metronidazole has been researched along with Sinusitis in 21 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Sinusitis: Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We describe a patient who developed hemorrhagic colitis shortly after starting a course of amoxicillin therapy for sinusitis prophylaxis." | 3.74 | Amoxicillin-associated hemorrhagic colitis in the presence of Klebsiella oxytoca. ( Ernst, ME; Philbrick, AM, 2007) |
| "Periorbital cellulitis is a potential sight-threatening complication of sinusitis." | 2.94 | The management of periorbital cellulitis secondary to sinonasal infection: a multicenter prospective study in the United Kingdom. ( Al-Lami, A; Grounds, R; Hone, R; Hopkins, C; Lloyd, G; Mahalingam, S; Pervez, A; Poon, JS; Riley, P; Rudd, J; Shamil, E; Wong, G, 2020) |
| "Disseminated acanthamoebiasis is a rare, often fatal, infection most commonly affecting immunocompromised patients." | 2.55 | Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature. ( Ali, I; Babik, JM; Brondfield, MN; Cope, JR; DeMarco, T; Doernberg, SB; Hilts-Horeczko, A; Klein, L; Matanock, A; Reid, MJ; Ritter, JM; Rutishauser, RL; Tang, J, 2017) |
| "Rhinosinusitis-induced brain abscesses are rare but can result in devastating long-term sequalae and mortality; they require a high index of suspicion with early imaging to start early empiric parenteral antibiotic treatment covering aerobes and anaerobes." | 1.72 | A surgical protocol for sinogenic brain abscess: the Oxford experience and a review of the literature. ( Bandino, F; Chaidas, K; Jeyaretna, S; Lawrence, T; Martinez-Devesa, P; Pendolino, AL; Qureishi, A; Thota, R, 2022) |
| "In particular parietal subdural empyema of odontogenic origin has not been described." | 1.40 | Parietal subdural empyema as complication of acute odontogenic sinusitis: a case report. ( Ferrara, S; Gambino, A; Martines, F; Mucia, M; Salvago, P; Sireci, F, 2014) |
| "Sinusitis was suspected as the cause in only one patient initially." | 1.31 | Suppurative intracranial complications of sinusitis in children. ( Ong, YK; Tan, HK, 2002) |
| "24 days after the onset of infectious mononucleosis, clinically and serologically confirmed, an otherwise healthy 18-year-old schoolboy developed a fulminant septicaemia with acute meningitis and loss of consciousness, consumptive coagulopathy and acute renal failure." | 1.29 | [Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis]. ( Busch, N; Haase, G; Kierdorf, H; Marschall, HU; Matern, S; Mertens, PR; Nguyen, H; Schönfelder, T; Sieberth, HG; Urhahn, R, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (14.29) | 18.7374 |
| 1990's | 3 (14.29) | 18.2507 |
| 2000's | 4 (19.05) | 29.6817 |
| 2010's | 8 (38.10) | 24.3611 |
| 2020's | 3 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Bandino, F | 1 |
| Thota, R | 1 |
| Pendolino, AL | 1 |
| Chaidas, K | 1 |
| Jeyaretna, S | 1 |
| Lawrence, T | 1 |
| Martinez-Devesa, P | 1 |
| Qureishi, A | 1 |
| Diouf, MS | 1 |
| Tall, A | 1 |
| Ndiaye, C | 1 |
| Thiam, A | 1 |
| Deguenonvo, R | 1 |
| Ndiaye, M | 1 |
| Mahalingam, S | 1 |
| Hone, R | 1 |
| Lloyd, G | 1 |
| Grounds, R | 1 |
| Shamil, E | 1 |
| Wong, G | 1 |
| Al-Lami, A | 1 |
| Pervez, A | 1 |
| Rudd, J | 1 |
| Poon, JS | 1 |
| Riley, P | 1 |
| Hopkins, C | 1 |
| Thomas, J | 1 |
| Fayad, M | 1 |
| Tong, D | 1 |
| Richards, BF | 1 |
| Fakhar, M | 1 |
| Nakhaei, M | 1 |
| Sharifpour, A | 1 |
| Kalani, H | 1 |
| Banimostafavi, ES | 1 |
| Abedi, S | 1 |
| Safanavaei, S | 1 |
| Aliyali, M | 1 |
| Martines, F | 1 |
| Salvago, P | 1 |
| Ferrara, S | 1 |
| Mucia, M | 1 |
| Gambino, A | 1 |
| Sireci, F | 1 |
| Miller, B | 1 |
| Brondfield, MN | 1 |
| Reid, MJ | 1 |
| Rutishauser, RL | 1 |
| Cope, JR | 1 |
| Tang, J | 1 |
| Ritter, JM | 1 |
| Matanock, A | 1 |
| Ali, I | 1 |
| Doernberg, SB | 1 |
| Hilts-Horeczko, A | 1 |
| DeMarco, T | 1 |
| Klein, L | 1 |
| Babik, JM | 1 |
| Mittal, MK | 1 |
| Zimmerman, RA | 1 |
| Olwoch, IP | 1 |
| Parvizi, N | 1 |
| Choudhury, N | 1 |
| Singh, A | 1 |
| Kromberg, R | 1 |
| Mozet, C | 1 |
| Fritzsch, D | 1 |
| Dawczynski, J | 1 |
| Dietz, A | 1 |
| Ong, YK | 1 |
| Tan, HK | 1 |
| Li, C | 1 |
| Zhao, Y | 1 |
| Liang, C | 1 |
| An, H | 1 |
| Philbrick, AM | 1 |
| Ernst, ME | 1 |
| Jokipii, AM | 1 |
| Jokipii, L | 1 |
| Mann, W | 1 |
| Pelz, K | 1 |
| Weiner, GM | 1 |
| Williams, B | 1 |
| Busch, N | 1 |
| Mertens, PR | 1 |
| Schönfelder, T | 1 |
| Nguyen, H | 1 |
| Marschall, HU | 1 |
| Kierdorf, H | 1 |
| Haase, G | 1 |
| Urhahn, R | 1 |
| Sieberth, HG | 1 |
| Matern, S | 1 |
| O'Connor Reina, C | 1 |
| García Iriarte, M | 1 |
| García Monge, E | 1 |
| Gómez Angel, D | 1 |
| Lundberg, C | 1 |
| Carenfelt, C | 1 |
| Engquist, S | 1 |
| Nord, CE | 1 |
2 reviews available for metronidazole and Sinusitis
| Article | Year |
|---|---|
Disseminated Acanthamoeba infection in a heart transplant recipient treated successfully with a miltefosine-containing regimen: Case report and review of the literature.
Topics: Acanthamoeba; Amebiasis; Amebicides; Amphotericin B; Anti-Bacterial Agents; Antilymphocyte Serum; Bi | 2017 |
[Anerobic infections in otolaryngology (author's transl)].
Topics: Adult; Anaerobiosis; Bacteria; Bacterial Infections; Carcinoma, Squamous Cell; Cephalosporins; Chron | 1981 |
2 trials available for metronidazole and Sinusitis
| Article | Year |
|---|---|
The management of periorbital cellulitis secondary to sinonasal infection: a multicenter prospective study in the United Kingdom.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Cellulitis; Child; Drug Therapy, Combination; Humans; Len | 2020 |
[Observations of the curative effect with various liquid for post operative irrigation of ESS of treating chronic sinusitis and nasal polyps].
Topics: Adolescent; Adult; Aged; Child; Chronic Disease; Dexamethasone; Drugs, Chinese Herbal; Endoscopy; Fe | 2001 |
17 other studies available for metronidazole and Sinusitis
| Article | Year |
|---|---|
A surgical protocol for sinogenic brain abscess: the Oxford experience and a review of the literature.
Topics: Adult; Anti-Bacterial Agents; Brain Abscess; Ceftriaxone; Child; Humans; Metronidazole; Retrospectiv | 2022 |
Complications of sinusitis: An 80-case series from the ENT and neurosurgery departments of the Fann university hospital center of Dakar, Senegal.
Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Brain Abscess; Child; Child, Preschool; Cla | 2020 |
Use of ventriculostomy in the treatment of septic cavernous sinus thrombosis (SCST).
Topics: Administration, Intravenous; Aftercare; Aged; Angiography; Anti-Bacterial Agents; Cavernous Sinus; C | 2019 |
First Molecular Diagnosis of Lophomoniasis: the End of a Controversial Story.
Topics: Adult; Antiprotozoal Agents; Female; Humans; Immunocompetence; Iran; Lung Diseases, Parasitic; Metro | 2019 |
Parietal subdural empyema as complication of acute odontogenic sinusitis: a case report.
Topics: Acute Disease; Adolescent; Anti-Bacterial Agents; Craniotomy; Diagnosis, Differential; Empyema, Subd | 2014 |
A 60-year-old man with forehead swelling.
Topics: Anti-Infective Agents; Ceftriaxone; Endoscopy; Humans; Magnetic Resonance Imaging; Male; Metronidazo | 2016 |
Meningitis and epidural abscess related to pansinusitis.
Topics: Bacteroidaceae Infections; Cefotaxime; Ceftriaxone; Child; Combined Modality Therapy; Consciousness | 2009 |
Microbiology of acute complicated bacterial sinusitis at the University of the Witwatersrand.
Topics: Acute Disease; Adolescent; Adult; Bacterial Infections; Brain Diseases; Child; Drug Resistance, Bact | 2010 |
Complicated periorbital cellulitis: case report and literature review.
Topics: Abscess; Adolescent; Anti-Infective Agents; Cefuroxime; Contrast Media; Decompression, Surgical; Dra | 2012 |
[A rare complication of acute sinusitis].
Topics: Aged; Cavernous Sinus Thrombosis; Cefuroxime; Combined Modality Therapy; Decompression, Surgical; Di | 2012 |
Suppurative intracranial complications of sinusitis in children.
Topics: Adolescent; Anti-Bacterial Agents; Ceftriaxone; Child; Empyema, Subdural; Humans; Male; Meningitis; | 2002 |
Amoxicillin-associated hemorrhagic colitis in the presence of Klebsiella oxytoca.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Enterocolitis, Pseudomembranous; Humans; | 2007 |
Metronidazole, tinidazole, ornidazole and anaerobic infections of the middle ear, maxillary sinus and central nervous system.
Topics: Bacterial Infections; Central Nervous System Diseases; Humans; Maxillary Sinus; Metronidazole; Nitro | 1981 |
Prevention of intracranial problems in ear and sinus surgery: a possible role for cefotaxime.
Topics: Bacteria; Brain Abscess; Cefotaxime; Chloramphenicol; Empyema, Subdural; Humans; Metronidazole; Micr | 1993 |
[Lemierre's post-tonsillitis sepsis with meningitis and intravascular consumption coagulopathy as complication of infectious mononucleosis with pansinusitis].
Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Bacteremia; Chloramphenicol; Disseminated In | 1996 |
[Complications of sinusitis].
Topics: Adolescent; Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammator | 1998 |
Anaerobic bacteria in maxillary sinusitis.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Infections; Gram-Negative Anaerobic Bacteria; Humans; Max | 1979 |