metronidazole has been researched along with Atrophy of Gingiva in 8 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 9.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 5.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 2 (25.00) | 29.6817 |
| 2010's | 3 (37.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Kaufmann, ME | 1 |
| Wiedemeier, DB | 1 |
| Zellweger, U | 1 |
| Solderer, A | 1 |
| Attin, T | 1 |
| Schmidlin, PR | 1 |
| Agrawal, N | 1 |
| Kallury, A | 1 |
| Khurana, R | 1 |
| Jain, V | 1 |
| Agarwal, K | 1 |
| Cionca, N | 2 |
| Giannopoulou, C | 2 |
| Ugolotti, G | 1 |
| Mombelli, A | 2 |
| Casarin, RC | 1 |
| Peloso Ribeiro, ED | 1 |
| Sallum, EA | 1 |
| Nociti, FH | 1 |
| Gonçalves, RB | 1 |
| Casati, MZ | 1 |
| Almaghlouth, A | 1 |
| Décaillet, F | 1 |
| Courvoisier, DS | 1 |
| Sander, L | 1 |
| Frandsen, EV | 1 |
| Arnbjerg, D | 1 |
| Warrer, K | 1 |
| Karring, T | 1 |
| Sculean, A | 2 |
| Donos, N | 2 |
| Blaes, A | 2 |
| Lauermann, M | 1 |
| Reich, E | 2 |
| Brecx, M | 2 |
| Arweiler, N | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial[NCT02829983] | 40 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Distance from bottom of pocket to the cement-enamel junction (CEJ). (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.71 |
| Placebo Group | 3.03 |
Distance from the bottom of sulcus/pocket to gingival margin (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.53 |
| Placebo Group | 2.86 |
1 review available for metronidazole and Atrophy of Gingiva
| Article | Year |
|---|---|
Gingival recession after scaling and root planing with or without systemic metronidazole and amoxicillin: a re-review.
Topics: Amoxicillin; Anti-Bacterial Agents; Dental Scaling; Gingival Recession; Humans; Metronidazole; Root | 2020 |
6 trials available for metronidazole and Atrophy of Gingiva
| Article | Year |
|---|---|
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Are there specific benefits of amoxicillin plus metronidazole in Aggregatibacter actinomycetemcomitans-associated periodontitis? Double-masked, randomized clinical trial of efficacy and safety.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infecti | 2013 |
Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings.
Topics: Administration, Topical; Adult; Alveolar Bone Loss; Dental Plaque; Female; Gels; Gingival Hemorrhage | 1994 |
Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study.
Topics: Absorbable Implants; Alveolar Bone Loss; Amoxicillin; Anti-Infective Agents; Dental Enamel Proteins; | 1999 |
The effect of postsurgical antibiotics on the healing of intrabony defects following treatment with enamel matrix proteins.
Topics: Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Substitutes; Den | 2001 |
1 other study available for metronidazole and Atrophy of Gingiva
| Article | Year |
|---|---|
Interdisciplinary management of aggressive periodontitis.
Topics: Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conn | 2015 |