metronidazole has been researched along with Infantile Diarrhea in 17 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with metronidazole had no significant effect on the clinical outcome." | 1.33 | Limited clinical utility of Clostridium difficile toxin testing in infants in a pediatric hospital. ( Richardson, SE; Roscoe, M; Tang, P, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (58.82) | 18.7374 |
| 1990's | 4 (23.53) | 18.2507 |
| 2000's | 2 (11.76) | 29.6817 |
| 2010's | 1 (5.88) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kusztrich, A | 1 |
| Garten, L | 1 |
| Hüseman, D | 1 |
| Bührer, C | 1 |
| DEPEDRE, O | 1 |
| Kader, A | 1 |
| O'Hare, B | 1 |
| Valappil, MK | 1 |
| Tang, P | 1 |
| Roscoe, M | 1 |
| Richardson, SE | 1 |
| di Martino, L | 1 |
| Ecuba, P | 1 |
| De Campora, E | 1 |
| Cucchiara, S | 1 |
| de Ritis, G | 1 |
| Minichino, AM | 1 |
| Guandalini, S | 1 |
| Clements, CJ | 1 |
| Lentze, MJ | 1 |
| Hill, ID | 1 |
| Mann, MD | 1 |
| Bowie, MD | 1 |
| Iacono, G | 1 |
| Carroccio, A | 1 |
| Montalto, G | 1 |
| Cavataio, F | 1 |
| Lo Cascio, M | 1 |
| Notarbatolo, A | 1 |
| Bahl, R | 1 |
| Bhandari, N | 1 |
| Bhan, MK | 1 |
| Saxena, M | 1 |
| Bagati, A | 1 |
| Shann, F | 1 |
| Hocking, B | 1 |
| Sullivan, PB | 1 |
| Lunn, PG | 1 |
| Northrop-Clewes, C | 1 |
| Crowe, PT | 1 |
| Marsh, MN | 1 |
| Neale, G | 1 |
| Tedeschi, A | 1 |
| Scorza, A | 1 |
| Sferlazzas, C | 1 |
| Conti-Nibali, S | 1 |
| Grazia Saccà, M | 1 |
| Magazzù, G | 1 |
| Larchet, M | 1 |
| Duhamel, G | 1 |
| Pariente, D | 1 |
| Dumont, M | 1 |
| Degott, C | 1 |
| Godeau, E | 1 |
| Erlinger, S | 1 |
| Goulet, O | 1 |
| Ricour, C | 1 |
| Axton, JH | 1 |
| Garti, R | 1 |
| Kaplan, M | 1 |
1 review available for metronidazole and Infantile Diarrhea
| Article | Year |
|---|---|
[Hepatobiliary changes during exclusive parenteral feeding in infants with severe diarrhea].
Topics: Bile Acids and Salts; Bile Duct Diseases; Diarrhea, Infantile; Female; Humans; Infant; Liver; Liver | 1988 |
3 trials available for metronidazole and Infantile Diarrhea
| Article | Year |
|---|---|
Efficacy of antimicrobial treatment in non-dysenteric persistent diarrhoea in a community setting.
Topics: Anti-Infective Agents; Antitrichomonal Agents; Child, Preschool; Diarrhea, Infantile; Double-Blind M | 1996 |
Metronidazole for chronic diarrhoea in children.
Topics: Chronic Disease; Clinical Trials as Topic; Diarrhea, Infantile; Double-Blind Method; Humans; Infant; | 1979 |
[Hepatobiliary changes during exclusive parenteral feeding in infants with severe diarrhea].
Topics: Bile Acids and Salts; Bile Duct Diseases; Diarrhea, Infantile; Female; Humans; Infant; Liver; Liver | 1988 |
14 other studies available for metronidazole and Infantile Diarrhea
| Article | Year |
|---|---|
Hemolytic uremic syndrome in a preterm infant.
Topics: Anti-Infective Agents; Clostridioides difficile; Colitis; Combined Modality Therapy; Diarrhea, Infan | 2010 |
[CHRONIC DIARRHEA DUE TO LAMBLIAS].
Topics: Antiprotozoal Agents; Child; Diarrhea; Diarrhea, Infantile; Epidemiology; Giardia; Giardiasis; Human | 1963 |
Non-antibiotic associated C. difficile diarrhea in a 7 week-old infant.
Topics: Anti-Infective Agents; Clostridioides difficile; Clostridium Infections; Diarrhea, Infantile; Humans | 2004 |
Limited clinical utility of Clostridium difficile toxin testing in infants in a pediatric hospital.
Topics: Anti-Infective Agents; Bacterial Toxins; Case-Control Studies; Clostridioides difficile; Clostridium | 2005 |
[Colitis associated with giardiasis. Description of 2 cases].
Topics: Colitis; Diarrhea, Infantile; Giardiasis; Humans; Infant; Intestinal Diseases, Parasitic; Male; Metr | 1984 |
Metronidazole and breast feeding.
Topics: Breast Feeding; Cesarean Section; Diarrhea, Infantile; Female; Humans; Infant; Infant, Newborn; Lact | 1980 |
[Useful and superfluous measures in the treatment of infant diarrhea].
Topics: Bacterial Infections; Child, Preschool; Chromosome Aberrations; Chromosome Disorders; Diarrhea; Diar | 1982 |
Successful management of persistent diarrhoea in infants.
Topics: Cholestyramine Resin; Chronic Disease; Diarrhea, Infantile; Drug Therapy, Combination; Feces; Gentam | 1980 |
Extreme short bowel syndrome: a case for reviewing the guidelines for predicting survival.
Topics: Acidosis; Bacterial Infections; Bicarbonates; Breast Feeding; Catheters, Indwelling; Diarrhea, Infan | 1993 |
Metronidazole in recurrent diarrhoea of malnutrition.
Topics: Child, Preschool; Diarrhea, Infantile; Female; Humans; Infant; Infant Nutrition Disorders; Male; Met | 1976 |
Persistent diarrhea and malnutrition--the impact of treatment on small bowel structure and permeability.
Topics: Anti-Bacterial Agents; Antifungal Agents; Blood Proteins; Body Weight; Cell Membrane Permeability; C | 1992 |
Bowel cocktail and severe persistent diarrhea.
Topics: Cholestyramine Resin; Diarrhea, Infantile; Drug Therapy, Combination; Gentamicins; Humans; Infant; I | 1990 |
Amoebic proctocolitis and liver abscess in a neonate.
Topics: Colitis; Diarrhea, Infantile; Dysentery, Amebic; Female; Humans; Infant, Newborn; Infant, Newborn, D | 1972 |
[Amebic liver abscess in an infant].
Topics: Amoeba; Diarrhea, Infantile; Feces; Humans; Infant; Infant, Newborn; Liver; Liver Abscess, Amebic; M | 1972 |