Angle Class II

Malocclusion in which the mandible is posterior to the maxilla as reflected by the relationship of the first permanent molar (distoclusion).

Synonym
Malocclusion, Angle Class II
Malocclusion, Angle Class II, Division 2
Angle Class II, Division 1
Angle Class II, Division 2
Angle Class II
Malocclusion, Angle Class II, Division 1
Class II Malocclusion, Division 2
Class II Malocclusion, Division 1

Excerpt	Reference
"Diagnosis and treatment planning of the Angle class II/2 malocclusion of the dentition are discussed."	( Kuijpers-Jagtman, AM; Ruiken, HM, 1992)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	54 (9.33)	23.3326
1990's	98 (16.93)	12.5806
2000's	186 (32.12)	18.1394
2010's	201 (34.72)	28.8240
2020's	40 (6.91)	9.53

Drug	Relationship Strength	Studies	Trials
cytosine	low	2	0
lactic acid	medium	3	1
nickel	medium	68	10
thymine	low	2	0
bupivacaine	low	1	0
fentanyl	low	1	0
glutaral	low	1	0
indomethacin	low	1	0
2-propanol	low	1	0
metronidazole	low	1	0
miconazole	low	1	0
tranexamic acid	medium	1	1
urethane	low	1	0
thyroxine	low	2	0
edetic acid	low	1	0
methionine	low	1	0
cytidine	low	1	0
threonine	low	1	0
arginine	low	1	0
isoprene	medium	25	3
nandrolone decanoate	low	1	0
nandrolone	low	1	0
durapatite	low	3	0
zinc oxide	low	1	0
bisphenol a-glycidyl methacrylate	low	1	0
isopropyl methylphosphonic acid	low	1	0
samarium	low	4	0
tantalum	low	2	0
titanium	medium	93	13
cadmium	low	1	0
chromium	low	1	0
zirconium	low	2	0
barium sulfate	low	1	0
calcium sulfate	low	1	0
trolamine salicylate	low	1	0
stanozolol	low	1	0
fluorides	low	1	0
amoxicillin	low	1	0
propiconazole	low	19	0
fomesafen	low	1	0
raiser	low	1	0
glucuronic acid	low	1	0
cobalt	low	4	0
c & b metabond	low	1	0
technetium tc 99m hydroxymethylene diphosphonate	low	1	0
maltotriose	low	1	0
delrin	low	1	0
inositol 3-phosphate	medium	228	13
pancuronium	low	1	0
nitinol	medium	4	1
osteoprotegerin	low	1	0
dinoprostone	low	1	0
cholecalciferol	low	1	0
leukotriene e4	low	1	0
phenylephrine hydrochloride	medium	106	6
sulfur	medium	1	1
amoxicillin-potassium clavulanate combination	low	1	0
jaw	medium	35	1
vendex	medium	53	4
silicate cement	low	1	0
interleukin-8	medium	1	1
tetracycline	low	1	0
transforming growth factor beta	low	1	0
feldspar	low	1	0
transforming growth factor alpha	low	1	0
technetium tc 99m medronate	low	1	0
chondroitin sulfates	medium	1	1
exudates	low	5	0
eye	low	3	0

Protein Targets (553)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
hypoxia-inducible factor 1 alpha subunit	9	0	0	9
RAR-related orphan receptor gamma	14	0	0	14
GLI family zinc finger 3	9	0	0	9
AR protein	20	0	0	20
aldehyde dehydrogenase 1 family, member A1	5	0	0	5
retinoic acid nuclear receptor alpha variant 1	11	0	0	11
retinoid X nuclear receptor alpha	12	0	0	12
estrogen nuclear receptor alpha	22	0	0	22
peroxisome proliferator-activated receptor delta	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	9	0	0	9
activating transcription factor 6	4	0	0	4
v-jun sarcoma virus 17 oncogene homolog (avian)	7	0	0	7
Histone H2A.x	6	0	0	6
thyroid hormone receptor beta isoform a	7	0	0	7
heat shock protein beta-1	4	0	0	4
nuclear factor erythroid 2-related factor 2 isoform 1	13	0	0	13
lamin isoform A-delta10	8	0	0	8
Voltage-dependent calcium channel gamma-2 subunit	5	0	0	5
Glutamate receptor 2	5	0	0	5
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	6	0	0	6
Chain A, Beta-lactamase	4	0	0	4
Chain A, 2-oxoglutarate Oxygenase	3	0	0	3
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
apical membrane antigen 1, AMA1	2	0	0	2
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	2	0	0	2
DNA polymerase eta isoform 1	3	0	0	3
DNA polymerase iota isoform a (long)	5	0	0	5
urokinase-type plasminogen activator precursor	2	0	0	2
plasminogen precursor	2	0	0	2
urokinase plasminogen activator surface receptor precursor	2	0	0	2
DNA polymerase kappa isoform 1	6	0	0	6
ATP-binding cassette sub-family C member 3	0	6	0	6
Multidrug resistance-associated protein 4	0	6	0	7
Bile salt export pump	0	1	0	1
Bile salt export pump	0	9	0	9
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	1
Cytochrome P450 2C9	0	4	1	6
Beta-lactamase	0	0	0	1
Kappa-type opioid receptor	0	2	1	4
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	1	0	1
B2 metallo-beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Canalicular multispecific organic anion transporter 1	0	6	0	6
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
thioredoxin reductase	5	0	0	5
phosphopantetheinyl transferase	3	0	0	3
NFKB1 protein, partial	1	0	0	1
GLS protein	2	0	0	2
thyroid stimulating hormone receptor	4	0	0	4
alpha-galactosidase	1	0	0	1
euchromatic histone-lysine N-methyltransferase 2	9	0	0	9
cytochrome P450 2C19 precursor	2	0	0	2
chromobox protein homolog 1	5	0	0	5
flap endonuclease 1	1	0	0	1
muscarinic acetylcholine receptor M1	1	0	0	1
lethal factor (plasmid)	1	0	0	1
Cytochrome P450 3A4	0	5	1	8
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
ATP-dependent phosphofructokinase	2	0	0	2
glp-1 receptor, partial	4	0	0	4
SMAD family member 2	5	0	0	5
ATAD5 protein, partial	2	0	0	2
SMAD family member 3	5	0	0	5
TDP1 protein	11	0	0	11
TSHR protein	1	0	0	1
estrogen receptor 2 (ER beta)	6	0	0	6
nuclear receptor subfamily 1, group I, member 3	5	0	0	5
progesterone receptor	9	0	0	9
glucocorticoid receptor [Homo sapiens]	14	0	0	14
estrogen-related nuclear receptor alpha	14	0	0	14
farnesoid X nuclear receptor	5	0	0	5
pregnane X nuclear receptor	11	0	0	11
67.9K protein	2	0	0	2
peroxisome proliferator activated receptor gamma	11	0	0	11
vitamin D (1,25- dihydroxyvitamin D3) receptor	7	0	0	7
IDH1	4	0	0	4
aryl hydrocarbon receptor	7	0	0	7
thyroid stimulating hormone receptor	4	0	0	4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	4	0	0	4
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	1	0	0	1
thyroid hormone receptor beta isoform 2	9	0	0	9
geminin	10	0	0	10
Cellular tumor antigen p53	13	0	0	13
Alpha-synuclein	1	1	0	2
ATPase family AAA domain-containing protein 5	4	0	0	4
Ataxin-2	4	0	0	4
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 3	0	1	0	1
Potassium channel subfamily K member 2	0	0	1	1
Potassium channel subfamily K member 9	0	1	0	1
Chain A, Vitamin D Nuclear Receptor	0	0	1	1
Chain A, Ferritin light chain	5	0	0	5
Vitamin D3 receptor	0	0	1	1
USP1 protein, partial	7	0	0	7
PPM1D protein	2	0	0	2
Microtubule-associated protein tau	4	0	0	4
thioredoxin glutathione reductase	1	0	0	1
mitogen-activated protein kinase 1	3	0	0	3
nuclear receptor ROR-gamma isoform 1	6	0	0	6
peripheral myelin protein 22	5	0	0	5
Interferon beta	7	0	0	7
Vitamin D-binding protein	0	0	1	1
Cytochrome P450 1A2	0	1	0	2
Androgen receptor	0	1	1	2
Cytochrome P450 2D6	0	3	0	3
Vitamin D3 receptor	0	2	3	8
Vitamin D3 receptor	0	1	1	3
Retinoic acid receptor RXR-alpha	0	0	3	3
Cytochrome P450 2C19	0	3	0	3
Vitamin D3 receptor	0	0	2	2
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial	0	0	1	1
Vitamin D3 receptor	0	1	1	2
Transporter	0	1	0	1
Vitamin D3 receptor A	0	0	2	2
Chain A, HADH2 protein	1	0	0	1
Chain B, HADH2 protein	1	0	0	1
Chain A, Cruzipain	3	0	0	3
Luciferase	4	0	0	4
interleukin 8	4	0	0	4
15-lipoxygenase, partial	2	0	0	2
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	2	0	0	2
vitamin D3 receptor isoform VDRA	7	0	0	7
survival motor neuron protein isoform d	1	0	0	1
cytochrome P450 3A4 isoform 1	2	0	0	2
Gamma-aminobutyric acid receptor subunit pi	2	0	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit delta	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-5	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	2	0	0	2
Glycine receptor subunit alpha-1	0	0	1	1
Gamma-aminobutyric acid receptor subunit gamma-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	2	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	2	0	0	2
Nuclear receptor ROR-gamma	3	0	0	3
10 kDa heat shock protein, mitochondrial	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-3	2	0	0	2
Gamma-aminobutyric acid receptor subunit beta-2	2	0	0	2
Thiosulfate sulfurtransferase	0	1	0	1
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
GABA theta subunit	2	0	0	2
Gamma-aminobutyric acid receptor subunit epsilon	2	0	0	2
EWS/FLI fusion protein	7	0	0	7
Glucose transporter	0	1	0	1
Cdk-related protein kinase 6	0	1	0	1
Protein kinase domain-containing protein	0	1	0	1
Hexose transporter 1	0	1	0	1
Solute carrier family 2, facilitated glucose transporter member 1	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Cytidine deaminase	0	0	0	1
Spike glycoprotein	5	0	0	5
Calcium-dependent protein kinase 1	0	1	0	1
Mitogen-activated protein kinase	0	1	0	1
Proline--tRNA ligase	0	1	0	1
Calcium-dependent protein kinase 4	0	1	0	1
Lysine--tRNA ligase	0	1	0	1
Uridine-cytidine kinase 1	0	0	0	1
Deoxycytidine kinase	0	0	0	1
regulator of G-protein signaling 4	2	0	0	2
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier family 22 member 2	0	0	0	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier organic anion transporter family member 1A5	0	0	0	2
Prostaglandin E2 receptor EP3 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	0	2
Prostaglandin E2 receptor EP1 subtype	0	2	1	3
Prostaglandin E2 receptor EP1 subtype	0	2	0	2
Prostaglandin E2 receptor EP4 subtype	0	2	1	3
Prostaglandin F2-alpha receptor	0	0	1	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP3 subtype	0	2	1	3
Prostaglandin E2 receptor EP2 subtype	0	2	1	3
Prostacyclin receptor	0	2	1	3
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 7	0	0	0	2
Prostaglandin E2 receptor EP2 subtype	0	2	0	2
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 20	0	1	0	1
Solute carrier family 22 member 8	0	1	0	3
Solute carrier family 22 member 6	0	1	0	1
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Solute carrier family 22 member 11	0	0	0	2
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Solute carrier family 22 member 7	0	0	0	2
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	1	0	0	1
Eyes absent homolog 2	0	1	0	1
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
Amyloid-beta precursor protein	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Histamine H2 receptor	4	0	0	4
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	7	0	0	7
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
ATP-dependent translocase ABCB1	0	4	0	4
D(2) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	3	0	3
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	2	1	3
Kappa-type opioid receptor	0	1	0	1
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	4	1	5
D(3) dopamine receptor	0	3	0	3
Delta-type opioid receptor	0	4	0	4
Kappa-type opioid receptor	0	4	0	4
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	1	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase 4	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 15	0	1	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	3	0	0	3
Chain A, membrane-associated prostaglandin E synthase-2	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	1	0	0	1
G	5	0	0	5
glucocerebrosidase	2	0	0	2
Parkin	1	0	0	1
bromodomain adjacent to zinc finger domain 2B	1	0	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	2	0	0	2
cytochrome P450 2D6 isoform 1	2	0	0	2
peripheral myelin protein 22 isoform 1	1	0	0	1
cytochrome P450 2C9 precursor	2	0	0	2
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
M-phase phosphoprotein 8	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin E synthase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	2
Prostaglandin G/H synthase 2	0	1	0	2
3',5'-cyclic-AMP phosphodiesterase	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	2	0	2
Cytochrome c oxidase subunit 2	0	1	0	1
Epidermal growth factor receptor	0	2	0	2
Phospholipase A2, major isoenzyme	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	5	0	0	5
Albumin	0	1	1	2
Prostaglandin G/H synthase 1	0	2	0	3
Procathepsin L	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-4	1	1	0	2
Interleukin-8	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	1	1	0	2
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	2
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Aldo-keto reductase family 1 member C4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Sodium-dependent dopamine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Thromboxane-A synthase	0	2	0	2
Adenosine receptor A1	0	1	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	2	0	2
Caspase-1	0	0	0	1
Adenosine receptor A2a	0	1	0	1
Substance-P receptor	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Multidrug resistance-associated protein 1	0	1	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Prostaglandin G/H synthase 2	0	3	1	4
Prostaglandin G/H synthase 2	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	3	3
Aldo-keto reductase family 1 member C3	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
C-X-C chemokine receptor type 3	0	1	0	1
Aldo-keto reductase family 1 member C2	0	1	0	1
Guanine nucleotide-binding protein G	2	0	0	2
Prostaglandin D2 receptor	0	2	0	2
Solute carrier organic anion transporter family member 1A3	0	1	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Lactoylglutathione lyase	0	1	0	1
Aldo-keto reductase family 1 member C1	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Sigma intracellular receptor 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Nicotinate phosphoribosyltransferase	0	1	0	1
Inositol hexakisphosphate kinase 1	5	0	0	5
Multidrug and toxin extrusion protein 1	0	1	0	1
Dehydrogenase/reductase SDR family member 9	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Cytosolic phospholipase A2 gamma	0	1	0	1
Prostaglandin D2 receptor 2	0	1	1	2
Solute carrier organic anion transporter family member 1B1	0	3	0	4
cytochrome P450 2C9, partial	5	0	0	5
cellular tumor antigen p53 isoform a	2	0	0	2
Integrin beta-3	2	0	0	2
Integrin alpha-IIb	2	0	0	2
Chymotrypsinogen A	0	2	0	2
acetylcholinesterase	1	0	0	1
cytochrome P450 2D6	4	0	0	4
Canalicular multispecific organic anion transporter 1	0	1	0	1
P2Y purinoceptor 12	0	1	1	2
Cysteinyl leukotriene receptor 2	0	0	1	1
Cysteinyl leukotriene receptor 1	0	0	1	1
Chain A, Maltodextrin-binding Protein	0	1	0	1
Chain A, maltose/maltodextrin-binding protein	0	0	1	1
Chain A, Maltodextrin-binding Protein	0	1	0	1
Chain A, Maltodextrin Binding Protein	0	1	0	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Methionyl-tRNA synthetase	0	0	1	1
Chain A, Aminopeptidase	0	1	0	1
Chain A, Methionine aminopeptidase	0	1	0	1
S-ribosylhomocysteine lyase	0	1	0	1
Adenylate cyclase type 5	0	0	0	1
S-adenosylmethionine synthase isoform type-1	0	0	0	1
S-adenosylmethionine synthase isoform type-2	0	0	0	1
Fatty acid synthase	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	1	0	1
Thioredoxin reductase	0	1	0	1
muscleblind-like protein 1 isoform 1	1	0	0	1
Flavodoxin	0	0	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
TAR DNA-binding protein 43	2	0	0	2
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Lanosterol 14-alpha demethylase	0	2	0	2
Chain A, JmjC domain-containing histone demethylation protein 3A	1	0	0	1
Fumarate hydratase	1	0	0	1
Smad3	1	0	0	1
polyprotein	1	0	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	1	0	0	1
serine/threonine-protein kinase PLK1	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
Vpr	2	0	0	2
Metabotropic glutamate receptor 6	0	1	0	1
Acetylcholinesterase	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	0	2
Cytochrome P450 1A2	0	1	0	1
Beta-lactamase	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Tyrosine-protein kinase Fyn	0	1	0	1
Heme oxygenase 1	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Epoxide hydrolase 1	0	0	0	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Muscarinic acetylcholine receptor M2	0	3	0	3
Muscarinic acetylcholine receptor M4	0	2	0	2
Beta-1 adrenergic receptor	0	2	0	2
Alpha-2A adrenergic receptor	0	2	0	2
Adenosine receptor A3	0	4	0	4
Muscarinic acetylcholine receptor M1	0	2	0	2
Aromatase	0	1	0	1
Beta-3 adrenergic receptor	0	2	0	2
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Androgen receptor	0	6	0	6
Alpha-1B adrenergic receptor	0	5	0	5
Alpha-2B adrenergic receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	2	0	2
Muscarinic acetylcholine receptor M3	0	2	0	2
ATP-dependent translocase ABCB1	0	2	0	2
Substance-K receptor	0	2	0	2
Cannabinoid receptor 1	0	2	0	2
D(1A) dopamine receptor	0	2	0	2
Acetylcholinesterase	0	1	0	1
Aromatase	0	0	1	1
Heme oxygenase 2	0	1	0	1
Sodium-dependent noradrenaline transporter	0	2	0	2
Histamine H2 receptor	0	2	0	2
Alpha-1D adrenergic receptor	0	2	0	2
Substance-P receptor	0	2	0	2
5-hydroxytryptamine receptor 2A	0	2	0	2
5-hydroxytryptamine receptor 2C	0	2	0	2
5-hydroxytryptamine receptor 1B	0	2	0	2
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	2	0	2
Sodium-dependent serotonin transporter	0	2	0	2
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Malate dehydrogenase, cytoplasmic	0	1	0	1
5-hydroxytryptamine receptor 2B	0	2	0	2
Melanocortin receptor 3	0	2	0	2
Alpha-1A adrenergic receptor	0	5	0	5
Type-2 angiotensin II receptor	0	2	0	2
5-hydroxytryptamine receptor 6	0	2	0	2
Beta-lactamase TEM	0	1	0	1
Cholinesterase	0	1	0	1
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sodium-dependent dopamine transporter	0	2	0	2
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Calcium release-activated calcium channel protein 1	0	1	0	1
heat shock protein 90, putative	0	0	0	2
methionyl-tRNA synthetase, putative	0	1	0	1
Rap guanine nucleotide exchange factor 3	2	0	0	2
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
5-hydroxytryptamine receptor 7	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial	0	1	0	1
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial	0	1	0	1
arylsulfatase A	1	0	0	1
GALC protein	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
Bloom syndrome protein isoform 1	1	0	0	1
lysosomal alpha-glucosidase preproprotein	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
pregnane X receptor	1	0	0	1
nonstructural protein 1	1	0	0	1
15-cis-phytoene desaturase	0	1	0	1
Zeta-carotene desaturase, chloroplastic/chromoplastic	0	1	0	1
Estrogen receptor	0	2	0	2
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Dihydroxyacetone phosphate acyltransferase	0	0	0	1
30S ribosomal protein S6	0	1	0	1
30S ribosomal protein S7	0	1	0	1
50S ribosomal protein L15	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Stromelysin-1	0	1	0	1
50S ribosomal protein L10	0	1	0	1
50S ribosomal protein L11	0	1	0	1
50S ribosomal protein L7/L12	0	1	0	1
50S ribosomal protein L19	0	1	0	1
50S ribosomal protein L1	0	1	0	1
50S ribosomal protein L20	0	1	0	1
50S ribosomal protein L27	0	1	0	1
50S ribosomal protein L28	0	1	0	1
50S ribosomal protein L29	0	1	0	1
50S ribosomal protein L31	0	1	0	1
50S ribosomal protein L31 type B	0	1	0	1
50S ribosomal protein L32	0	1	0	1
50S ribosomal protein L33	0	1	0	1
50S ribosomal protein L34	0	1	0	1
50S ribosomal protein L35	0	1	0	1
50S ribosomal protein L36	0	1	0	1
30S ribosomal protein S10	0	1	0	1
30S ribosomal protein S11	0	1	0	1
30S ribosomal protein S12	0	1	0	1
30S ribosomal protein S13	0	1	0	1
30S ribosomal protein S16	0	1	0	1
30S ribosomal protein S18	0	1	0	1
30S ribosomal protein S19	0	1	0	1
30S ribosomal protein S20	0	1	0	1
30S ribosomal protein S2	0	1	0	1
30S ribosomal protein S3	0	1	0	1
30S ribosomal protein S4	0	1	0	1
30S ribosomal protein S5	0	1	0	1
30S ribosomal protein S8	0	1	0	1
30S ribosomal protein S9	0	1	0	1
50S ribosomal protein L13	0	1	0	1
50S ribosomal protein L14	0	1	0	1
50S ribosomal protein L16	0	1	0	1
50S ribosomal protein L23	0	1	0	1
30S ribosomal protein S15	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
50S ribosomal protein L17	0	1	0	1
50S ribosomal protein L21	0	1	0	1
50S ribosomal protein L30	0	1	0	1
50S ribosomal protein L6	0	1	0	1
30S ribosomal protein S14	0	1	0	1
30S ribosomal protein S17	0	1	0	1
30S ribosomal protein S1	0	1	0	1
50S ribosomal protein L18	0	1	0	1
Neutrophil collagenase	0	1	0	1
Alpha-1D adrenergic receptor	0	1	0	1
Collagenase 3	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
50S ribosomal protein L2	0	1	0	1
50S ribosomal protein L3	0	1	0	1
50S ribosomal protein L24	0	1	0	1
50S ribosomal protein L4	0	1	0	1
50S ribosomal protein L22	0	1	0	1
50S ribosomal protein L5	0	1	0	1
30S ribosomal protein S21	0	1	0	1
50S ribosomal protein L25	0	1	0	1
50S ribosomal protein L36 2	0	1	0	1
Integrase	0	1	0	1
Protein-arginine deiminase type-4	0	1	0	1
Thymidine phosphorylase	0	1	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Chain X, Thyroid hormone receptor beta-1	0	0	1	1
Solute carrier organic anion transporter family member 1A4	0	0	0	1
Transthyretin	0	1	0	2
Thyroid hormone receptor alpha	0	0	1	1
Thyroid hormone receptor beta	0	0	1	1
Proliferating cell nuclear antigen	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	1	0	1
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 1A2	0	0	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	1
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, PLASMINOGEN	0	0	1	1
Chain A, PLASMINOGEN	0	0	1	1
Plasminogen	0	2	1	3
Urokinase-type plasminogen activator	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(8)

Research Excerpts

Treatment

Research

Studies (579)

Protein Targets (553)

Angle Class II

Synonyms(8)

Research Excerpts

Treatment

Research

Studies (579)

Drugs Studied (82)

Protein Targets (553)