metronidazole has been researched along with Fetal Membranes, Premature Rupture in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Fetal Membranes, Premature Rupture: Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Our purpose was to determine whether treatment of bacterial vaginosis with metronidazole in patients with preterm delivery in the penultimate pregnancy from preterm labor or premature rupture of membranes reduces the risk of subsequent preterm birth." | 9.07 | Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: a placebo-controlled, double-blind study. ( Albritton, J; Morales, WJ; Schorr, S, 1994) |
| " After 8 days of prophylactic pivampicillin and metronidazol, culture from the cervix showed profuse growth of Group B Streptococci (GBS) and the patient developed symptoms of chorioamnionitis." | 7.68 | Group B streptococcal chorioamnionitis and neonatal septicemia following 8 days pivampicillin and metronidazol prophylaxis after premature rupture of membranes; a case report. ( Andersen, LF; Bruun, BB; Jensen, ET; Langhoff-Roos, J; Madsen, H; Svare, J, 1991) |
| "Our purpose was to determine whether treatment of bacterial vaginosis with metronidazole in patients with preterm delivery in the penultimate pregnancy from preterm labor or premature rupture of membranes reduces the risk of subsequent preterm birth." | 5.07 | Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: a placebo-controlled, double-blind study. ( Albritton, J; Morales, WJ; Schorr, S, 1994) |
| "A new antibiotic combination consisting of ceftriaxone, clarithromycin, and metronidazole prolonged the latency period, reduced acute histologic chorioamnionitis/funisitis, and improved neonatal outcomes in patients with preterm PROM." | 3.83 | A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM. ( Chaemsaithong, P; Jun, JK; Kim, SM; Lee, J; Park, CW; Park, JS; Romero, R; Yoon, BH, 2016) |
| " After 8 days of prophylactic pivampicillin and metronidazol, culture from the cervix showed profuse growth of Group B Streptococci (GBS) and the patient developed symptoms of chorioamnionitis." | 3.68 | Group B streptococcal chorioamnionitis and neonatal septicemia following 8 days pivampicillin and metronidazol prophylaxis after premature rupture of membranes; a case report. ( Andersen, LF; Bruun, BB; Jensen, ET; Langhoff-Roos, J; Madsen, H; Svare, J, 1991) |
| "The latter category includes pelvic inflammatory disease, pelvic thrombophlebitis, septic abortion, and premature rupture of the membranes." | 2.36 | Infections in the female genital tract. ( Gall, SA, 1983) |
| "Bacterial vaginosis is associated with preterm labor." | 1.31 | The role of bacterial vaginosis in preterm labor and preterm birth: a case-control study. ( Denoit, V; Husson, MO; Le Gouëff, F; Puech, F; Subtil, D; Trivier, D, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (7.69) | 18.7374 |
| 1990's | 6 (46.15) | 18.2507 |
| 2000's | 2 (15.38) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 2 (15.38) | 2.80 |
| Authors | Studies |
|---|---|
| Cenkowski, M | 1 |
| Wudel, B | 1 |
| Poliquin, V | 1 |
| Germano, C | 1 |
| Messina, A | 1 |
| Massaro, A | 1 |
| Attini, R | 1 |
| Leo, L | 1 |
| Manzoni, P | 1 |
| Masturzo, B | 1 |
| Lee, J | 2 |
| Romero, R | 2 |
| Kim, SM | 2 |
| Chaemsaithong, P | 2 |
| Park, CW | 1 |
| Park, JS | 1 |
| Jun, JK | 1 |
| Yoon, BH | 2 |
| Darwish, A | 1 |
| Elnshar, EM | 1 |
| Hamadeh, SM | 1 |
| Makarem, MH | 1 |
| Gall, SA | 1 |
| McCoy, MC | 1 |
| Katz, VL | 1 |
| Kuller, JA | 1 |
| Killam, AP | 1 |
| Livengood, CH | 1 |
| Khan, Z | 1 |
| Morales, WJ | 1 |
| Schorr, S | 1 |
| Albritton, J | 1 |
| Kyle, P | 1 |
| Turner, DP | 1 |
| Subtil, D | 1 |
| Denoit, V | 1 |
| Le Gouëff, F | 1 |
| Husson, MO | 1 |
| Trivier, D | 1 |
| Puech, F | 1 |
| Bergström, S | 1 |
| Andersen, LF | 1 |
| Svare, J | 1 |
| Madsen, H | 1 |
| Langhoff-Roos, J | 1 |
| Jensen, ET | 1 |
| Bruun, BB | 1 |
3 reviews available for metronidazole and Fetal Membranes, Premature Rupture
| Article | Year |
|---|---|
Maternal Origins of Neonatal Infections: What Do Obstetrician-Gynecologist Should/Could Do?
Topics: Ampicillin; Anti-Bacterial Agents; Bacteriuria; Cesarean Section; Chorioamnionitis; Clindamycin; Com | 2022 |
Infections in the female genital tract.
Topics: Abortion, Septic; Animals; Anti-Bacterial Agents; Bacteria; Bacterial Infections; Cephalosporins; En | 1983 |
Bacterial vaginosis in pregnancy: an approach for the 1990s.
Topics: Clindamycin; Female; Fetal Membranes, Premature Rupture; Gestational Age; Humans; Metronidazole; Obs | 1995 |
2 trials available for metronidazole and Fetal Membranes, Premature Rupture
| Article | Year |
|---|---|
Treatment options for bacterial vaginosis in patients at high risk of preterm labor and premature rupture of membranes.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Anti-Bacterial Agents; Clindamycin; Femal | 2007 |
Effect of metronidazole in patients with preterm birth in preceding pregnancy and bacterial vaginosis: a placebo-controlled, double-blind study.
Topics: Adult; Double-Blind Method; Female; Fetal Membranes, Premature Rupture; Humans; Infant, Newborn; Inf | 1994 |
8 other studies available for metronidazole and Fetal Membranes, Premature Rupture
| Article | Year |
|---|---|
Vaginal trichomoniasis.
Topics: Administration, Oral; Anti-Infective Agents; Canada; Drug Resistance; Female; Fetal Membranes, Prema | 2022 |
A new anti-microbial combination prolongs the latency period, reduces acute histologic chorioamnionitis as well as funisitis, and improves neonatal outcomes in preterm PROM.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Chorioamnionitis; Clarithromycin; Drug Therapy, Combinati | 2016 |
A new antibiotic regimen treats and prevents intra-amniotic inflammation/infection in patients with preterm PROM.
Topics: Adult; Anti-Bacterial Agents; Antibiotic Prophylaxis; Ceftriaxone; Chorioamnionitis; Clarithromycin; | 2016 |
Active management of preterm labour and preterm prelabour rupture of membranes.
Topics: Analgesics; Anti-Bacterial Agents; Embryonic and Fetal Development; Female; Fetal Membranes, Prematu | 1994 |
Chorioamnionitis due to pseudomonas aeruginosa: a complication of prolonged antibiotic therapy for premature rupture of membranes.
Topics: Adult; Cephalexin; Chorioamnionitis; Drug Therapy, Combination; Female; Fetal Membranes, Premature R | 1996 |
The role of bacterial vaginosis in preterm labor and preterm birth: a case-control study.
Topics: Adult; Anti-Infective Agents; Case-Control Studies; Female; Fetal Membranes, Premature Rupture; Gest | 2002 |
A prospective study on the perinatal outcome in Mozambican pregnant women with preterm rupture of membranes using two different methods of clinical management.
Topics: Adult; Amoxicillin; Chloroquine; Female; Fetal Membranes, Premature Rupture; Humans; Infant Mortalit | 1991 |
Group B streptococcal chorioamnionitis and neonatal septicemia following 8 days pivampicillin and metronidazol prophylaxis after premature rupture of membranes; a case report.
Topics: Adult; Cervix Uteri; Chorioamnionitis; Female; Fetal Membranes, Premature Rupture; Humans; Infant, N | 1991 |