metronidazole has been researched along with Injuries, Radiation in 21 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To evaluate the effectiveness of metronidazole in combination with corticosteroids in enema and mesalazine (5-aminosalicylic acid) in comparison with the same protocol without metronidazole in the treatment of chronic radiation proctitis." | 9.09 | Metronidazole in the treatment of chronic radiation proctitis: clinical trial. ( Cavcić, J; Jelincić, Z; Martinac, P; Panijan-Pezerović, R; Turcić, J; Unusić, J; Zupancić, B, 2000) |
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 5.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "To evaluate the effectiveness of metronidazole in combination with corticosteroids in enema and mesalazine (5-aminosalicylic acid) in comparison with the same protocol without metronidazole in the treatment of chronic radiation proctitis." | 5.09 | Metronidazole in the treatment of chronic radiation proctitis: clinical trial. ( Cavcić, J; Jelincić, Z; Martinac, P; Panijan-Pezerović, R; Turcić, J; Unusić, J; Zupancić, B, 2000) |
| "Four patients had had cervical cancer, five had uterine cancer, one had prostatic cancer, one had vesical cancer and one had vaginal cancer." | 1.37 | A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration. ( Atittharnsakul, P; Patiwongpaisarn, A; Rojanasakul, A; Sahakitrungruang, C; Thum-Umnuaysuk, S, 2011) |
| " Treatment with penicillin G was very effective in the acute stage, and chronic administration of metronidazole prevented relapse of the disease." | 1.35 | An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis. ( Fujimuro, M; Jackson, M; Kawarabayashi, T; Kimura, T; Matsubara, E; Nakahata, N; Seino, Y; Shirahama, I; Shoji, M; Suzuki, C; Takamura, A; Tomiyama, M; Wakasaya, Y; Watanabe, M; Yamamoto-Watanabe, Y, 2009) |
| "Helium is a more efficient cryogen than nitrogen, and for macromolecular data collection at high-flux beamlines will deliver lower temperatures." | 1.31 | Experiments testing the abatement of radiation damage in D-xylose isomerase crystals with cryogenic helium. ( Bunick, GJ; DeWitt, K; Hanson, BL; Harp, JM; Howard, A; Kirschbaum, K; Pinkerton, AA; Schall, CA, 2002) |
| "The results of radiation treatment for cervical cancer obtained at the Institute Clinic are discussed." | 1.28 | [Effectiveness of radiotherapy of patients with cancer of the cervix uteri at the Central Research Roentgeno-Radiological Institute of the USSR Ministry of Health]. ( Kholin, VV; Zharinov, GM, 1989) |
| " An evaluation of the different radiotherapy schedules used during this period allowed a dose-response curve to be constructed." | 1.27 | Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole. ( Elbrønd, O; Johansen, LV; Overgaard, J, 1988) |
| "Conventional treatment of osteoradionecrosis of mandible is by antibiotics combined if necessary with a hemimandibulectomy." | 1.27 | [Current treatment of osteoradionecrosis]. ( Blanc, JL; Cheynet, F; Lachard, A; Lachard, J; Lagier, JP; Rakotobe, P, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (33.33) | 18.7374 |
| 1990's | 2 (9.52) | 18.2507 |
| 2000's | 6 (28.57) | 29.6817 |
| 2010's | 4 (19.05) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Pui, WC | 1 |
| Chieng, TH | 1 |
| Siow, SL | 1 |
| Nik Abdullah, NA | 1 |
| Sagap, I | 1 |
| Babakhanlou, R | 1 |
| Larkin, K | 1 |
| Yamamoto, Y | 1 |
| Asai, N | 1 |
| Furuhashi, A | 1 |
| Ono, T | 1 |
| Yamagishi, Y | 1 |
| Mikamo, H | 1 |
| Kazaoka, Y | 1 |
| Weiner, JP | 1 |
| Wong, AT | 1 |
| Schwartz, D | 1 |
| Martinez, M | 1 |
| Aytaman, A | 1 |
| Schreiber, D | 1 |
| Wakasaya, Y | 1 |
| Watanabe, M | 1 |
| Tomiyama, M | 1 |
| Suzuki, C | 1 |
| Jackson, M | 1 |
| Fujimuro, M | 1 |
| Kimura, T | 1 |
| Seino, Y | 1 |
| Kawarabayashi, T | 1 |
| Yamamoto-Watanabe, Y | 1 |
| Matsubara, E | 1 |
| Shirahama, I | 1 |
| Takamura, A | 1 |
| Nakahata, N | 1 |
| Shoji, M | 1 |
| Sahakitrungruang, C | 2 |
| Thum-Umnuaysuk, S | 1 |
| Patiwongpaisarn, A | 2 |
| Atittharnsakul, P | 2 |
| Rojanasakul, A | 1 |
| Kanjanasilp, P | 1 |
| Malakorn, S | 1 |
| Murray, J | 1 |
| Garman, E | 1 |
| Ravelli, RB | 1 |
| Theveneau, P | 1 |
| McSweeney, S | 1 |
| Caffrey, M | 1 |
| Hanson, BL | 1 |
| Harp, JM | 1 |
| Kirschbaum, K | 1 |
| Schall, CA | 1 |
| DeWitt, K | 1 |
| Howard, A | 1 |
| Pinkerton, AA | 1 |
| Bunick, GJ | 1 |
| Vorob'ev, IuI | 1 |
| Limarova, IV | 1 |
| Cavcić, J | 1 |
| Turcić, J | 1 |
| Martinac, P | 1 |
| Jelincić, Z | 1 |
| Zupancić, B | 1 |
| Panijan-Pezerović, R | 1 |
| Unusić, J | 1 |
| Denton, AS | 1 |
| Andreyev, HJ | 1 |
| Forbes, A | 1 |
| Maher, EJ | 1 |
| Chekalina, SI | 1 |
| Guseva, LI | 1 |
| Tokarev, OIu | 1 |
| Karpitskaia, VS | 1 |
| Millett, DT | 1 |
| Chapple, IL | 1 |
| Hirschmann, PN | 1 |
| Corrigan, AM | 1 |
| Kholin, VV | 1 |
| Zharinov, GM | 1 |
| Johansen, LV | 1 |
| Overgaard, J | 1 |
| Elbrønd, O | 1 |
| Khanna, AK | 1 |
| Khanna, A | 1 |
| Asthana, AK | 1 |
| Lagier, JP | 1 |
| Blanc, JL | 1 |
| Lachard, A | 1 |
| Cheynet, F | 1 |
| Rakotobe, P | 1 |
| Lachard, J | 1 |
| Dar'ialova, SL | 1 |
| Poliakov, PIu | 1 |
| Kiseleva, ES | 1 |
| Zimina, ES | 1 |
| Zel'vin, BM | 1 |
| Taylor, JA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Postoperative or Salvage Radiotherapy for Node Negative Prostate Cancer Following Radical Prostatectomy[NCT00969111] | 70 participants (Anticipated) | Interventional | 2009-08-31 | Recruiting | |||
| An Expanded Phase II Study of Hypofractionated Dose Intense Image Guided Proton Radiation Therapy for Low and Intermediate Risk Adenocarcinoma of the Prostate[NCT01368055] | 361 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for metronidazole and Injuries, Radiation
| Article | Year |
|---|---|
Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding.
Topics: Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Hyperbaric Oxygenation; Metronidaz | 2016 |
Investigation of possible free-radical scavengers and metrics for radiation damage in protein cryocrystallography.
Topics: Animals; Crystallography, X-Ray; Egg Proteins; Free Radical Scavengers; Humans; Metronidazole; Muram | 2002 |
Systematic review for non-surgical interventions for the management of late radiation proctitis.
Topics: Administration, Rectal; Anti-Inflammatory Agents; Chronic Disease; Combined Modality Therapy; Cross- | 2002 |
5 trials available for metronidazole and Injuries, Radiation
| Article | Year |
|---|---|
A Randomized Controlled Trial of Novel Treatment for Hemorrhagic Radiation Proctitis.
Topics: Administration, Oral; Adult; Aged; Anti-Infective Agents; Disinfectants; Electrocoagulation; Female; | 2020 |
A randomized controlled trial comparing colonic irrigation and oral antibiotics administration versus 4% formalin application for treatment of hemorrhagic radiation proctitis.
Topics: Administration, Oral; Administration, Rectal; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; | 2012 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
Metronidazole in the treatment of chronic radiation proctitis: clinical trial.
Topics: Aged; Anti-Infective Agents; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Beta | 2000 |
[Metronidazole in the radiotherapy of malignant neoplasms].
Topics: Clinical Trials as Topic; Combined Modality Therapy; Humans; Metronidazole; Neoplasm Recurrence, Loc | 1986 |
Pharmacodynamic observations on metronidazole therapy. Side effects in endocrine, metabolic and auto-immune disorders. 3. Anti-ischemic and anti-inflammatory action in peripheral vascular disorders.
Topics: Blood Circulation; Blood Flow Velocity; Blood Pressure; Clinical Trials as Topic; Diabetes Complicat | 1966 |
13 other studies available for metronidazole and Injuries, Radiation
| Article | Year |
|---|---|
The value of Metronidazole in the management of acute radiation proctitis.
Topics: Gastritis; Humans; Metronidazole; Proctitis; Radiation Injuries | 2021 |
Metronidazole-induced encephalopathy caused by hyperbaric oxygen therapy in a patient with mandibular osteomyelitis.
Topics: Aged; Anti-Bacterial Agents; Cerebellar Ataxia; Cerebellar Nuclei; Chemoradiotherapy; Drug Therapy, | 2019 |
An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitis.
Topics: Anti-Bacterial Agents; Chronic Disease; Gallium Radioisotopes; Head and Neck Neoplasms; Humans; Lymp | 2009 |
A novel treatment for haemorrhagic radiation proctitis using colonic irrigation and oral antibiotic administration.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Ciprofloxacin; Combined Modality Therapy; Female; Ga | 2011 |
Unit-cell volume change as a metric of radiation damage in crystals of macromolecules.
Topics: Crystallization; Dose-Response Relationship, Radiation; Humans; Linear Energy Transfer; Macromolecul | 2002 |
Experiments testing the abatement of radiation damage in D-xylose isomerase crystals with cryogenic helium.
Topics: Aldose-Ketose Isomerases; Animals; Cats; Cold Temperature; Crystallization; Crystallography, X-Ray; | 2002 |
[Radiation treatment with metronidazole in patients with oral mucosa cancer in the late stages].
Topics: Aged; Carcinoma, Squamous Cell; Combined Modality Therapy; Female; Gamma Rays; Humans; Male; Metroni | 1983 |
[The prevention of radiation complications by using metronidazole experimentally and in the oncology clinic].
Topics: Animals; Combined Modality Therapy; Drug Evaluation; Drug Evaluation, Preclinical; Female; Male; Met | 1991 |
Septic osteoradionecrosis of the mandible associated with pathological fracture: report of two cases.
Topics: Aged; Female; Fractures, Spontaneous; Humans; Mandibular Diseases; Mandibular Fractures; Metronidazo | 1990 |
[Effectiveness of radiotherapy of patients with cancer of the cervix uteri at the Central Research Roentgeno-Radiological Institute of the USSR Ministry of Health].
Topics: Dimethyl Sulfoxide; Drug Therapy, Combination; Evaluation Studies as Topic; Female; Humans; Metronid | 1989 |
Pharyngo-cutaneous fistulae after laryngectomy. Influence of previous radiotherapy and prophylactic metronidazole.
Topics: Fistula; Humans; Laryngeal Neoplasms; Laryngectomy; Metronidazole; Pharyngeal Diseases; Radiation In | 1988 |
Postirradiation ulcer and topical metronidazole.
Topics: Breast Neoplasms; Carcinoma, Squamous Cell; Female; Humans; Metronidazole; Middle Aged; Radiation In | 1988 |
[Current treatment of osteoradionecrosis].
Topics: Combined Modality Therapy; Drug Therapy, Combination; Humans; Mandible; Mandibular Diseases; Metroni | 1986 |