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metronidazole and Agammaglobulinemia

metronidazole has been researched along with Agammaglobulinemia in 9 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Agammaglobulinemia: An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood.

Research Excerpts

ExcerptRelevanceReference
"The giardiasis was eventually controlled by initial metronidazole and subsequent mepacrine therapy, but side effects necessitated the withdrawal of both of these drugs."1.28Common variable hypogammaglobulinemia. A case report. ( Girdwood, AH; Marks, IN; Price, SK; Ress, SR; Ruttenberg, D, 1990)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19908 (88.89)18.7374
1990's1 (11.11)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
LoGalbo, PR1
Sampson, HA1
Buckley, RH1
Webster, AD1
Hartong, WA1
Gourley, WK1
Arvanitakis, C1
Longy, M1
Delmas, M1
Costa, JM1
Roussy, P1
Sarrat, P1
Le Bras, M1
Veyret, V1
Moretti, G1
Raizman, RE1
Ruttenberg, D1
Ress, SR1
Price, SK1
Girdwood, AH1
Marks, IN1
Taylor, GD1
Wenman, WM1
Tyrrell, DL1
Ament, ME2
Rubin, CE1
Ochs, HD1
Davis, SD1

Other Studies

9 other studies available for metronidazole and Agammaglobulinemia

ArticleYear
Symptomatic giardiasis in three patients with X-linked agammaglobulinemia.
    The Journal of pediatrics, 1982, Volume: 101, Issue:1

    Topics: Agammaglobulinemia; Child; Child, Preschool; Female; Genetic Linkage; Giardiasis; Humans; Immunoglob

1982
Giardiasis and immunodeficiency diseases.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980, Volume: 74, Issue:4

    Topics: Adolescent; Agammaglobulinemia; Bacteria; Diarrhea; Giardiasis; Humans; Immunologic Deficiency Syndr

1980
Giardiasis: clinical spectrum and functional--structural abnormalities of the small intestinal mucosa.
    Gastroenterology, 1979, Volume: 77, Issue:1

    Topics: Adolescent; Adult; Agammaglobulinemia; Aged; Child; Child, Preschool; Esterases; Female; Giardiasis;

1979
[Total atrophy of the villi during primary agammaglobulinemia in adults. Therapeutic problems (author's transl)].
    Annales de medecine interne, 1979, Volume: 130, Issue:12

    Topics: Adjuvants, Immunologic; Adult; Agammaglobulinemia; Atrophy; Diarrhea; Giardiasis; Humans; Intestine,

1979
Giardiasis: an overview for the clinician.
    The American journal of digestive diseases, 1976, Volume: 21, Issue:12

    Topics: Adult; Agammaglobulinemia; Giardia; Giardiasis; Humans; Metronidazole; Quinacrine

1976
Common variable hypogammaglobulinemia. A case report.
    Journal of clinical gastroenterology, 1990, Volume: 12, Issue:3

    Topics: Agammaglobulinemia; Anemia, Pernicious; Female; Giardiasis; Humans; Immunization, Passive; Metronida

1990
Combined metronidazole and quinacrine hydrochloride therapy for chronic giardiasis.
    CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1987, Jun-01, Volume: 136, Issue:11

    Topics: Agammaglobulinemia; Chronic Disease; Drug Therapy, Combination; Giardiasis; Humans; Male; Metronidaz

1987
Relation of giardiasis to abnormal intestinal structure and function in gastrointestinal immunodeficiency syndromes.
    Gastroenterology, 1972, Volume: 62, Issue:2

    Topics: Adult; Agammaglobulinemia; Celiac Disease; Duodenum; Female; Gastrointestinal Diseases; Giardiasis;

1972
Giardiasis with malabsorption in X-linked agammaglobulinemia.
    The New England journal of medicine, 1972, Aug-17, Volume: 287, Issue:7

    Topics: Agammaglobulinemia; Biopsy; Child; Duodenum; Giardiasis; Humans; Intestinal Absorption; Intestinal M

1972