Page last updated: 2024-10-31

metronidazole and Chronic Hepatitis C

metronidazole has been researched along with Chronic Hepatitis C in 2 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Research Excerpts

ExcerptRelevanceReference
"Leukocytosis is a sign of severe CDI and is predictive for a complicated course."1.39[Case report. Leukocytosis in the course of Clostridium difficile infection]. ( Defosse, JM; Sakka, SG; Wappler, F; Weber, KS, 2013)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (50.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Weber, KS1
Defosse, JM1
Wappler, F1
Sakka, SG1
Marchioretto, MA1
Ecclissato, C1
da Silva, CM1
Cassiano, NM1
Calafatti, SA1
Mendonça, S1
Ribeiro, ML1
Bernasconi, GC1
Degger, MF1
Piovesan, H1
Pedrazzoli, J1

Other Studies

2 other studies available for metronidazole and Chronic Hepatitis C

ArticleYear
[Case report. Leukocytosis in the course of Clostridium difficile infection].
    Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS, 2013, Volume: 48, Issue:6

    Topics: Aged; Anti-Bacterial Agents; Clostridioides difficile; Colon; Colonoscopy; Diabetes Mellitus, Type 2

2013
Plasma hydroxy-metronidazole/metronidazole ratio in hepatitis C virus-induced liver disease.
    Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2005, Volume: 38, Issue:3

    Topics: Adult; Anti-Infective Agents; Biomarkers; Case-Control Studies; Chromatography, High Pressure Liquid

2005
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