Esophageal Achalasia

A motility disorder of the ESOPHAGUS in which the LOWER ESOPHAGEAL SPHINCTER (near the CARDIA) fails to relax resulting in functional obstruction of the esophagus, and DYSPHAGIA. Achalasia is characterized by a grossly contorted and dilated esophagus (megaesophagus).

Synonym
Esophageal Achalasia

Excerpt	Reference
"A case of esophageal achalasia is reported in a 12 year-old child."	( Cargill, G; Contencin, P; Foucaud, P; Le Guillou, C; Narcy, C; Navarro, J; Sablier, G, 1987)
"The treatment of esophageal achalasia is still controversial: current therapies are palliative and aim to relieve dysphagia by disrupting or relaxing the lower esophageal sphincter muscle fibers with botulinum toxin."	( Ancona, E; Annese, V; Costantini, M; Costantino, M; Epifani, M; Molena, D; Nicoletti, L; Rizzetto, C; Ruol, A; Vergadoro, V; Zaninotto, G, 2004)
"Esophageal achalasia is a rare disease in children and its origin is generally indeterminable."	( Gangopadhyaya, AN; Gopal, SC; Gupta, DK; Kumar, V; Sharma, SP; Upadhyaya, VD, 2008)
"Esophageal achalasia is characterized by the absence of esophageal peristalsis and by a dysfunctional lower esophageal sphincter (LES)."	( Fisichella, PM; Niponmick, I; Palazzo, F; Patti, MG; Raz, D, 2008)
"Esophageal achalasia is a rare disease and there have been very few reports about it, especially in children."	( Cai, W; Xu, CD; Zaouche, A; Zhang, Y, 2009)
"Esophageal achalasia is a type of motility disorder characterized by incomplete relaxation of lower esophageal sphincter (LES) and absence of esophageal peristalsis."	( Ji, M; Jiao, Y; Liu, J; Niu, Y; Yu, L; Zhang, S, 2018)
"Esophageal achalasia is a disease characterized by the impaired esophageal peristalsis and non-relaxation of the lower esophageal sphincter muscle with unknown causes."	( Abe, M; Akaishi, T; Ishii, T; Kamei, T; Koseki, K; Nakano, T; Takayama, S, 2019)

Excerpt	Reference
"To establish less invasive permanent treatment for esophageal achalasia, per-oral endoscopic myotomy (POEM) was addressed."	( Inoue, H; Kudo, SE, 2010)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	259 (37.76)	23.3326
1990's	133 (19.39)	12.5806
2000's	92 (13.41)	18.1394
2010's	142 (20.70)	28.8240
2020's	60 (8.75)	9.53

Drug	Relationship Strength	Studies	Trials
bromide	low	1	0
aminooxyacetic acid	low	1	0
methane	low	1	0
choline	low	1	0
chlorine	low	3	0
hydrochloric acid	low	5	0
hydrogen sulfide	low	2	0
lactic acid	low	1	0
ethanolamine	medium	3	1
glycine	low	1	0
glycolic acid	low	1	0
glyoxylic acid	low	1	0
hydrogen carbonate	low	1	0
histamine	low	3	0
iodine	low	2	0
phytic acid	low	1	0
nitrates	low	19	0
nitrites	medium	4	1
thiamine	low	2	0
theophylline	low	2	0
aspirin	low	4	0
bethanechol	low	1	0
caffeine	low	2	0
verapamil	medium	6	2
chloroquine	low	1	0
chlorpromazine	low	1	0
cimetidine	low	1	0
ciprofloxacin	low	1	0
cisapride	low	1	0
dantrolene	low	1	0
diazoxide	low	1	0
pentetic acid	medium	3	1
dipyridamole	low	1	0
edrophonium	low	6	0
fendiline	low	1	0
berotek	low	1	0
fluconazole	low	3	0
fluorouracil	low	3	0
furosemide	low	1	0
gentamicin	low	1	0
guanethidine	low	1	0
haloperidol	low	1	0
halothane	low	2	0
hexobarbital	low	1	0
hydralazine	low	4	0
iohexol	low	1	0
iopromide	low	1	0
isoflurane	low	1	0
isoproterenol	medium	1	1
ketamine	low	1	0
khellin	low	1	0
lidoflazine	low	1	0
loperamide	medium	1	1
mebeverine	low	1	0
mechlorethamine	low	1	0
meperidine	low	1	0
metaproterenol	low	1	0
metoclopramide	low	4	0
metronidazole	low	1	0
molsidomine	low	2	0
apnea	low	3	0
neostigmine	low	4	0
nicardipine	low	1	0
nifedipine	medium	44	8
nitroglycerin	medium	13	3
omeprazole	low	3	0
oxotremorine	low	1	0
papaverine	low	3	0
phenobarbital	low	3	0
phenoxybenzamine	low	1	0
potassium chloride	low	1	0
procaine	low	8	0
propofol	low	1	0
propranolol	low	5	0
sevoflurane	low	1	0
sodium iodide	low	1	0
succinylcholine	low	6	0
sulpiride	low	1	0
terbutaline	medium	1	1
thiotepa	low	1	0
thiothixene	low	1	0
triclosan	low	1	0
hydrocortisone acetate	low	1	0
prednisolone	low	6	0
reserpine	low	1	0
phentolamine	low	2	0
thyroxine	low	3	0
dibenzylchlorethamine	low	1	0
carbachol	low	7	0
aldosterone	low	7	0
prednisone	low	5	0
triiodothyronine	low	1	0
aspartic acid	low	1	0
apomorphine	low	1	0
aminopyrine	low	2	0
acepromazine	low	1	0
methacholine chloride	low	5	0
n-pentanol	low	1	0
tryptophan	low	1	0
arginine	low	1	0
perflutren	low	1	0
acrylamide	low	1	0
methylprednisolone	low	1	0
isosorbide dinitrate	medium	14	2
pyridostigmine bromide	low	2	0
betazole	low	1	0
ergotamine	low	1	0
diatrizoate meglumine	low	6	0
thiazoles	low	2	0
aminophylline	medium	1	1
galantamine	low	1	0
betamethasone	low	1	0
prenylamine	medium	1	1
n-pentyl nitrite	medium	6	1
dihydroergotamine	low	1	0
echothiophate iodide	low	1	0
acetylcysteine	low	1	0
dehydroepiandrosterone sulfate	low	1	0
isosorbide	low	2	0
sodium hydroxide	low	1	0
paraquat	low	1	0
beta-methylcholine	low	1	0
streptomycin	low	1	0
iodinated glycerol	low	1	0
mercury	low	1	0
molybdenum	low	1	0
rhenium	low	1	0
technetium	low	13	0
thulium	low	1	0
helium	medium	1	1
barium sulfate	medium	129	6
trolamine salicylate	low	1	0
n-amyl-n-methylnitrosamine	low	1	0
iodine	low	3	0
phenyl acetate	low	1	0
amoxicillin	low	1	0
tramadol	low	1	0
etoposide	low	1	0
substance p	low	5	0
carbuterol	low	1	0
amikacin	low	1	0
diltiazem	medium	6	1
ng-nitroarginine methyl ester	low	2	0
epirubicin	low	1	0
desflurane	low	1	0
cefaclor anhydrous	low	1	0
fomesafen	medium	7	1
detomidine	low	2	0
remifentanil	low	1	0
amyl nitrate	low	1	0
iopamidol	low	1	0
fluorodeoxyglucose f18	low	2	0
clarithromycin	low	1	0
nicotine	low	1	0
dextromoramide	low	1	0
glucuronic acid	low	1	0
imipenem, anhydrous	low	1	0
dihydrorhodamine 123	low	1	0
deoxyglucose	low	1	0
tadalafil	low	1	0
imatinib mesylate	low	1	0
angiotensin ii, des-phe(8)-	low	1	0
methotrexate	low	1	0
cholesta-5,8-dien-3 beta-ol	low	1	0
docetaxel anhydrous	low	1	0
impletol	low	2	0
technetium tc 99m pentetate	medium	6	2
atropine	low	17	0
propargylglycine	low	1	0
cortisone	low	1	0
bradykinin	low	2	0
7-dehydrocholesterol	low	1	0
puromycin	low	1	0
ergonovine	low	10	0
arachidonic acid	low	1	0
tacrolimus	low	1	0
enkephalin, leucine	low	1	0
dipyrone	low	1	0
bromochloroacetic acid	low	2	0
polidocanol	medium	2	2
chlorprothixene	low	1	0
benztropine	low	1	0
nadp	low	1	0
thiopental	low	1	0
ovalbumin	low	1	0
cathepsin g	low	1	0
bilirubin	low	1	0
pulmicort	low	2	0
ethamolin	medium	3	2
thromboxane b2	low	1	0
codeine	low	1	0
phenylephrine hydrochloride	low	3	0
hydrocodone	low	1	0
nalorphine	low	1	0
naloxone	medium	2	2
oxycodone	low	1	0
morphine	medium	2	1
tin	low	1	0
barium	medium	52	4
sulfur	low	2	0
phosphorus	low	1	0
tetrodotoxin	low	2	0
butylscopolammonium bromide	low	4	0
morphinans	low	1	0
sincalide	low	3	0
pentagastrin	medium	15	1
z 338	low	1	0
oxadiazoles	low	1	0
nystatin a1	low	1	0
indocyanine green	low	1	0
scopolamine hydrobromide	low	2	0
pituitrin	low	2	0
mefloquine	low	1	0
cholecystokinin	medium	13	1
ceruletide	low	6	0
gastrins	medium	37	1
glucagon	low	9	0
neuropeptide y	low	2	0
cimetropium	medium	1	1
mesna	low	1	0
ro13-9904	low	2	0
sodium pertechnetate tc 99m	low	6	0
cardiovascular agents	low	3	0
piperidines	low	4	0
technetium tc 99m gluceptate	low	1	0
vasoactive intestinal peptide	medium	17	1
mobic	low	1	0
saxitoxin	low	1	0
naloxegol	low	1	0
cyclin d1	low	1	0
technetium tc 99m sulfur colloid	medium	10	1
angiotensin i	low	1	0
hyaluronoglucosaminidase	low	1	0
oxyntomodulin	low	1	0
cyclosporine	low	2	0
digitonin	low	1	0
exudates	low	1	0
cyclic gmp	low	1	0
guanosine diphosphate mannose	low	1	0
olanzapine	low	1	0
sildenafil citrate	medium	5	3
vardenafil dihydrochloride	low	1	0

Protein Targets (1,425)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Solute carrier organic anion transporter family member 2A1	0	1	0	4
Vitamin D3 receptor	0	0	0	1
thyroid stimulating hormone receptor	25	0	0	25
cytochrome P450 2D6 isoform 1	16	0	0	16
geminin	54	0	0	54
lethal factor (plasmid)	15	0	0	15
lamin isoform A-delta10	52	0	0	52
Bile salt export pump	0	77	0	77
Major prion protein	0	0	5	5
Trypanothione reductase	0	5	0	5
Chain A, JmjC domain-containing histone demethylation protein 3A	8	0	0	8
Chain A, 2-oxoglutarate Oxygenase	20	0	0	20
Chain A, ATP-DEPENDENT DNA HELICASE Q1	2	0	0	2
acetylcholinesterase	25	0	0	25
dopamine D1 receptor	6	0	0	6
15-lipoxygenase, partial	11	0	0	11
pregnane X receptor	6	0	0	6
phosphopantetheinyl transferase	23	0	0	23
RAR-related orphan receptor gamma	45	0	0	45
USP1 protein, partial	32	0	0	32
NFKB1 protein, partial	8	0	0	8
Microtubule-associated protein tau	23	0	0	23
Thrombopoietin	12	0	0	12
AR protein	60	0	0	60
regulator of G-protein signaling 4	23	0	0	23
glucocorticoid receptor [Homo sapiens]	51	0	0	51
retinoic acid nuclear receptor alpha variant 1	43	0	0	43
retinoid X nuclear receptor alpha	33	0	0	33
farnesoid X nuclear receptor	26	0	0	26
estrogen nuclear receptor alpha	69	0	0	69
vitamin D (1,25- dihydroxyvitamin D3) receptor	29	0	0	29
arylsulfatase A	23	0	0	23
euchromatic histone-lysine N-methyltransferase 2	64	0	0	64
Bloom syndrome protein isoform 1	16	0	0	16
D(1A) dopamine receptor	20	0	0	20
thyroid hormone receptor beta isoform a	17	0	0	17
thyroid hormone receptor beta isoform 2	43	0	0	43
heat shock protein beta-1	15	0	0	15
flap endonuclease 1	13	0	0	13
peripheral myelin protein 22	35	0	0	35
survival motor neuron protein isoform d	21	0	0	21
muscarinic acetylcholine receptor M1	21	0	0	21
Histone deacetylase 3	0	2	0	2
Solute carrier family 22 member 6	0	5	0	5
Histone deacetylase 4	0	2	0	2
Guanine nucleotide-binding protein G	4	0	0	4
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Ataxin-2	28	0	0	28
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
ATP-dependent phosphofructokinase	26	0	0	26
caspase 7, apoptosis-related cysteine protease	12	0	0	12
aldehyde dehydrogenase 1 family, member A1	32	0	0	32
estrogen-related nuclear receptor alpha	53	0	0	53
pregnane X nuclear receptor	44	0	0	44
caspase-3	12	0	0	12
nuclear factor erythroid 2-related factor 2 isoform 1	44	0	0	44
Alcohol dehydrogenase E chain	0	1	0	1
Alcohol dehydrogenase S chain	0	1	0	1
Cellular tumor antigen p53	40	0	0	40
Fibroblast growth factor receptor 4	0	1	0	1
nuclear factor erythroid 2-related factor 2 isoform 2	14	0	0	15
Sex hormone-binding globulin	0	0	2	2
Corticosteroid-binding globulin	0	4	0	4
Mineralocorticoid receptor	0	4	4	8
Androgen receptor	0	6	0	6
Mineralocorticoid receptor	0	1	1	2
Solute carrier organic anion transporter family member 1A1	0	0	0	2
histone acetyltransferase KAT2A isoform 1	19	0	0	19
ATP-binding cassette sub-family C member 3	0	53	0	53
Multidrug resistance-associated protein 4	0	54	0	57
Canalicular multispecific organic anion transporter 1	0	54	0	55
Aminoglycoside 3'-phosphotransferase	0	0	0	1
thioredoxin reductase	43	0	0	43
atrial natriuretic peptide receptor 1 precursor	5	0	0	5
Cystathionine gamma-lyase	0	1	0	1
Cystathionine beta-synthase	0	1	0	1
Chain A, Ferritin light chain	10	0	0	10
Luciferase	16	0	0	16
interleukin 8	6	0	0	6
GLS protein	34	0	0	34
GLI family zinc finger 3	53	0	0	53
estrogen receptor 2 (ER beta)	24	0	0	24
nuclear receptor subfamily 1, group I, member 3	35	0	0	35
cytochrome P450 family 3 subfamily A polypeptide 4	47	0	0	47
G	26	0	0	26
peroxisome proliferator-activated receptor delta	29	0	0	29
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	26	0	0	26
activating transcription factor 6	15	0	0	15
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	18	0	0	18
v-jun sarcoma virus 17 oncogene homolog (avian)	29	0	0	29
chromobox protein homolog 1	31	0	0	31
histone deacetylase 9 isoform 3	3	0	0	3
Voltage-dependent calcium channel gamma-2 subunit	26	0	0	26
Interferon beta	32	0	0	32
HLA class I histocompatibility antigen, B alpha chain	26	0	0	26
Glutamate receptor 2	26	0	0	28
Nicotinate phosphoribosyltransferase	0	2	0	2
Inositol hexakisphosphate kinase 1	26	0	0	26
cytochrome P450 2C9, partial	26	0	0	26
ORF73	0	0	2	2
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	25	0	0	25
Chain A, Beta-lactamase	18	0	0	18
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
apical membrane antigen 1, AMA1	6	0	0	6
Beta-lactamase	0	0	0	1
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	20	0	0	20
urokinase-type plasminogen activator precursor	7	0	0	7
plasminogen precursor	7	0	0	7
urokinase plasminogen activator surface receptor precursor	7	0	0	7
DNA polymerase kappa isoform 1	15	0	0	15
Bile salt export pump	0	10	0	10
Beta-lactamase SHV-1	0	0	0	1
Beta-lactamase SHV-1	0	0	0	2
Cytochrome P450 2C9	0	21	0	21
Beta-lactamase	0	0	0	2
Kappa-type opioid receptor	0	10	1	13
Solute carrier family 15 member 1	0	3	0	3
Solute carrier family 15 member 1	0	1	0	1
Cytochrome P450 2J2	0	14	0	14
B2 metallo-beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Solute carrier family 15 member 2	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
ATAD5 protein, partial	18	0	0	18
TDP1 protein	58	0	0	58
neuropeptide S receptor isoform A	4	0	0	4
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	16	0	0	16
Chain A, Putative fructose-1,6-bisphosphate aldolase	7	0	0	7
Chain A, HADH2 protein	14	0	0	14
Chain B, HADH2 protein	14	0	0	14
hypoxia-inducible factor 1 alpha subunit	18	0	0	18
progesterone receptor	35	0	0	35
cytochrome P450 2D6	31	0	0	31
peroxisome proliferator activated receptor gamma	30	0	0	30
aryl hydrocarbon receptor	24	0	0	24
thyroid stimulating hormone receptor	26	0	0	26
Histone H2A.x	17	0	0	17
cellular tumor antigen p53 isoform a	8	0	0	8
cytochrome P450 2C19 precursor	11	0	0	11
cytochrome P450 2C9 precursor	8	0	0	8
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	13	0	0	13
vitamin D3 receptor isoform VDRA	19	0	0	19
potassium voltage-gated channel subfamily H member 2 isoform d	19	0	0	19
mitogen-activated protein kinase 1	10	0	0	10
nuclear receptor ROR-gamma isoform 1	18	0	0	18
cytochrome P450 3A4 isoform 1	21	0	0	21
Gamma-aminobutyric acid receptor subunit pi	21	5	3	29
Solute carrier family 22 member 1	0	24	0	28
Polyunsaturated fatty acid lipoxygenase ALOX15B	13	0	0	13
Integrin beta-3	6	1	0	7
Integrin alpha-IIb	6	1	0	7
5-hydroxytryptamine receptor 1A	0	8	1	9
5-hydroxytryptamine receptor 2C	0	9	0	10
Tryptophan 5-hydroxylase 1	0	1	0	1
D(2) dopamine receptor	0	26	5	37
5-hydroxytryptamine receptor 2A	0	11	1	12
Gamma-aminobutyric acid receptor subunit beta-1	21	5	3	29
Alpha-1B adrenergic receptor	0	16	4	20
Gamma-aminobutyric acid receptor subunit delta	21	5	3	29
Gamma-aminobutyric acid receptor subunit gamma-2	21	5	3	29
D	0	12	0	12
D(3) dopamine receptor	0	12	0	12
5-hydroxytryptamine receptor 1A	0	22	1	24
Alpha-2B adrenergic receptor	0	12	4	16
Gamma-aminobutyric acid receptor subunit alpha-5	21	5	3	29
Gamma-aminobutyric acid receptor subunit alpha-3	21	5	3	29
D(2) dopamine receptor	0	6	0	6
D(1A) dopamine receptor	0	20	3	27
D(4) dopamine receptor	0	11	2	17
D(1B) dopamine receptor	0	6	0	9
Alpha-2C adrenergic receptor	0	12	4	16
Alpha-2A adrenergic receptor	0	12	4	16
Gamma-aminobutyric acid receptor subunit gamma-1	21	5	3	29
Gamma-aminobutyric acid receptor subunit alpha-2	21	5	3	29
Alpha-1D adrenergic receptor	0	14	4	19
D(1B) dopamine receptor	0	8	0	8
5-hydroxytryptamine receptor 2A	0	28	1	29
Gamma-aminobutyric acid receptor subunit alpha-4	21	5	3	29
Gamma-aminobutyric acid receptor subunit gamma-3	21	5	3	29
5-hydroxytryptamine receptor 1B	0	19	0	19
5-hydroxytryptamine receptor 1D	0	5	0	5
Gamma-aminobutyric acid receptor subunit alpha-6	21	5	3	29
D(4) dopamine receptor	0	9	1	10
5-hydroxytryptamine receptor 1F	0	5	0	5
5-hydroxytryptamine receptor 2B	0	8	0	8
5-hydroxytryptamine receptor 6	0	1	0	1
5-hydroxytryptamine receptor 7	0	5	0	5
5-hydroxytryptamine receptor 5A	0	1	0	1
5-hydroxytryptamine receptor 5B	0	1	0	1
D(3) dopamine receptor	0	30	3	39
5-hydroxytryptamine receptor 3A	0	5	0	5
Alpha-1A adrenergic receptor	0	16	4	20
Histamine H2 receptor	16	2	3	24
5-hydroxytryptamine receptor 7	0	13	0	13
Spike glycoprotein	35	3	5	43
D(2) dopamine receptor	0	16	3	20
Gamma-aminobutyric acid receptor subunit alpha-1	21	6	3	30
Gamma-aminobutyric acid receptor subunit beta-3	21	5	3	29
Gamma-aminobutyric acid receptor subunit beta-2	21	5	3	29
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
D	0	1	0	1
5-hydroxytryptamine receptor 4	0	2	1	5
GABA theta subunit	21	5	3	29
D	0	4	0	4
ATPase family AAA domain-containing protein 5	20	0	0	20
Sigma non-opioid intracellular receptor 1	0	20	1	21
Gamma-aminobutyric acid receptor subunit epsilon	21	5	3	29
5-hydroxytryptamine receptor 3B	0	5	0	5
Chain A, ADIPOCYTE LIPID-BINDING PROTEIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, SERUM ALBUMIN	0	0	1	1
Chain A, Cruzipain	4	0	0	4
thioredoxin glutathione reductase	4	0	0	4
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	7	0	0	7
lethal(3)malignant brain tumor-like protein 1 isoform I	3	0	0	3
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
caspase-1 isoform alpha precursor	5	0	0	5
Fatty-acid amide hydrolase 1	0	2	0	2
Prostaglandin G/H synthase 1	0	1	0	2
Trypsin	0	1	0	1
Coagulation factor VII	0	2	0	2
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Aromatase	0	3	0	3
Tissue factor	0	2	0	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Prostaglandin G/H synthase 2	0	5	1	7
Nuclear receptor subfamily 4 group A member 2	0	0	2	2
10 kDa heat shock protein, mitochondrial	0	1	0	1
Calmodulin	0	2	5	8
Disintegrin and metalloproteinase domain-containing protein 17	7	0	0	7
Prostaglandin G/H synthase 2	0	1	0	2
Fatty acid-binding protein 5	0	1	0	1
Fatty acid-binding protein 5	0	0	1	1
Thiosulfate sulfurtransferase	0	1	0	1
Lanosterol 14-alpha demethylase	0	3	1	4
60 kDa chaperonin	0	1	0	1
10 kDa chaperonin	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	7	0	12
Cytosolic phospholipase A2 gamma	0	1	0	1
Transient receptor potential cation channel subfamily V member 2	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	8	0	12
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	5	0	0	5
Cytochrome P450 3A4	0	26	1	31
Nitric oxide synthase, endothelial	0	1	0	3
Nitric oxide synthase, brain	0	1	0	2
Nitric oxide synthase, brain	0	0	0	2
Nitric oxide synthase, inducible	0	1	0	2
Nitric oxide synthase, inducible	0	1	1	5
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
IDH1	17	0	0	17
Polyphenol oxidase 2	0	1	0	1
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	21	3	26
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
Metabotropic glutamate receptor 6	0	0	1	1
Excitatory amino acid transporter 4	0	1	0	1
Glutamate transporter homolog	0	0	1	1
Carbonic anhydrase 1	0	18	0	25
Carbonic anhydrase 2	0	18	1	27
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	0	1	0	1
5-hydroxytryptamine receptor 1D	0	1	0	3
Glutamate receptor ionotropic, NMDA 1	0	7	2	13
Excitatory amino acid transporter 1	0	1	0	1
Excitatory amino acid transporter 2	0	1	0	1
Excitatory amino acid transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	7	2	13
Glutamate receptor ionotropic, NMDA 2B	0	7	2	13
Glutamate receptor ionotropic, NMDA 2C	0	7	2	13
Metabotropic glutamate receptor 1	0	0	1	1
Metabotropic glutamate receptor 2	0	0	1	1
Carbonic anhydrase-like protein, putative	0	0	0	4
Glutamate receptor ionotropic, NMDA 2D	0	7	2	13
Glutamate receptor ionotropic, NMDA 3B	0	7	2	13
Carbonic anhydrase 4	0	1	0	3
Glutamate receptor ionotropic, NMDA 3A	0	7	2	13
Chain A, Phospholipase A2 isoform 3	0	0	1	1
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
hypothetical protein, conserved	2	0	0	2
EWS/FLI fusion protein	25	0	0	25
glucocerebrosidase	9	0	0	9
Rac1 protein	0	0	1	1
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 2	0	1	0	1
Epidermal growth factor receptor	0	3	0	3
Fatty acid-binding protein, liver	0	2	0	2
Myeloperoxidase	0	4	0	4
Prostaglandin G/H synthase 1	0	1	0	1
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	7	0	11
Adenosine receptor A2a	0	6	1	13
Substance-P receptor	0	3	0	3
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	8	0	0	8
Ras-related protein Rab-2A	0	0	1	1
Rho-associated protein kinase 2	0	1	0	1
Solute carrier family 22 member 20	0	2	0	2
Solute carrier family 22 member 6	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	1	4
cystic fibrosis transmembrane conductance regulator	0	1	0	1
DNA polymerase beta	4	0	0	4
short transient receptor potential channel 6 isoform 1	0	0	1	1
5-hydroxytryptamine receptor 4	0	32	1	33
Muscarinic acetylcholine receptor M2	0	18	6	29
Muscarinic acetylcholine receptor M4	0	19	5	28
Muscarinic acetylcholine receptor M1	0	15	2	21
Muscarinic acetylcholine receptor M3	0	13	2	18
Muscarinic acetylcholine receptor M4	0	14	1	18
Muscarinic acetylcholine receptor M5	0	13	1	17
Muscarinic acetylcholine receptor M5	0	18	5	27
Muscarinic acetylcholine receptor M2	0	15	2	21
Muscarinic acetylcholine receptor M1	0	20	7	32
Muscarinic acetylcholine receptor M1	0	1	2	4
Muscarinic acetylcholine receptor M3	0	18	6	28
Alpha-1D adrenergic receptor	0	20	4	25
5-hydroxytryptamine receptor 2C	0	32	1	33
Muscarinic acetylcholine receptor M4	0	2	0	2
Reverse transcriptase/RNaseH	0	0	0	1
Muscarinic acetylcholine receptor	0	5	1	7
Glyceraldehyde-3-phosphate dehydrogenase	0	1	0	1
Cytochrome P450 1A2	0	7	1	8
Cytochrome P450 2D6	0	13	1	14
Cytochrome P450 2C19	0	6	0	7
Potassium voltage-gated channel subfamily H member 2	0	31	0	32
Aurora kinase B	0	1	0	1
Spike glycoprotein	0	3	5	8
Replicase polyprotein 1ab	0	3	5	8
Transmembrane protease serine 2	0	3	5	8
Procathepsin L	0	3	5	8
Aldo-keto reductase family 1 member B1	0	10	0	10
Alpha-2A adrenergic receptor	0	28	4	34
Replicase polyprotein 1a	0	3	5	8
Replicase polyprotein 1ab	0	3	5	8
Replicase polyprotein 1ab	0	7	5	12
Replicase polyprotein 1ab	0	8	5	13
Alpha-2C adrenergic receptor	0	20	3	25
Sodium-dependent noradrenaline transporter	0	11	0	11
Sodium-dependent dopamine transporter	0	8	0	8
Histamine H2 receptor	0	15	2	17
Sodium-dependent serotonin transporter	0	17	0	17
Sodium-dependent serotonin transporter	0	5	0	5
Histamine H1 receptor	0	15	3	18
5-hydroxytryptamine receptor 2B	0	31	1	32
5-hydroxytryptamine receptor 6	0	18	1	19
Sodium-dependent dopamine transporter	0	4	0	4
Angiotensin-converting enzyme 2	0	3	5	8
glp-1 receptor, partial	19	0	0	19
beta-2 adrenergic receptor	6	0	0	6
Beta-2 adrenergic receptor	0	10	7	18
Beta-2 adrenergic receptor	0	5	4	11
nuclear receptor subfamily 1, group I, member 2	8	0	0	8
galanin receptor type 3	0	2	0	2
Glucocorticoid receptor	0	12	3	20
Glycine receptor subunit alpha-1	0	12	0	12
Glycine receptor subunit beta	0	12	0	12
Glycine receptor subunit alpha-2	0	12	0	12
Glycine receptor subunit alpha-3	0	12	0	12
Caspase-7	4	0	0	4
Inositol monophosphatase 1	10	0	0	10
Angiotensin-converting enzyme	0	0	0	1
B2 bradykinin receptor	0	1	0	1
B2 bradykinin receptor	0	2	1	5
B1 bradykinin receptor	0	1	0	1
Olfactory receptor 51E2	0	0	2	2
Carbonic anhydrase 4	0	10	0	15
Carbonic anhydrase	0	9	0	12
Carbonic anhydrase 15	0	7	0	10
Chain A, Glycogen Phosphorylase	0	1	0	1
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Glycogen phosphorylase, liver form	0	0	2	2
Chain A, Chitinase	0	1	0	1
Potassium channel subfamily K member 2	0	2	3	5
Glycogen phosphorylase, muscle form	0	1	0	1
Renin	0	2	0	2
Cholinesterase	0	6	0	6
Glycogen phosphorylase, liver form	0	1	0	1
Glycogen phosphorylase, muscle form	0	1	0	1
Adenosine receptor A3	0	6	1	7
Amine oxidase [flavin-containing] A	0	1	0	1
Acetylcholinesterase	0	10	1	12
Amine oxidase [flavin-containing] B	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	6	0	6
Adenosine receptor A3	0	3	0	3
Adenosine receptor A2a	0	6	4	12
Adenosine receptor A2b	0	2	0	4
Adenosine receptor A2b	0	3	0	5
Adenosine receptor A1	0	8	2	14
Vasopressin V2 receptor	0	0	0	2
Serine/threonine-protein kinase mTOR	0	3	0	3
Adenosine receptor A2a	0	2	0	2
Adenosine receptor A1	0	3	0	3
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	0	2	0	2
DNA-dependent protein kinase catalytic subunit	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	1	0	1
Adenylate cyclase type 1	0	0	0	2
Chitotriosidase-1	0	2	0	2
Serine-protein kinase ATM	0	1	0	1
Serine/threonine-protein kinase ATR	0	1	0	1
Adenosine receptor A2b	0	1	0	3
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	1	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	3	4
Endochitinase B1	0	2	0	2
Phosphodiesterase	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	11	1	13
Guanine deaminase	0	2	0	2
GALC protein	7	0	0	7
thyrotropin-releasing hormone receptor	5	0	0	5
Neuronal acetylcholine receptor subunit alpha-3	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-4	2	4	2	9
Neuronal acetylcholine receptor subunit alpha-2	0	4	2	7
Neuronal acetylcholine receptor subunit beta-2	2	4	2	9
Neuronal acetylcholine receptor subunit beta-3	0	4	2	7
Neuronal acetylcholine receptor subunit beta-4	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-5	0	4	2	7
Delta-type opioid receptor	0	12	2	18
Neuronal acetylcholine receptor subunit alpha-6	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-9	0	4	2	7
Neuronal acetylcholine receptor subunit alpha-7	0	4	2	7
Sigma non-opioid intracellular receptor 1	0	5	2	7
Muscarinic acetylcholine receptor M3	0	0	1	3
Muscarinic acetylcholine receptor M2	0	0	0	3
Neuronal acetylcholine receptor subunit alpha-10	0	4	2	7
bromodomain adjacent to zinc finger domain 2B	10	0	0	10
importin subunit beta-1 isoform 1	12	0	0	12
serine/threonine-protein kinase PLK1	6	0	0	6
snurportin-1	12	0	0	12
carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1	0	1	0	1
streptokinase A precursor	0	0	2	2
Estrogen receptor	0	0	1	1
Estrogen receptor beta	0	0	1	1
Solute carrier family 22 member 8	0	4	0	6
PPM1D protein	7	0	0	7
glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase	0	1	0	1
glucose-6-phosphate 1-dehydrogenase isoform b	0	1	0	1
Dihydrofolate reductase	0	2	0	2
DNA ligase	0	1	0	1
Riboflavin-binding protein	0	0	1	1
Amyloid-beta precursor protein	1	1	0	2
Histidine-rich protein PFHRP-II	0	1	0	2
Spike glycoprotein	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	1	0	1
DNA ligase 1	0	1	0	1
Beta-secretase 1	0	1	0	1
Calcium-dependent protein kinase 1	0	0	1	1
MO15-related protein kinase Pfmrk	0	1	0	1
DNA ligase A	0	1	0	1
Sigma intracellular receptor 2	0	2	0	2
Phosphoethanolamine N-methyltransferase	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Cysteine proteinase falcipain 2a	0	1	0	1
Proteasome subunit beta type-11	0	0	0	1
Fumarate hydratase	10	0	0	10
Smad3	7	0	0	7
NADPH oxidase 1	0	1	0	1
polyprotein	10	0	0	10
67.9K protein	8	0	0	8
Snq2p	0	0	0	3
Adenylate cyclase type 1	0	3	0	3
Caspase-7	4	0	0	4
caspase-3	4	0	0	4
atrial natriuretic peptide receptor 2 precursor	5	0	0	5
ras-related protein Rab-9A	5	0	0	5
serine/threonine-protein kinase mTOR isoform 1	9	0	0	9
M-phase phosphoprotein 8	11	0	0	11
Proteasome subunit alpha type-7	0	0	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	8	0	8
Albumin	0	2	3	5
Albumin	0	0	3	3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Tyrosine-protein kinase Fyn	0	3	0	3
ATP-dependent translocase ABCB1	0	25	1	38
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Polyunsaturated fatty acid lipoxygenase ALOX15	0	8	0	8
Angiotensin-converting enzyme	0	8	0	8
Sphingomyelin phosphodiesterase	0	2	0	2
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
Adenylate cyclase type 3	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	2	0	6
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	3	0	3
Adenylate cyclase type 4	0	3	0	3
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
Histamine H1 receptor	0	3	4	7
Melanocortin receptor 4	0	2	0	2
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	3	0	6
5-hydroxytryptamine receptor 7	0	6	1	7
Mu-type opioid receptor	0	22	9	33
Sodium channel protein type 1 subunit alpha	0	6	0	6
Sodium channel protein type 4 subunit alpha	0	6	0	6
Adenylate cyclase type 8	0	3	0	3
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	15	7	24
Kappa-type opioid receptor	0	16	6	24
Melanocortin receptor 3	0	2	0	2
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	6	1	0	7
Gastrin/cholecystokinin type B receptor	0	4	0	4
Proteasome subunit alpha type-6	0	0	1	2
Aldehyde oxidase 1	0	1	0	1
Sodium channel protein type 7 subunit alpha	0	5	0	5
Voltage-dependent L-type calcium channel subunit alpha-1D	0	8	0	8
Adenylate cyclase type 6	0	3	0	3
Adenylate cyclase type 5	0	3	0	3
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	3	0	3
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1S	0	8	0	8
Voltage-dependent L-type calcium channel subunit alpha-1C	0	12	0	13
Sodium channel protein type 5 subunit alpha	0	11	0	11
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	6	0	6
Nuclear receptor subfamily 3 group C member 3	0	7	0	7
Adenylyl cyclase 7	0	3	0	3
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Sodium channel protein type 2 subunit alpha	0	6	0	6
Proteasome subunit beta type-7	0	0	0	1
Sodium channel protein type 3 subunit alpha	0	6	0	6
Sodium channel protein type 11 subunit alpha	0	5	0	5
Sodium channel protein type 8 subunit alpha	0	5	0	5
Histamine H3 receptor	0	3	2	5
Sodium channel protein type 10 subunit alpha	0	5	0	5
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Acetylcholinesterase	0	0	2	2
Chain A, Putative Glycine Betaine-binding Abc Transporter Protein	0	0	1	1
Chain A, PUTATIVE GLYCINE BETAINE-BINDING ABC TRANSPORTER PROTEIN	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Glycine betaine/carnitine/choline-binding protein	0	0	1	1
Chain A, Choline-binding protein	0	0	1	1
Solute carrier family 22 member 1	0	2	0	3
Solute carrier family 22 member 2	0	5	0	8
Solute carrier family 22 member 2	0	2	0	2
Sodium- and chloride-dependent creatine transporter 1	0	1	0	1
Choline O-acetyltransferase	0	0	0	1
Solute carrier family 22 member 1	0	7	0	9
High affinity choline transporter 1	0	1	0	1
Solute carrier family 22 member 2	0	6	0	8
cGMP-specific 3',5'-cyclic phosphodiesterase	0	7	1	8
ATP-dependent translocase ABCB1	0	11	0	11
Potassium-transporting ATPase alpha chain 1	0	2	0	2
ATP-dependent translocase ABCB1	0	11	0	12
Potassium-transporting ATPase subunit beta	0	2	0	2
Solute carrier family 22 member 6	0	1	0	3
Multidrug and toxin extrusion protein 2	0	3	0	3
Multidrug and toxin extrusion protein 1	0	5	0	5
Histamine H4 receptor	0	2	2	4
Solute carrier family 22 member 11	0	1	0	3
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	2	0	4
DNA gyrase subunit B	0	2	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	2	1	11
DNA gyrase subunit A	0	1	0	2
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	2	0	4
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
5-hydroxytryptamine receptor 3E	0	3	1	4
5-hydroxytryptamine receptor 3B	0	3	1	4
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Beta-1 adrenergic receptor	0	7	3	10
Beta-3 adrenergic receptor	0	4	3	7
Dipeptidyl peptidase 4	0	1	0	1
Insulin receptor	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	2	2	4
Alpha-1A adrenergic receptor	0	6	5	12
Alpha-1B adrenergic receptor	0	5	4	10
5-hydroxytryptamine receptor 3A	0	3	1	4
5-hydroxytryptamine receptor 4	0	2	1	3
Neutral alpha-glucosidase AB	0	1	0	1
5-hydroxytryptamine receptor 3D	0	3	1	4
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 3C	0	3	1	4
Heparanase	0	0	1	1
GTP-binding nuclear protein Ran isoform 1	9	0	0	9
Cytochrome P450 2D1	0	1	0	1
Cytochrome P450 2D26	0	1	0	1
Cytochrome P450 2D3	0	1	0	1
UDP-glucuronosyltransferase 2B7	0	3	0	8
Kappa-type opioid receptor	0	7	2	11
Mu-type opioid receptor	0	7	2	12
Cytochrome P450 2D4	0	1	0	1
Mas-related G-protein coupled receptor member X2	0	0	4	4
endonuclease IV	5	0	0	5
peripheral myelin protein 22 isoform 1	8	0	0	8
Potassium voltage-gated channel subfamily A member 1	0	2	1	3
TAR DNA-binding protein 43	11	0	0	11
Phosphodiesterase	0	4	0	4
Multidrug resistance-associated protein 5	0	1	0	2
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	6	0	6
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	6	0	6
Solute carrier organic anion transporter family member 1A4	0	1	0	4
Solute carrier organic anion transporter family member 1A5	0	0	0	3
Steryl-sulfatase	0	0	0	1
Multidrug resistance-associated protein 1	0	2	1	6
Solute carrier organic anion transporter family member 1A2	0	0	0	3
Solute carrier organic anion transporter family member 1A3	0	0	0	4
G-protein coupled bile acid receptor 1	0	0	1	1
ATP-binding cassette sub-family C member 11	0	0	0	2
Solute carrier organic anion transporter family member 1A1	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	2
Hsf1 protein	0	0	2	2
Glutamate receptor 1	0	0	0	2
Glutamate receptor 3	0	0	0	2
Glutamate receptor 4	0	0	0	2
Nicotinamide phosphoribosyltransferase	0	0	1	1
ATP-binding cassette sub-family C member 8	0	1	1	2
ATP-sensitive inward rectifier potassium channel 11	0	1	1	2
SMAD family member 2	11	0	0	11
SMAD family member 3	11	0	0	11
huntingtin isoform 2	7	0	0	7
Voltage-dependent L-type calcium channel subunit alpha-1C	0	6	0	6
Voltage-dependent L-type calcium channel subunit alpha-1C	0	7	0	7
Voltage-dependent L-type calcium channel subunit alpha-1D	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	4	0	4
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
acid sphingomyelinase	2	0	0	2
RGS12	1	0	0	1
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
DNA polymerase III, partial	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	11	0	0	11
isocitrate dehydrogenase 1, partial	1	0	0	1
nonstructural protein 1	7	0	0	7
LANA	0	0	0	1
NPYLR7B	0	0	2	2
serine-protein kinase ATM isoform a	1	0	0	1
lysosomal alpha-glucosidase preproprotein	4	0	0	4
guanine nucleotide-binding protein G(i) subunit alpha-1 isoform 1	1	0	0	1
eyes absent homolog 2 isoform a	2	0	0	2
heat shock protein HSP 90-alpha isoform 2	0	1	0	3
histone-lysine N-methyltransferase 2A isoform 2 precursor	4	0	0	4
tumor susceptibility gene 101 protein	1	0	0	1
muscleblind-like protein 1 isoform 1	8	0	0	8
DNA dC->dU-editing enzyme APOBEC-3F isoform a	2	0	0	2
kelch-like ECH-associated protein 1	0	0	0	2
cGMP-dependent 3',5'-cyclic phosphodiesterase	0	4	0	4
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	2	0	2
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	0	3	0	3
3',5'-cyclic-AMP phosphodiesterase	0	2	0	2
Rap guanine nucleotide exchange factor 3	4	0	0	4
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	2	0	2
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	2	0	2
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	2	0	2
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	4	0	4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	4	0	4
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	5	0	5
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	0	3	0	3
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	2	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	0	5	0	5
Exopolyphosphatase PRUNE1	0	1	0	1
Rap guanine nucleotide exchange factor 4	1	0	0	1
Equilibrative nucleoside transporter 1	0	4	0	4
Single-stranded DNA cytosine deaminase	2	0	0	2
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	0	2	0	2
cAMP-specific 3',5'-cyclic phosphodiesterase 7B	0	2	0	2
Phosphodiesterase	0	2	0	2
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	3	0	4
polyunsaturated fatty acid lipoxygenase ALOX12	5	0	0	5
Serum paraoxonase/arylesterase 1	0	3	0	3
Kinesin-like protein KIF11	0	1	0	1
Nucleotide-binding oligomerization domain-containing protein 2	0	1	0	1
POU domain, class 2, transcription factor 1	0	0	0	1
Acetylcholinesterase	0	3	0	3
Opioid receptor, delta 1b	0	2	0	2
Opioid receptor homologue	0	2	0	2
Proenkephalin-B	0	0	1	1
Delta-type opioid receptor	0	12	4	17
Mu-type opioid receptor	0	15	5	23
Kappa-type opioid receptor	0	8	4	13
Mu-type opioid receptor	0	9	2	11
Mu-type opioid receptor	0	2	0	2
Genome polyprotein	0	1	0	1
Adenylate cyclase	0	1	0	1
Tyrosine-protein kinase Lck	0	1	0	1
Thromboxane-A synthase	0	2	0	2
5-hydroxytryptamine receptor 1B	0	3	1	4
5-hydroxytryptamine receptor 5A	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
LMP1 [Human herpesvirus 4]	0	0	0	1
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Prothrombin	0	0	1	2
Regulatory protein E2	0	0	1	1
DNA topoisomerase 1	0	2	0	3
DNA topoisomerase 2	0	0	0	1
UDP-glucuronosyltransferase 1A1	0	3	0	5
Caspase-3	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
DNA topoisomerase 2-beta	0	1	1	8
Tubulin beta-2B chain	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Similar to alpha-tubulin isoform 1	0	1	0	1
Transcriptional activator protein LuxR	0	1	0	1
Extracellular calcium-sensing receptor	0	0	1	1
Chain A, BCL-2-RELATED PROTEIN A1	0	0	1	1
unnamed protein product	0	1	0	1
transcriptional regulator ERG isoform 3	4	0	0	4
bcl-2-like protein 11 isoform 1	0	0	1	1
Chymotrypsinogen A	0	2	0	2
Beta-lactamase	0	2	0	2
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Heme oxygenase 1	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	1	2
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Heme oxygenase 2	0	1	0	1
Malate dehydrogenase, cytoplasmic	0	2	0	2
Cytochrome P450 144	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Steroid C26-monooxygenase	0	0	1	1
Mycocyclosin synthase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Lanosterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	0	1	1
Sterol 14-alpha demethylase	0	1	1	2
14-alpha sterol demethylase	0	0	1	1
heat shock protein 90, putative	0	0	0	2
likely tRNA 2'-phosphotransferase	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
hemoglobin subunit beta	3	0	0	3
Vpr	3	0	0	3
Solute carrier family 22 member 8	0	0	0	1
Thymidylate synthase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Carbonic anhydrase 12	0	2	0	7
Carbonic anhydrase 3	0	2	0	6
Glucose-6-phosphate 1-dehydrogenase	0	4	0	4
Carbonic anhydrase 6	0	5	0	10
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
Carbonic anhydrase 5A, mitochondrial	0	5	0	10
Carbonic anhydrase 7	0	4	0	9
Corticosteroid 11-beta-dehydrogenase isozyme 1	0	1	0	1
6-phosphogluconate dehydrogenase, decarboxylating	0	4	0	4
Holo-[acyl-carrier-protein] synthase	0	1	0	1
Sodium/bile acid cotransporter	0	2	0	2
Carbonic anhydrase 9	0	5	0	11
Carbonic anhydrase 13	0	3	0	8
G-protein coupled receptor 35	0	1	1	2
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
Carbonic anhydrase 14	0	1	0	6
Carbonic anhydrase 5B, mitochondrial	0	4	0	9
Chain A, ACETYLCHOLINESTERASE	0	1	0	1
Chain A, Acetylcholinesterase	0	1	0	1
Acetylcholinesterase	0	6	0	6
Acetylcholinesterase	0	2	0	2
Vascular endothelial growth factor receptor 1	0	2	0	2
Acetylcholinesterase	0	1	0	1
Vascular endothelial growth factor receptor 3	0	2	0	2
Vascular endothelial growth factor receptor 2	0	2	0	2
Acetylcholinesterase	0	2	0	2
Prolyl endopeptidase	0	1	0	1
Small conductance calcium-activated potassium channel protein 3	0	1	0	1
Cholinesterase	0	4	0	4
Carboxylic ester hydrolase	0	2	0	2
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Large neutral amino acids transporter small subunit 1	0	3	0	4
Proton-coupled amino acid transporter 1	0	1	0	1
Serine racemase	0	1	0	1
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
4-hydroxy-tetrahydrodipicolinate synthase	0	1	0	1
transient receptor potential cation channel subfamily V member 1	1	0	0	1
Cocaine esterase	0	3	0	3
UDP-glucuronosyltransferase 1A9	0	1	0	3
Vitamin D-binding protein	0	1	0	1
HLA class I histocompatibility antigen, A alpha chain	0	0	1	1
Integrin beta-1	0	1	0	1
Beta-2 adrenergic receptor	0	6	1	8
Integrin alpha-4	0	1	0	1
Carbonyl reductase [NADPH] 1	0	2	0	3
Beta-1 adrenergic receptor	0	5	2	9
5-hydroxytryptamine receptor 3A	0	2	0	2
Beta-3 adrenergic receptor	0	4	1	5
Histamine H1 receptor	0	4	1	5
C-8 sterol isomerase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
D(2) dopamine receptor	0	1	0	1
D(3) dopamine receptor	0	1	0	1
AP-2 complex subunit sigma	0	1	0	1
N-acetyltransferase Eis	0	2	0	2
5-hydroxytryptamine receptor 2B	0	1	0	1
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase	0	1	0	1
Calcitonin gene-related peptide type 1 receptor	0	1	0	1
Genome polyprotein	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Zinc finger protein 664	0	1	0	1
Vesicular acetylcholine transporter	0	1	0	1
Transporter	0	2	0	2
Cholecystokinin receptor type A	0	3	0	3
Protease	0	2	0	2
Transient receptor potential cation channel subfamily V member 4	0	1	0	1
Chain A, CARBONIC ANHYDRASE II	0	0	1	1
Chain A, Protein (female-specific Histamine Binding Protein 2)	0	0	1	1
aryl hydrocarbon receptor nuclear translocator	0	0	0	1
transforming acidic coiled-coil-containing protein 3	0	0	0	1
Solute carrier family 22 member 3	0	2	0	3
Plasma kallikrein	0	0	0	3
Macrophage migration inhibitory factor	0	2	0	2
Metabotropic glutamate receptor 5	0	1	1	2
Carbonic anhydrase	0	1	0	5
Histamine H3 receptor	0	1	0	1
Histamine N-methyltransferase	0	1	0	1
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	2	0	6
Carbonic anhydrase	0	1	0	5
Carbonic anhydrase	0	1	0	5
Equilibrative nucleoside transporter 4	0	0	0	1
Carbonic anhydrase 13	0	0	0	2
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	2	3
Histamine H4 receptor	0	1	0	1
Histamine H3 receptor	0	1	0	2
Carboxylic ester hydrolase	0	0	0	1
Parkin	4	0	0	4
pyruvate kinase	1	0	0	1
NPC intracellular cholesterol transporter 1 precursor	2	0	0	2
pyruvate kinase PKM isoform b	1	0	0	1
N-glycosylase/DNA lyase	0	1	0	1
Ornithine decarboxylase	1	0	0	1
Aspartate aminotransferase, cytoplasmic	0	1	0	1
Lactoperoxidase	0	2	0	2
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase	0	3	0	3
Carbonic anhydrase, alpha family	0	3	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	4	0	0	4
DNA repair protein RAD52 homolog isoform a	0	0	0	1
Tyrosine-protein kinase ABL1	0	1	2	3
Cytochrome P450 2C8	0	2	0	3
Mast/stem cell growth factor receptor Kit	0	1	1	2
Breakpoint cluster region protein	0	0	1	1
Platelet-derived growth factor receptor alpha	0	1	1	2
Cytochrome P450 3A5	0	1	0	2
Beta-lactamase	0	1	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Metallo-beta-lactamase VIM-11	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	1	0	1
Metallo-beta-lactamase VIM-19	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase TEM	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-13	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-b-lactamase	0	0	0	1
Beta-lactamase IMP-1	0	0	0	1
BlaVIM-1	0	0	0	1
Beta-lactamase	0	0	0	1
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	1
Beta-lactamase class B VIM-2	0	0	0	1
Beta-lactamase	0	0	0	1
Beta-lactamase VIM-1	0	0	0	1
Neuronal acetylcholine receptor subunit beta-2	0	3	1	4
Neuronal acetylcholine receptor subunit alpha-7	0	3	2	5
Beta-1 adrenergic receptor	0	1	2	5
hexokinase-4 isoform 1	2	0	0	2
glucokinase regulatory protein	2	0	0	2
Beta-2 adrenergic receptor	0	0	1	1
Beta-adrenergic receptor kinase 1	0	0	3	3
Beta-3 adrenergic receptor	0	0	1	1
Vasopressin V1a receptor	0	0	1	1
Beta-1 adrenergic receptor	0	2	1	3
Beta-2 adrenergic receptor	0	2	0	2
Taste receptor type 2 member 38	0	0	1	1
Taste receptor type 2 member 39	0	0	1	1
Taste receptor type 2 member 40	0	0	1	1
Taste receptor type 2 member 41	0	0	1	1
Taste receptor type 2 member 43	0	0	1	1
Taste receptor type 2 member 31	0	0	2	2
Taste receptor type 2 member 45	0	0	1	1
Taste receptor type 2 member 46	0	0	1	1
Taste receptor type 2 member 30	0	0	1	1
Taste receptor type 2 member 19	0	0	1	1
Taste receptor type 2 member 20	0	0	1	1
Taste receptor type 2 member 50	0	0	1	1
Taste receptor type 2 member 60	0	0	2	2
Oxytocin receptor	0	0	1	1
Beta-2 adrenergic receptor	0	1	3	6
Taste receptor type 2 member 42	0	0	1	1
Taste receptor type 2 member 16	0	0	1	1
Taste receptor type 2 member 14	0	0	2	2
Taste receptor type 2 member 13	0	0	2	2
Taste receptor type 2 member 10	0	0	1	1
Taste receptor type 2 member 9	0	0	2	2
Taste receptor type 2 member 8	0	0	1	1
Taste receptor type 2 member 7	0	0	1	1
Taste receptor type 2 member 5	0	0	1	1
Taste receptor type 2 member 4	0	0	2	2
Taste receptor type 2 member 3	0	0	1	1
Taste receptor type 2 member 1	0	0	1	1
2,3-bisphosphoglycerate-independent phosphoglycerate mutase	1	0	0	1
Cytochrome P450 1A1	0	2	0	2
Cytochrome P450 1B1	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
Menin	0	1	0	1
Nociceptin receptor	0	1	0	1
Angiopoietin-1 receptor	0	0	1	1
Liver carboxylesterase 1	0	0	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	3	0	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	4	0	5
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	3	4
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Cyclin-dependent kinase 2	0	0	1	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Dihydrofolate reductase	0	1	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Protein-arginine deiminase type-4	0	3	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
Nuclear receptor subfamily 1 group I member 2	0	0	1	1
5-hydroxytryptamine receptor 3B	0	1	0	1
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
Translocator protein	0	2	1	3
UDP-glucuronosyltransferase 1-6	0	2	0	2
UDP-glucuronosyltransferase 2B10	0	2	0	2
Glutathione reductase, mitochondrial	0	3	0	3
Prostaglandin G/H synthase 2	0	1	0	1
Acyl-CoA desaturase 1	0	1	0	1
Proteinase-activated receptor 1	0	1	1	2
UDP-glucuronosyltransferase 1A3	0	0	0	1
Nociceptin receptor	0	1	0	1
Mu-type opioid receptor	0	1	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	2
Neuropeptide Y receptor type 1	0	2	0	2
Neuropeptide Y receptor type 2	0	2	0	2
Neutrophil elastase	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Collagenase 3	0	1	0	1
Equilibrative nucleoside transporter 1	0	1	0	1
B2 bradykinin receptor	0	1	0	1
Quinolone resistance protein NorA	0	2	0	3
Transient receptor potential cation channel subfamily A member 1	0	0	3	3
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Transient receptor potential cation channel subfamily A member 1	0	0	1	1
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit alpha	0	2	1	3
Acetylcholine receptor subunit beta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Acetylcholine receptor subunit delta	0	2	1	3
Acetylcholine receptor subunit gamma	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	1	0	1
Acetylcholine receptor subunit beta	0	2	1	3
Cytochrome P450 2A6	0	2	1	3
Cytochrome P450 2A5	0	1	0	1
Acetylcholine receptor subunit beta-like 2	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-5	0	0	1	1
Neuronal acetylcholine receptor subunit beta-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-3	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-4	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-7	0	2	0	2
Acetylcholine-binding protein	0	1	1	2
Acetylcholine receptor subunit epsilon	0	0	1	1
Neuronal acetylcholine receptor subunit beta-3	0	1	1	2
Acetylcholine receptor subunit delta	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-6	0	1	1	2
Cytochrome P450 2A13	0	1	1	2
Neuronal acetylcholine receptor subunit alpha-5	0	2	0	2
Liver carboxylesterase B-1	0	1	0	1
Neuronal acetylcholine receptor subunit beta-3	0	2	0	2
Neuronal acetylcholine receptor subunit beta-4	0	2	0	2
Neuronal acetylcholine receptor subunit alpha-3	0	2	0	2
Soluble acetylcholine receptor	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-2	0	2	0	2
Neuronal acetylcholine receptor subunit beta-2	0	2	1	3
Neuronal acetylcholine receptor subunit alpha-6	0	2	0	2
Integrin beta	0	0	1	1
Glycoprotein IIb	0	0	1	1
Transporter	0	2	1	4
tumor necrosis factor	1	0	0	1
perilipin-5	0	1	0	1
perilipin-1	0	1	0	1
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a	0	1	0	1
Phospholipase A2, membrane associated	0	0	0	1
Potassium voltage-gated channel subfamily A member 5	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 1	0	1	0	1
Platelet-activating factor receptor	0	0	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	1
3-oxo-5-alpha-steroid 4-dehydrogenase 2	0	1	0	1
C-C chemokine receptor type 2	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1S	0	1	0	1
C-terminal-binding protein 1	1	0	0	1
Leukotriene B4 receptor 1	0	0	0	1
Myosin light chain kinase, smooth muscle	0	1	0	1
Potassium channel subfamily K member 2	0	1	0	1
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1F	0	1	0	1
Leukotriene B4 receptor 2	0	0	0	1
Sodium/iodide cotransporter	0	1	0	1
FAD-linked sulfhydryl oxidase ALR	0	0	0	1
3-hydroxy-3-methylglutaryl-coenzyme A reductase	0	1	0	1
Mcl-1	0	1	0	1
pyruvate kinase PKM isoform a	1	0	0	1
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-1	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit beta-2	0	1	0	1
Bifunctional cytochrome P450/NADPH--P450 reductase	0	0	1	1
Potassium-transporting ATPase subunit beta	0	1	0	1
Potassium-transporting ATPase alpha chain 1	0	1	0	1
Bombesin receptor subtype-3	0	0	1	1
Fatty acid synthase	0	2	0	2
Sodium/potassium-transporting ATPase subunit alpha-2	0	1	0	1
Potassium-transporting ATPase alpha chain 2	0	0	0	1
Sodium/potassium-transporting ATPase subunit beta-3	0	1	0	1
Sodium/potassium-transporting ATPase subunit gamma	0	1	0	1
WD repeat-containing protein 5	0	1	0	1
Glutathione S-transferase omega-1	0	1	0	1
Histone-lysine N-methyltransferase 2A	0	1	0	1
Sodium/potassium-transporting ATPase subunit alpha-4	0	1	0	1
Cytosolic endo-beta-N-acetylglucosaminidase	0	1	0	1
MCOLN3 protein	0	0	1	1
transient receptor potential cation channel, subfamily N, member 1	0	0	1	1
Muscarinic acetylcholine receptor DM1	0	1	0	1
Chain A, cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	1	0	1
Serine hydroxymethyltransferase, mitochondrial	0	1	0	1
CREB-binding protein	1	0	0	1
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	0	2	0	2
Photosystem I iron-sulfur center	0	0	0	1
Cholecystokinin receptor type A	0	3	0	3
Gastrin/cholecystokinin type B receptor	0	3	3	6
estrogen receptor beta isoform 1	0	1	0	1
Alpha-1A adrenergic receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	1	0	1
Alpha-1B adrenergic receptor	0	1	0	1
Nischarin	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	4	0	4
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	3	0	3
Intestinal-type alkaline phosphatase	0	1	0	1
5'-nucleotidase	0	1	0	1
E3 ubiquitin-protein ligase XIAP	0	1	0	1
SLC16A10 protein	0	0	0	2
Large neutral amino acids transporter small subunit 1	0	1	0	1
Monocarboxylate transporter 10	0	0	0	2
Phospholipase A-2-activating protein	0	3	0	3
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Chain D, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, PROTEIN (PHOSPHOGLYCERATE MUTASE 1)	0	1	0	1
Chain A, Beta-arrestin 1	0	0	1	1
Sodium/potassium/calcium exchanger 4	0	1	1	2
Sodium/potassium/calcium exchanger 2	0	1	1	2
luciferase	0	0	0	1
Estrogen receptor	0	3	0	3
Progesterone receptor	0	3	0	4
Glucocorticoid receptor	0	2	1	3
Glucocorticoid receptor	0	0	1	1
Androgen receptor	0	3	0	3
Glutamine synthetase	0	0	1	1
Nociceptin receptor	0	0	1	1
Estrogen receptor beta	0	3	0	3
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	2	0	2
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Chain A, Ferritin light chain	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit beta-1	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	0	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	1	3
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	0	0	2
Gamma-aminobutyric acid receptor subunit gamma-2	0	0	0	2
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit beta-3	0	2	1	3
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-2	0	1	1	2
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Fatty-acid amide hydrolase 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Endothelin-1 receptor	0	1	1	2
Neuromedin-K receptor	0	0	1	1
Type-1 angiotensin II receptor	0	1	1	2
Cholecystokinin receptor type A	0	3	3	6
Vasopressin V1a receptor	0	1	1	2
Nuclear receptor subfamily 2 group E member 1	0	0	3	3
Interleukin-5	0	1	0	1
Interleukin-5	0	1	0	1
Matrix metalloproteinase-9	0	1	0	1
Interleukin-5 receptor subunit alpha	0	1	0	1
30S ribosomal protein S6	0	1	0	2
30S ribosomal protein S7	0	1	0	2
50S ribosomal protein L15	0	1	0	2
50S ribosomal protein L10	0	1	0	2
50S ribosomal protein L11	0	1	0	2
50S ribosomal protein L7/L12	0	1	0	2
50S ribosomal protein L19	0	1	0	2
50S ribosomal protein L1	0	1	0	2
50S ribosomal protein L20	0	1	0	2
50S ribosomal protein L27	0	1	0	2
50S ribosomal protein L28	0	1	0	2
50S ribosomal protein L29	0	1	0	2
50S ribosomal protein L31	0	1	0	2
50S ribosomal protein L31 type B	0	1	0	2
50S ribosomal protein L32	0	1	0	2
50S ribosomal protein L33	0	1	0	2
50S ribosomal protein L34	0	1	0	2
50S ribosomal protein L35	0	1	0	2
50S ribosomal protein L36	0	1	0	2
30S ribosomal protein S10	0	1	0	2
30S ribosomal protein S11	0	1	0	2
30S ribosomal protein S12	0	1	0	2
30S ribosomal protein S13	0	1	0	2
30S ribosomal protein S16	0	1	0	2
30S ribosomal protein S18	0	1	0	2
30S ribosomal protein S19	0	1	0	2
30S ribosomal protein S20	0	1	0	2
30S ribosomal protein S2	0	1	0	2
30S ribosomal protein S3	0	1	0	2
30S ribosomal protein S4	0	1	0	2
30S ribosomal protein S5	0	1	0	2
30S ribosomal protein S8	0	1	0	2
30S ribosomal protein S9	0	1	0	2
50S ribosomal protein L13	0	1	0	2
50S ribosomal protein L14	0	1	0	2
50S ribosomal protein L16	0	1	0	2
50S ribosomal protein L23	0	1	0	2
30S ribosomal protein S15	0	1	0	2
50S ribosomal protein L17	0	1	0	2
50S ribosomal protein L21	0	1	0	2
50S ribosomal protein L30	0	1	0	2
50S ribosomal protein L6	0	1	0	2
30S ribosomal protein S14	0	1	0	2
30S ribosomal protein S17	0	1	0	2
30S ribosomal protein S1	0	1	0	2
50S ribosomal protein L18	0	1	0	2
Aminopeptidase N	0	1	0	1
Aminopeptidase N	0	1	0	1
Puromycin-sensitive aminopeptidase	0	1	0	1
50S ribosomal protein L2	0	1	0	2
50S ribosomal protein L3	0	1	0	2
50S ribosomal protein L24	0	1	0	2
50S ribosomal protein L4	0	1	0	2
50S ribosomal protein L22	0	1	0	2
50S ribosomal protein L5	0	1	0	2
30S ribosomal protein S21	0	1	0	2
50S ribosomal protein L25	0	1	0	2
50S ribosomal protein L36 2	0	1	0	2
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Chromaffin granule amine transporter	0	1	0	1
Synaptic vesicular amine transporter	0	2	0	2
Synaptic vesicular amine transporter	0	2	1	3
Synaptic vesicular amine transporter	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Carbonic anhydrase	0	2	0	2
Carbonic anhydrase	0	1	0	1
Substance-P receptor	0	2	0	2
Neuromedin-K receptor	0	0	1	1
Substance-K receptor	0	1	1	2
Substance-P receptor	0	2	1	3
Neuromedin-K receptor	0	1	1	2
Substance-K receptor	0	1	0	1
Substance-K receptor	0	1	0	1
Growth hormone secretagogue receptor type 1	0	0	1	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
D(2) dopamine receptor	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain B, cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Chain A, cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	1	2
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	0	1	0	1
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha	0	1	0	1
Cystic fibrosis transmembrane conductance regulator	0	0	1	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	2	0	2
Potassium voltage-gated channel subfamily E member 1	0	1	0	1
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'	0	1	0	1
Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	0	1	0	1
Rod cGMP-specific 3',5'-cyclic phosphodiesterase subunit beta	0	1	0	1
Potassium voltage-gated channel subfamily KQT member 1	0	1	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	2	0	2
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta	0	1	0	1
Chain A, Pyridoxal kinase	0	1	0	1
Chain A, Pyridoxal Kinase	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4C	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4B	0	1	0	1
Thyroid hormone receptor beta	0	2	0	2
Adenosine receptor A1	0	2	0	2
Adenosine receptor A1	0	1	0	1
cAMP-specific 3',5'-cyclic phosphodiesterase 4A	0	1	0	1
Chain A, ykoF	0	0	1	1
Chain B, ykoF	0	0	1	1
Chain A, ThiT	0	0	1	1
Thiamine transporter ThiT	0	0	1	1
Transketolase	0	0	1	1
Thiamine-binding periplasmic protein	0	0	1	1
Cytochrome P450 2B1	0	1	0	1
Cytochrome P450 2B6	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	0	0	1
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Chain X, Thyroid hormone receptor beta-1	0	0	2	2
Transthyretin	0	2	1	5
Thyroid hormone receptor alpha	0	2	3	5
Thyroid hormone receptor beta	0	2	3	5
Proliferating cell nuclear antigen	0	2	0	2
Retinoic acid receptor RXR-alpha	0	0	2	2
Peroxisome proliferator-activated receptor gamma	0	0	4	4
Malate dehydrogenase, mitochondrial	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	1	0	2
Monocarboxylate transporter 8	0	0	0	1
Bile acid receptor	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	0	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, enoyl-acyl carrier reductase	0	1	0	1
Chain C, enoyl-acyl carrier reductase	0	1	0	1
Chain A, Repressor	0	0	1	1
PINK1	1	0	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
twin arginine protein translocation system - TatA protein	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Endoplasmic reticulum chaperone BiP	0	1	0	1
Alpha-synuclein	1	0	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADPH] FabI	0	2	0	2
Enoyl-acyl carrier reductase	0	1	0	1
Enoyl-acyl-carrier protein reductase	0	2	0	2
Enoyl-ACP reductase II	0	1	0	1
Gamma-aminobutyric acid receptor subunit pi	0	1	0	1
Gamma-aminobutyric acid receptor subunit delta	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	0	1	0	1
Solute carrier organic anion transporter family member 4C1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	0	1
Solute carrier organic anion transporter family member 4A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	0	1
Solute carrier organic anion transporter family member 1C1	0	1	0	1
Gamma-aminobutyric acid receptor subunit theta	0	1	0	1
Chain A, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain K, Trp Rna-binding Attenuation Protein	0	0	1	1
Chain B, tryptophanyl-tRNA synthetase	0	0	1	1
Chain C, Tryptophanyl-tRNA synthetase II	0	0	1	1
Stromelysin-1	0	1	0	1
Indoleamine 2,3-dioxygenase 1	0	1	0	2
Tryptophan 2,3-dioxygenase	0	1	0	2
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Tryprostatin B synthase	0	0	0	1
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	0	0	1	1
Solute carrier family 2, facilitated glucose transporter member 9	0	1	1	2
Glycoprotein	0	1	0	1
Muscarinic acetylcholine receptor M2	0	0	1	1
Catechol O-methyltransferase	0	1	0	1
Potassium voltage-gated channel subfamily A member 3	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (686)

Protein Targets (1,425)

Esophageal Achalasia

Synonyms(1)

Research Excerpts

Overview

Treatment

Research

Studies (686)

Drugs Studied (275)

Protein Targets (1,425)