metronidazole has been researched along with Skin Ulcer in 23 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Skin Ulcer: An ULCER of the skin and underlying tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily." | 6.68 | Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996) |
| "Metronidazole 0." | 2.82 | Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013). ( Ikoma, A; Miyai, E; Nakamura, S; Shimo, A; Takemura, K; Tokuda, Y; Tsugawa, K; Watanabe, K; Yamauchi, H, 2016) |
| "The patient received treatment with anti-tetanus globulin and metronidazole; sound insulation and shielding were also performed in a dark room." | 2.72 | Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review. ( Aisaka, W; Narimatsu, E; Nomura, K; Okamoto, H; Sakawaki, E; Sakawaki, S; Takeyama, Y; Uemura, S; Yamaoka, A, 2021) |
| "Metronidazole gel was applied to the surface of ulcerated tumors once or twice daily." | 2.68 | Use of metronidazole gel to control malodor in advanced and recurrent breast cancer. ( Kubota, M; Kuge, S; Makuuchi, H; Mitomi, T; Ninomiya, S; Ohta, M; Okumura, A; Sawamura, S; Tajima, T; Tokuda, Y, 1996) |
| "Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer." | 2.50 | Topical agents and dressings for fungating wounds. ( Adderley, UJ; Holt, IG, 2014) |
| "Fungating wounds arise from primary, secondary or recurrent malignant disease and are associated with advanced cancer." | 2.44 | Topical agents and dressings for fungating wounds. ( Adderley, U; Smith, R, 2007) |
| "Primary cutaneous amoebiasis occurs from contamination of pre-existing wounds." | 1.36 | Amoebiasis cutis: clinical suspicion is the key to early diagnosis. ( Jindal, N; Kaushik, R; Mahajan, VK; Shanker, V; Sharma, NL; Verma, GK; Verma, S, 2010) |
| "We report a case of Crohn's disease affecting penile and scrotal skin." | 1.32 | Metastatic crohn's disease--penile and scrotal involvement. ( Berenguer, J; Del Valle, E; Hernández, C; Jara, J; Martínez-Salamanca, JI; Miralles, P, 2004) |
| "Cutaneous amebiasis is a rare complication of Entamoeba histolytica infection which should be considered in the differential diagnosis of perineovulvar or penile ulcers." | 1.27 | Cutaneous amebiasis. ( Berg, RA; Rimsza, ME, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (34.78) | 18.7374 |
| 1990's | 5 (21.74) | 18.2507 |
| 2000's | 4 (17.39) | 29.6817 |
| 2010's | 5 (21.74) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Niu, KY | 1 |
| Lin, YK | 1 |
| Nomura, K | 1 |
| Sakawaki, E | 1 |
| Sakawaki, S | 1 |
| Yamaoka, A | 1 |
| Aisaka, W | 1 |
| Okamoto, H | 1 |
| Takeyama, Y | 1 |
| Uemura, S | 1 |
| Narimatsu, E | 1 |
| Tambe, S | 1 |
| Zambare, U | 1 |
| Nayak, C | 1 |
| Adderley, UJ | 1 |
| Holt, IG | 1 |
| Watanabe, K | 1 |
| Shimo, A | 1 |
| Tsugawa, K | 1 |
| Tokuda, Y | 2 |
| Yamauchi, H | 1 |
| Miyai, E | 1 |
| Takemura, K | 1 |
| Ikoma, A | 1 |
| Nakamura, S | 1 |
| Verma, GK | 1 |
| Sharma, NL | 1 |
| Shanker, V | 1 |
| Mahajan, VK | 1 |
| Kaushik, R | 1 |
| Verma, S | 1 |
| Jindal, N | 1 |
| Morsy, TA | 1 |
| Mangoud, AM | 1 |
| Saleh, WA | 1 |
| Schaller, M | 1 |
| Sander, CA | 1 |
| Plewig, G | 1 |
| Martínez-Salamanca, JI | 1 |
| Jara, J | 1 |
| Miralles, P | 1 |
| Berenguer, J | 1 |
| Del Valle, E | 1 |
| Hernández, C | 1 |
| Adderley, U | 1 |
| Smith, R | 1 |
| Ashford, RF | 1 |
| Plant, GT | 1 |
| Maher, J | 1 |
| Pickering, D | 1 |
| Coe, MA | 1 |
| Drury, A | 1 |
| Goold, MA | 1 |
| Teare, EL | 1 |
| Rimsza, ME | 1 |
| Berg, RA | 1 |
| Beurey, J | 1 |
| Canton, P | 1 |
| Weber, M | 1 |
| Gérard, A | 1 |
| Ducommun, F | 1 |
| Schooneman, F | 1 |
| Janot, C | 1 |
| Dureux, JB | 1 |
| Kuge, S | 1 |
| Ohta, M | 1 |
| Okumura, A | 1 |
| Kubota, M | 1 |
| Ninomiya, S | 1 |
| Sawamura, S | 1 |
| Makuuchi, H | 1 |
| Tajima, T | 1 |
| Mitomi, T | 1 |
| Finlay, IG | 2 |
| Bowszyc, J | 1 |
| Ramlau, C | 1 |
| Gwiezdzinski, Z | 1 |
| Sunarwan, I | 1 |
| Rosekrans, PC | 1 |
| Tanga, MR | 1 |
| Antani, JA | 1 |
| Kabade, SS | 1 |
| Wolfsen, HC | 1 |
| Brubacher, LL | 1 |
| Ng, CS | 1 |
| Kayne, AL | 1 |
| Kozarek, RA | 1 |
| Djawari, D | 1 |
| McCulloch, AJ | 1 |
| McEvoy, A | 1 |
| Jackson, JD | 1 |
| Jarvis, EH | 1 |
| Kale, OO | 1 |
| Rytter, M | 1 |
| Buchholz, W | 1 |
3 reviews available for metronidazole and Skin Ulcer
| Article | Year |
|---|---|
Non-surgical treatment of tetanus infection associated with breast cancer skin ulcer: a case report and literature review.
Topics: Breast Neoplasms; Female; Humans; Lymphatic Metastasis; Metronidazole; Middle Aged; Neoplasm Recurre | 2021 |
Topical agents and dressings for fungating wounds.
Topics: Anti-Infective Agents, Local; Antineoplastic Agents; Biological Dressings; Disease Progression; Fema | 2014 |
Topical agents and dressings for fungating wounds.
Topics: Anti-Infective Agents, Local; Antineoplastic Agents; Biological Dressings; Disease Progression; Fema | 2007 |
5 trials available for metronidazole and Skin Ulcer
| Article | Year |
|---|---|
Safe and effective deodorization of malodorous fungating tumors using topical metronidazole 0.75 % gel (GK567): a multicenter, open-label, phase III study (RDT.07.SRE.27013).
Topics: Administration, Cutaneous; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Female; Humans; | 2016 |
Use of metronidazole gel to control malodor in advanced and recurrent breast cancer.
Topics: Administration, Topical; Aged; Bacteria, Anaerobic; Bacterial Infections; Breast Neoplasms; Female; | 1996 |
The effect of topical 0.75% metronidazole gel on malodorous cutaneous ulcers.
Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Anti-Infective Agents; Female; Humans; Male | 1996 |
Clinical evaluation of metronidazole as an anti-inflammatory agent.
Topics: Adolescent; Adult; Child; Clinical Trials as Topic; Female; Humans; Male; Metronidazole; Middle Aged | 1975 |
A controlled field trial of the treatment of dracontiasis with metronidazole and niridazole.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Dracunculiasis; Gastrointestinal Diseases; Humans; | 1974 |
15 other studies available for metronidazole and Skin Ulcer
| Article | Year |
|---|---|
Generalized tetanus.
Topics: Anti-Bacterial Agents; Ceftriaxone; Critical Care; Debridement; Humans; Male; Metronidazole; Middle | 2019 |
Nodulo-ulcerative and erythrodermic secondary syphilis in human immunodeficiency virus-infected individuals.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Chancre; | 2019 |
Amoebiasis cutis: clinical suspicion is the key to early diagnosis.
Topics: Adult; Amebiasis; Entamoeba histolytica; Humans; Male; Metronidazole; Skin Ulcer; Suppuration; Troph | 2010 |
A patient with intestinal amoebiasis and cutaneous amoebic ulcer.
Topics: Adult; Animals; Antiprotozoal Agents; Entamoeba histolytica; Entamoebiasis; Humans; Intestinal Disea | 2002 |
Demodex abscesses: clinical and therapeutic challenges.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Diagnosis, Differential; Erythema; Facial Derm | 2003 |
Metastatic crohn's disease--penile and scrotal involvement.
Topics: Adult; Biopsy, Needle; Crohn Disease; Drug Therapy, Combination; Follow-Up Studies; Humans; Immunohi | 2004 |
Metronidazole in smelly tumours.
Topics: Bacterial Infections; Breast Neoplasms; Female; Humans; Metronidazole; Middle Aged; Odorants; Qualit | 1980 |
Cutaneous amebiasis.
Topics: Amebiasis; Antiparasitic Agents; Female; Humans; Infant; Liver Abscess, Amebic; Metronidazole; Skin | 1983 |
[Cervical Pyoderma gangrenosum: treatment by plasma exchanges].
Topics: Adolescent; Crohn Disease; Female; Humans; Metronidazole; Minocycline; Plasma Exchange; Pyoderma; Sk | 1982 |
[An efficient method to reduce odors].
Topics: Administration, Cutaneous; Anti-Infective Agents; Gels; Humans; Metronidazole; Necrosis; Odorants; S | 1999 |
[Cutaneous amebiases (stimulating pyoderma gangrenosum in ulcerative colitis)].
Topics: Amebiasis; Colitis, Ulcerative; Colostomy; Entamoeba histolytica; Entamoebiasis; Humans; Male; Metro | 1976 |
Refractory parastomal ulcers: a multidisciplinary approach.
Topics: Chronic Disease; Colonic Neoplasms; Enterostomy; Female; Humans; Inflammatory Bowel Diseases; Male; | 1990 |
[Cutaneous manifestation of Crohn disease].
Topics: Administration, Oral; Adult; Crohn Disease; Drug Administration Schedule; Female; Foot Diseases; Hum | 1990 |
Severe steroid responsive pneumonitis associated with pyoderma gangrenosum and ulcerative colitis.
Topics: Ampicillin; Colitis, Ulcerative; Erythromycin; Female; Gentamicins; Humans; Metronidazole; Middle Ag | 1985 |
[Case report on the diagnosis of trichomonas ulcers].
Topics: Adult; Diagnosis, Differential; Female; Humans; Metronidazole; Penicillins; Pregnancy; Pregnancy Com | 1973 |