with ulcerative colitis].
    Nihon rinsho. Japanese journal of clinical medicine, 2005, Volume: 63, Issue:5

    Topics: Acute Disease; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Immunologic Factor

2005
A critical survey of controlled studies in the treatment of ulcerative colitis and Crohn's disease.
    Clinics in gastroenterology, 1980, Volume: 9, Issue:2

    Topics: BCG Vaccine; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Glucocor

1980
Fertility, sterility, and pregnancy in chronic inflammatory bowel disease.
    Scandinavian journal of gastroenterology, 1982, Volume: 17, Issue:1

    Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Crohn Disease; Female; Fertility; Humans; Infant, Newb

1982
Perianal inflammatory conditions in inflammatory bowel disease.
    Current opinion in general surgery, 1993

    Topics: Abscess; Adult; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease; Female; Humans; Male;

1993
Maintenance therapy in ulcerative colitis and Crohn's disease.
    Journal of clinical gastroenterology, 1995, Volume: 20, Issue:2

    Topics: Adjuvants, Immunologic; Adrenal Cortex Hormones; Aminosalicylic Acids; Anti-Inflammatory Agents; Col

1995
Pouchitis--a poorly understood entity.
    Diseases of the colon and rectum, 1995, Volume: 38, Issue:1

    Topics: Anal Canal; Anastomosis, Surgical; Colitis, Ulcerative; Humans; Inflammatory Bowel Diseases; Metroni

1995
[Possibilities of drug treatment in inflammatory intestinal diseases].
    Nederlands tijdschrift voor geneeskunde, 1994, Dec-17, Volume: 138, Issue:51

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis,

1994
Medical management of patients with difficult-to-treat inflammatory bowel disease.
    The Netherlands journal of medicine, 1994, Volume: 45, Issue:2

    Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine

1994
[Ileo-anal "pouchitis": a still misunderstood pathology].
    Annales de chirurgie, 1993, Volume: 47, Issue:10

    Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Glutamine; Humans; Ileitis; Inflammation; Metronidazol

1993
[Ileoanal anastomosis with pouch: a rigorous surgical technique is necessary, but the most frequent long-term postoperative complication remains inflammation of the pouch].
    Gastroenterologie clinique et biologique, 1993, Volume: 17, Issue:8-9

    Topics: Adenomatous Polyposis Coli; Adrenal Cortex Hormones; Colitis, Ulcerative; Diarrhea; Female; Humans;

1993
Current medical therapy for inflammatory bowel disease.
    Southern medical journal, 1996, Volume: 89, Issue:6

    Topics: Administration, Topical; Adrenal Cortex Hormones; Aminosalicylic Acid; Aminosalicylic Acids; Anti-In

1996
The treatment of inflammatory bowel disease in children.
    Clinical pediatrics, 1998, Volume: 37, Issue:7

    Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Child; Colitis, Ulcerative; Crohn Disease; Fe

1998
[Therapeutic strategy for severe and fulminating ulcerative colitis].
    Nihon rinsho. Japanese journal of clinical medicine, 1999, Volume: 57, Issue:11

    Topics: Adrenocorticotropic Hormone; Anti-Inflammatory Agents; Colectomy; Colitis, Ulcerative; Cyclosporine;

1999
Complications after ileal pouch-anal anastomosis.
    Seminars in gastrointestinal disease, 2000, Volume: 11, Issue:1

    Topics: Anastomosis, Surgical; Ciprofloxacin; Colitis, Ulcerative; Crohn Disease; Humans; Male; Metronidazol

2000
Review article: treatment of mild to moderate ulcerative colitis and pouchitis.
    Alimentary pharmacology & therapeutics, 2002, Volume: 16 Suppl 4

    Topics: Administration, Oral; Administration, Rectal; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-

2002
Drug treatment of inflammatory bowel disease.
    Clinics in gastroenterology, 1979, Volume: 8, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antidiarrheals; Azathio

1979
Immunotherapy in inflammatory bowel disease.
    The Medical clinics of North America, 1978, Volume: 62, Issue:1

    Topics: Adult; Alkylating Agents; Antimetabolites; Azathioprine; Child; Clinical Trials as Topic; Colitis, U

1978
[New developments in the treatment of inflammatory bowel diseases. What is certain?].
    Zeitschrift fur Gastroenterologie. Verhandlungsband, 1990, Volume: 25

    Topics: Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Humans; Immunosu

1990
[Conservative therapy of ulcerative colitis and Crohn disease].
    Fortschritte der Medizin, 1991, Apr-10, Volume: 109, Issue:11

    Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Humans; Immunosup

1991
Antibiotics and inflammatory bowel diseases.
    Gastroenterology clinics of North America, 1989, Volume: 18, Issue:1

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Antibiotics, Antitubercular; Colitis, Ulcerative; Croh

1989
Current management of inflammatory bowel disease.
    Radiologic clinics of North America, 1987, Volume: 25, Issue:1

    Topics: Adrenal Cortex Hormones; Aza Compounds; Colitis, Ulcerative; Combined Modality Therapy; Crohn Diseas

1987
Medical treatment of inflammatory bowel disease: new therapies, new drugs.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1987, Nov-01, Volume: 137, Issue:9

    Topics: Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; F

1987
[Therapy of chronic inflammatory bowel diseases. Clinical aspects and therapy of drug-induced side effects].
    Verhandlungen der Deutschen Gesellschaft fur Innere Medizin, 1988, Volume: 94

    Topics: Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Glucocorticoids; Humans; Immunosuppressive

1988
[What is secured in the therapy of chronic inflammatory colonic diseases?].
    Der Internist, 1974, Volume: 15, Issue:12

    Topics: Administration, Topical; Amebiasis; Azathioprine; Chronic Disease; Colitis; Colitis, Ulcerative; Col

1974

Trials

30 trials available for metronidazole and Colitis Gravis

ArticleYear
Adjuvant use of combination of antibiotics in acute severe ulcerative colitis: A placebo controlled randomized trial.
    Expert review of anti-infective therapy, 2021, Volume: 19, Issue:7

    Topics: Acute Disease; Adult; Anti-Bacterial Agents; Ceftriaxone; Colitis, Ulcerative; Double-Blind Method;

2021
Preoperative oral antibiotics and intravenous antimicrobial prophylaxis reduce the incidence of surgical site infections in patients with ulcerative colitis undergoing IPAA.
    Diseases of the colon and rectum, 2013, Volume: 56, Issue:10

    Topics: Administration, Intravenous; Administration, Oral; Adult; Anal Canal; Anastomosis, Surgical; Anti-Ba

2013
Long-term alteration of intestinal microbiota in patients with ulcerative colitis by antibiotic combination therapy.
    PloS one, 2014, Volume: 9, Issue:1

    Topics: Actins; Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Colitis, Ulcerative; Double-Bli

2014
Adjunct antibiotic combination therapy for steroid-refractory or -dependent ulcerative colitis: an open-label multicentre study.
    Alimentary pharmacology & therapeutics, 2014, Volume: 39, Issue:9

    Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Colectomy; Colitis, Ulcerative; Colonos

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Effect of MMX® mesalamine coadministration on the pharmacokinetics of amoxicillin, ciprofloxacin XR, metronidazole, and sulfamethoxazole: results from four randomized clinical trials.
    Drug design, development and therapy, 2014, Volume: 8

    Topics: Adult; Amoxicillin; Ciprofloxacin; Colitis, Ulcerative; Cross-Over Studies; Drug Interactions; Femal

2014
Changes in Intestinal Microbiota Following Combination Therapy with Fecal Microbial Transplantation and Antibiotics for Ulcerative Colitis.
    Inflammatory bowel diseases, 2017, Volume: 23, Issue:1

    Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Colitis, Ulcerative; Colon; Colonoscopy; Combined M

2017
Newly developed antibiotic combination therapy for ulcerative colitis: a double-blind placebo-controlled multicenter trial.
    The American journal of gastroenterology, 2010, Volume: 105, Issue:8

    Topics: Administration, Oral; Adrenal Cortex Hormones; Adult; Amoxicillin; Colitis, Ulcerative; Double-Blind

2010
Efficacy of antibiotic combination therapy in patients with active ulcerative colitis, including refractory or steroid-dependent cases.
    Journal of gastroenterology and hepatology, 2010, Volume: 25 Suppl 1

    Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Biomarkers; Colitis, Ulcerative; Colon; Colonoscopy; Drug

2010
Antibiotic combination therapy for steroid withdrawal in steroid-dependent ulcerative colitis.
    Digestion, 2011, Volume: 83, Issue:3

    Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Azathioprine; Colitis, Ulcerative; Drug

2011
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
    Diseases of the colon and rectum, 2004, Volume: 47, Issue:9

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti

2004
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
    Diseases of the colon and rectum, 2004, Volume: 47, Issue:9

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti

2004
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
    Diseases of the colon and rectum, 2004, Volume: 47, Issue:9

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti

2004
Eradication of pathogenic bacteria and restoration of normal pouch flora: comparison of metronidazole and ciprofloxacin in the treatment of pouchitis.
    Diseases of the colon and rectum, 2004, Volume: 47, Issue:9

    Topics: Adult; Anti-Infective Agents; Ciprofloxacin; Clostridium Infections; Clostridium perfringens; Coliti

2004
Mucosa-associated bacteria in ulcerative colitis before and after antibiotic combination therapy.
    Alimentary pharmacology & therapeutics, 2005, Apr-15, Volume: 21, Issue:8

    Topics: Amoxicillin; Colitis, Ulcerative; Drug Therapy, Combination; Fusobacterium; Fusobacterium Infections

2005
Effectiveness of antibiotic combination therapy in patients with active ulcerative colitis: a randomized, controlled pilot trial with long-term follow-up.
    Scandinavian journal of gastroenterology, 2005, Volume: 40, Issue:11

    Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Colitis, Ulcerative; Dose-Response Relationsh

2005
A critical survey of controlled studies in the treatment of ulcerative colitis and Crohn's disease.
    Clinics in gastroenterology, 1980, Volume: 9, Issue:2

    Topics: BCG Vaccine; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Glucocor

1980
Metronidazole in Crohn's disease.
    Gastroenterology, 1982, Volume: 83, Issue:3

    Topics: Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Double-Blind Method; Humans; Metronida

1982
Audit of sepsis in operations for inflammatory bowel disease.
    Diseases of the colon and rectum, 1984, Volume: 27, Issue:9

    Topics: Abscess; Adult; Colitis, Ulcerative; Crohn Disease; Female; Gentamicins; Humans; Male; Metronidazole

1984
Clinical trials of the efficacy and duration of antibacterial cover for elective resection in inflammatory bowel disease.
    The British journal of surgery, 1982, Volume: 69, Issue:4

    Topics: Adult; Bacterial Infections; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Double-Bl

1982
Topical metronidazole treatment in pouchitis.
    Scandinavian journal of gastroenterology, 1994, Volume: 29, Issue:5

    Topics: Adenomatous Polyposis Coli; Administration, Topical; Adolescent; Adult; Colitis, Ulcerative; Fatty A

1994
Double-blind crossover trial of metronidazole versus placebo in chronic unremitting pouchitis.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:6

    Topics: C-Reactive Protein; Chronic Disease; Colitis, Ulcerative; Defecation; Double-Blind Method; Humans; I

1994
Intravenous tobramycin and metronidazole as an adjunct to corticosteroids in acute, severe ulcerative colitis.
    The American journal of gastroenterology, 1994, Volume: 89, Issue:1

    Topics: Acute Disease; Adolescent; Adult; Aged; Chemotherapy, Adjuvant; Colitis, Ulcerative; Drug Therapy, C

1994
[Perioperative use of ampicillin/sulbactam, cefoxitin and piperacillin/ metronidazole in elective colon and rectal surgery. A prospective randomized quality assurance study of 422 patients].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1993, Volume: 64, Issue:8

    Topics: Aged; Ampicillin; Anti-Bacterial Agents; Bacterial Infections; Cefoxitin; Colitis, Ulcerative; Colon

1993
Comparison of 5-amino salicylic acid plus glucocorticosteroid with metronidazole and ciprofloxacin in patients with active ulcerative colitis.
    Journal of clinical gastroenterology, 2001, Volume: 33, Issue:1

    Topics: Adult; Ciprofloxacin; Colitis, Ulcerative; Drug Therapy, Combination; Female; Glucocorticoids; Human

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
A randomized clinical trial of ciprofloxacin and metronidazole to treat acute pouchitis.
    Inflammatory bowel diseases, 2001, Volume: 7, Issue:4

    Topics: Acute Disease; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female; Humans; Mal

2001
Drug treatment of inflammatory bowel disease.
    Clinics in gastroenterology, 1979, Volume: 8, Issue:1

    Topics: Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Anti-Bacterial Agents; Antidiarrheals; Azathio

1979
Immunotherapy in inflammatory bowel disease.
    The Medical clinics of North America, 1978, Volume: 62, Issue:1

    Topics: Adult; Alkylating Agents; Antimetabolites; Azathioprine; Child; Clinical Trials as Topic; Colitis, U

1978
[New developments in the treatment of inflammatory bowel diseases. What is certain?].
    Zeitschrift fur Gastroenterologie. Verhandlungsband, 1990, Volume: 25

    Topics: Aminosalicylic Acids; Clinical Trials as Topic; Colitis, Ulcerative; Crohn Disease; Humans; Immunosu

1990
Azathioprine and the treatment of chronic inflammatory bowel disease.
    The Journal of pediatrics, 1990, Volume: 117, Issue:5

    Topics: Adolescent; Adult; Azathioprine; Child; Colitis, Ulcerative; Crohn Disease; Double-Blind Method; Hum

1990
A comparison of metronidazole and sulfasalazine in the maintenance of remission in patients with ulcerative colitis.
    Journal of clinical gastroenterology, 1989, Volume: 11, Issue:4

    Topics: Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Female; Follow-Up Studies; Human

1989
[Drug therapy of chronic inflammatory intestinal diseases--current status of 5-aminosalicylic acid].
    Wiener klinische Wochenschrift, 1986, Nov-21, Volume: 98, Issue:22

    Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Azathioprine; Clinical Trials as Topic; Colitis, Ulce

1986
A comparative study of metronidazole and sulfasalazine in active, not severe, ulcerative colitis. An Israeli multicenter trial.
    Journal of clinical gastroenterology, 1987, Volume: 9, Issue:4

    Topics: Acute Disease; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Female; Humans; I

1987
Controlled trial of intravenous metronidazole as an adjunct to corticosteroids in severe ulcerative colitis.
    Gut, 1986, Volume: 27, Issue:10

    Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Colitis, Ulcerative; Double-Blind Method; Drug Th

1986

Other Studies

81 other studies available for metronidazole and Colitis Gravis

ArticleYear
Long-term Antibiotic Treatment in Pouchitis-Patterns of Use and Safety.
    Inflammatory bowel diseases, 2022, 07-01, Volume: 28, Issue:7

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Metronidazole; Pouchitis; Proctoc

2022
Effect of DSS-Induced Ulcerative Colitis and Butyrate on the Cytochrome P450 2A5: Contribution of the Microbiome.
    International journal of molecular sciences, 2022, Oct-01, Volume: 23, Issue:19

    Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Butyrates; Colitis, Ulcerative; Cytochrome

2022
The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study.
    The American journal of gastroenterology, 2023, 11-01, Volume: 118, Issue:11

    Topics: Anti-Bacterial Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Male; Metronidazole; Pouchitis; P

2023
Recommendations of the Spanish Working Group on Crohn's Disease and Ulcerative Colitis (GETECCU) on pouchitis in ulcerative colitis. Part 2: Treatment.
    Gastroenterologia y hepatologia, 2020, Volume: 43, Issue:10

    Topics: Acute Disease; Advisory Committees; Algorithms; Anti-Bacterial Agents; Biological Products; Budesoni

2020
Clinical Challenge: From Ulcerative Colitis to Crohn's Disease-Like Pouch Inflammation.
    Digestive diseases and sciences, 2021, Volume: 66, Issue:10

    Topics: Adult; Anti-Infective Agents; Anti-Inflammatory Agents; Ciprofloxacin; Colitis, Ulcerative; Crohn Di

2021
Learning points from a case of severe amoebic colitis.
    Le infezioni in medicina, 2017, Sep-01, Volume: 25, Issue:3

    Topics: Colitis, Ulcerative; Combined Modality Therapy; Delayed Diagnosis; Diagnosis, Differential; Diagnost

2017
Human intestinal spirochetosis mimicking ulcerative colitis.
    Clinical journal of gastroenterology, 2018, Volume: 11, Issue:2

    Topics: Aged; Anti-Infective Agents; Brachyspira; Colitis; Colitis, Ulcerative; Colonoscopy; Diagnosis, Diff

2018
Combination Antibiotics Improves Disease Activity and Alters Microbial Communities in Children With Ulcerative Colitis.
    Journal of pediatric gastroenterology and nutrition, 2018, Volume: 67, Issue:3

    Topics: Adolescent; Adult; Amoxicillin; Anti-Bacterial Agents; Child; Colitis, Ulcerative; Doxycycline; Fema

2018
The Microbial Composition of Bacteroidetes Species in Ulcerative Colitis Is Effectively Improved by Combination Therapy With Fecal Microbiota Transplantation and Antibiotics.
    Inflammatory bowel diseases, 2018, 11-29, Volume: 24, Issue:12

    Topics: Amoxicillin; Anti-Bacterial Agents; Bacteroidetes; Colitis, Ulcerative; Combined Modality Therapy; D

2018
What is causing this patient's multiple skin abscesses?
    JAAPA : official journal of the American Academy of Physician Assistants, 2018, Volume: 31, Issue:11

    Topics: Abscess; Adolescent; Colitis, Ulcerative; Cyclosporine; Dermatologic Agents; Female; Gastrointestina

2018
Treatment and prevention of pouchitis after ileal pouch-anal anastomosis for chronic ulcerative colitis.
    The Cochrane database of systematic reviews, 2019, 05-28, Volume: 5

    Topics: Anastomosis, Surgical; Anti-Bacterial Agents; Budesonide; Ciprofloxacin; Colitis, Ulcerative; Enema;

2019
Antibiotic Use in Childhood and Adolescence and Risk of Inflammatory Bowel Disease: A Case-Control Study in the UK Clinical Practice Research Datalink.
    Inflammatory bowel diseases, 2020, 02-11, Volume: 26, Issue:3

    Topics: Adolescent; Age Factors; Anti-Bacterial Agents; Case-Control Studies; Child; Child, Preschool; Colit

2020
From clinical practice guideline development to trial registration: A systematic investigation of research pipeline for inflammatory bowel disease.
    Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology, 2019, Volume: 38, Issue:3

    Topics: Adrenal Cortex Hormones; Anti-Infective Agents; Bibliometrics; Biomedical Research; Clinical Trials

2019
Long-term antibiotic therapy in late onset pouch-urethral fistula after ileoanal anastomosis for ulcerative colitis may be effective and well tolerated.
    BMJ case reports, 2013, Mar-15, Volume: 2013

    Topics: Adult; Anal Canal; Anastomosis, Surgical; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative;

2013
Role of probiotics in the management of pouchitis.
    Current pharmaceutical design, 2014, Volume: 20, Issue:28

    Topics: Animals; Anti-Bacterial Agents; Ciprofloxacin; Colitis, Ulcerative; Humans; Intestines; Metronidazol

2014
Combination of oral antibiotics may be effective in severe pediatric ulcerative colitis: a preliminary report.
    Journal of Crohn's & colitis, 2014, Volume: 8, Issue:11

    Topics: Adolescent; Amoxicillin; Anti-Bacterial Agents; C-Reactive Protein; Child; Colitis, Ulcerative; Doxy

2014
Amoebiasis masquerading as inflammatory bowel disease.
    BMJ case reports, 2015, Nov-25, Volume: 2015

    Topics: Antiprotozoal Agents; Colitis, Ulcerative; Diagnosis, Differential; Diagnostic Errors; Diarrhea; Dys

2015
Reversible Posterior Leukoencephalopathy Syndrome Associated with Treatment for Acute Exacerbation of Ulcerative Colitis.
    Internal medicine (Tokyo, Japan), 2016, Volume: 55, Issue:5

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Blood Transfusion; Colitis, Ulcerative; Contraindic

2016
The effects of preoperative oral antibiotic use on the development of surgical site infection after elective colorectal resections: A retrospective cohort analysis in consecutively operated 90 patients.
    International journal of surgery (London, England), 2016, Volume: 33 Pt A

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anastomotic Leak; Anti-Bacterial Agents; Antib

2016
All that glitters is not gold. A different cause for an "ulcerative colitis".
    Revista espanola de enfermedades digestivas, 2017, Volume: 109, Issue:1

    Topics: Adult; Antitrichomonal Agents; Colitis, Ulcerative; Entamoeba histolytica; Entamoebiasis; Humans; Ma

2017
[Intestinal parasitoses and worm infestations].
    Zeitschrift fur Gastroenterologie, 2008, Volume: 46, Issue:4

    Topics: Amebiasis; Antiprotozoal Agents; Colitis, Ulcerative; Diagnosis, Differential; Dysentery, Amebic; En

2008
Absence of pseudomembranes in Clostridium difficile-associated diarrhea in patients using immunosuppression agents.
    Scandinavian journal of gastroenterology, 2009, Volume: 44, Issue:1

    Topics: Adolescent; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Toxins; Clostridioides di

2009
Diversity of mucosa-associated microbiota in active and inactive ulcerative colitis.
    Scandinavian journal of gastroenterology, 2009, Volume: 44, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Infective Agents; Case-Control Studies; Colitis, U

2009
Incidence and short-term implications of prepouch ileitis following restorative proctocolectomy with ileal pouch-anal anastomosis for ulcerative colitis.
    Diseases of the colon and rectum, 2009, Volume: 52, Issue:5

    Topics: Adult; Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Budesonide; Ciprofloxacin; Colitis, Ul

2009
Recurrent cytomegalovirus infection in ileal pouch-anal anastomosis for ulcerative colitis.
    Inflammatory bowel diseases, 2010, Volume: 16, Issue:6

    Topics: Ciprofloxacin; Colitis, Ulcerative; Colonic Pouches; Cytomegalovirus Infections; Dietary Supplements

2010
Six ulcerative colitis patients with refractory symptoms co-infective with Blastocystis hominis in China.
    Parasitology research, 2011, Volume: 108, Issue:5

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antiprotozoal Agents; Blastocystis hominis; Blastocy

2011
Low risk of Clostridium difficile infections in hospitalized patients with inflammatory bowel disease in a German tertiary referral center.
    Digestion, 2011, Volume: 84, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Azathiop

2011
[Left-sided ulcerative colitis reactivated and aggravated during clostridium difficile infection].
    The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2011, Volume: 57, Issue:6

    Topics: Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; C-Reactive Protein; Clostridioides d

2011
Azathioprine hypersensitivity presenting as sweet syndrome in a child with ulcerative colitis.
    Indian pediatrics, 2011, Volume: 48, Issue:12

    Topics: Azathioprine; Child; Colitis, Ulcerative; Drug Hypersensitivity; Female; Humans; Immunosuppressive A

2011
The long-term clinical course of pouchitis after total proctocolectomy and IPAA for ulcerative colitis.
    Diseases of the colon and rectum, 2012, Volume: 55, Issue:3

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Colonic Pou

2012
Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor-alpha in diverticular disease of the colon: a case-control study.
    Neurogastroenterology and motility, 2012, Volume: 24, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Anti-Inflammatory Agents, Non-Steroidal; Case

2012
Clinical features and management of pouchitis in Japanese ulcerative colitis patients.
    Surgery today, 2013, Volume: 43, Issue:9

    Topics: Acute Disease; Adolescent; Adult; Age Factors; Age of Onset; Aged; Anti-Bacterial Agents; Asian Peop

2013
Cytomegalovirus infection associated with onset of ulcerative colitis.
    BMC research notes, 2013, Feb-02, Volume: 6

    Topics: Adult; Aged; Anti-Infective Agents; Colitis, Ulcerative; Cytomegalovirus Infections; Female; Gastroi

2013
Incidence and therapeutic outcome of pouchitis for ulcerative colitis in Japanese patients.
    Digestive surgery, 2004, Volume: 21, Issue:3

    Topics: Adenomatous Polyposis Coli; Adult; Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Female

2004
Clinical management of pouchitis.
    Gastroenterology, 2004, Volume: 127, Issue:6

    Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H

2004
Clinical management of pouchitis.
    Gastroenterology, 2004, Volume: 127, Issue:6

    Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H

2004
Clinical management of pouchitis.
    Gastroenterology, 2004, Volume: 127, Issue:6

    Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H

2004
Clinical management of pouchitis.
    Gastroenterology, 2004, Volume: 127, Issue:6

    Topics: Adult; Anti-Infective Agents; Biopsy; Ciprofloxacin; Colitis, Ulcerative; Diagnosis, Differential; H

2004
Steroid-refractory ulcerative colitis treated with corticosteroids, metronidazole and vancomycin: a case report.
    BMC gastroenterology, 2005, Jan-24, Volume: 5

    Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Clostridioides diffic

2005
[Pouchitis, on the basis of a single observation].
    Khirurgiia, 2004, Volume: 60, Issue:2

    Topics: Adolescent; Anti-Infective Agents; Bulgaria; Colitis, Ulcerative; Follow-Up Studies; Humans; Male; M

2004
Association between fecal hydrogen sulfide production and pouchitis.
    Diseases of the colon and rectum, 2005, Volume: 48, Issue:3

    Topics: Anti-Infective Agents; Ciprofloxacin; Colitis, Ulcerative; Feces; Female; Humans; Hydrogen Sulfide;

2005
Reversible visual deficit and Corpus callosum lesions due to metronidazole toxicity.
    European neurology, 2005, Volume: 53, Issue:2

    Topics: Adult; Anti-Infective Agents; Colitis, Ulcerative; Corpus Callosum; Diagnosis, Differential; Evoked

2005
"Diversion" colitis caused by Clostridium difficile infection: report of a case.
    Diseases of the colon and rectum, 2006, Volume: 49, Issue:7

    Topics: Administration, Rectal; Adult; Anti-Infective Agents; Clostridioides difficile; Clostridium Infectio

2006
Inflammatory Bowel Disease and Clostridium difficile-associated diarrhea: a growing problem.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2007, Volume: 5, Issue:3

    Topics: Bacterial Toxins; Clostridioides difficile; Clostridium Infections; Cohort Studies; Colitis, Ulcerat

2007
Acute pancreatitis as a possible consequence of metronidazole during a relapse of ulcerative colitis.
    European journal of gastroenterology & hepatology, 2007, Volume: 19, Issue:9

    Topics: Acute Disease; Adult; Colitis, Ulcerative; Gastrointestinal Agents; Humans; Male; Metronidazole; Pan

2007
Medical therapy of inflammatory bowel disease.
    The Medical clinics of North America, 1980, Volume: 64, Issue:6

    Topics: Acute Disease; Adjuvants, Immunologic; Anus Diseases; Azathioprine; Colitis, Ulcerative; Crohn Disea

1980
[Crohn disease and ulcerative colitis - current status: internal medicine aspects].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1981, Volume: 52, Issue:12

    Topics: Adrenal Cortex Hormones; Azathioprine; Colitis, Ulcerative; Crohn Disease; Diagnosis, Differential;

1981
Current status of medical treatment for inflammatory bowel disease.
    The American journal of gastroenterology, 1983, Volume: 78, Issue:12

    Topics: Adrenal Cortex Hormones; Azathioprine; Colitis, Ulcerative; Crohn Disease; Humans; Mercaptopurine; M

1983
Acute ulcerative colitis--a rare complication of sulfasalazine therapy.
    Hepato-gastroenterology, 1984, Volume: 31, Issue:4

    Topics: Acute Disease; Adult; Colitis, Ulcerative; Female; Humans; Metronidazole; Sulfasalazine

1984
[Therapy of chronic inflammatory bowel diseases].
    Zeitschrift fur Gastroenterologie. Verhandlungsband, 1983, Volume: 18

    Topics: Acute Disease; Azathioprine; Colitis, Ulcerative; Crohn Disease; Humans; Mercaptopurine; Methylpredn

1983
[Clinical studies on the isolation of Clastridium difficile--13 cases].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1983, Volume: 80, Issue:4

    Topics: Adult; Aged; Clostridium; Colitis, Ulcerative; Enterocolitis, Pseudomembranous; Feces; Female; Human

1983
Pouch ileitis: report of a case with severe systemic manifestations.
    Journal of clinical gastroenterology, 1983, Volume: 5, Issue:2

    Topics: Adult; Colitis, Ulcerative; Endoscopy; Humans; Ileitis; Ileostomy; Intestinal Mucosa; Male; Metronid

1983
[Ulcerative colitis and Crohn disease. Conservative therapy].
    ZFA. Zeitschrift fur Allgemeinmedizin, 1982, Jun-10, Volume: 58, Issue:16

    Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Humans; Metro

1982
[Isolation of Clostridium difficile toxin from the feces of a patient with ulcerative colitis (author's transl)].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1981, Volume: 78, Issue:6

    Topics: Adult; Bacterial Toxins; Clostridium Infections; Colitis, Ulcerative; Feces; Female; Humans; Metroni

1981
Anal canal inflammation after ileal pouch-anal anastomosis. The need for treatment.
    Diseases of the colon and rectum, 1995, Volume: 38, Issue:8

    Topics: Administration, Rectal; Adolescent; Adult; Aged; Anal Canal; Biopsy; Ciprofloxacin; Colitis, Ulcerat

1995
Blastocystis hominis in inflammatory bowel disease.
    Journal of clinical gastroenterology, 1993, Volume: 16, Issue:2

    Topics: Adult; Animals; Blastocystis hominis; Blastocystis Infections; Child; Colitis, Ulcerative; Crohn Dis

1993
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
    Archives of surgery (Chicago, Ill. : 1960), 1996, Volume: 131, Issue:5

    Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis,

1996
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
    Archives of surgery (Chicago, Ill. : 1960), 1996, Volume: 131, Issue:5

    Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis,

1996
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
    Archives of surgery (Chicago, Ill. : 1960), 1996, Volume: 131, Issue:5

    Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis,

1996
Prospective study of the incidence, timing and treatment of pouchitis in 104 consecutive patients after restorative proctocolectomy.
    Archives of surgery (Chicago, Ill. : 1960), 1996, Volume: 131, Issue:5

    Topics: Adenomatous Polyposis Coli; Adolescent; Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Colitis,

1996
Crohn's disease and ulcerative colitis with onset in the same year in two sisters.
    Journal of pediatric gastroenterology and nutrition, 1996, Volume: 23, Issue:3

    Topics: Adolescent; Adrenal Cortex Hormones; Azathioprine; Child; Colitis, Ulcerative; Colonoscopy; Crohn Di

1996
Immune thrombocytopenia and ulcerative colitis: response to nonoperative therapy.
    Journal of clinical gastroenterology, 1996, Volume: 23, Issue:3

    Topics: Adult; Aminosalicylic Acids; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Drug Ther

1996
Functional results after restorative proctocolectomy complicated by pouchitis.
    Diseases of the colon and rectum, 1997, Volume: 40, Issue:7

    Topics: Adolescent; Adult; Aged; Anal Canal; Anastomosis, Surgical; Case-Control Studies; Chronic Disease; C

1997
Arthritis related to ileal pouchitis following total proctocolectomy for ulcerative colitis.
    Seminars in arthritis and rheumatism, 2001, Volume: 30, Issue:4

    Topics: Adult; Anti-Bacterial Agents; Arthritis, Reactive; Colitis, Ulcerative; Female; Humans; Male; Metron

2001
Pouchitis following restorative proctocolectomy for ulcerative colitis: incidence and therapeutic outcome.
    Journal of the Royal College of Surgeons of Edinburgh, 2001, Volume: 46, Issue:6

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Child; Colitis, Ulcerative; Female; Humans; Incidenc

2001
Inflammatory bowel diseases 1977.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1977, Volume: 26, Issue:2

    Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Cromolyn Sodium; Diet; Eye Diseases; Humans; Joint

1977
Chronic inflammatory bowel disease.
    Clinics in gastroenterology, 1977, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Azathioprine; Bile Acids and Salts; Child; Cholestyramine Resin; Colitis, Ulcerat

1977
Drugs used in treatment of large bowel disease.
    Drugs, 1979, Volume: 18, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Antidiarrheals; Azathioprine; Cathartics; Colitis, U

1979
[Cutaneous amebiases (stimulating pyoderma gangrenosum in ulcerative colitis)].
    Nederlands tijdschrift voor geneeskunde, 1976, Feb-21, Volume: 120, Issue:8

    Topics: Amebiasis; Colitis, Ulcerative; Colostomy; Entamoeba histolytica; Entamoebiasis; Humans; Male; Metro

1976
Protective effect of metronidazole in experimental ulcerative colitis.
    Gastroenterology, 1978, Volume: 74, Issue:3

    Topics: Animals; Carrageenan; Cecum; Colitis, Ulcerative; Enterobacter; Escherichia coli; Gentamicins; Guine

1978
[Long-term therapy in ulcerative colitis and Crohn's disease].
    Fortschritte der Medizin, 1979, Aug-02, Volume: 97, Issue:29

    Topics: Aminosalicylic Acids; Azathioprine; Colitis, Ulcerative; Crohn Disease; Humans; Metronidazole; Patie

1979
Occurrence of dysplasia and adenocarcinoma after experimental chronic ulcerative colitis in hamsters induced by dextran sulphate sodium.
    Gut, 1992, Volume: 33, Issue:11

    Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Animals; Bacteria; Colitis, Ulcerative; Colon; Colonic Neo

1992
Substitution of factor XIII: a therapeutic approach to ulcerative colitis.
    Haemostasis, 1991, Volume: 21, Issue:1

    Topics: Adrenal Cortex Hormones; Adult; Blood Coagulation Disorders; Colitis, Ulcerative; Factor XIII; Facto

1991
Peripheral blood neutrophils in inflammatory bowel disease: morphological evidence of in vivo activation in active disease.
    Clinical and experimental immunology, 1991, Volume: 86, Issue:3

    Topics: Adult; Azathioprine; Blood Cell Count; Colitis, Ulcerative; Crohn Disease; Female; Humans; Inflammat

1991
Blastocystis hominis complicating ulcerative colitis.
    Journal of the Royal Society of Medicine, 1991, Volume: 84, Issue:10

    Topics: Adult; Animals; Blastocystis; Colitis, Ulcerative; Feces; Humans; Male; Metronidazole; Protozoan Inf

1991
[Crohn disease and ulcerative colitis].
    Medizinische Monatsschrift fur Pharmazeuten, 1990, Volume: 13, Issue:9

    Topics: Adrenal Cortex Hormones; Colitis, Ulcerative; Combined Modality Therapy; Crohn Disease; Cyclosporins

1990
Pouchitis and gastric hyposecretion: cause or effect?
    International journal of colorectal disease, 1990, Volume: 5, Issue:3

    Topics: Adenomatous Polyposis Coli; Adult; Anal Canal; Anastomosis, Surgical; Cimetidine; Colitis, Ulcerativ

1990
[Protective effect of metronidazole in experimental ulcerative colitis induced by dextran sulfate sodium].
    Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterology, 1987, Volume: 84, Issue:10

    Topics: Animals; Bacteroidaceae; Colitis, Ulcerative; Cricetinae; Dextran Sulfate; Dextrans; Feces; Intestin

1987
Cyclosporin A treatment in inflammatory bowel disease.
    Digestive diseases and sciences, 1989, Volume: 34, Issue:9

    Topics: Adrenal Cortex Hormones; Adult; Colitis, Ulcerative; Crohn Disease; Cyclosporins; Drug Therapy, Comb

1989
Pregnancy, fertility, and inflammatory bowel disease.
    The American journal of gastroenterology, 1985, Volume: 80, Issue:5

    Topics: Adrenal Cortex Hormones; Anti-Bacterial Agents; Azathioprine; Colitis, Ulcerative; Crohn Disease; Fe

1985
Therapeutical experiments in ulcerative colitis and Crohn's disease.
    Acta medica Hungarica, 1985, Volume: 42, Issue:3-4

    Topics: Azathioprine; Colitis, Ulcerative; Crohn Disease; Drug Therapy, Combination; Follow-Up Studies; Huma

1985
Disposition of metronidazole and its effects on sulphasalazine metabolism in patients with inflammatory bowel disease.
    British journal of clinical pharmacology, 1986, Volume: 21, Issue:4

    Topics: Administration, Oral; Biological Availability; Colitis, Ulcerative; Crohn Disease; Drug Evaluation;

1986
[Inflammatory bowel disease; internal therapy].
    Nihon rinsho. Japanese journal of clinical medicine, 1988, Volume: 46, Issue:2

    Topics: Adrenal Cortex Hormones; Aminosalicylic Acids; Colitis, Ulcerative; Crohn Disease; Drug Combinations

1988
Severe steroid responsive pneumonitis associated with pyoderma gangrenosum and ulcerative colitis.
    Thorax, 1985, Volume: 40, Issue:4

    Topics: Ampicillin; Colitis, Ulcerative; Erythromycin; Female; Gentamicins; Humans; Metronidazole; Middle Ag

1985
Studies of human amebiasis. I. Clinical and laboratory findings in eight cases of acute amebic colitis.
    Gastroenterology, 1973, Volume: 65, Issue:4

    Topics: Adolescent; Adult; Barium Sulfate; Biopsy; Colitis; Colitis, Ulcerative; Colon; Colon, Sigmoid; Colo

1973
Intestinal amebiasis. A roentgen analysis of 19 cases including 2 case reports.
    The American journal of roentgenology, radium therapy, and nuclear medicine, 1974, Volume: 122, Issue:2

    Topics: Abscess; Aged; Cecal Diseases; Colitis, Ulcerative; Colonic Diseases; Colonic Neoplasms; Diagnosis,

1974
[Treatment of acute amebic rectocolitis].
    Archivos de investigacion medica, 1970, Volume: 1

    Topics: Acute Disease; Adult; Arsenicals; Child, Preschool; Colitis, Ulcerative; Dysentery, Amebic; Emetine;

1970