metronidazole has been researched along with Bacterial Infections, Gram-Negative in 32 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Linezolid was selected as a first-line antimicrobial drug." | 1.39 | Otogenic cerebellar abscess by Enterococcus avium, a very rare infectious agent. ( Escribano, JA; Lozano, J; Rivin, E; Solivera, J; Vidal, E, 2013) |
| "Although polymicrobial infections, such as peri-implantitis or periodontitis, were postulated in the literature to be caused by synergistic effects of bacteria, these effects remain unclear looking at antibiotic susceptibility." | 1.37 | Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model. ( Al-Nawas, B; d'Hoedt, B; Karbach, J; Mouratidou, A, 2011) |
| "Total excision of dermal sinus tract, dermoid cyst, and the intramedullary abscess by means of a L2-S3 laminectomy, followed by antibiotic therapy resulted in good functional recovery." | 1.35 | Infected lumbar dermoid cyst presenting with tetraparesis secondary to holocord central lesion. ( Cekinmez, M; Erdogan, B; Sener, L; Tufan, K, 2008) |
| "This case emphasizes the importance of adequately dosed antibiotic therapy, also for unusual bacteria such as species of Aeromonas." | 1.33 | [Postoperative infection of an epigastric hematoma caused by Aeromonas veronii biovar sobria]. ( Bomke, AK; Feyerherd, P; Podbielski, A, 2006) |
| " The virtual peak levels which had been determined by pharmacokinetic dosage calculation were compared with the serum concentrations obtained directly after the administration as well as after 15, 30, 60 and 180 min." | 1.29 | Studies on drug monitoring in thrice and once daily treatment with aminoglycosides. ( Georgieff, M; Konrad, F; Neumeister, B; Rommel, H; Wagner, R, 1993) |
| "Infectious myositis is rather uncommon." | 1.29 | Veillonella myositis in an immunocompromised patient. ( Beumont, MG; Duncan, J; Edelstein, PH; Esterhai, JL; Mitchell, SD, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 13 (40.63) | 29.6817 |
| 2010's | 13 (40.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Morio, F | 1 |
| Jean-Pierre, H | 1 |
| Dubreuil, L | 1 |
| Jumas-Bilak, E | 1 |
| Calvet, L | 1 |
| Mercier, G | 1 |
| Devine, R | 1 |
| Marchandin, H | 1 |
| Amsler, KM | 1 |
| Davies, TA | 1 |
| Shang, W | 1 |
| Jacobs, MR | 1 |
| Bush, K | 1 |
| Chatani, M | 1 |
| Kishita, M | 1 |
| Inatomi, O | 1 |
| Takahashi, K | 1 |
| Sugimoto, M | 1 |
| Sonoda, A | 1 |
| Kawahara, M | 1 |
| Bamba, S | 1 |
| Kito, K | 1 |
| Kushima, R | 1 |
| Andoh, A | 1 |
| Prabhu, V | 1 |
| Foo, J | 1 |
| Ahir, H | 1 |
| Sarpong, E | 1 |
| Merchant, S | 1 |
| Nishii, S | 1 |
| Higashiyama, M | 1 |
| Ogata, S | 1 |
| Komoto, S | 1 |
| Ito, S | 1 |
| Mizoguchi, A | 1 |
| Terada, H | 1 |
| Furuhashi, H | 1 |
| Takajo, T | 1 |
| Shirakabe, K | 1 |
| Watanabe, C | 1 |
| Tomita, K | 1 |
| Nagao, S | 1 |
| Miura, S | 1 |
| Hokari, R | 1 |
| Cobo, F | 1 |
| Rodríguez-Granger, J | 1 |
| Sampedro, A | 1 |
| Navarro-Marí, JM | 1 |
| Escribano, JA | 1 |
| Solivera, J | 1 |
| Vidal, E | 1 |
| Rivin, E | 1 |
| Lozano, J | 1 |
| Pérez-Jacoiste Asín, MA | 1 |
| Fernández-Ruiz, M | 1 |
| Serrano-Navarro, I | 1 |
| Prieto-Rodriguez, S | 1 |
| Aguado, JM | 1 |
| Buckman, SA | 1 |
| Krekel, T | 1 |
| Muller, AE | 1 |
| Mazuski, JE | 1 |
| Choi, YJ | 1 |
| Won, EJ | 1 |
| Kim, SH | 1 |
| Shin, MG | 1 |
| Shin, JH | 1 |
| Suh, SP | 1 |
| Epstein, DJ | 2 |
| Ernst, K | 2 |
| Rogers, R | 2 |
| Carmody, E | 2 |
| Aguero-Rosenfeld, M | 2 |
| Chandra, A | 1 |
| Dhar, P | 1 |
| Dharap, S | 1 |
| Goel, A | 1 |
| Gupta, R | 2 |
| Hardikar, JV | 1 |
| Kapoor, VK | 1 |
| Mathur, AK | 1 |
| Modi, P | 1 |
| Narwaria, M | 1 |
| Ramesh, MK | 1 |
| Ramesh, H | 1 |
| Sastry, RA | 1 |
| Shah, S | 1 |
| Virk, S | 1 |
| Sudheer, OV | 1 |
| Sreevathsa, MR | 1 |
| Varshney, S | 1 |
| Kochhar, P | 1 |
| Somasundaram, S | 1 |
| Desai, C | 1 |
| Schou, M | 1 |
| Tufan, K | 1 |
| Cekinmez, M | 1 |
| Sener, L | 1 |
| Erdogan, B | 1 |
| Barakat, SS | 1 |
| Campbell, WN | 1 |
| Mittal, MK | 1 |
| Zimmerman, RA | 1 |
| Mouratidou, A | 1 |
| Karbach, J | 1 |
| d'Hoedt, B | 1 |
| Al-Nawas, B | 1 |
| Wang'ondu, RW | 1 |
| Murray, TS | 1 |
| Wellman, G | 1 |
| Hussain, SZ | 1 |
| Isenmann, R | 1 |
| Rünzi, M | 1 |
| Kron, M | 1 |
| Kahl, S | 1 |
| Kraus, D | 1 |
| Jung, N | 1 |
| Maier, L | 1 |
| Malfertheiner, P | 1 |
| Goebell, H | 1 |
| Beger, HG | 1 |
| Dinubile, MJ | 1 |
| Friedland, I | 1 |
| Chan, CY | 1 |
| Motyl, MR | 1 |
| Giezek, H | 1 |
| Shivaprakash, M | 1 |
| Weinstein, RA | 1 |
| Quinn, JP | 1 |
| Papaparaskevas, J | 1 |
| Pantazatou, A | 1 |
| Katsandri, A | 1 |
| Legakis, NJ | 1 |
| Avlamis, A | 1 |
| Bomke, AK | 1 |
| Feyerherd, P | 1 |
| Podbielski, A | 1 |
| Manjunath, M | 1 |
| Siboni, A | 1 |
| Graversen, K | 1 |
| Olsen, H | 1 |
| Konrad, F | 1 |
| Wagner, R | 1 |
| Neumeister, B | 1 |
| Rommel, H | 1 |
| Georgieff, M | 1 |
| Beumont, MG | 1 |
| Duncan, J | 1 |
| Mitchell, SD | 1 |
| Esterhai, JL | 1 |
| Edelstein, PH | 1 |
| Wack, RF | 1 |
| Eaton, KA | 1 |
| Kramer, LW | 1 |
| Rose, C | 1 |
| Tellion, C | 1 |
| Ferri, F | 1 |
| Donazzan, M | 1 |
| Ziuzio, S | 1 |
| Sakson, B | 1 |
| Kuriyama, T | 1 |
| Karasawa, T | 1 |
| Nakagawa, K | 1 |
| Yamamoto, E | 1 |
| Nakamura, S | 1 |
| Melhus, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Open Label, Multicentre Phase Iv Study To Evaluate The Efficacy And Safety Of Magnex (Cefoperazone-Sulbactam) In Comparison With Ceftazidime Plus Amikacin And Metronidazole In The Treatment Of Intra-Abdominal Infections[NCT00360607] | Phase 4 | 307 participants (Actual) | Interventional | 2004-07-31 | Completed | ||
| Randomized Trial of Standard vs. Enhanced Hydration in Patients With a Diagnosis of Acute Pancreatitis Within the First Hour of the Diagnosis[NCT02709044] | Phase 2/Phase 3 | 903 participants (Anticipated) | Interventional | 2016-02-29 | Recruiting | ||
| The Use of Single Dose vs Short-Term Peri-Operative Cefazolin in the Prevention of Surgical Site Infection Following Orthognathic Surgery[NCT05852158] | Phase 4 | 400 participants (Anticipated) | Interventional | 2024-01-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for metronidazole and Bacterial Infections, Gram-Negative
| Article | Year |
|---|---|
Polymicrobial endocarditis involving Veillonella parvula in an intravenous drug user: case report and literature review of Veillonella endocarditis.
Topics: Adult; Anti-Bacterial Agents; Ceftriaxone; Endocarditis, Bacterial; Gram-Negative Bacterial Infectio | 2013 |
Ceftazidime-avibactam for the treatment of complicated intra-abdominal infections.
Topics: Azabicyclo Compounds; Bacterial Proteins; beta-Lactamase Inhibitors; beta-Lactamases; Ceftazidime; D | 2016 |
4 trials available for metronidazole and Bacterial Infections, Gram-Negative
| Article | Year |
|---|---|
In vitro activity of ceftobiprole against pathogens from two phase 3 clinical trials of complicated skin and skin structure infections.
Topics: Anti-Bacterial Agents; Cephalosporins; Enterobacteriaceae; Gram-Negative Bacteria; Gram-Negative Bac | 2008 |
Cefoperazone-sulbactam for treatment of intra-abdominal infections: results from a randomized, parallel group study in India.
Topics: Abdominal Abscess; Adolescent; Adult; Aged; Amikacin; Anti-Bacterial Agents; Cefoperazone; Ceftazidi | 2008 |
Prophylactic antibiotic treatment in patients with predicted severe acute pancreatitis: a placebo-controlled, double-blind trial.
Topics: Adult; Aged; Anti-Infective Agents; Ciprofloxacin; Double-Blind Method; Female; Gram-Negative Bacter | 2004 |
Bowel colonization with resistant gram-negative bacilli after antimicrobial therapy of intra-abdominal infections: observations from two randomized comparative clinical trials of ertapenem therapy.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactams; Carrier State; Ceft | 2005 |
26 other studies available for metronidazole and Bacterial Infections, Gram-Negative
| Article | Year |
|---|---|
Antimicrobial susceptibilities and clinical sources of Dialister species.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Negative Bacterial Infections; Humans; Micro | 2007 |
Severe Colitis with Portal Venous Gas Caused by Brachyspira pilosicoli Infection.
Topics: Abdominal Pain; Aged; Animals; Anti-Bacterial Agents; Brachyspira; Colitis; Diarrhea; Dog Diseases; | 2019 |
Cost-effectiveness of ceftolozane/tazobactam plus metronidazole compared with piperacillin/tazobactam as empiric therapy for the treatment of complicated intra-abdominal infections based on the in-vitro surveillance of bacterial isolates in the UK.
Topics: Anti-Bacterial Agents; Bacteriological Techniques; Cephalosporins; Clinical Protocols; Drug Combinat | 2017 |
Human intestinal spirochetosis mimicking ulcerative colitis.
Topics: Aged; Anti-Infective Agents; Brachyspira; Colitis; Colitis, Ulcerative; Colonoscopy; Diagnosis, Diff | 2018 |
Bartholin's abscess due to Dialister micraerophilus in a woman presenting with repetitive bartholinitis episodes.
Topics: Abscess; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Bartholin's Gl | 2018 |
Otogenic cerebellar abscess by Enterococcus avium, a very rare infectious agent.
Topics: Acetamides; Anti-Bacterial Agents; Brain Abscess; Cerebellar Diseases; Ciprofloxacin; Enterococcus; | 2013 |
First Case Report of Bacteremia Due to Catabacter hongkongensis in a Korean Patient.
Topics: Aged; Anti-Bacterial Agents; Cefotaxime; Cholangiopancreatography, Endoscopic Retrograde; Gallstones | 2017 |
The Brief Case: Anaerobiospirillum succiniciproducens Bacteremia and Pyomyositis.
Topics: Adult; Anaerobiospirillum; Anti-Infective Agents; Bacteremia; Bacteriological Techniques; Blood; Dra | 2017 |
Closing the Brief Case: Anaerobiospirillum succiniciproducens Bacteremia and Pyomyositis.
Topics: Adult; Anaerobiospirillum; Anti-Infective Agents; Bacteremia; Bacteriological Techniques; Blood; Dra | 2017 |
Infected lumbar dermoid cyst presenting with tetraparesis secondary to holocord central lesion.
Topics: Abscess; Cefotaxime; Child; Dermoid Cyst; Drug Therapy, Combination; Follow-Up Studies; Gram-Negativ | 2008 |
Refractory diarrhea in a patient with HIV infection.
Topics: Adult; Anti-Bacterial Agents; Antiretroviral Therapy, Highly Active; Brachyspira; Colon; Diarrhea; G | 2009 |
Meningitis and epidural abscess related to pansinusitis.
Topics: Bacteroidaceae Infections; Cefotaxime; Ceftriaxone; Child; Combined Modality Therapy; Consciousness | 2009 |
Antibiotic susceptibility of cocultures in polymicrobial infections such as peri-implantitis or periodontitis: an in vitro model.
Topics: Acetamides; Actinobacillus Infections; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicill | 2011 |
Relapse of polymicrobial endocarditis in an intravenous drug user.
Topics: Adult; Ceftriaxone; Coinfection; Eikenella corrodens; Endocarditis, Bacterial; Gram-Negative Bacteri | 2011 |
A 14-year-old with rectal bleeding and abdominal pain.
Topics: Abdominal Pain; Adolescent; Brachyspira; Colonoscopy; Erythromycin; Female; Gastrointestinal Hemorrh | 2011 |
Multicentre survey of the in-vitro activity of seven antimicrobial agents, including ertapenem, against recently isolated Gram-negative anaerobic bacteria in Greece.
Topics: Anti-Bacterial Agents; Bacteria, Anaerobic; Bacteroides fragilis; beta-Lactams; Carbapenems; Drug Re | 2005 |
[Postoperative infection of an epigastric hematoma caused by Aeromonas veronii biovar sobria].
Topics: Aeromonas; Anti-Bacterial Agents; Carcinoma, Signet Ring Cell; Cefotaxime; Gram-Negative Bacterial I | 2006 |
Fatal septicaemia due to Chromobacterium violaceum.
Topics: Adult; Ceftriaxone; Chromobacterium; Fatal Outcome; Gram-Negative Bacterial Infections; Humans; Male | 2007 |
Significant decrease of gram-negative anaerobic bacteremia in a major hospital from 1967-73 to 1981-89: an effect of the introduction of metronidazole?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bacteremia; Denmark; Female; Gram-Negative Anaerobic Bac | 1993 |
Studies on drug monitoring in thrice and once daily treatment with aminoglycosides.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cefotaxime; Cross Infection; Dose-Response Relationship, | 1993 |
Veillonella myositis in an immunocompromised patient.
Topics: Anti-Bacterial Agents; Combined Modality Therapy; Female; Gram-Negative Bacterial Infections; Humans | 1995 |
Treatment of gastritis in cheetahs (Acinonyx jubatus).
Topics: Acinonyx; Animals; Anti-Bacterial Agents; Antitrichomonal Agents; Biopsy; Bismuth; Dose-Response Rel | 1997 |
[Severe diffuse facial cellulitis].
Topics: Adolescent; Amikacin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inflammatory Agents; Bacter | 1997 |
[Bacterial flora in chronic purulent maxillary sinusitis].
Topics: Adult; Anti-Bacterial Agents; Anti-Infective Agents; Child; Child, Preschool; Clindamycin; Gram-Nega | 1997 |
Incidence of beta-lactamase production and antimicrobial susceptibility of anaerobic gram-negative rods isolated from pus specimens of orofacial odontogenic infections.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ampicillin Resistance; Anti-Bacterial Agents; Bacteroida | 2001 |
First documented case of Aeromonas veronii biovar sobria infection in northern Europe.
Topics: Aeromonas; Aged; Anti-Bacterial Agents; Appendiceal Neoplasms; Cefuroxime; Gram-Negative Bacterial I | 2002 |