metronidazole has been researched along with Alcohol Drinking in 19 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Alcohol Drinking: Behaviors associated with the ingesting of ALCOHOLIC BEVERAGES, including social drinking.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was administered intravenously for 20 min to healthy volunteers, and to patients with alcohol-induced, non-cirrhotic hepatopathy and liver cirrhosis." | 1.30 | Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury. ( Da Silva, CM; David, FL; De Nucci, G; Ferraz, JG; Muscará, MN; Pedrazzoli, J; Polimeno, NC; Sousa, SS, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (84.21) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cole, JO | 1 |
| Ahmed, DS | 1 |
| Fecik, S | 1 |
| Da Silva, CM | 1 |
| David, FL | 1 |
| Muscará, MN | 1 |
| Sousa, SS | 1 |
| Ferraz, JG | 1 |
| De Nucci, G | 1 |
| Polimeno, NC | 1 |
| Pedrazzoli, J | 1 |
| Solms, H | 1 |
| Loft, S | 1 |
| Poulsen, HE | 1 |
| Sonne, J | 1 |
| Døssing, M | 1 |
| Alexander, I | 1 |
| Mottin, JL | 1 |
| Kaplan, R | 1 |
| Blume, S | 1 |
| Rosenberg, S | 1 |
| Pitrelli, J | 1 |
| Turner, WJ | 1 |
| Goodwin, DW | 1 |
| Reinhard, J | 1 |
| Wilson, CW | 1 |
| Roy, RB | 1 |
| Laird, SM | 1 |
| Egan, WP | 1 |
| Goetz, R | 1 |
| Lal, S | 1 |
| Tyndel, M | 1 |
| Fraser, JG | 1 |
| Hartleib, CJ | 1 |
| Penick, SB | 1 |
| Carrier, RN | 1 |
| Sheldon, JB | 1 |
| Strassman, HD | 1 |
| Adams, B | 1 |
| Pearson, AW | 1 |
| Ewing, JA | 1 |
| Leger, JM | 1 |
| Daudet, G | 1 |
2 reviews available for metronidazole and Alcohol Drinking
| Article | Year |
|---|---|
Drug-induced attenuation of alcohol consumption. A review and evaluation of claimed, potential or current therapies.
Topics: Alcohol Deterrents; Alcohol Drinking; Alcoholism; Aversive Therapy; Conditioning, Classical; Conditi | 1973 |
The pharmacological actions of alcohol in relation to nutrition.
Topics: Absorption; Adult; Alcohol Drinking; Animals; Barbiturates; Behavior, Animal; Diffusion; Disulfiram; | 1972 |
7 trials available for metronidazole and Alcohol Drinking
| Article | Year |
|---|---|
Phenytoin, Metronidazole and multivitamins in the treatment of alcoholism.
Topics: Adult; Affect; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Evaluation Studies as Topic; | 1972 |
Disulfiramlike effects of trichomonacidal drugs. A review and double-blind study.
Topics: Acetaldehyde; Adult; Alcohol Drinking; Antitrichomonal Agents; Clinical Trials as Topic; Drug Intera | 1972 |
Effect of metronidazole on drinking by alcoholics.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Humans; Male; Metronidazole; Mi | 1968 |
Metronidazole in the treatment of alcoholism. A clinical trial and review of the literature.
Topics: Adult; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Humans; Male; Metronidazole; Middle A | 1969 |
Metronidazole as an adjuvant in the treatment of alcoholism.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Clinical Trials as Topic; Female; Humans; Male; Metronida | 1969 |
Metronidazole in the treatment of alcoholism.
Topics: Adult; Aged; Alcohol Drinking; Alcoholism; Chronic Disease; Clinical Trials as Topic; Female; Hospit | 1969 |
Metronidazole effect on social drinkers.
Topics: Adult; Alcohol Drinking; Clinical Trials as Topic; Ethanol; Female; Humans; Inhibition, Psychologica | 1970 |
10 other studies available for metronidazole and Alcohol Drinking
| Article | Year |
|---|---|
Alcoholism.
Topics: Alcohol Drinking; Alcoholism; Chlormethiazole; District of Columbia; Humans; Metronidazole; Reinforc | 1966 |
[Metronidazole, alcohol and rosacea].
Topics: Administration, Topical; Alcohol Drinking; Disulfiram; Drug Synergism; Ethanol; Humans; Metronidazol | 1993 |
The fatigue factor. When long shifts harm patients.
Topics: Adult; Alcohol Drinking; Anti-Infective Agents; Drug Interactions; Fatigue; Female; Humans; Medicati | 1999 |
Plasma hydroxy-metronidazole/metronidazole ratio can detect early changes in hepatic function in ethanol-induced liver injury.
Topics: Adolescent; Adult; Aged; Alcohol Drinking; Anti-Infective Agents; Chromatography, High Pressure Liqu | 1999 |
[Overconsumption of alcohol as a component of eating habits (proceedings)].
Topics: Alcohol Drinking; Alcoholism; Europe; Feeding Behavior; Humans; Metronidazole; Socioeconomic Factors | 1976 |
Metronidazole clearance: a one-sample method and influencing factors.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Alcohol Drinking; Antipyrine; Chro | 1988 |
'Alcohol-antabuse' syndrome in patients receiving metronidazole during gynaecological treatment.
Topics: Adolescent; Alcohol Drinking; Female; Humans; Metronidazole; Middle Aged | 1985 |
Comparison of procaine penicillin alone with ampicillin plus probenecid in the treatment of gonorrhoea in the male.
Topics: Administration, Oral; Alcohol Drinking; Ampicillin; Drug Therapy, Combination; England; Female; Gono | 1974 |
How to help the chronic alcoholic.
Topics: Alcohol Drinking; Alcoholism; Antidepressive Agents; Chronic Disease; Disulfiram; Humans; Metronidaz | 1972 |
[Craving for alcohol and its treatment].
Topics: Alcohol Drinking; Alcoholism; Ambulatory Care; Ethanol; Humans; Metronidazole; Parent-Child Relation | 1971 |