metronidazole has been researched along with Cancer of Oropharnyx in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Poliakov, PIu | 1 |
| Karakulov, RK | 1 |
| Pelevina, II | 1 |
| Zazovskiĭ, LM | 1 |
| Dar'ialova, SL | 1 |
| Brusis, T | 1 |
| Luckhaupt, H | 1 |
2 other studies available for metronidazole and Cancer of Oropharnyx
| Article | Year |
|---|---|
[Use of the indicators of the proliferative activity of tumors of the oropharyngeal area as qualitative prognostic criteria of the radiotherapy].
Topics: Brachytherapy; Carcinoma, Squamous Cell; Humans; Hyperbaric Oxygenation; Metronidazole; Mouth Neopla | 1986 |
[Anaerobic infections in ulcerating tumors of the head and neck. A contribution to the problem of odors].
Topics: Bacteria, Anaerobic; Bacterial Infections; Bacteroides Infections; Clindamycin; Head and Neck Neopla | 1986 |