Anastomotic Leak

Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis.

Synonym
Anastomotic Leak
Anastomotic Leakage

Excerpt	Reference
"Anastomotic leakage is a common complication of colorectal surgery."	( Bettarini, F; De Stefano, A; Di Mare, G; Neri, A, 2011)
"Anastomotic leakage is a relatively common and potentially catastrophic complication after gastrointestinal surgery."	( Bettarini, F; De Stefano, A; Di Mare, G; Neri, A, 2011)
"Anastomotic leakage is a major complication of colon resection."	( Cai, X; Huang, D; Jin, R; Liang, Y; Peng, S; Wang, Y, 2011)
"Anastomotic leakage is a frequent postoperative complication of colorectal resection."	( Borel Rinkes, IH; Delvin, T; Parker, MC; Pohlen, U, 2013)
"Anastomotic leakage is the most important complication after colorectal surgery."	( Chalumeau, C; Facy, O; Jonval, L; Lagoutte, N; Ortega-Deballon, P; Rat, P; Ravoire, A, 2012)
"Anastomotic leakage is one of serious complications of colorectal surgery."	( Guo, X; Ji, C; Li, Z; Liao, WQ; Pan, X; Qian, S; Xiong, Y; Xu, C; Yu, DH, 2015)
"Anastomotic leak is considered the major complication following abdominal surgery."	( de la Portilla, F; de Marco, F; García-Cabrera, AM; Molero, M; Muntane, J; Padillo, FJ; Pereira, S, 2016)
"Anastomotic leakage is a serious complication after colorectal resection."	( Bakker, N; Cakir, H; Deelder, JD; Doodeman, HJ; Houdijk, AP; Richir, MC; Schreurs, WH, 2016)
"Anastomotic leakage is a serious complication which, more often than not, is diagnosed late; to date, C-reactive protein is the only available diagnostic marker."	( Havel, E; Hyšpler, R; Kaška, M; Plíšková, L; Tichá, A; Zadák, Z; Žaloudková, L, 2015)
"Anastomotic leakage is considered as an independent risk factor for postoperative mortality after esophagectomy, and an insufficient blood flow in the reconstructed conduit may be a risk factor of anastomotic leakage."	( Kazuno, A; Koyanagi, K; Ninomiya, Y; Ochiai, H; Oguma, J; Ozawa, S; Tachimori, Y; Yamazaki, Y, 2016)
"Anastomotic leakage is a severe complication after esophagectomy."	( de Jonge, J; de Vringer, T; Nederlof, N; Spaander, MC; Tilanus, HW; Tran, TC; Wijnhoven, BP, 2017)
"Postoperative anastomotic leakage is a severe complication after gastric tube reconstruction during esophagectomy."	( Fujisawa, K; Hanazaki, K; Iwabu, J; Kitagawa, H; Namikawa, T; Tsuda, S; Uemura, S, 2018)
"Anastomotic leakage is a feared complication of gastro-esophageal surgery, as it increases recurrence, morbidity, and mortality."	( Achiam, MP; Fjederholt, KT; Kirkegård, J; Mortensen, FV; Okholm, C; Svendsen, LB, 2018)
"Anastomotic leakage is a severe complication after colonic/rectal surgery."	( Chen, LL; Gheza, F; Giulianotti, PC; Mangano, A; Minerva, EM, 2018)
"Anastomotic leak is a life-threatening complication of colorectal surgery."	( Shen, R; Wang, T; Zhang, Y, 2018)
"Anastomotic leakage is a major cause of prolonged hospitalization after gastrectomy and sometimes leads to fatal complications, such as abdominal abscess and sepsis."	( Asada, T; Fujiwara, M; Ishigure, K; Ishiyama, A; Ito, S; Kanda, M; Kobayashi, D; Kodera, Y; Matsushita, H; Mochizuki, Y; Murai, T; Murotani, K; Tanaka, C; Teramoto, H, 2018)
"Anastomotic leakage is a severe complication after gastric cancer surgery."	( Choi, YS; Huh, YJ; Kim, TH; Kong, SH; Lee, HJ; Park, JH; Son, YG; Suh, YS; Yang, HK, 2019)
"Anastomotic leakage is a severe complication in gastrointestinal surgery."	( Ellebæk, MB; Larsen, KD; Le, DQS; Madsen, GI; Qvist, N; Westerholt, M, 2019)
"Anastomotic leak is one of the most serious postoperative complications, and intraoperative adequate perfusion plays a key role in preventing its development in gastric cancer surgery."	( Fujino, M; Hirano, A; Hosokawa, I; Koda, K; Kosugi, C; Mori, M; Narushima, K; Shimizu, H; Shuto, K; Yamazaki, M, 2020)
"Anastomotic leakage is one of the most feared postoperative complications in colorectal surgery."	( Ashwin, KR; Deshpande, AY; Kumar, R; Reddy, GRK; Somashekhar, SP, 2021)
"Anastomotic leakage is the most frequent complication and is likely caused by diminished anastomotic perfusion."	( Cecconello, I; de Freitas Busnardo, F; Ribeiro, U; Sallum, RAA; Takeda, FR; Tustumi, F; Tutihashi, R, 2021)
"Anastomotic leakage is a feared complication of anterior resection for rectal cancer."	( Higashijima, J; Ishikawa, D; Kashihara, H; Nishi, M; Shimada, M; Takasu, C; Tokunaga, T; Yoshikawa, K; Yoshimoto, T, 2020)
"Anastomotic leakage is a common complication following large abdominal surgery, often developing to life-threatening abdominal sepsis due to late diagnosis."	( Barratt-Due, A; Haugaa, H; Hødnebø, S; Kvernebo, K; Pischke, SE; Tønnessen, TI; Wester, T, 2021)
"Anastomotic leak is a serious complication following esophagectomy."	( Awad, ZT; Deladisma, AM; Guerrier, C; Kriley, IR; Pather, K, 2022)
"Anastomotic leak is one of the most severe complications following right hemicolectomy but rarely happens, which should be diagnosed based on clinical manifestations, laboratory and radiographic examinations."	( Han, JG; Wang, ZJ; Zhang, HY, 2021)
"Anastomotic leak is one of the most feared complications of colorectal anastomosis."	( Cano-Matias, A; Capitan-Morales, L; Cintas-Catena, J; Del Rio-Lafuente, FJ; Gomez-Rosado, JC; Oliva-Mompean, F; Perez-Sanchez, A; Torres-Arcos, C; Valdes-Hernandez, J, 2022)
"Colorectal anastomotic leakage is consistently more common in men, regardless of tumour location."	( Moshtaghi-Svensson, J; Nordenvall, C; Ottander, U; Rutegård, M; Sund, M; Weibull, CE, 2023)
"Anastomotic leakage is a severe complication after oesophageal resection with gastric conduit reconstruction."	( Faber, RA; Galema, HA; Hilling, DE; Tange, FP; van der Vorst, JR, 2023)
"Anastomotic leakage is a serious complication that can occur in bilioenteric anastomosis surgery, leading to significant morbidity and mortality."	( Chen, H; Deng, J; Ma, B; Ma, Z, 2023)
"Anastomotic leak is one of the most feared complications of colorectal surgery, and probably linked to poor blood supply to the anastomotic site."	( Bailey, J; Ebner, M; Grzeda, MT; Hainsworth, A; Ourselin, S; Renna, MS; Schizas, A; Shapey, J; Vercauteren, T, 2023)
"Postoperative anastomotic leaks are the most feared complications after gastric surgery."	( Anthis, AHC; Gerken, LRH; Herrmann, IK; Korcakova, E; Liska, V; Mergen, V; Rosendorf, J; Schlegel, AA; Suter, B; Zehnder, AK, 2023)

Excerpt	Reference
"It is known that anastomotic leakages particularly situated in the chest can be successfully treated with endoscopically placed self-expanding stents with/without additional drainage."	( Bauerfeind, P; Gubler, C; Schneider, PM, 2013)
"The rates of anastomotic leakage and stenosis were calculated for each treatment arm."	( Deng, Y; Ma, T; Qin, Q; Wang, H; Wang, J; Wang, L; Zheng, J; Zhou, Z, 2016)
"A minimal anastomotic leakage following Stapled Anopexy, when leading to air diffusion into soft tissues and not associated to abscess or peritonitis may be treated conservatively avoiding ileostomy or colostomy."	( Frassani, S; Gabrielli, F; Guttadauro, A; Macchini, D; Maternini, M, 2016)
"The primary endpoint was the anastomotic leakage rate (grade A+B+C, expected reduction rate of 6%) analyzed in the modified intention-to-treat population."	( Ishibe, A; Ishii, Y; Kato, T; Kimura, K; Kotake, M; Matoba, S; Munakata, K; Nitta, T; Noura, S; Saigusa, Y; Saito, S; Shiozawa, M; Suwa, H; Takano, Y; Takemasa, I; Tei, M; Watanabe, J; Watanabe, M; Yabuno, T; Yamagishi, S; Yasui, M, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	0 (0.00)	23.3326
1990's	0 (0.00)	12.5806
2000's	0 (0.00)	18.1394
2010's	312 (62.03)	28.8240
2020's	191 (37.97)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	2	0
butyric acid	low	1	0
carbon monoxide	low	1	0
citric acid, anhydrous	low	2	0
lactic acid	medium	5	1
dimethyl sulfoxide	low	2	0
glycerol	low	2	0
nickel	medium	4	3
pyruvic acid	low	3	0
1-anilino-8-naphthalenesulfonate	medium	1	1
acetaminophen	low	2	0
acetazolamide	low	1	0
diatrizoic acid	low	1	0
azathioprine	low	1	0
bupivacaine	medium	2	1
carprofen	low	2	0
celecoxib	medium	1	1
diclofenac	low	12	0
domperidone	low	1	0
etodolac	low	1	0
fentanyl	medium	2	1
fluorouracil	medium	17	1
gentamicin	medium	6	1
glutaral	medium	1	1
guaifenesin	low	3	0
ibuprofen	low	1	0
lidocaine	low	1	0
iodixanol	low	1	0
iohexol	low	2	0
iothalamic acid	low	1	0
ioversol	low	1	0
ketamine	low	1	0
ketorolac	low	8	0
lansoprazole	low	1	0
metoclopramide	low	1	0
metoprolol	low	1	0
metronidazole	medium	5	2
neostigmine	low	1	0
oxonic acid	low	2	0
pentoxifylline	low	1	0
phenazopyridine	low	1	0
potassium chloride	low	1	0
procaine	low	1	0
propofol	low	1	0
propranolol	low	1	0
protoporphyrin ix	low	1	0
resorcinol	low	1	0
tegafur	low	2	0
tranexamic acid	low	1	0
triclosan	medium	3	1
mitomycin	medium	2	1
prednisolone	low	2	0
hydroxyproline	low	19	0
prednisone	low	3	0
glutamine	medium	2	2
kanamycin a	medium	2	2
phenylephrine	low	1	0
methylene blue	medium	16	1
mannitol	low	1	0
arginine	medium	4	2
isoprene	medium	1	1
penicillanic acid	low	1	0
framycetin	low	1	0
diatrizoate meglumine	medium	17	1
meglumine	low	2	0
iminodiacetic acid	low	1	0
isoxazoles	low	1	0
citrulline	medium	2	2
caprolactone	low	1	0
azomycin	low	1	0
tricaprylin	low	1	0
trilaurin	low	1	0
malondialdehyde	low	1	0
trinitrobenzenesulfonic acid	low	2	0
glycopyrrolate	medium	3	1
erythromycin	low	1	0
calcium lactate	low	1	0
deoxycytidine	low	4	0
calcium peroxide	low	1	0
durapatite	low	1	0
vancomycin	low	1	0
sulfur hexafluoride	low	1	0
enbucrilate	low	3	0
octyl 2-cyanoacrylate	low	3	0
titanium	medium	4	3
phosphoric acid, trisodium salt	medium	1	1
camptothecin	low	3	0
barium sulfate	low	4	0
4-methoxyamphetamine	low	1	0
ioxitalamic acid	low	1	0
tobramycin	medium	2	2
paclitaxel	low	2	0
ticarcillin	low	1	0
ng-nitroarginine methyl ester	low	1	0
epirubicin	low	2	0
cefmetazole	medium	1	1
lidofenin	low	1	0
piperacillin	low	1	0
pimonidazole	low	1	0
technetium tc 99m mertiatide	low	1	0
irinotecan	low	1	0
capecitabine	low	5	0
adenosine	low	1	0
cephalosporin c	medium	1	1
flomoxef	medium	1	1
fluorodeoxyglucose f18	medium	2	1
tricaprin	low	1	0
beta-hydroxyisovaleric acid	medium	2	2
voriconazole	low	1	0
fibrinogen	medium	14	1
glucuronic acid	low	2	0
imipenem, anhydrous	low	1	0
valerates	medium	2	2
caprylates	low	1	0
parecoxib	low	1	0
imatinib mesylate	low	1	0
polytrimethylene carbonate	low	1	0
docetaxel anhydrous	low	2	0
naproxen	low	1	0
anidulafungin	low	1	0
carboplatin	low	1	0
fibrin	low	2	0
raffinose	low	1	0
lignans	low	1	0
vinpocetine	low	1	0
tacrolimus	low	1	0
buprenorphine	low	2	0
propylthiouracil	low	1	0
mercaptopurine	low	1	0
oxalylglycine	low	1	0
nitinol	medium	4	2
icodextrin	low	1	0
bilirubin	low	4	0
dinoprostone	low	2	0
alprostadil	low	1	0
amphotericin b	medium	2	2
phenylephrine hydrochloride	low	3	0
morphine	medium	2	1
barium	low	1	0
heroin	medium	1	1
carbocyanines	low	1	0
magnesium citrate	low	1	0
brl 28500	low	1	0
gadolinium dtpa	medium	5	2
mocetinostat	low	1	0
pasireotide	low	2	0
bpc 157	low	1	0
losartan potassium	low	1	0
indocyanine green	medium	193	16
nad	low	1	0
cellulose	low	1	0
chitosan	low	1	0
piperacillin, tazobactam drug combination	low	2	0
cabozantinib	low	1	0
colistin	medium	1	1
s 1 (combination)	low	2	0
epidermal growth factor	low	3	0
calca protein, human	low	6	0
transforming growth factor beta	low	1	0
glucagon-like peptide 2	low	1	0
gadoxetic acid disodium	medium	4	2
adrenomedullin	low	1	0
cyclosporine	low	1	0
levoleucovorin	low	4	0
allopurinol	low	1	0
sildenafil citrate	low	1	0
nintedanib	low	1	0
trypsinogen	low	1	0

Protein Targets (1,682)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	6	0	0	6
Chain A, RNA-directed RNA polymerase NS5	0	2	0	2
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	24	0	0	24
USP1 protein, partial	14	0	0	14
TDP1 protein	31	0	0	31
vitamin D3 receptor isoform VDRA	11	0	0	11
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	11	0	0	11
serine/threonine-protein kinase PLK1	4	0	0	4
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	12	0	0	12
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	35	0	0	35
DNA polymerase kappa isoform 1	6	0	0	6
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	1	2
Beta-lactamase	0	1	0	1
Transthyretin	0	1	3	6
Fatty acid-binding protein, intestinal	0	4	2	6
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	1	1	2
Cyclin-dependent kinase 2	0	2	3	5
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	1	2
Guanine nucleotide-binding protein G	2	0	0	2
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	2	3
Mitogen-activated protein kinase 14	0	2	2	4
5-hydroxytryptamine receptor 2C	0	3	1	4
5-hydroxytryptamine receptor 2A	0	3	1	4
5-hydroxytryptamine receptor 1A	0	6	3	10
5-hydroxytryptamine receptor 1B	0	4	1	5
5-hydroxytryptamine receptor 1D	0	2	1	3
5-hydroxytryptamine receptor 1F	0	2	1	3
5-hydroxytryptamine receptor 2B	0	3	1	4
5-hydroxytryptamine receptor 6	0	0	1	1
Sodium-dependent serotonin transporter	0	6	1	7
Sodium-dependent serotonin transporter	0	4	1	5
5-hydroxytryptamine receptor 7	0	0	1	1
5-hydroxytryptamine receptor 5A	0	0	1	1
5-hydroxytryptamine receptor 5B	0	0	1	1
5-hydroxytryptamine receptor 3A	0	3	1	4
5-hydroxytryptamine receptor 4	0	1	1	3
5-hydroxytryptamine receptor 3B	0	3	1	4
RAR-related orphan receptor gamma	23	0	0	23
ATAD5 protein, partial	10	0	0	10
GLS protein	13	0	0	13
Microtubule-associated protein tau	12	0	0	12
Smad3	7	0	0	7
aldehyde dehydrogenase 1 family, member A1	18	0	0	18
thyroid stimulating hormone receptor	16	0	0	16
nuclear receptor subfamily 1, group I, member 3	19	0	0	19
progesterone receptor	18	0	0	18
EWS/FLI fusion protein	24	0	0	24
retinoic acid nuclear receptor alpha variant 1	26	0	0	26
retinoid X nuclear receptor alpha	23	0	0	23
estrogen-related nuclear receptor alpha	34	0	0	34
estrogen nuclear receptor alpha	49	0	0	49
peroxisome proliferator activated receptor gamma	18	0	0	18
aryl hydrocarbon receptor	13	0	0	13
chromobox protein homolog 1	19	0	0	19
thyroid hormone receptor beta isoform 2	25	0	0	25
peripheral myelin protein 22	14	0	0	14
cytochrome P450 3A4 isoform 1	11	0	0	11
Gamma-aminobutyric acid receptor subunit pi	11	3	3	17
ATP-binding cassette sub-family C member 3	0	33	0	33
Multidrug resistance-associated protein 4	0	33	0	35
Solute carrier family 22 member 6	0	5	0	5
Carbonic anhydrase 12	0	5	1	9
UDP-glucuronosyltransferase 1A9	0	1	0	4
Bile salt export pump	0	4	0	4
Voltage-dependent calcium channel gamma-2 subunit	14	0	0	14
Bile salt export pump	0	43	0	43
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	10	1	17
Carbonic anhydrase 2	0	10	1	16
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	5	0	6
Prostaglandin G/H synthase 1	0	7	1	8
Carbonic anhydrase 3	0	5	1	9
Cytochrome P450 3A4	0	13	2	17
Cytochrome P450 2D6	0	11	0	11
Cytochrome P450 2C9	0	15	0	16
Polyunsaturated fatty acid lipoxygenase ALOX15	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-1	11	3	3	17
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	11	3	3	17
Gamma-aminobutyric acid receptor subunit gamma-2	11	3	3	17
UDP-glucuronosyltransferase 1-6	0	3	0	4
Glutamate receptor 2	15	0	0	15
Gamma-aminobutyric acid receptor subunit alpha-5	11	3	3	17
Gamma-aminobutyric acid receptor subunit alpha-3	11	3	3	17
Arachidonate 5-lipoxygenase-activating protein	0	2	0	2
UDP-glucuronosyltransferase 1A1	0	3	0	4
Carbonic anhydrase 4	0	7	1	10
Prostaglandin G/H synthase 1	0	10	0	11
Carbonic anhydrase 6	0	5	1	8
Gamma-aminobutyric acid receptor subunit gamma-1	11	3	3	17
Gamma-aminobutyric acid receptor subunit alpha-2	11	3	3	17
Gamma-aminobutyric acid receptor subunit alpha-4	11	3	3	17
Gamma-aminobutyric acid receptor subunit gamma-3	11	3	3	17
Gamma-aminobutyric acid receptor subunit alpha-6	11	3	3	17
Carbonic anhydrase 5A, mitochondrial	0	7	1	11
Prostaglandin G/H synthase 2	0	10	2	14
Carbonic anhydrase 7	0	5	1	8
Nuclear receptor ROR-gamma	7	0	0	7
Cytochrome P450 2J2	0	9	0	9
Gamma-aminobutyric acid receptor subunit alpha-1	11	4	3	18
Gamma-aminobutyric acid receptor subunit beta-3	11	3	3	17
Gamma-aminobutyric acid receptor subunit beta-2	11	3	3	17
Carbonic anhydrase 9	0	9	1	13
GABA theta subunit	11	3	3	17
Canalicular multispecific organic anion transporter 1	0	32	0	32
Carbonic anhydrase 15	0	4	0	5
Carbonic anhydrase 13	0	4	0	6
Gamma-aminobutyric acid receptor subunit epsilon	11	3	3	17
Carbonic anhydrase 14	0	5	1	9
Carbonic anhydrase 5B, mitochondrial	0	6	1	10
toxin B	0	0	0	1
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	10	0	0	10
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Carbonic Anhydrase Ii	0	0	1	1
Chain A, Beta-lactamase	9	0	0	9
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Endochitinase	0	1	0	1
Chain A, Class Iii Chitinase Chia1	0	1	0	1
Chain A, Carbonic anhydrase 13	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase	0	1	0	1
Chain B, Carbonic anhydrase	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	0	0	2
Carbonic anhydrase	0	2	0	2
GALC protein	3	0	0	3
GLI family zinc finger 3	27	0	0	27
cytochrome P450 family 3 subfamily A polypeptide 4	23	0	0	23
glucocorticoid receptor [Homo sapiens]	31	0	0	31
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	2	0	2
arylsulfatase A	14	0	0	14
Carbonic anhydrase	0	2	0	2
euchromatic histone-lysine N-methyltransferase 2	31	0	0	31
Bloom syndrome protein isoform 1	10	0	0	10
thyroid hormone receptor beta isoform a	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	27	0	0	27
survival motor neuron protein isoform d	11	0	0	11
muscleblind-like protein 1 isoform 1	8	0	0	8
Carbonic anhydrase	0	1	0	1
Prolyl endopeptidase	0	1	0	1
Carbonic anhydrase-related protein 11	0	1	0	2
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Cathepsin B	0	1	0	1
Steryl-sulfatase	0	1	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	3	0	3
Cytochrome P450 2C8	0	3	0	4
Cytochrome P450 2A6	0	1	0	1
Androgen receptor	0	2	0	2
Translocator protein	0	1	1	2
Cytochrome P450 2B6	0	3	0	3
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Adenosine receptor A1	0	5	1	6
Serum paraoxonase/arylesterase 1	0	3	0	3
Dipeptidyl peptidase 4	0	0	0	1
Endochitinase	0	1	0	1
Adenosine receptor A2a	0	4	1	5
Delta-type opioid receptor	0	5	0	6
Cytochrome P450 2C19	0	7	0	7
Delta-type opioid receptor	0	6	1	8
Mu-type opioid receptor	0	6	2	11
Carbonic anhydrase	0	2	0	2
Kappa-type opioid receptor	0	6	0	9
Carbonic anhydrase	0	2	0	2
D(1A) dopamine receptor	1	1	0	2
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase	0	2	0	2
D(2) dopamine receptor	0	5	0	6
Cholinesterase	0	3	0	3
Carbonic anhydrase	0	2	0	2
Mu-type opioid receptor	0	8	0	8
Fatty-acid amide hydrolase 1	0	4	0	4
Beta-carbonic anhydrase 1	0	2	0	2
Carbonic anhydrase 2	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Squalene synthase	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase, alpha family	0	2	0	2
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase 3	0	2	0	2
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase	0	2	0	2
Sigma intracellular receptor 2	0	2	0	2
Delta carbonic anhydrase	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Renin	0	1	0	1
Carbonic anhydrase	0	2	0	2
Endochitinase A1	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Carbonic anhydrase 13	0	3	1	5
Carbonic anhydrase 4	0	5	0	5
Acidic mammalian chitinase	0	1	0	1
Carbonic anhydrase 7	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2, isoform A	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	17	0	0	17
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain B, Structure of PAE2307 in complex with adenosine	0	0	1	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, ADENOSINE RECEPTOR A2A	0	1	0	1
Chain A, tRNA (guanine-N(1)-)-methyltransferase	0	0	1	1
Chain A, Uncharacterized protein MJ0883	0	0	1	1
AR protein	34	0	0	34
signal transducer and activator of transcription 6, interleukin-4 induced	1	0	0	1
regulator of G-protein signaling 4	8	0	0	8
NPYLR7B	0	0	1	1
IDH1	13	0	0	13
Histone H2A.x	11	0	0	11
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
mitogen-activated protein kinase 1	9	0	0	9
nuclear receptor ROR-gamma isoform 1	10	0	0	10
high affinity choline transporter 1 isoform a	0	1	0	1
Sodium/nucleoside cotransporter 1	0	2	0	2
Calcium dependent protein kinase	0	1	0	1
Mitogen-activated protein kinase kinase kinase 7	0	0	2	2
Sodium/nucleoside cotransporter 2	0	2	0	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
Purine nucleoside phosphorylase	0	1	0	1
Epidermal growth factor receptor	0	6	2	8
Phosphoglycerate kinase 1	0	1	0	1
Adenosine deaminase	0	0	0	1
Avidin	0	0	1	1
Adenosine deaminase	0	0	0	1
Glyceraldehyde-3-phosphate dehydrogenase	0	2	0	2
Receptor tyrosine-protein kinase erbB-2	0	3	1	4
Insulin receptor	0	1	2	4
Phosphoglycerate kinase 2	0	1	0	1
Heat shock protein HSP 90-alpha	0	1	1	2
Platelet-derived growth factor receptor beta	0	1	2	4
Adenosine receptor A3	0	5	3	9
Heat shock 70 kDa protein 1A	0	1	0	1
Heat shock cognate 71 kDa protein	0	0	1	1
Fibroblast growth factor receptor 1	0	3	2	6
Inosine-5'-monophosphate dehydrogenase 2	0	1	2	3
Endoplasmin	0	1	1	2
Inosine-5'-monophosphate dehydrogenase 1	0	1	0	1
Fibroblast growth factor receptor 2	0	1	1	3
Fibroblast growth factor receptor 4	0	1	1	3
Fibroblast growth factor receptor 3	0	1	1	3
Streptavidin	0	0	1	1
Adenosylhomocysteinase	0	0	0	1
Adenosine receptor A3	0	1	0	1
Adenosine receptor A2a	0	2	4	7
Adenosine receptor A2b	0	1	1	3
Adenosine receptor A2b	0	1	1	2
Adenylate kinase 2, mitochondrial	0	1	0	1
Adenosine receptor A1	0	2	2	5
Adenylate kinase isoenzyme 1	0	1	0	1
Phosphatidylinositol 4-kinase alpha	0	2	0	3
Adenosine receptor A1	0	0	1	1
Adenosine kinase	0	0	2	3
Adenosine deaminase	0	0	0	1
Equilibrative nucleoside transporter 2	0	2	0	2
Phosphatidylinositol 4-kinase type 2-beta	0	2	0	3
Histone-lysine N-methyltransferase, H3 lysine-79 specific	0	1	0	1
Equilibrative nucleoside transporter 1	0	2	0	2
Phosphatidylinositol 4-kinase type 2-alpha	0	2	0	3
Solute carrier family 28 member 3	0	2	0	2
Adenosine kinase	0	1	0	2
Phosphatidylinositol 4-kinase beta	0	2	1	4
5-methylthioadenosine/S-adenosylhomocysteine deaminase	0	0	0	1
Adenosine transporter 1	0	0	0	1
interleukin 8	8	0	0	8
estrogen receptor 2 (ER beta)	15	0	0	15
transcriptional regulator ERG isoform 3	3	0	0	3
ras-related protein Rab-9A	5	0	0	5
lamin isoform A-delta10	30	0	0	30
Polyphenol oxidase 2	0	2	0	4
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	2
Cellular tumor antigen p53	30	0	0	30
Xanthine dehydrogenase/oxidase [Includes: Xanthine dehydrogenase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	0	2
Nuclear receptor ROR-gamma	0	1	0	1
Xanthine dehydrogenase/oxidase	0	2	1	4
Purine nucleoside phosphorylase	0	0	2	2
TAR DNA-binding protein 43	7	0	0	7
Shiga toxin subunit A	0	1	0	1
Histamine H3 receptor	0	1	0	3
Thromboxane-A synthase	0	1	0	1
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostacyclin receptor	0	3	2	5
Nuclear receptor subfamily 4 group A member 2	0	1	1	2
Solute carrier organic anion transporter family member 2A1	0	0	0	2
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Nuclear receptor subfamily 4 group A member 2	0	0	1	1
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	1	0	3
Solute carrier organic anion transporter family member 2B1	0	1	0	1
Solute carrier organic anion transporter family member 3A1	0	0	0	1
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	3	0	3
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	2	0	2
Chain A, HADH2 protein	7	0	0	7
Chain B, HADH2 protein	7	0	0	7
Chain A, Cruzipain	6	0	0	6
phosphopantetheinyl transferase	11	0	0	11
farnesoid X nuclear receptor	16	0	0	16
peroxisome proliferator-activated receptor delta	14	0	0	14
vitamin D (1,25- dihydroxyvitamin D3) receptor	16	0	0	16
tumor necrosis factor	1	0	0	1
Potassium voltage-gated channel subfamily H member 2	0	12	0	12
Aurora kinase B	0	1	2	3
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	3	0	3
Replicase polyprotein 1ab	0	5	0	5
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
NFKB1 protein, partial	8	0	0	8
alpha-galactosidase	4	0	0	4
cytochrome P450 2C19 precursor	6	0	0	6
muscarinic acetylcholine receptor M1	10	0	0	10
lethal factor (plasmid)	3	0	0	3
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	2	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	4
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	10	0	0	10
Chain A, Ferritin light chain	8	0	0	8
acetylcholinesterase	10	0	0	10
SMAD family member 2	10	0	0	10
Fumarate hydratase	11	0	0	11
SMAD family member 3	10	0	0	10
thioredoxin glutathione reductase	6	0	0	6
pregnane X nuclear receptor	21	0	0	21
G	15	0	0	15
polyprotein	11	0	0	11
P53	1	0	0	1
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	17	0	0	17
thyroid stimulating hormone receptor	13	0	0	13
activating transcription factor 6	11	0	0	11
v-jun sarcoma virus 17 oncogene homolog (avian)	12	0	0	12
peripheral myelin protein 22 isoform 1	9	0	0	9
hemoglobin subunit beta	5	0	0	5
cellular tumor antigen p53 isoform a	5	0	0	5
heat shock protein beta-1	6	0	0	6
M-phase phosphoprotein 8	6	0	0	6
Interferon beta	21	0	0	21
HLA class I histocompatibility antigen, B alpha chain	15	0	0	15
Inositol hexakisphosphate kinase 1	15	0	0	15
ATPase family AAA domain-containing protein 5	12	0	0	12
Ataxin-2	15	0	0	15
Protein-arginine deiminase type-4	0	1	0	1
cytochrome P450 2C9, partial	15	0	0	15
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, 2-oxoglutarate Oxygenase	7	0	0	7
caspase-1 isoform alpha precursor	1	0	0	1
Caspase-7	1	0	0	1
Inositol monophosphatase 1	5	0	0	5
Solute carrier organic anion transporter family member 1B3	0	4	0	5
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Potassium channel subfamily K member 3	0	2	0	2
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	1	1	2
Potassium channel subfamily K member 9	0	1	0	1
Kappa-type opioid receptor	0	8	2	11
Chain A, Nitrile Hydratase alpha subunit	0	1	0	1
Chain B, Nitrile Hydratase beta subunit	0	1	0	1
Lysine-specific demethylase 4E	0	2	0	2
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
Free fatty acid receptor 3	0	0	1	1
Histone deacetylase 3	0	6	0	6
Histone deacetylase 4	0	5	0	5
Histone deacetylase 1	0	6	0	6
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Histone deacetylase 7	0	5	0	5
Histone deacetylase 2	0	6	0	6
Polyamine deacetylase HDAC10	0	3	0	3
Histone deacetylase 11	0	4	0	4
Histone deacetylase 8	0	5	0	5
Histone deacetylase 6	0	5	0	5
Histone deacetylase 9	0	4	0	4
Histone deacetylase 5	0	5	0	5
Methyl-accepting chemotaxis protein NahY	0	0	1	1
PPM1D protein	9	0	0	9
tyrosine-protein kinase Yes	2	0	0	2
Bone morphogenetic protein receptor type-1B	0	0	2	2
Membrane-associated progesterone receptor component 1	0	0	1	1
Cell division cycle 7-related protein kinase	0	0	1	1
Serine/threonine-protein kinase PLK4	0	0	2	2
ATP-dependent RNA helicase DDX3X	0	0	2	2
Pyridoxal kinase	0	0	2	2
Citron Rho-interacting kinase	0	0	2	2
Serine/threonine-protein kinase Chk1	0	1	3	4
Aurora kinase A	0	0	2	2
Cyclin-G-associated kinase	0	0	2	2
Ephrin type-B receptor 6	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 3	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 2	0	0	2	2
Mitotic checkpoint serine/threonine-protein kinase BUB1	0	0	2	2
Dynamin-like 120 kDa protein, mitochondrial	0	0	2	2
Tyrosine-protein kinase JAK2	0	0	2	2
Eukaryotic translation initiation factor 5B	0	0	1	1
Rho-associated protein kinase 2	0	0	2	2
Serine/threonine-protein kinase ULK1	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE1	0	0	2	2
Ribosomal protein S6 kinase alpha-5	0	0	2	2
U5 small nuclear ribonucleoprotein 200 kDa helicase	0	0	2	2
Ribosomal protein S6 kinase alpha-4	0	0	2	2
Serine/threonine-protein kinase 16	0	0	2	2
Serine/threonine-protein kinase 10	0	0	2	2
Serine/threonine-protein kinase D3	0	0	2	2
Structural maintenance of chromosomes protein 2	0	0	2	2
Mitogen-activated protein kinase kinase kinase 6	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 4	0	0	2	2
Serine/threonine-protein kinase LATS1	0	0	2	2
Serine/threonine-protein kinase PAK 4	0	0	2	2
Tyrosine-protein kinase ABL1	0	2	3	5
High affinity nerve growth factor receptor	0	1	2	3
Guanine nucleotide-binding protein G(i) subunit alpha-2	0	0	2	2
ADP/ATP translocase 2	0	0	2	2
Protein kinase C beta type	0	0	2	2
Tyrosine-protein kinase Lck	0	1	2	3
Tyrosine-protein kinase Fyn	0	2	2	4
Cyclin-dependent kinase 1	0	1	2	3
Glycogen phosphorylase, liver form	0	0	2	2
Acyl-CoA desaturase 1	0	2	0	2
Tyrosine-protein kinase Fes/Fps	0	0	2	2
Adenine phosphoribosyltransferase	0	0	1	1
Tyrosine-protein kinase Yes	0	0	2	2
Tyrosine-protein kinase Lyn	0	1	2	3
Proto-oncogene tyrosine-protein kinase receptor Ret	0	2	2	4
Insulin-like growth factor 1 receptor	0	2	2	4
Signal recognition particle receptor subunit alpha	0	0	2	2
Cytochrome c1, heme protein, mitochondrial	0	0	2	2
Hepatocyte growth factor receptor	0	1	2	4
Tyrosine-protein kinase HCK	0	0	2	2
Serine/threonine-protein kinase A-Raf	0	0	2	2
Mast/stem cell growth factor receptor Kit	0	2	2	4
Glycogen phosphorylase, brain form	0	0	2	2
Breakpoint cluster region protein	0	0	3	3
Serine/threonine-protein kinase pim-1	0	0	2	2
Cyclin-dependent kinase 4	0	1	2	3
ADP/ATP translocase 3	0	0	2	2
Proto-oncogene tyrosine-protein kinase Src	0	4	2	6
cAMP-dependent protein kinase type II-alpha regulatory subunit	0	0	2	2
Serine/threonine-protein kinase B-raf	0	0	2	2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform	0	0	2	2
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	0	2	2
Platelet-derived growth factor receptor alpha	0	3	2	5
Tyrosine-protein kinase Fer	0	0	2	2
Protein kinase C alpha type	0	0	2	2
cAMP-dependent protein kinase catalytic subunit alpha	0	0	2	2
Vascular endothelial growth factor receptor 1	0	2	1	3
General transcription and DNA repair factor IIH helicase subunit XPD	0	0	2	2
Casein kinase II subunit alpha'	0	0	2	2
Ras-related protein Rab-6A	0	0	2	2
Multifunctional protein ADE2	0	0	2	2
cAMP-dependent protein kinase catalytic subunit gamma	0	0	2	2
cAMP-dependent protein kinase catalytic subunit beta	0	0	2	2
Ferrochelatase, mitochondrial	0	0	2	2
Ribosomal protein S6 kinase beta-1	0	0	2	2
Tyrosine-protein kinase JAK1	0	0	2	2
Beta-adrenergic receptor kinase 1	0	0	2	2
Probable ATP-dependent RNA helicase DDX6	0	0	2	2
Mitogen-activated protein kinase 3	0	0	2	2
MAP/microtubule affinity-regulating kinase 3	0	0	2	2
Deoxycytidine kinase	0	0	2	3
Mitogen-activated protein kinase 1	0	0	2	2
Ephrin type-A receptor 2	0	0	2	2
Ephrin type-B receptor 2	0	0	2	2
Non-receptor tyrosine-protein kinase TYK2	0	0	2	2
UMP-CMP kinase	0	0	1	1
Phosphatidylethanolamine-binding protein 1	0	0	1	1
Wee1-like protein kinase	0	0	2	2
Heme oxygenase 2	0	0	2	2
Tyrosine-protein kinase receptor UFO	0	1	1	2
S-adenosylmethionine synthase isoform type-2	0	0	2	2
DnaJ homolog subfamily A member 1	0	0	2	2
RAC-alpha serine/threonine-protein kinase	0	0	2	2
RAC-beta serine/threonine-protein kinase	0	0	2	2
Kinesin-1 heavy chain	0	2	0	2
Dual specificity protein kinase TTK	0	0	2	2
DNA replication licensing factor MCM4	0	0	2	2
Myosin-10	0	0	2	2
Vascular endothelial growth factor receptor 3	0	2	1	3
Vascular endothelial growth factor receptor 2	0	3	1	5
Dual specificity mitogen-activated protein kinase kinase 2	0	0	2	2
Receptor-type tyrosine-protein kinase FLT3	0	2	2	4
Bone morphogenetic protein receptor type-1A	0	0	2	2
Activin receptor type-1B	0	0	2	2
TGF-beta receptor type-1	0	0	2	2
TGF-beta receptor type-2	0	0	2	2
Electron transfer flavoprotein subunit beta	0	0	1	1
Tyrosine-protein kinase CSK	0	0	2	2
Glycine--tRNA ligase	0	0	2	2
Protein kinase C iota type	0	0	2	2
Exosome RNA helicase MTR4	0	0	2	2
Tyrosine-protein kinase Tec	0	0	2	2
Tyrosine-protein kinase ABL2	0	0	2	2
Tyrosine-protein kinase FRK	0	0	2	2
Tyrosine-protein kinase SYK	0	0	2	2
26S proteasome regulatory subunit 6B	0	0	2	2
Mitogen-activated protein kinase 8	0	0	2	2
Mitogen-activated protein kinase 9	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 3	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	1	0	2	3
Casein kinase I isoform alpha	0	0	2	2
Casein kinase I isoform delta	0	0	2	2
MAP kinase-activated protein kinase 2	0	0	2	2
Elongation factor Tu, mitochondrial	0	0	2	2
Cysteine--tRNA ligase, cytoplasmic	0	0	1	1
Casein kinase I isoform epsilon	0	0	2	2
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial	0	0	2	2
Dual specificity protein kinase CLK1	0	0	2	2
Dual specificity protein kinase CLK2	0	0	2	2
Dual specificity protein kinase CLK3	0	0	2	2
Glycogen synthase kinase-3 alpha	0	0	2	2
Glycogen synthase kinase-3 beta	0	0	2	2
Cyclin-dependent kinase 7	0	0	2	2
Cyclin-dependent kinase 9	0	0	2	2
Ras-related protein Rab-27A	0	0	2	2
Interleukin-1 receptor-associated kinase 1	0	0	2	2
Ribosomal protein S6 kinase alpha-3	0	0	2	2
Serine/threonine-protein kinase Nek2	0	0	2	2
Serine/threonine-protein kinase Nek3	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 6	0	0	2	2
Serine/threonine-protein kinase PLK1	0	1	2	3
LIM domain kinase 1	0	0	2	2
LIM domain kinase 2	0	0	2	2
Mitogen-activated protein kinase 10	0	0	2	2
Tyrosine--tRNA ligase, cytoplasmic	0	0	1	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	2	2
Ephrin type-B receptor 3	0	0	2	2
Ephrin type-A receptor 5	0	0	2	2
Ephrin type-B receptor 4	0	0	2	2
Ephrin type-A receptor 4	0	0	2	2
Adenylate kinase 2, mitochondrial	0	0	2	2
Spike glycoprotein	15	0	0	15
Ras-related protein Rab-10	0	0	2	2
Actin-related protein 3	0	0	2	2
Actin-related protein 2	0	0	2	2
GTP-binding nuclear protein Ran	0	0	2	2
Casein kinase I isoform gamma-2	0	0	2	2
Cyclin-dependent kinase 3	0	0	2	2
Cyclin-dependent kinase 6	0	0	2	2
Cyclin-dependent-like kinase 5	0	0	2	2
Cyclin-dependent kinase 16	0	0	2	2
Cyclin-dependent kinase 17	0	0	2	2
ATP-dependent 6-phosphofructokinase, platelet type	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 1	0	0	2	2
Angiopoietin-1 receptor	0	1	1	2
DNA topoisomerase 2-beta	0	0	2	3
Protein kinase C theta type	0	0	2	2
Activin receptor type-1	0	0	2	2
Macrophage-stimulating protein receptor	0	1	2	3
Focal adhesion kinase 1	0	0	2	2
Protein kinase C zeta type	0	0	2	2
Protein kinase C delta type	0	0	2	2
Tyrosine-protein kinase BTK	0	0	2	2
Activated CDC42 kinase 1	0	0	2	2
Epithelial discoidin domain-containing receptor 1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 2	0	0	2	2
Serine/threonine-protein kinase 4	0	0	2	2
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	2	2
Dual specificity mitogen-activated protein kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase 7	0	0	2	2
Serine/threonine-protein kinase PAK 2	0	0	2	2
Serine/threonine-protein kinase 3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 1	0	0	2	2
Integrin-linked protein kinase	0	0	2	2
Rho-associated protein kinase 1	0	0	2	2
Non-receptor tyrosine-protein kinase TNK1	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit gamma	0	0	2	2
Calcium/calmodulin-dependent protein kinase type II subunit delta	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	2	2
Activin receptor type-2B	0	0	2	2
Bone morphogenetic protein receptor type-2	0	0	2	2
Protein-tyrosine kinase 6	0	0	2	2
cGMP-dependent protein kinase 1	0	0	2	2
Cyclin-dependent kinase 13	0	0	2	2
Inhibitor of nuclear factor kappa-B kinase subunit epsilon	0	0	2	2
Protein-tyrosine kinase 2-beta	0	0	2	2
Maternal embryonic leucine zipper kinase	0	2	2	4
Structural maintenance of chromosomes protein 1A	0	0	2	2
Chromodomain-helicase-DNA-binding protein 4	0	0	2	2
Peroxisomal acyl-coenzyme A oxidase 1	0	0	2	2
Ephrin type-A receptor 7	0	0	2	2
Delta(24)-sterol reductase	0	0	2	2
Ribosomal protein S6 kinase alpha-1	0	0	2	2
Myosin light chain kinase, smooth muscle	0	0	2	2
Serine/threonine-protein kinase STK11	0	0	2	2
Coiled-coil domain-containing protein 6	0	2	0	2
Serine/threonine-protein kinase N1	0	0	2	2
Serine/threonine-protein kinase N2	0	0	2	2
Calcium/calmodulin-dependent protein kinase type IV	0	0	2	2
Mitogen-activated protein kinase kinase kinase 11	0	0	2	2
Discoidin domain-containing receptor 2	0	0	2	2
AP2-associated protein kinase 1	0	0	2	2
Myosin light chain kinase 3	0	0	2	2
Putative heat shock protein HSP 90-beta 2	0	0	2	2
Rab-like protein 3	0	0	2	2
Serine/threonine-protein kinase MRCK alpha	0	0	2	2
Serine/threonine-protein kinase MRCK gamma	0	0	2	2
Acyl-CoA dehydrogenase family member 10	0	0	2	2
Serine/threonine-protein kinase ULK3	0	0	2	2
Uncharacterized protein FLJ45252	0	0	2	2
Acyl-CoA dehydrogenase family member 11	0	0	2	2
Serine/threonine-protein kinase/endoribonuclease IRE2	0	0	2	2
Serine/threonine-protein kinase MARK2	0	0	2	2
ATP-dependent RNA helicase DHX30	0	0	2	2
Serine/threonine-protein kinase TAO1	0	0	2	2
STE20-related kinase adapter protein alpha	0	0	2	2
Myosin-14	0	0	2	2
AarF domain-containing protein kinase 1	0	0	2	2
ATP-dependent RNA helicase DDX42	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 3	0	0	2	2
MAP kinase-activated protein kinase 5	0	0	2	2
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	0	0	1	1
Atypical kinase COQ8A, mitochondrial	0	0	2	2
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma	0	0	2	2
Mitogen-activated protein kinase 15	0	0	2	2
Serine/threonine-protein kinase Nek9	0	0	2	2
Serine/threonine-protein kinase Nek7	0	0	2	2
ATP-dependent RNA helicase DDX1	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 1	0	0	2	2
MAP/microtubule affinity-regulating kinase 4	0	0	2	2
Serine/threonine-protein kinase Nek1	0	0	2	2
Calcium/calmodulin-dependent protein kinase kinase 2	0	0	2	2
EKC/KEOPS complex subunit TP53RK	0	0	2	2
Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase	0	0	2	2
Mitogen-activated protein kinase kinase kinase 5	0	0	2	2
Mitogen-activated protein kinase kinase kinase 3	0	0	2	2
Eukaryotic translation initiation factor 2-alpha kinase 1	0	0	2	2
Nucleolar GTP-binding protein 1	0	0	2	2
Serine/threonine-protein kinase D2	0	0	2	2
NUAK family SNF1-like kinase 2	0	0	2	2
RNA cytidine acetyltransferase	0	0	2	2
Serine/threonine-protein kinase SIK2	0	0	2	2
STE20-like serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO3	0	0	2	2
dCTP pyrophosphatase 1	0	0	2	2
Dual specificity protein kinase CLK4	0	0	2	2
Casein kinase I isoform gamma-1	0	0	2	2
Serine/threonine-protein kinase PAK 6	0	0	2	2
Phenylalanine--tRNA ligase beta subunit	0	0	2	2
Isoleucine--tRNA ligase, mitochondrial	0	0	1	1
BMP-2-inducible protein kinase	0	0	2	2
Obg-like ATPase 1	0	0	1	1
Midasin	0	0	2	2
SAFB-like transcription modulator	0	1	0	1
Interleukin-1 receptor-associated kinase 4	0	0	2	2
Mitogen-activated protein kinase kinase kinase 20	0	0	2	2
Cyclin-dependent kinase 12	0	0	2	2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	0	0	2	2
Serine/threonine-protein kinase 26	0	0	2	2
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial	0	0	1	1
Serine/threonine-protein kinase NLK	0	0	2	2
5'-AMP-activated protein kinase subunit gamma-2	0	0	2	2
Serine/threonine-protein kinase TBK1	0	0	2	2
Septin-9	0	0	2	2
Ribosomal protein S6 kinase alpha-6	0	0	2	2
TRAF2 and NCK-interacting protein kinase	0	0	2	2
Serine/threonine-protein kinase TAO2	0	0	2	2
Long-chain-fatty-acid--CoA ligase 5	0	0	2	2
ALK tyrosine kinase receptor	0	0	2	2
Serine/threonine-protein kinase ICK	0	0	2	2
RAC-gamma serine/threonine-protein kinase	0	0	2	2
Serine/threonine-protein kinase SIK3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 2	0	0	2	2
Thyroid hormone receptor-associated protein 3	0	0	2	2
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	0	0	2	2
Mitogen-activated protein kinase kinase kinase kinase 5	0	0	2	2
Receptor-interacting serine/threonine-protein kinase 3	0	0	2	2
Serine/threonine-protein kinase MRCK beta	0	0	2	2
Interleukin-1 receptor-associated kinase 3	0	0	2	2
Serine/threonine-protein kinase 24	0	0	2	2
Casein kinase I isoform gamma-3	0	0	2	2
Mitogen-activated protein kinase kinase kinase 4	0	0	2	2
DNA topoisomerase	0	1	0	1
15-lipoxygenase, partial	5	0	0	5
Thrombopoietin	2	0	0	2
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	10	0	0	10
67.9K protein	9	0	0	9
glucocerebrosidase	1	0	0	1
putative alpha-glucosidase	1	0	0	1
lysosomal alpha-glucosidase preproprotein	3	0	0	3
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	7	0	0	7
nuclear factor erythroid 2-related factor 2 isoform 2	9	0	0	9
huntingtin isoform 2	3	0	0	3
eukaryotic translation initiation factor 2-alpha kinase 3 isoform 1 precursor	0	0	1	1
serine/threonine-protein kinase mTOR isoform 1	4	0	0	4
histone acetyltransferase KAT2A isoform 1	6	0	0	6
relaxin receptor 1 isoform 1	2	0	0	2
Telomerase reverse transcriptase	0	1	0	1
Type-2 restriction enzyme ScaI	0	1	0	1
Deoxyribonuclease-2-alpha	0	1	0	1
Tyrosyl-DNA phosphodiesterase 2	0	1	0	1
Deoxyribonuclease-1	0	1	0	1
Type-2 restriction enzyme PstI	0	1	0	1
Type-2 restriction enzyme EcoRI	0	1	0	1
Prothrombin	0	0	0	1
DNA ligase	0	1	0	1
Integrin beta-3	4	1	0	5
Integrin alpha-IIb	4	0	0	4
Heterogeneous nuclear ribonucleoprotein A1	0	0	1	1
DNA topoisomerase 1	0	1	1	7
DNA topoisomerase 2-alpha	0	1	1	2
Type-2 restriction enzyme BamHI	0	1	0	1
Somatostatin receptor type 1	0	2	0	2
Somatostatin receptor type 2	0	2	0	2
Somatostatin receptor type 4	0	2	0	2
Somatostatin receptor type 3	0	2	0	2
Somatostatin receptor type 5	0	2	0	2
5-hydroxytryptamine receptor 2B	0	10	1	11
Type-2 restriction enzyme HindIII	0	1	0	1
Ribonuclease pancreatic	0	1	0	1
DNA topoisomerase 1	0	1	0	2
DNA topoisomerase 1	0	1	0	1
Integrase	0	1	0	1
DNA topoisomerase type IB small subunit	0	0	1	1
Tyrosyl-DNA phosphodiesterase 1	0	2	0	2
Liver carboxylesterase 1	0	0	0	3
Chain A, Beta-lactoglobulin	0	0	1	1
Chain A, Beta-lactoglobulin	0	0	1	1
UDP-3-O-acyl-N-acetylglucosamine deacetylase	0	0	1	1
cytochrome P450 2D6	14	0	0	14
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
Luciferase	12	0	0	12
nonstructural protein 1	3	0	0	3
histone deacetylase 9 isoform 3	2	0	0	2
Complement C5	0	0	1	1
Solute carrier family 22 member 8	0	2	0	4
Insulin-degrading enzyme	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Chain A, Carbonic anhydrase II	0	1	0	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
glp-1 receptor, partial	7	0	0	7
pregnane X receptor	4	0	0	4
hypoxia-inducible factor 1 alpha subunit	7	0	0	7
caspase 7, apoptosis-related cysteine protease	8	0	0	8
Rac1 protein	0	0	1	1
caspase-3	8	0	0	8
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
thyrotropin-releasing hormone receptor	2	0	0	2
Caspase-7	2	0	0	2
interferon gamma precursor	0	0	0	3
prostaglandin E2 receptor EP2 subtype	1	0	0	2
potassium voltage-gated channel subfamily H member 2 isoform d	9	0	0	9
caspase-3	2	0	0	2
Prostaglandin E synthase	0	1	0	1
3-phosphoinositide-dependent protein kinase 1	0	1	1	2
Prostaglandin G/H synthase 1	0	4	0	4
Prostaglandin G/H synthase 2	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	3	0	3
Cytochrome c oxidase subunit 1	0	1	0	1
Cytochrome c oxidase subunit 2	0	1	0	1
Catechol O-methyltransferase	0	1	0	1
Cytochrome c oxidase subunit 2	0	2	0	2
Procathepsin L	0	1	0	1
Aldo-keto reductase family 1 member B1	0	6	0	6
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Quinolone resistance protein NorA	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Beta-3 adrenergic receptor	0	4	3	7
Alpha-1B adrenergic receptor	0	7	1	8
Calpain-2 catalytic subunit	0	1	0	1
Alpha-2B adrenergic receptor	0	5	1	7
D(1A) dopamine receptor	0	3	1	4
Prostaglandin G/H synthase 1	0	2	0	2
Sodium-dependent noradrenaline transporter	0	6	2	8
Cruzipain	0	2	0	2
Sodium/hydrogen exchanger 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	4	0	6
Alpha-1A adrenergic receptor	0	7	1	8
Urotensin-2 receptor	0	1	0	1
Ras-related protein Rab-2A	0	0	1	1
Prostaglandin G/H synthase 2	0	6	0	6
Sodium-dependent dopamine transporter	0	2	0	2
Prostaglandin G/H synthase 2	0	3	0	3
Prostaglandin G/H synthase 1	0	4	0	6
Prostaglandin G/H synthase 1	0	1	0	1
Cyclooxygenase-2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
P2Y purinoceptor 12	0	2	0	2
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, Proto-oncogene Tyrosine-protein Kinase Src	0	1	0	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain A, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
Chain B, N5-carboxyaminoimidazole ribonucleotide mutase	0	0	1	1
hepatocyte nuclear factor 4-alpha isoform 2	0	1	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Beta-lactamase	0	1	0	1
3-dehydroquinate dehydratase	0	0	1	1
ATP-citrate synthase	0	0	0	1
Ribonuclease T	0	0	0	1
Cell death-related nuclease 4	0	0	0	1
3-dehydroquinate dehydratase	0	0	1	1
Prolyl 4-hydroxylase	0	4	0	4
Alpha-ketoglutarate-dependent dioxygenase FTO	0	3	0	3
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	2	0	2
General amino-acid permease GAP1	0	0	0	1
Thymidine kinase 2	0	1	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	0	0	1
AAA family ATPase	0	0	0	1
Reverse transcriptase/RNaseH	0	0	1	1
Hsf1 protein	0	0	2	2
Aldo-keto reductase family 1 member B10	0	1	0	1
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Dihydrofolate reductase	0	4	0	4
Fatty acid-binding protein, liver	0	4	0	4
Albumin	0	3	5	8
Interleukin-8	0	1	0	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	2	0	6
UDP-glucuronosyltransferase 1A4	0	2	0	3
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
C-X-C chemokine receptor type 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
UDP-glucuronosyltransferase 1A3	0	0	0	3
UDP-glucuronosyltransferase 2B10	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Solute carrier family 22 member 6	0	4	0	5
Multidrug and toxin extrusion protein 1	0	5	0	5
UDP-glucuronosyltransferase 1A7	0	1	0	1
UDP-glucuronosyltransferase 1A10	0	1	0	1
Cereblon isoform 4	0	2	0	2
Insulin-like growth factor-binding protein 5	0	0	1	1
Choline O-acetyltransferase	0	1	0	1
Protein cereblon	0	2	0	2
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	5	0	6
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Solute carrier family 22 member 7	0	0	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 8	0	1	0	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier family 22 member 11	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	1
nuclear receptor subfamily 1, group I, member 2	6	0	0	6
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	2	0	2
cytochrome P450 2D6 isoform 1	5	0	0	5
D(1A) dopamine receptor	6	0	0	6
atrial natriuretic peptide receptor 2 precursor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	4	0	0	4
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
5-hydroxytryptamine receptor 4	0	8	0	8
Alpha-2A adrenergic receptor	0	7	4	12
D(2) dopamine receptor	0	6	1	7
Alpha-2C adrenergic receptor	0	6	3	10
D	0	1	0	2
Retinoic acid receptor RXR-alpha	0	0	1	1
Alpha-1D adrenergic receptor	0	2	1	4
5-hydroxytryptamine receptor 2A	0	6	1	7
5-hydroxytryptamine receptor 2C	0	8	1	9
Histamine H1 receptor	0	3	0	3
Mu-type opioid receptor	0	7	3	11
D(3) dopamine receptor	0	5	0	5
Histamine H2 receptor	4	0	0	4
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Multidrug and toxin extrusion protein 2	0	2	0	2
Genome polyprotein	0	2	0	2
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
streptokinase A precursor	0	0	1	1
Motilin receptor	0	1	1	2
30S ribosomal protein S6	0	2	1	3
30S ribosomal protein S7	0	2	1	3
50S ribosomal protein L15	0	2	1	3
ATP-dependent translocase ABCB1	0	3	0	3
ATP-dependent translocase ABCB1	0	10	1	15
60 kDa chaperonin	0	3	0	3
50S ribosomal protein L10	0	2	1	3
50S ribosomal protein L11	0	2	1	3
50S ribosomal protein L7/L12	0	2	1	3
50S ribosomal protein L19	0	2	1	3
50S ribosomal protein L1	0	2	1	3
50S ribosomal protein L20	0	2	1	3
50S ribosomal protein L27	0	2	1	3
50S ribosomal protein L28	0	2	1	3
50S ribosomal protein L29	0	2	1	3
50S ribosomal protein L31	0	2	1	3
50S ribosomal protein L31 type B	0	2	1	3
50S ribosomal protein L32	0	2	1	3
50S ribosomal protein L33	0	2	1	3
50S ribosomal protein L34	0	2	1	3
50S ribosomal protein L35	0	2	1	3
50S ribosomal protein L36	0	2	1	3
30S ribosomal protein S10	0	2	1	3
30S ribosomal protein S11	0	2	1	3
30S ribosomal protein S12	0	2	1	3
30S ribosomal protein S13	0	2	1	3
30S ribosomal protein S16	0	2	1	3
30S ribosomal protein S18	0	2	1	3
30S ribosomal protein S19	0	2	1	3
30S ribosomal protein S20	0	2	1	3
30S ribosomal protein S2	0	2	1	3
30S ribosomal protein S3	0	2	1	3
30S ribosomal protein S4	0	2	1	3
30S ribosomal protein S5	0	2	1	3
30S ribosomal protein S8	0	2	1	3
30S ribosomal protein S9	0	2	1	3
50S ribosomal protein L13	0	2	1	3
50S ribosomal protein L14	0	2	1	3
50S ribosomal protein L16	0	2	1	3
50S ribosomal protein L23	0	2	1	3
30S ribosomal protein S15	0	2	1	3
50S ribosomal protein L17	0	2	1	3
50S ribosomal protein L21	0	2	1	3
50S ribosomal protein L30	0	2	1	3
50S ribosomal protein L6	0	2	1	3
30S ribosomal protein S14	0	2	1	3
30S ribosomal protein S17	0	2	1	3
30S ribosomal protein S1	0	2	1	3
50S ribosomal protein L18	0	2	1	3
60 kDa heat shock protein, mitochondrial	0	4	0	4
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	4	0	4
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
50S ribosomal protein L2	0	2	1	3
50S ribosomal protein L3	0	2	1	3
50S ribosomal protein L24	0	2	1	3
50S ribosomal protein L4	0	2	1	3
50S ribosomal protein L22	0	2	1	3
10 kDa heat shock protein, mitochondrial	0	4	0	4
50S ribosomal protein L5	0	2	1	3
30S ribosomal protein S21	0	2	1	3
50S ribosomal protein L25	0	2	1	3
Cytochrome P450 1B1	0	1	0	1
Thiosulfate sulfurtransferase	0	4	0	4
Lanosterol 14-alpha demethylase	0	2	0	2
50S ribosomal protein L36 2	0	2	1	3
60 kDa chaperonin	0	4	0	4
10 kDa chaperonin	0	4	0	4
atrial natriuretic peptide receptor 1 precursor	2	0	0	2
Nuclear receptor subfamily 1 group I member 2	0	0	2	2
Amine oxidase [flavin-containing] A	0	2	0	2
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Kappa-type opioid receptor	0	3	1	5
Delta-type opioid receptor	0	7	2	10
Mu-type opioid receptor	0	3	1	6
Sigma non-opioid intracellular receptor 1	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
endonuclease IV	2	0	0	2
Skn7p	0	0	0	1
Vpr	4	0	0	4
Amyloid-beta precursor protein	2	1	0	3
Thymidylate synthase	0	1	0	1
Aromatase	0	1	0	1
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	2	2
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Chain A, Glutamine Binding Protein	0	0	1	1
Neutral amino acid transporter A	0	2	0	2
Asc-type amino acid transporter 1	0	2	0	2
Neutral amino acid transporter B(0)	0	2	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Amino acid transporter	0	2	0	2
Chain B, EUKARYOTIC TRANSLATION INITIATION FACTOR 4E	0	0	1	1
Muscarinic acetylcholine receptor M2	0	3	1	4
Muscarinic acetylcholine receptor M4	0	3	0	3
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M1	0	2	1	3
Muscarinic acetylcholine receptor M3	0	3	1	4
Proton-coupled amino acid transporter 1	0	1	0	1
Acid-sensing ion channel 3	0	1	0	1
Solute carrier organic anion transporter family member 1A4	0	1	0	1
Albumin	0	1	0	2
Albumin	0	0	2	2
Cholinesterase	0	4	0	4
Polyunsaturated fatty acid 5-lipoxygenase	0	2	0	5
Acetylcholinesterase	0	7	0	7
Caspase-1	0	3	0	3
Substance-P receptor	0	1	0	1
Aldo-keto reductase family 1 member C3	0	2	0	2
Caspase-3	0	3	0	3
Solute carrier organic anion transporter family member 1A1	0	1	0	1
Caspase-4	0	3	0	3
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Caspase-5	0	3	0	3
Caspase-9	0	3	0	3
Acid-sensing ion channel 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
DNA repair protein RAD52 homolog isoform a	0	0	0	2
Cytochrome P450 3A5	0	1	0	2
Beta-lactamase	0	2	0	2
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase type 2	0	0	0	2
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	2
Beta-lactamase	0	0	0	3
Metallo-beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	3
Beta-lactamase	0	0	0	2
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase TEM	0	0	0	1
B2 metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	2
Metallo-beta-lactamase VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	2
Beta-lactamase class B VIM-2	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	2
Chain A, Acetylcholinesterase	0	1	0	1
Solute carrier family 22 member 3	0	1	0	1
Interstitial collagenase	0	1	0	1
Acetylcholinesterase	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
Gap junction alpha-1 protein	0	1	0	1
Gap junction beta-2 protein	0	1	0	1
Acyl-protein thioesterase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	1	0	1
Acetylcholinesterase	0	3	0	3
Glutamate receptor ionotropic, NMDA 3B	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 2A	0	2	0	2
Glutamate receptor ionotropic, NMDA 2B	0	2	0	2
Glutamate receptor ionotropic, NMDA 2C	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
NPC intracellular cholesterol transporter 1 precursor	3	0	0	3
Cell division control protein 42 homolog	0	1	0	1
Ras-related C3 botulinum toxin substrate 1	0	1	0	1
Serine/threonine-protein kinase PAK 1	0	1	1	2
apical membrane antigen 1, AMA1	3	0	0	3
Parkin	2	0	0	2
Replicase polyprotein 1ab	0	1	0	1
cytochrome P450 2C9 precursor	3	0	0	3
phosphoethanolamine/phosphocholine phosphatase isoform 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Microtubule-associated protein tau	0	2	1	3
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Alpha-synuclein	3	0	0	3
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 2	0	1	0	1
Potassium channel subfamily K member 18	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	2	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	3	0	3
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucose 6-dehydrogenase	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Chain E, Fibrin beta chain	0	1	0	1
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
T cell receptor, partial	1	0	0	1
luteinizing hormone receptor	1	0	0	1
integrase, partial	0	1	0	1
chaperonin-containing TCP-1 beta subunit homolog	1	0	0	1
lens epithelium-derived growth factor p75	0	1	0	1
Caspase 6, apoptosis-related cysteine peptidase	0	0	0	1
TSHR protein	1	0	0	1
Apoptotic peptidase activating factor 1	0	1	0	1
hypothetical protein, conserved	1	0	0	1
isocitrate dehydrogenase 1, partial	2	0	0	2
luciferase	1	0	0	1
serine-protein kinase ATM isoform a	1	0	0	1
neutrophil cytosol factor 1	0	1	0	1
caspase-9 isoform alpha precursor	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
DNA polymerase beta	2	0	0	2
caspase-3 isoform a preproprotein	0	1	0	1
protein AF-9 isoform a	0	0	0	1
replicative DNA helicase	0	0	0	1
recombinase A	0	0	1	1
POsterior Segregation	0	0	2	2
neuropeptide S receptor isoform A	2	0	0	2
Glutathione reductase	0	1	0	1
Glutathione reductase, mitochondrial	0	1	0	2
Glycoprotein hormones alpha chain	1	0	0	1
Dihydrolipoyl dehydrogenase, mitochondrial	0	1	0	2
Alpha-1D adrenergic receptor	0	5	1	6
Thioredoxin reductase 1, cytoplasmic	0	1	0	2
Dihydrolipoyl dehydrogenase	0	1	0	2
Zinc finger protein mex-5	0	0	2	2
phosphoglycerate kinase	2	0	0	2
5-hydroxytryptamine receptor 3E	0	0	1	1
5-hydroxytryptamine receptor 3B	0	0	1	1
Myeloperoxidase	0	2	0	2
D(3) dopamine receptor	0	2	0	2
Alpha-2B adrenergic receptor	0	3	1	4
D(2) dopamine receptor	0	1	0	1
Alpha-2C adrenergic receptor	0	3	1	4
Alpha-2A adrenergic receptor	0	3	1	4
5-hydroxytryptamine receptor 3A	0	1	0	1
D(1B) dopamine receptor	0	1	0	1
D(4) dopamine receptor	0	1	0	1
5-hydroxytryptamine receptor 3A	0	0	1	1
5-hydroxytryptamine receptor 7	0	3	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Lactoperoxidase	0	1	0	1
5-hydroxytryptamine receptor 3D	0	0	1	1
5-hydroxytryptamine receptor 3C	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Beta-1 adrenergic receptor	0	1	2	4
Beta-2 adrenergic receptor	0	4	3	7
Beta-1 adrenergic receptor	0	4	3	7
Beta-1 adrenergic receptor	0	4	2	7
Beta-1 adrenergic receptor	0	2	0	2
Beta-2 adrenergic receptor	0	2	2	5
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	4	0	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor corepressor 1	0	1	0	1
Integrin beta-1	0	1	0	1
Leukotriene A-4 hydrolase	0	1	0	1
Integrin alpha-4	0	1	0	1
Nuclear receptor corepressor 2	0	1	0	1
Opioid receptor, delta 1b	0	1	0	1
Opioid receptor homologue	0	1	0	1
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Muscarinic acetylcholine receptor M2	0	1	0	1
Histidine decarboxylase	0	0	1	1
Proteinase-activated receptor 1	0	1	1	2
Kappa-type opioid receptor	0	2	1	4
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	1	1
Mu-type opioid receptor	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Hormone-sensitive lipase	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Leukotriene C4 synthase	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform	0	0	1	1
Serine/threonine-protein kinase 25	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta	0	0	1	1
Serine/threonine-protein kinase RIO3	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 7	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	1	1
Peripheral plasma membrane protein CASK	0	0	1	1
Serine/threonine-protein kinase DCLK1	0	0	1	1
Inhibitor of nuclear factor kappa-B kinase subunit alpha	0	0	1	1
Muscle, skeletal receptor tyrosine-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 13	0	0	1	1
Death-associated protein kinase 3	0	0	1	1
NUAK family SNF1-like kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma	0	0	1	1
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma	0	0	1	1
Serine/threonine-protein kinase PAK 3	0	0	1	1
Cyclin-dependent kinase-like 5	0	0	1	1
Serine/threonine-protein kinase 17B	0	0	1	1
Cyclin-dependent kinase 14	0	0	1	1
Serine/threonine-protein kinase OSR1	0	0	1	1
Serine/threonine-protein kinase Chk2	0	0	1	1
RAF proto-oncogene serine/threonine-protein kinase	0	0	1	1
Platelet-derived growth factor receptor beta	0	1	0	1
Macrophage colony-stimulating factor 1 receptor	0	0	1	1
Proto-oncogene tyrosine-protein kinase ROS	0	0	1	1
Tyrosine-protein kinase Fgr	0	0	1	1
Wee1-like protein kinase 2	0	0	1	1
Uncharacterized serine/threonine-protein kinase SBK3	0	0	1	1
Insulin receptor-related protein	0	0	1	1
Interferon-induced, double-stranded RNA-activated protein kinase	0	0	1	1
Serine/threonine-protein kinase MAK	0	0	1	1
Cyclin-dependent kinase 11B	0	0	1	1
Ephrin type-A receptor 1	0	0	1	1
Receptor tyrosine-protein kinase erbB-3	0	0	1	1
Protein kinase C eta type	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	0	1
Activin receptor type-2A	0	0	1	1
Ephrin type-A receptor 3	0	0	1	1
Ephrin type-A receptor 8	0	0	1	1
Leukocyte tyrosine kinase receptor	0	0	1	1
Mitogen-activated protein kinase 4	0	0	1	1
G protein-coupled receptor kinase 4	0	0	1	1
Tyrosine-protein kinase receptor Tie-1	0	0	1	1
Vascular endothelial growth factor receptor 2	0	1	0	1
Serine/threonine-protein kinase receptor R3	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform	0	0	1	1
Serine/threonine-protein kinase mTOR	0	1	1	2
Megakaryocyte-associated tyrosine-protein kinase	0	0	1	1
Tyrosine-protein kinase TXK	0	0	1	1
G protein-coupled receptor kinase 6	0	0	1	1
Tyrosine-protein kinase ZAP-70	0	0	1	1
Dual specificity mitogen-activated protein kinase kinase 4	0	0	1	1
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	0	1	1
Cyclin-dependent kinase 8	0	0	1	1
Choline-phosphate cytidylyltransferase A	0	0	1	1
Tyrosine-protein kinase Blk	0	0	1	1
Cytoplasmic tyrosine-protein kinase BMX	0	0	1	1
cAMP-dependent protein kinase catalytic subunit PRKX	0	0	1	1
Serine/threonine-protein kinase Nek4	0	0	1	1
Tyrosine-protein kinase JAK3	0	0	1	1
Death-associated protein kinase 1	0	0	1	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	1	1
Ephrin type-B receptor 1	0	0	1	1
Hormonally up-regulated neu tumor-associated kinase	0	0	1	1
Serine/threonine-protein kinase SIK1	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 4	0	0	1	1
Cell division control protein 2 homolog	0	0	1	1
Calcium-dependent protein kinase 1	0	0	1	1
Casein kinase II subunit alpha	0	0	1	1
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0	0	1	1
SRSF protein kinase 2	0	0	1	1
Mitogen-activated protein kinase kinase kinase 9	0	0	1	1
Serine/threonine-protein kinase PknB	0	0	1	1
Cyclin-dependent kinase-like 1	0	0	1	1
Protein kinase C epsilon type	0	0	1	1
Mitogen-activated protein kinase kinase kinase 10	0	0	1	1
Tyrosine-protein kinase receptor TYRO3	0	0	1	1
Cyclin-dependent kinase 18	0	0	1	1
Tyrosine-protein kinase ITK/TSK	0	0	1	1
Myotonin-protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 12	0	0	1	1
Tyrosine-protein kinase Mer	0	1	1	2
cGMP-dependent protein kinase 2	0	0	1	1
Serine/threonine-protein kinase PRP4 homolog	0	0	1	1
Serine/threonine-protein kinase ATR	0	0	1	1
Receptor-interacting serine/threonine-protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit beta	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1	0	0	1	1
Cyclin-dependent kinase 10	0	0	1	1
Serine/threonine-protein kinase D1	0	0	1	1
Serine/threonine-protein kinase 38	0	0	1	1
Receptor tyrosine-protein kinase erbB-4	0	0	1	1
Ribosomal protein S6 kinase alpha-2	0	0	1	1
Dual specificity testis-specific protein kinase 1	0	0	1	1
Rhodopsin kinase GRK1	0	0	1	1
NT-3 growth factor receptor	0	0	1	1
BDNF/NT-3 growth factors receptor	0	0	1	1
Mitogen-activated protein kinase 6	0	0	1	1
Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform	0	0	1	1
Serine/threonine-protein kinase SBK1	0	0	1	1
Mitogen-activated protein kinase kinase kinase 19	0	0	1	1
Serine/threonine-protein kinase TNNI3K	0	0	1	1
Leucine-rich repeat serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek5	0	0	1	1
Serine/threonine-protein kinase N3	0	0	1	1
Dual serine/threonine and tyrosine protein kinase	0	0	1	1
Mitogen-activated protein kinase kinase kinase 15	0	0	1	1
Serine/threonine-protein kinase tousled-like 2	0	0	1	1
Serine/threonine-protein kinase 32C	0	0	1	1
Serine/threonine-protein kinase pim-3	0	0	1	1
Serine/threonine-protein kinase VRK2	0	0	1	1
Myosin light chain kinase family member 4	0	0	1	1
Homeodomain-interacting protein kinase 1	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1D	0	0	1	1
Cyclin-dependent kinase-like 3	0	0	1	1
Serine/threonine-protein kinase BRSK2	0	0	1	1
Serine/threonine-protein kinase NIM1	0	0	1	1
Serine/threonine-protein kinase ULK2	0	0	1	1
Misshapen-like kinase 1	0	0	1	1
Serine/threonine-protein kinase DCLK2	0	0	1	1
Calcium/calmodulin-dependent protein kinase kinase 1	0	0	1	1
Casein kinase I isoform alpha-like	0	0	1	1
Homeodomain-interacting protein kinase 4	0	0	1	1
Myosin-IIIa	0	0	1	1
Ankyrin repeat and protein kinase domain-containing protein 1	0	0	1	1
Serine/threonine-protein kinase Nek11	0	0	1	1
Serine/threonine-protein kinase BRSK1	0	0	1	1
Serine/threonine-protein kinase 35	0	0	1	1
Rhodopsin kinase GRK7	0	0	1	1
Serine/threonine-protein kinase 32A	0	0	1	1
Myosin-IIIb	0	0	1	1
Dual specificity tyrosine-phosphorylation-regulated kinase 2	0	0	1	1
Cyclin-dependent kinase-like 2	0	0	1	1
Serine/threonine-protein kinase Sgk3	0	0	1	1
Atypical kinase COQ8B, mitochondrial	0	0	1	1
Calcium/calmodulin-dependent protein kinase type 1G	0	0	1	1
Cyclin-dependent kinase 15	0	0	1	1
PAS domain-containing serine/threonine-protein kinase	0	0	1	1
SRSF protein kinase 1	0	0	1	1
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha	0	0	1	1
Serine/threonine-protein kinase RIO1	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase RIO2	0	0	1	1
Cyclin-dependent kinase 19	0	0	1	1
Transient receptor potential cation channel subfamily M member 6	0	0	1	1
Testis-specific serine/threonine-protein kinase 1	0	0	1	1
Serine/threonine-protein kinase 33	0	0	1	1
Serine/threonine-protein kinase DCLK3	0	0	1	1
Myosin light chain kinase 2, skeletal/cardiac muscle	0	0	1	1
Homeodomain-interacting protein kinase 2	0	0	1	1
Tyrosine-protein kinase Srms	0	0	1	1
Homeodomain-interacting protein kinase 3	0	0	1	1
Serine/threonine-protein kinase PLK3	0	0	1	1
MAP kinase-interacting serine/threonine-protein kinase 2	0	0	1	1
Serine/threonine-protein kinase Nek6	0	0	1	1
SNF-related serine/threonine-protein kinase	0	0	1	1
Serine/threonine-protein kinase LATS2	0	0	1	1
Serine/threonine-protein kinase 36	0	0	1	1
Serine/threonine-protein kinase 32B	0	0	1	1
Serine/threonine-protein kinase PLK2	0	0	1	1
Serine/threonine-protein kinase MARK1	0	0	1	1
Serine/threonine-protein kinase pim-2	0	0	1	1
Serine/threonine-protein kinase PAK 5	0	0	1	1
eIF-2-alpha kinase GCN2	0	0	1	1
Serine/threonine-protein kinase 17A	0	0	1	1
STE20/SPS1-related proline-alanine-rich protein kinase	0	0	1	1
Ephrin type-A receptor 6	0	0	1	1
Death-associated protein kinase 2	0	0	1	1
Serine/threonine-protein kinase tousled-like 1	0	0	1	1
SRSF protein kinase 3	0	0	1	1
Cyclin-dependent kinase 11A	0	0	1	1
Aurora kinase C	0	0	1	1
Calcium/calmodulin-dependent protein kinase type II subunit alpha	0	0	1	1
Serine/threonine-protein kinase 38-like	0	0	1	1
Microtubule-associated serine/threonine-protein kinase 1	0	0	1	1
Lysine-specific demethylase 6B	0	1	0	1
Kynurenine 3-monooxygenase	0	1	0	1
Lysine-specific demethylase 4A	0	1	0	1
Lysine-specific demethylase 5A	0	1	0	1
Lysine-specific demethylase 5C	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	2	0	2
Peptidyl-prolyl cis-trans isomerase A	0	1	0	1
Methylcytosine dioxygenase TET2	0	1	0	1
Lysine-specific demethylase 7A	0	1	0	1
Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial	0	1	0	1
Prolyl hydroxylase EGLN2	0	1	0	1
Lysine-specific demethylase 5D	0	1	0	1
Egl nine homolog 1	0	2	1	3
Lysine-specific demethylase 4C	0	1	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	2	0	2
Lysine-specific demethylase 5B	0	1	0	1
Histone lysine demethylase PHF8	0	1	0	1
Lysine-specific demethylase 2A	0	1	0	1
Lysine-specific demethylase 3A	0	1	0	1
Tubulin alpha-1A chain	0	0	1	2
Tubulin beta chain	0	0	1	1
Tubulin beta-4A chain	0	1	1	3
Integrin alpha-V	0	1	0	1
Tubulin beta chain	0	1	1	3
Tubulin alpha-3C chain	0	1	1	3
Botulinum neurotoxin type A	0	1	0	1
Apoptosis regulator Bcl-2	0	1	0	1
Substance-K receptor	0	2	0	2
Cholecystokinin receptor type A	0	3	1	4
Melanocortin receptor 5	0	2	0	2
Tubulin alpha-1B chain	0	1	1	3
Tubulin alpha-4A chain	0	1	1	3
Tubulin beta-4B chain	0	1	1	3
Bcl-2-like protein 1	0	1	0	1
Tubulin beta-3 chain	0	2	1	4
Tubulin beta-2A chain	0	1	1	3
Beta-tubulin	0	1	0	1
Tubulin beta-8 chain	0	1	1	3
Tubulin beta-2B chain	0	0	1	3
Tubulin alpha-3E chain	0	1	1	3
Tubulin alpha-1A chain	0	1	1	3
Similar to alpha-tubulin isoform 1	0	0	1	3
Similar to alpha-tubulin isoform 1	0	0	0	2
Tubulin alpha-1C chain	0	1	1	3
Tubulin beta-6 chain	0	1	1	3
Tubulin beta-2B chain	0	1	1	3
Tubulin beta-1 chain	0	1	1	3
dopamine D1 receptor	2	0	0	2
vasopressin V1b receptor	1	0	0	1
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	1	0	1
Tumor necrosis factor	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chitotriosidase-1	0	2	1	3
Endochitinase B1	0	2	1	3
Alpha-1B adrenergic receptor	0	0	1	1
POU domain, class 2, transcription factor 1	0	0	0	1
Alpha-1A adrenergic receptor	0	1	1	2
Alpha-1B adrenergic receptor	0	1	0	1
Alpha-2B adrenergic receptor	0	0	0	1
Alpha-1A adrenergic receptor	0	2	3	6
Alpha-1B adrenergic receptor	0	1	2	4
Alpha-2C adrenergic receptor	0	0	0	1
Alpha-2A adrenergic receptor	0	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase OXA-7	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Class D beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Taste receptor type 2 member 31	0	0	1	1
Taste receptor type 2 member 60	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Taste receptor type 2 member 14	0	0	1	1
Taste receptor type 2 member 13	0	0	1	1
Taste receptor type 2 member 9	0	0	1	1
Taste receptor type 2 member 4	0	0	1	1
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	2	0	2
Glucocorticoid receptor	0	4	2	11
Progesterone receptor	0	2	0	3
Glucocorticoid receptor	0	1	1	2
Glucocorticoid receptor	0	0	1	1
Glycine receptor subunit alpha-1	0	4	0	4
Corticosteroid-binding globulin	0	1	0	1
Mineralocorticoid receptor	0	2	1	3
Androgen receptor	0	2	0	2
Glutamine synthetase	0	0	1	1
Glycine receptor subunit beta	0	4	0	4
Glycine receptor subunit alpha-2	0	4	0	4
Glycine receptor subunit alpha-3	0	4	0	4
Histamine H1 receptor	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	2	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Fatty-acid amide hydrolase 1	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	1
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-5	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit beta-2	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	0	1	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Beta-2 adrenergic receptor	0	2	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Endothelin-1 receptor	0	1	1	2
Beta-3 adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	1	3
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
5-hydroxytryptamine receptor 7	0	1	1	2
Vasopressin V1a receptor	0	1	1	2
5-hydroxytryptamine receptor 6	0	2	1	3
Beta-2 adrenergic receptor	0	1	0	1
Sodium/bile acid cotransporter	0	1	0	1
Nuclear receptor subfamily 2 group E member 1	0	0	2	2
NADH-cytochrome b5 reductase 3	0	1	0	1
Thyroid peroxidase	0	1	0	1
Taste receptor type 2 member 38	0	0	1	2
SUMO-1	0	1	0	1
WRN	1	0	0	1
pyruvate kinase	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
chaperonin GroEL	1	0	0	1
Replicase polyprotein 1ab	0	2	0	2
Glutamate receptor 1	1	0	0	1
Glutamate receptor 3	1	0	0	1
Glutamate receptor 4	1	0	0	1
Exoribonuclease H	0	1	0	1
Coproheme decarboxylase	0	0	1	1
Protease	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
PA-I galactophilic lectin	0	0	1	1
Chain A, Bacterial regulatory proteins, tetR family	0	0	1	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Chain A, Carbonic anhydrase 2	0	1	0	1
Tyrosinase	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
PINK1	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
heat shock protein HSP 90-alpha isoform 2	0	0	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	2
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
heat shock protein 90, putative	0	0	0	1
D-alanyl-D-alanine dipeptidase	0	1	0	1
Transporter	0	1	0	1
Phosphodiesterase	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Sterol 14-alpha-demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol side-chain cleavage enzyme, mitochondrial	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
14-alpha sterol demethylase	0	0	1	1
Cholesterol 24-hydroxylase	0	2	1	3
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (503)

Protein Targets (1,682)

Anastomotic Leak

Synonyms(2)

Research Excerpts

Overview

Treatment

Research

Studies (503)

Drugs Studied (194)

Protein Targets (1,682)