metronidazole has been researched along with Schistosoma mansoni Infection in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole pharmacokinetics were studied in patients with different degrees of liver cirrhosis, classified according to the Child-Pugh algorithm (A, B or C, as liver disease severity increases) and in schistosomic patients." | 5.08 | Plasma hydroxy-metronidazole/metronidazole ratio in patients with liver disease and in healthy volunteers. ( De Nucci, G; Ferraz, JG; Hofstätter, E; Leite, G; Leonardi, S; Magalhães, AF; Miranda, EL; Muscará, MN; Pedrazzoli, J, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| van der Werf, MJ | 1 |
| de Vlas, SJ | 1 |
| Landouré, A | 1 |
| Bosompem, KM | 1 |
| Habbema, JD | 1 |
| Muscará, MN | 1 |
| Pedrazzoli, J | 1 |
| Miranda, EL | 1 |
| Ferraz, JG | 1 |
| Hofstätter, E | 1 |
| Leite, G | 1 |
| Magalhães, AF | 1 |
| Leonardi, S | 1 |
| De Nucci, G | 1 |
1 trial available for metronidazole and Schistosoma mansoni Infection
| Article | Year |
|---|---|
Plasma hydroxy-metronidazole/metronidazole ratio in patients with liver disease and in healthy volunteers.
Topics: Adult; Biotransformation; Female; Half-Life; Humans; Liver Cirrhosis; Liver Function Tests; Male; Me | 1995 |
1 other study available for metronidazole and Schistosoma mansoni Infection
| Article | Year |
|---|---|
Measuring schistosomiasis case management of the health services in Ghana and Mali.
Topics: Adult; Analysis of Variance; Anthelmintics; Anti-Bacterial Agents; Case Management; Child; Delivery | 2004 |