metronidazole has been researched along with Ovarian Neoplasms in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Ovarian Neoplasms: Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (44.44) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 2 (22.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ugianskiene, A | 1 |
| Sakar, MN | 1 |
| Gul, T | 1 |
| Atay, AE | 1 |
| Koren, R | 1 |
| Dekel, Y | 1 |
| Ramadan, E | 1 |
| Veltman, V | 1 |
| Dreznik, Z | 1 |
| LOCK, FR | 1 |
| Anand, S | 1 |
| Dieh, A | 1 |
| Mahmood, T | 1 |
| Atanasov, A | 1 |
| Katranushkova, N | 1 |
| Katsulov, A | 1 |
| Whitmore, GF | 1 |
| Bower, M | 1 |
| Stein, R | 1 |
| Evans, TR | 1 |
| Hedley, A | 1 |
| Pert, P | 1 |
| Coombes, RC | 1 |
| Amosov, IS | 1 |
| Malygina, AI | 1 |
| Morozova, TG | 1 |
| Kurpeshev, OK | 1 |
1 review available for metronidazole and Ovarian Neoplasms
| Article | Year |
|---|---|
The potential for radiation sensitizers and possible strategy for use.
Topics: Animals; Female; Humans; Hypoxia; Laryngeal Neoplasms; Metronidazole; Nitro Compounds; Ovarian Neopl | 1975 |
1 trial available for metronidazole and Ovarian Neoplasms
| Article | Year |
|---|---|
A double-blind study of the efficacy of metronidazole gel in the treatment of malodorous fungating tumours.
Topics: Administration, Topical; Aged; Aged, 80 and over; Bacteria, Anaerobic; Bacterial Infections; Breast | 1992 |
7 other studies available for metronidazole and Ovarian Neoplasms
| Article | Year |
|---|---|
[Chlamydial infection with marked ascites that simulated ovarian cancer].
Topics: Anti-Bacterial Agents; Ascites; Chlamydia Infections; Chlamydia trachomatis; Diagnosis, Differential | 2013 |
Tubo-ovarian abscess presenting as an ovarian tumor in a virginal adolescent: a case report.
Topics: Abdominal Pain; Abscess; Adolescent; Anti-Infective Agents; Ceftriaxone; Diagnosis, Differential; Dr | 2012 |
Periappendiceal actinomycosis mimicking malignancy report of a case.
Topics: Abscess; Actinomyces; Actinomycosis; Aged; Aged, 80 and over; Anti-Bacterial Agents; Appendectomy; A | 2002 |
GYNECOLOGY AND OBSTETRICS.
Topics: Congenital Abnormalities; Endometriosis; Female; Fetal Diseases; Gynecology; Humans; Maternal-Fetal | 1964 |
A large pelvic actinomycoma managed conservatively.
Topics: Actinomyces; Actinomycosis; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Di | 2008 |
[Treatment of the complications of an anaerobic infection in obstetrics and gynecology using metronidazole (Flagyl)].
Topics: Bacteria, Anaerobic; Bacterial Infections; Cesarean Section; Drug Evaluation; Female; Humans; Hyster | 1984 |
[Microcirculation of tumors and adjacent tissues during combined exposure to metronidazole and hyperthermia].
Topics: Adenocarcinoma; Animals; Combined Modality Therapy; Female; Hyperthermia, Induced; Metronidazole; Mi | 1987 |