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metronidazole and Aneurysm, Aortic

metronidazole has been researched along with Aneurysm, Aortic in 1 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"A giant mycotic aneurysm of the thoracic aorta, which is a rare presentation of infective endocarditis, is reported."1.28Giant mycotic aneurysm of the thoracic aorta. ( Illangasekera, U, 1989)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19901 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Illangasekera, U1

Other Studies

1 other study available for metronidazole and Aneurysm, Aortic

ArticleYear
Giant mycotic aneurysm of the thoracic aorta.
    The Ceylon medical journal, 1989, Volume: 34, Issue:1

    Topics: Adult; Aneurysm, Infected; Aorta, Thoracic; Aortic Aneurysm; Cloxacillin; Female; Gentamicins; Human

1989