metronidazole has been researched along with Cancer of Gastrointestinal Tract in 4 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nine patients with low-grade gastric MALT lymphoma were treated with amoxicillin, metronidazole, and omeprazole for 14 days in a prospective study." | 2.68 | Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies. ( Alvarez, I; Bellas, C; Boixeda, D; Calleja, JL; Manzanal, A; Montalban, C; Redondo, C, 1997) |
| "Severe exanthema (grade III/IV) develops in about 9-19 % of patients with the necessity of cetuximab dose reduction or cessation." | 1.39 | Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective. ( Berger, MR; Galle, PR; Gockel, I; Graf, C; Herzog, J; Lang, H; Möhler, M; Schimanski, CC; Theobald, M; Wehler, TC, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (75.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wehler, TC | 1 |
| Graf, C | 1 |
| Möhler, M | 1 |
| Herzog, J | 1 |
| Berger, MR | 1 |
| Gockel, I | 1 |
| Lang, H | 1 |
| Theobald, M | 1 |
| Galle, PR | 1 |
| Schimanski, CC | 1 |
| Schweizer, W | 1 |
| Striffeler, H | 1 |
| Lüdi, D | 1 |
| Fröscher, R | 1 |
| Montalban, C | 1 |
| Manzanal, A | 1 |
| Boixeda, D | 1 |
| Redondo, C | 1 |
| Alvarez, I | 1 |
| Calleja, JL | 1 |
| Bellas, C | 1 |
| Furusyo, N | 1 |
| Kanamoto, K | 1 |
| Nakamura, S | 1 |
| Yao, T | 1 |
| Suekane, H | 1 |
| Yano, Y | 1 |
| Ariyama, I | 1 |
| Hayashi, J | 1 |
| Kashiwagi, S | 1 |
2 trials available for metronidazole and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
["Single shot" prevention in abdominal surgery. Antibiotics with long half-life (ceftriaxone, ornidazole) vs. antibiotics with short half-life (cefazolin, metronidazole, clindamycin)].
Topics: Adult; Aged; Anti-Bacterial Agents; Cefazolin; Ceftriaxone; Clindamycin; Cross Infection; Double-Bli | 1994 |
Helicobacter pylori eradication for the treatment of low-grade gastric MALT lymphoma: follow-up together with sequential molecular studies.
Topics: Aged; Amoxicillin; Drug Therapy, Combination; Follow-Up Studies; Gastrointestinal Neoplasms; Genes, | 1997 |
2 other studies available for metronidazole and Cancer of Gastrointestinal Tract
| Article | Year |
|---|---|
Cetuximab-induced skin exanthema: prophylactic and reactive skin therapy are equally effective.
Topics: Administration, Oral; Administration, Topical; Anti-Bacterial Agents; Antibiotic Prophylaxis; Antibo | 2013 |
Rapidly growing primary gastric B-cell lymphoma after eradication of Helicobacter pylori.
Topics: Anti-Bacterial Agents; Anti-Ulcer Agents; Clarithromycin; Gastrointestinal Neoplasms; Helicobacter I | 1999 |