metronidazole has been researched along with Vulvar Diseases in 22 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Vulvar Diseases: Pathological processes of the VULVA.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Methotrexate (MTX) is an antimetabolite of folic acid, which is used for management of ectopic pregnancy." | 5.01 | Low-dose methotrexate-induced vulvar edema: A case report. ( Chai, W; Cui, L; Gong, F; He, Z; Jia, G; Liu, X; Wen, Y, 2019) |
| "The diagnosis of Crohn's disease was never confirmed histologically." | 2.40 | [Vulvar involvement as a rare extra-intestinal manifestation of Crohn disease]. ( Horn, LC; Keim, V; Leupold, U; Mössner, J; Pohl, K; Witzigmann, H, 1998) |
| "Extra-intestinal manifestations of Crohn's disease are well described." | 2.39 | [Crohn's disease with isolated vulvar localization and pregnancy. A case report]. ( Ben Osmane, A; Bitri, M; Chelly, H; Haouet, S, 1994) |
| "A case of "metastatic" vulvar Crohn's disease occurring in a 23-yr-old woman, status post-ileocolectomy, is described." | 2.37 | Crohn's disease of the vulva. ( Beck, LS; Roberts, IM; Schulman, D; Schwartz, AM, 1987) |
| "Genital fistulas are a significant problem in female Crohn's disease patients." | 1.38 | Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy. ( Bermejo, F; de la Poza, G; Gisbert, JP; López-Sanroman, A; Marín-Jimenez, I; Muriel, A; Opio, V; Taxonera, C, 2012) |
| "There are many skin manifestations of Crohn's disease including specific lesions occurring late after digestive signs." | 1.29 | [Vulvar involvement in Crohn disease]. ( Doassans, S; Guillot, B; Joujoux, JM; Osman, H, 1994) |
| "Cutaneous amebiasis is a rare complication of Entamoeba histolytica infection which should be considered in the differential diagnosis of perineovulvar or penile ulcers." | 1.27 | Cutaneous amebiasis. ( Berg, RA; Rimsza, ME, 1983) |
| "Metastatic Crohn's disease is a rare cutaneous manifestation of intestinal Crohn's disease, for which existing treatment is unsatisfactory." | 1.27 | Metastatic Crohn's disease responding to metronidazole. ( Duhra, P; Paul, CJ, 1988) |
| "The term "metastatic" Crohn's disease is used to define the cutaneous lesions, distant from the gastrointestinal tract and separated from other ulcerations by normal skin, showing granulomatous histology." | 1.27 | [Cutaneous Crohn disease]. ( Bakos, L; Kuhl, IC; Wissbluth, ML; Zampese, MS, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (31.82) | 18.7374 |
| 1990's | 5 (22.73) | 18.2507 |
| 2000's | 1 (4.55) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 2 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Foti, C | 1 |
| Calianno, G | 1 |
| Cassano, N | 1 |
| Vena, GA | 1 |
| Hansel, K | 1 |
| Stingeni, L | 1 |
| Romita, P | 1 |
| Jia, G | 1 |
| Chai, W | 1 |
| He, Z | 1 |
| Liu, X | 1 |
| Wen, Y | 1 |
| Cui, L | 1 |
| Gong, F | 1 |
| Sodje, JD | 1 |
| Ilevbare, FO | 1 |
| Granese, R | 1 |
| Calagna, G | 1 |
| Morabito, G | 1 |
| Carriero, C | 1 |
| Perino, A | 1 |
| Tonni, G | 1 |
| Romano, C | 1 |
| Mayor-Ibarguren, A | 1 |
| Maseda-Pedrero, R | 1 |
| Feito-Rodríguez, M | 1 |
| Ferreira, C | 1 |
| Soares, J | 1 |
| Maia, T | 1 |
| Pardal, J | 1 |
| Nogueira, A | 1 |
| Tavares, M | 1 |
| Trindade, E | 1 |
| Amil Dias, J | 1 |
| Geva, A | 1 |
| Sabo, E | 1 |
| Levy, J | 1 |
| Blumenthal, M | 1 |
| Ophir, E | 1 |
| Geva, H | 1 |
| Bornstein, J | 1 |
| Andreani, SM | 1 |
| Ratnasingham, K | 1 |
| Dang, HH | 1 |
| Gravante, G | 1 |
| Giordano, P | 1 |
| Lawford, AM | 1 |
| Scott, K | 1 |
| Lust, K | 1 |
| de la Poza, G | 1 |
| López-Sanroman, A | 1 |
| Taxonera, C | 1 |
| Marín-Jimenez, I | 1 |
| Gisbert, JP | 1 |
| Bermejo, F | 1 |
| Opio, V | 1 |
| Muriel, A | 1 |
| Rimsza, ME | 1 |
| Berg, RA | 1 |
| Levine, EM | 1 |
| Barton, JJ | 1 |
| Grier, EA | 1 |
| Doassans, S | 1 |
| Osman, H | 1 |
| Joujoux, JM | 1 |
| Guillot, B | 1 |
| Bitri, M | 1 |
| Chelly, H | 1 |
| Ben Osmane, A | 1 |
| Haouet, S | 1 |
| Bourrat, E | 1 |
| Faure, C | 1 |
| Vignon-Pennamen, MD | 1 |
| Rybojad, M | 1 |
| Morel, P | 1 |
| Navarro, J | 1 |
| Leupold, U | 1 |
| Horn, LC | 1 |
| Witzigmann, H | 1 |
| Pohl, K | 1 |
| Mössner, J | 1 |
| Keim, V | 1 |
| Kingsland, CR | 1 |
| Alderman, B | 1 |
| Davidson, F | 1 |
| Gnaanachelvan, K | 1 |
| Marsden, RA | 1 |
| Cooke, M | 1 |
| Holohan, M | 1 |
| Coughlan, M | 1 |
| O'Loughlin, S | 1 |
| Dervan, P | 1 |
| Schulman, D | 1 |
| Beck, LS | 1 |
| Roberts, IM | 1 |
| Schwartz, AM | 1 |
| Duhra, P | 1 |
| Paul, CJ | 1 |
| Zampese, MS | 1 |
| Bakos, L | 1 |
| Kuhl, IC | 1 |
| Wissbluth, ML | 1 |
6 reviews available for metronidazole and Vulvar Diseases
| Article | Year |
|---|---|
Low-dose methotrexate-induced vulvar edema: A case report.
Topics: Abdominal Pain; Administration, Oral; Adult; China; Female; Glycyrrhizic Acid; Humans; Injections, I | 2019 |
Vulvar involvement in pediatric Crohn's disease: a systematic review.
Topics: Administration, Oral; Administration, Topical; Child; Crohn Disease; Edema; Female; Humans; Metronid | 2018 |
Crohn's disease of the vulva.
Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Combined Modality Therapy; Crohn Disease; Female; H | 2010 |
[Crohn's disease with isolated vulvar localization and pregnancy. A case report].
Topics: Adult; Crohn Disease; Drug Therapy, Combination; Female; Humans; Metronidazole; Pregnancy; Pregnancy | 1994 |
[Vulvar involvement as a rare extra-intestinal manifestation of Crohn disease].
Topics: Administration, Oral; Anti-Infective Agents; Biopsy; Crohn Disease; Female; Humans; Long-Term Care; | 1998 |
Crohn's disease of the vulva.
Topics: Adult; Crohn Disease; Female; Humans; Methylprednisolone; Metronidazole; Triamcinolone Acetonide; Vu | 1987 |
16 other studies available for metronidazole and Vulvar Diseases
| Article | Year |
|---|---|
Vulvar allergic contact dermatitis to metronidazole.
Topics: Dermatitis, Allergic Contact; Female; Humans; Metronidazole; Patch Tests; Vulvar Diseases | 2023 |
Transcultural influence on female genital mutilation done in late pregnancy: A case report.
Topics: Anti-Bacterial Agents; Ceftriaxone; Cesarean Section; Circumcision, Female; Drainage; Emergency Trea | 2020 |
Periorificial Lesions in a Young Girl.
Topics: Adrenal Cortex Hormones; Age of Onset; Child; Contraindications; Dermatitis, Perioral; Drug Substitu | 2016 |
Vulvar inflammation: a presentation of Crohn's disease.
Topics: Adolescent; Adult; Antirheumatic Agents; Azathioprine; Biopsy; Colonoscopy; Crohn Disease; Disease P | 2017 |
A search for Helicobacter pyloriin localized vulvodynia.
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Ulcer Agents; Biopsy; Clarithromycin; Dysp | 2008 |
A case of massive vulvar oedema due to septic pubic symphysitis complicating pregnancy.
Topics: Adult; Anti-Bacterial Agents; C-Reactive Protein; Ceftriaxone; Edema; Female; Fever; Gentamicins; Hu | 2010 |
Genital fistulas in female Crohn's disease patients.: clinical characteristics and response to therapy.
Topics: Adalimumab; Adolescent; Adult; Age Factors; Anti-Infective Agents; Anti-Inflammatory Agents; Antibod | 2012 |
Cutaneous amebiasis.
Topics: Amebiasis; Antiparasitic Agents; Female; Humans; Infant; Liver Abscess, Amebic; Metronidazole; Skin | 1983 |
Metastatic Crohn disease of the vulva.
Topics: Adult; Ascorbic Acid; Crohn Disease; Female; Humans; Metronidazole; Prednisone; Vulvar Diseases; Zin | 1982 |
[Vulvar involvement in Crohn disease].
Topics: Adult; Crohn Disease; Edema; Female; Humans; Metronidazole; Vulvar Diseases | 1994 |
[Anitis, vulvar edema and macrocheilitis disclosing Crohn disease in a child: value of metronidazole].
Topics: Cheilitis; Child; Crohn Disease; Edema; Female; Granuloma; Humans; Metronidazole; Proctitis; Treatme | 1997 |
Crohn's disease of the vulva.
Topics: Crohn Disease; Female; Humans; Metronidazole; Middle Aged; Vulvar Diseases | 1991 |
Deep and acute vulval ulceration. Case report.
Topics: Adult; Anti-Infective Agents, Urinary; Drug Therapy, Combination; Female; Humans; Metronidazole; Tri | 1989 |
Crohn's disease of the vulva. Case report.
Topics: Adult; Crohn Disease; Female; Humans; Metronidazole; Vulva; Vulvar Diseases | 1988 |
Metastatic Crohn's disease responding to metronidazole.
Topics: Anus Diseases; Crohn Disease; Female; Humans; Metronidazole; Middle Aged; Vulva; Vulvar Diseases | 1988 |
[Cutaneous Crohn disease].
Topics: Aged; Crohn Disease; Female; Humans; Metronidazole; Skin Diseases; Vaginal Diseases; Vulvar Diseases | 1986 |