metronidazole has been researched along with Cancer of Cecum in 5 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pathological examination showed pseudomembranous colitis confined to the cecum." | 1.27 | Localized pseudomembranous colitis simulating carcinoma of the cecum. ( Amir, G; Arber, N; Nissan, S; Udassin, R; Zamir, O, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (60.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Villegas-Betanzo, P | 1 |
| Martínez-Jiménez, MA | 1 |
| Guevara-Torres, L | 1 |
| Quintero-Meza, K | 1 |
| Sánchez-Aguilar, M | 1 |
| Arriaga-Caballero, JE | 1 |
| Simşek, H | 1 |
| Elsürer, R | 1 |
| Sökmensüer, C | 1 |
| Balaban, HY | 1 |
| Tatar, G | 1 |
| Hibberd, AD | 1 |
| Nicoll, RJ | 1 |
| Macbeth, WA | 1 |
| Arber, N | 1 |
| Udassin, R | 1 |
| Amir, G | 1 |
| Zamir, O | 1 |
| Nissan, S | 1 |
| Viswanathan, R | 1 |
| Paul, J | 1 |
| Jayaraman, L | 1 |
| Venugopal, K | 1 |
| Natarajan, R | 1 |
5 other studies available for metronidazole and Cancer of Cecum
| Article | Year |
|---|---|
[Ameboma: possible therapeutic decisions in an amebiasis-endemic region].
Topics: Abdomen, Acute; Adult; Aged; Appendectomy; Cecal Neoplasms; Colectomy; Combined Modality Therapy; Di | 2015 |
Ameboma mimicking carcinoma of the cecum: case report.
Topics: Abdominal Pain; Aged; Amebiasis; Animals; Biopsy, Needle; Carcinoma; Cecal Neoplasms; Colonoscopy; D | 2004 |
Deafness is an adverse reaction to the prophylactic use of metronidazole.
Topics: Aged; Bacterial Infections; Cecal Neoplasms; Deafness; Female; Humans; Metronidazole; Premedication | 1984 |
Localized pseudomembranous colitis simulating carcinoma of the cecum.
Topics: Aged; Carcinoma; Cecal Neoplasms; Colonoscopy; Diagnosis, Differential; Enterocolitis, Pseudomembran | 1987 |
An ameboma--lest we forget.
Topics: Aged; Amebiasis; Cecal Neoplasms; Diagnosis, Differential; Humans; Male; Metronidazole | 1986 |