Page last updated: 2024-10-31

metronidazole and Stroke

metronidazole has been researched along with Stroke in 5 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
" Through the Cockayne Syndrome Natural History Study, we have identified 8 cases of acute hepatic failure after metronidazole administration (8% of our cohort), 3 of which were fatal."7.81Metronidazole Toxicity in Cockayne Syndrome: A Case Series. ( Munkley, J; O'Kelly, S; Stark, Z; Strong, A; Wilson, BT, 2015)
" Through the Cockayne Syndrome Natural History Study, we have identified 8 cases of acute hepatic failure after metronidazole administration (8% of our cohort), 3 of which were fatal."3.81Metronidazole Toxicity in Cockayne Syndrome: A Case Series. ( Munkley, J; O'Kelly, S; Stark, Z; Strong, A; Wilson, BT, 2015)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's1 (20.00)2.80

Authors

AuthorsStudies
Liu, C2
Cheng, X1
Zhong, S1
Liu, Z1
Liu, F1
Lin, X1
Zhao, Y1
Guan, M1
Xiao, T1
Jolkkonen, J1
Wang, Y1
Zhao, C1
Takada, K1
Maki, Y1
Kinosada, M1
Ishibashi, R1
Chin, M1
Yamagata, S1
Wilson, BT1
Strong, A1
O'Kelly, S1
Munkley, J1
Stark, Z1
Aebischer, B1
Elsig, S1
Taeymans, J1
Pomp, S1
Kuhness, D1
Barcaro, G1
Sementa, L1
Mankad, V1
Fortunelli, A1
Sterrer, M1
Netzer, FP1
Surnev, S1
Schmieder, AH1
Caruthers, SD1
Keupp, J1
Wickline, SA1
Lanza, GM1
Lowe, J1
Wodarcyk, AJ1
Floyd, KT1
Rastogi, N1
Schultz, EJ1
Swager, SA1
Chadwick, JA1
Tran, T1
Raman, SV1
Janssen, PM1
Rafael-Fortney, JA1
Alcalay, RN1
Levy, OA1
Wolf, P1
Oliva, P1
Zhang, XK1
Waters, CH1
Fahn, S1
Kang, U1
Liong, C1
Ford, B1
Mazzoni, P1
Kuo, S1
Johnson, A1
Xiong, L1
Rouleau, GA1
Chung, W1
Marder, KS1
Gan-Or, Z1
Kamei, K1
Terao, T1
Katayama, Y1
Hatano, K1
Kodama, K1
Shirahama, M1
Sakai, A1
Hirakawa, H1
Mizokami, Y1
Shiotsuki, I1
Ishii, N1
Inoue, Y1
Akboga, MK1
Yayla, C1
Balci, KG1
Ozeke, O1
Maden, O1
Kisacik, H1
Temizhan, A1
Aydogdu, S1
Zhu, J2
Ying, SH1
Feng, MG1
Zhang, XG1
Li, H1
Wang, L1
Hao, YY1
Liang, GD1
Ma, YH1
Yang, GS1
Hu, JH1
Pfeifer, L1
Goertz, RS1
Neurath, MF1
Strobel, D1
Wildner, D1
Lin, JT1
Yang, XN1
Zhong, WZ1
Liao, RQ1
Dong, S1
Nie, Q1
Weng, SX1
Fang, XJ1
Zheng, JY1
Wu, YL1
Řezanka, T1
Kaineder, K1
Mezricky, D1
Řezanka, M1
Bišová, K1
Zachleder, V1
Vítová, M1
Rinker, JA1
Marshall, SA1
Mazzone, CM1
Lowery-Gionta, EG1
Gulati, V1
Pleil, KE1
Kash, TL1
Navarro, M1
Thiele, TE1
Zhang, Y1
Huang, Y1
Jin, Z1
Li, X1
Li, B1
Xu, P1
Huang, P1
Fokdal, L1
Sturdza, A1
Mazeron, R1
Haie-Meder, C1
Tan, LT1
Gillham, C1
Šegedin, B1
Jürgenliemk-Schultz, I1
Kirisits, C1
Hoskin, P1
Pötter, R1
Lindegaard, JC1
Tanderup, K1
Levin, DE1
Schmitz, AJ1
Hines, SM1
Hines, KJ1
Tucker, MJ1
Brewer, SH1
Fenlon, EE1
Álvarez-Pérez, S1
Blanco, JL1
Peláez, T1
Martínez-Nevado, E1
García, ME1
Puckerin, AA1
Chang, DD1
Subramanyam, P1
Colecraft, HM1
Dogan, H1
Coteli, E1
Karatas, F1
Ceylan, O1
Sahin, MD1
Akdamar, G1
Kryczyk, A1
Żmudzki, P1
Hubicka, U1
Giovannelli, D1
Chung, M1
Staley, J1
Starovoytov, V1
Le Bris, N1
Vetriani, C1
Chen, W1
Wu, L1
Liu, X1
Shen, Y1
Liang, Y1
Tan, H1
Yang, Y1
Liu, Q1
Wang, M1
Liu, L1
Wang, X1
Liu, B1
Liu, GH1
Zhu, YJ1
Wang, JP1
Che, JM1
Chen, QQ1
Chen, Z1
Maucksch, U1
Runge, R1
Wunderlich, G1
Freudenberg, R1
Naumann, A1
Kotzerke, J1
Song, HC1
Bom, HS1
Cho, KH1
Kim, BC1
Seo, JJ1
Kim, CG1
Yang, DJ1
Kim, EE1

Reviews

1 review available for metronidazole and Stroke

ArticleYear
    Hand therapy, 2016, Volume: 21, Issue:1

    Topics: AC133 Antigen; Acenaphthenes; Acer; Acrosome Reaction; Adult; Agaricales; Aged; Aged, 80 and over; A

2016

Trials

1 trial available for metronidazole and Stroke

ArticleYear
Prognostication of recovery in patients with acute ischemic stroke through the use of brain SPECT with Technetium-99m--labeled metronidazole.
    Stroke, 2003, Volume: 34, Issue:4

    Topics: Acute Disease; Aged; Brain; Brain Ischemia; Cysteine; Diffusion Magnetic Resonance Imaging; Female;

2003

Other Studies

3 other studies available for metronidazole and Stroke

ArticleYear
Long-term modification of gut microbiota by broad-spectrum antibiotics improves stroke outcome in rats.
    Stroke and vascular neurology, 2022, Volume: 7, Issue:5

    Topics: Ampicillin; Animals; Anti-Bacterial Agents; Ciprofloxacin; Cytokines; Endothelin-1; Fatty Acids, Vol

2022
Metronidazole Induced Encephalopathy Mimicking an Acute Ischemic Stroke Event.
    Neurologia medico-chirurgica, 2018, Sep-15, Volume: 58, Issue:9

    Topics: Aged, 80 and over; Anti-Bacterial Agents; Brain Ischemia; Diagnosis, Differential; Female; Humans; M

2018
Metronidazole Toxicity in Cockayne Syndrome: A Case Series.
    Pediatrics, 2015, Volume: 136, Issue:3

    Topics: Adolescent; Anti-Infective Agents; Cockayne Syndrome; Fatal Outcome; Female; Gastrointestinal Diseas

2015