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metronidazole and Neuroblastoma

metronidazole has been researched along with Neuroblastoma in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)

Research Excerpts

ExcerptRelevanceReference
"The authors conclude that although there was no increase in risk for all cancers associated with in utero exposure to metronidazole, the observed increased risk for neuroblastomas, although not significant, requires further evaluation."3.70Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years. ( Brockman Worrell, KG; Gideon, P; Mitchel, EF; Pais, R; Ray, WA; Roberson, P; Thapa, PB; Whitlock, JA, 1998)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carvajal, A1
Sánchez, A1
Hurtarte, G1
Thapa, PB1
Whitlock, JA1
Brockman Worrell, KG1
Gideon, P1
Mitchel, EF1
Roberson, P1
Pais, R1
Ray, WA1

Other Studies

2 other studies available for metronidazole and Neuroblastoma

ArticleYear
Metronidazole during pregnancy.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 1995, Volume: 48, Issue:3

    Topics: Adrenal Gland Neoplasms; Adult; Female; Gardnerella vaginalis; Humans; Infant, Newborn; Male; Metron

1995
Prenatal exposure to metronidazole and risk of childhood cancer: a retrospective cohort study of children younger than 5 years.
    Cancer, 1998, Oct-01, Volume: 83, Issue:7

    Topics: Adolescent; Adult; Carcinogens; Child, Preschool; Cohort Studies; Databases, Factual; Female; Humans

1998
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