metronidazole has been researched along with Agammaglobulinemia in 9 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Agammaglobulinemia: An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.
Excerpt | Relevance | Reference |
---|---|---|
"The giardiasis was eventually controlled by initial metronidazole and subsequent mepacrine therapy, but side effects necessitated the withdrawal of both of these drugs." | 1.28 | Common variable hypogammaglobulinemia. A case report. ( Girdwood, AH; Marks, IN; Price, SK; Ress, SR; Ruttenberg, D, 1990) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 8 (88.89) | 18.7374 |
1990's | 1 (11.11) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
LoGalbo, PR | 1 |
Sampson, HA | 1 |
Buckley, RH | 1 |
Webster, AD | 1 |
Hartong, WA | 1 |
Gourley, WK | 1 |
Arvanitakis, C | 1 |
Longy, M | 1 |
Delmas, M | 1 |
Costa, JM | 1 |
Roussy, P | 1 |
Sarrat, P | 1 |
Le Bras, M | 1 |
Veyret, V | 1 |
Moretti, G | 1 |
Raizman, RE | 1 |
Ruttenberg, D | 1 |
Ress, SR | 1 |
Price, SK | 1 |
Girdwood, AH | 1 |
Marks, IN | 1 |
Taylor, GD | 1 |
Wenman, WM | 1 |
Tyrrell, DL | 1 |
Ament, ME | 2 |
Rubin, CE | 1 |
Ochs, HD | 1 |
Davis, SD | 1 |
9 other studies available for metronidazole and Agammaglobulinemia
Article | Year |
---|---|
Symptomatic giardiasis in three patients with X-linked agammaglobulinemia.
Topics: Agammaglobulinemia; Child; Child, Preschool; Female; Genetic Linkage; Giardiasis; Humans; Immunoglob | 1982 |
Giardiasis and immunodeficiency diseases.
Topics: Adolescent; Agammaglobulinemia; Bacteria; Diarrhea; Giardiasis; Humans; Immunologic Deficiency Syndr | 1980 |
Giardiasis: clinical spectrum and functional--structural abnormalities of the small intestinal mucosa.
Topics: Adolescent; Adult; Agammaglobulinemia; Aged; Child; Child, Preschool; Esterases; Female; Giardiasis; | 1979 |
[Total atrophy of the villi during primary agammaglobulinemia in adults. Therapeutic problems (author's transl)].
Topics: Adjuvants, Immunologic; Adult; Agammaglobulinemia; Atrophy; Diarrhea; Giardiasis; Humans; Intestine, | 1979 |
Giardiasis: an overview for the clinician.
Topics: Adult; Agammaglobulinemia; Giardia; Giardiasis; Humans; Metronidazole; Quinacrine | 1976 |
Common variable hypogammaglobulinemia. A case report.
Topics: Agammaglobulinemia; Anemia, Pernicious; Female; Giardiasis; Humans; Immunization, Passive; Metronida | 1990 |
Combined metronidazole and quinacrine hydrochloride therapy for chronic giardiasis.
Topics: Agammaglobulinemia; Chronic Disease; Drug Therapy, Combination; Giardiasis; Humans; Male; Metronidaz | 1987 |
Relation of giardiasis to abnormal intestinal structure and function in gastrointestinal immunodeficiency syndromes.
Topics: Adult; Agammaglobulinemia; Celiac Disease; Duodenum; Female; Gastrointestinal Diseases; Giardiasis; | 1972 |
Giardiasis with malabsorption in X-linked agammaglobulinemia.
Topics: Agammaglobulinemia; Biopsy; Child; Duodenum; Giardiasis; Humans; Intestinal Absorption; Intestinal M | 1972 |