metronidazole has been researched along with Hypoxia in 37 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The influence of metronidazole, misonidazole, and desmethylmisonidazole on the induction of lung adenomas in the strain A mouse was examined." | 3.66 | Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation. ( Grdina, DJ; Mian, TA; Theiss, JC, 1983) |
| " Using comparable dosage Ro-07-0582 seems approximately three times more effective than metronidazole." | 1.26 | Clinical testing of the radiosensitiser Ro-07-0582. II. Radiosensitisation of normal and hypoxic skin. ( Dische, S; Gray, AJ; Zanelli, GD, 1976) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (67.57) | 18.7374 |
| 1990's | 2 (5.41) | 18.2507 |
| 2000's | 4 (10.81) | 29.6817 |
| 2010's | 4 (10.81) | 24.3611 |
| 2020's | 2 (5.41) | 2.80 |
| Authors | Studies |
|---|---|
| Linder, KE | 1 |
| Chan, YW | 1 |
| Cyr, JE | 1 |
| Malley, MF | 1 |
| Nowotnik, DP | 1 |
| Nunn, AD | 1 |
| Gupta, RK | 1 |
| Thakur, TS | 1 |
| Desiraju, GR | 1 |
| Tyagi, JS | 1 |
| Spector, DV | 1 |
| Erofeev, AS | 1 |
| Gorelkin, PV | 1 |
| Vaneev, AN | 1 |
| Akasov, RA | 1 |
| Ul'yanovskiy, NV | 1 |
| Nikitina, VN | 1 |
| Semkina, AS | 1 |
| Vlasova, KY | 1 |
| Soldatov, MA | 1 |
| Trigub, AL | 1 |
| Skvortsov, DA | 1 |
| Finko, AV | 1 |
| Zyk, NV | 1 |
| Sakharov, DA | 1 |
| Majouga, AG | 1 |
| Beloglazkina, EK | 1 |
| Krasnovskaya, OO | 1 |
| Yang, L | 1 |
| Afshari, MJ | 1 |
| Ge, J | 1 |
| Kou, D | 1 |
| Chen, L | 1 |
| Zhou, D | 1 |
| Li, C | 1 |
| Wu, S | 1 |
| Zhang, L | 1 |
| Zeng, J | 1 |
| Zhong, J | 1 |
| Stauber, RH | 1 |
| Gao, M | 1 |
| Sano, K | 1 |
| Okada, M | 1 |
| Hisada, H | 1 |
| Shimokawa, K | 1 |
| Saji, H | 1 |
| Maeda, M | 1 |
| Mukai, T | 1 |
| O'Connor, LJ | 1 |
| Cazares-Körner, C | 1 |
| Saha, J | 1 |
| Evans, CN | 1 |
| Stratford, MR | 1 |
| Hammond, EM | 1 |
| Conway, SJ | 1 |
| Wang, R | 1 |
| Sun, Y | 1 |
| Yin, Q | 1 |
| Xie, H | 1 |
| Li, W | 1 |
| Wang, C | 1 |
| Guo, J | 1 |
| Hao, Y | 1 |
| Tao, R | 1 |
| Jia, Z | 1 |
| Splith, K | 1 |
| Bergmann, R | 1 |
| Pietzsch, J | 1 |
| Neundorf, I | 1 |
| Ballinger, JR | 1 |
| Hsue, V | 1 |
| Rauth, AM | 3 |
| Mallia, MB | 1 |
| Mathur, A | 1 |
| Subramanian, S | 1 |
| Banerjee, S | 1 |
| Sarma, HD | 1 |
| Venkatesh, M | 1 |
| Via, LE | 1 |
| Lin, PL | 1 |
| Ray, SM | 1 |
| Carrillo, J | 1 |
| Allen, SS | 1 |
| Eum, SY | 1 |
| Taylor, K | 1 |
| Klein, E | 1 |
| Manjunatha, U | 1 |
| Gonzales, J | 1 |
| Lee, EG | 1 |
| Park, SK | 1 |
| Raleigh, JA | 1 |
| Cho, SN | 1 |
| McMurray, DN | 1 |
| Flynn, JL | 1 |
| Barry, CE | 1 |
| Gutin, PH | 1 |
| Wara, WM | 1 |
| Phillips, TL | 2 |
| Wilson, CB | 1 |
| Mian, TA | 1 |
| Theiss, JC | 1 |
| Grdina, DJ | 1 |
| Korbelik, M | 1 |
| Horvat, D | 1 |
| Ivnitskiĭ, IuIu | 1 |
| Malakhovskiĭ, VN | 1 |
| Karim, AB | 1 |
| Dische, S | 2 |
| Fowler, JF | 2 |
| Postescu, ID | 1 |
| Mustea, I | 1 |
| Suciu, D | 1 |
| Comes, R | 1 |
| Eriksen, T | 1 |
| Sjöberg, L | 1 |
| Révész, L | 1 |
| Littbrand, B | 1 |
| Kelly, JP | 1 |
| Hannam, TW | 1 |
| Giles, GR | 1 |
| Magdon, E | 1 |
| Schröder, E | 1 |
| Hofer, KG | 1 |
| Hofer, MG | 1 |
| Ieracitano, J | 1 |
| McLaughlin, WH | 1 |
| Sheldon, PW | 2 |
| Hill, SA | 1 |
| Whitmore, GF | 1 |
| Foster, JL | 4 |
| Flockhart, IR | 1 |
| Adams, GE | 1 |
| Kaufman, K | 1 |
| Mohindra, JK | 1 |
| Conroy, PJ | 1 |
| Searle, AJ | 1 |
| Willson, RL | 2 |
| Gray, AJ | 1 |
| Zanelli, GD | 1 |
| Jerabek, PA | 1 |
| Patrick, TB | 1 |
| Kilbourn, MR | 1 |
| Dischino, DD | 1 |
| Welch, MJ | 1 |
| Wideł, M | 1 |
| Watras, J | 1 |
| Suwiński, J | 1 |
| Salwińska, E | 1 |
| Stone, HB | 1 |
| Withers, HR | 1 |
| Begg, AC | 1 |
4 reviews available for metronidazole and Hypoxia
| Article | Year |
|---|---|
Radiation sensitizers.
Topics: Animals; Antineoplastic Agents; Bromodeoxycytidine; Bromodeoxyuridine; Carcinoma; Deoxyuridine; Dogs | 1976 |
Chemical modification of radiation effects.
Topics: Animals; Antineoplastic Agents; Bromodeoxyuridine; Cell Survival; Cysteamine; DNA; Drug Evaluation; | 1977 |
Radiosensitizers in the treatment of squamous cell carcinoma of the head and neck.
Topics: Animals; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Hyperbaric Oxygenation; Hypoxia; | 1977 |
The potential for radiation sensitizers and possible strategy for use.
Topics: Animals; Female; Humans; Hypoxia; Laryngeal Neoplasms; Metronidazole; Nitro Compounds; Ovarian Neopl | 1975 |
1 trial available for metronidazole and Hypoxia
| Article | Year |
|---|---|
Hypoxic cell radiosensitizers.
Topics: Animals; Clinical Trials as Topic; Humans; Hyperbaric Oxygenation; Hypoxia; Metronidazole; Mice; Mis | 1978 |
32 other studies available for metronidazole and Hypoxia
| Article | Year |
|---|---|
TcO(PnA.O-1-(2-nitroimidazole)) [BMS-181321], a new technetium-containing nitroimidazole complex for imaging hypoxia: synthesis, characterization, and xanthine oxidase-catalyzed reduction.
Topics: Chromatography, High Pressure Liquid; Crystallization; Crystallography, X-Ray; Dimethylformamide; El | 1994 |
Structure-based design of DevR inhibitor active against nonreplicating Mycobacterium tuberculosis.
Topics: Aerobiosis; Antitubercular Agents; Bacterial Proteins; Binding Sites; Computational Biology; DNA, Ba | 2009 |
Electrochemical Detection of a Novel Pt(IV) Prodrug with the Metronidazole Axial Ligand in the Hypoxic Area.
Topics: Antineoplastic Agents; Carbon; Cell Line, Tumor; Cisplatin; Humans; Hypoxia; Ligands; Metronidazole; | 2022 |
Functionalized Ultrasmall Iron Oxide Nanoparticles for
Topics: Contrast Media; Humans; Hypoxia; Magnetic Iron Oxide Nanoparticles; Magnetic Resonance Imaging; Magn | 2022 |
In vivo evaluation of a radiogallium-labeled bifunctional radiopharmaceutical, Ga-DOTA-MN2, for hypoxic tumor imaging.
Topics: Animals; Cell Line, Tumor; Contrast Media; Female; Gallium Radioisotopes; Heterocyclic Compounds, 1- | 2013 |
Design, synthesis and evaluation of molecularly targeted hypoxia-activated prodrugs.
Topics: Antineoplastic Agents; Cell Line, Tumor; Checkpoint Kinase 1; Enzyme Inhibitors; Humans; Hypoxia; Me | 2016 |
The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300m.
Topics: Acclimatization; Altitude; Animals; Anti-Bacterial Agents; Blood Gas Analysis; Cytochrome P-450 CYP1 | 2017 |
Specific targeting of hypoxic tumor tissue with nitroimidazole-peptide conjugates.
Topics: Amino Acid Sequence; Animals; Cell-Penetrating Peptides; Drug Delivery Systems; Hypoxia; Metronidazo | 2012 |
Accumulation of technetium-99m glucarate: in vitro cell cultures and in vivo tumour models.
Topics: Animals; Azides; Carcinoma, Squamous Cell; CHO Cells; Cricetinae; Cricetulus; Fibrosarcoma; Fructose | 2003 |
A novel [99mTc[triple bond]N]2+ complex of metronidazole xanthate as a potential agent for targeting hypoxia.
Topics: Animals; Hypoxia; Imidazoles; Ligands; Metronidazole; Mice; Molecular Structure; Neoplasm Transplant | 2005 |
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates.
Topics: Animals; Antitubercular Agents; Disease Models, Animal; Granuloma; Guinea Pigs; Humans; Hypoxia; Imm | 2008 |
Hypoxic cell radiosensitizers in the treatment of malignant brain tumors.
Topics: Animals; Brain Neoplasms; Cricetinae; DNA; Glioblastoma; Humans; Hypoxia; In Vitro Techniques; Metro | 1980 |
Lung tumorigenic response of strain A mice exposed to hypoxic cell sensitizers alone and in combination with gamma-radiation.
Topics: Adenoma; Animals; Hypoxia; Lung; Lung Neoplasms; Metronidazole; Mice; Mice, Inbred A; Misonidazole; | 1983 |
The mutagenicity of nitroaromatic drugs: effect of metronidazole after incubation in hypoxia in vitro.
Topics: Animals; Cell Line; Chromosome Aberrations; Chromosomes; Cricetinae; Cricetulus; Hypoxia; Lung; Metr | 1980 |
[Gas exchange as a factor of the body radiation resistance].
Topics: Animals; Blood Gas Analysis; Body Weight; Cerebrovascular Circulation; Hypoxia; Male; Metronidazole; | 1998 |
Hypoxic-cell sensitisers.
Topics: Dose-Response Relationship, Drug; Drug Evaluation; Humans; Hypoxia; Metronidazole; Misonidazole; Neo | 1978 |
Characterization of metronidazole-phosphate, a water-soluble metronidazole derivative, as a radiosensitizer of hypoxic cells.
Topics: Animals; Cricetinae; Electrons; Half-Life; Hypoxia; Male; Metronidazole; Mice; Oxygen Consumption; S | 1979 |
The cytocidal action of metronidazole in combination with other antineoplastic agents.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Survival; Cells, Cultured; Colonic Neoplasms; D | 1979 |
[The effect of metronidazol on the survival rate of whole-body irradiated mice and DNA repair synthesis of lymphocytes].
Topics: Animals; Cells, Cultured; DNA; DNA Repair; Hypoxia; Lymphocytes; Metronidazole; Mice; Mice, Inbred C | 1978 |
Radiosensitization of hypoxic tumor cells by simultaneous administration of hyperthermia and nitroimidazoles.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Deoxyuridine; Female; Hyperthermia, Induced; Hypox | 1977 |
Hypoxic cell radiosensitizers and local control by X-ray of a transplanted tumour in mice.
Topics: Animals; Hypoxia; Metronidazole; Mice; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Exp | 1977 |
Proceedings: Some pharmacological considerations important in the selection of radiosensitizing drugs.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Humans; Hypoxia; In Vitro Techniques; Metronidazole | 1975 |
Proceedings: Radiosensitization of hypoxic cells in solid tumours in mice.
Topics: Animals; Fast Neutrons; Guinea Pigs; Humans; Hypoxia; Metronidazole; Mice; Nausea; Neoplasms, Experi | 1975 |
In vivo testing of hypoxic radiosensitizers using the KHT murine tumour assayed by the lung-colony technique.
Topics: Animals; Cell Division; Cell Survival; Dose-Response Relationship, Radiation; Hypoxia; Kinetics; Let | 1975 |
Increased cell killing by metronidazole and nitrofurazone of hypoxic compared to aerobic mammalian cells.
Topics: Air; Cell Division; Cell Line; Cells, Cultured; HeLa Cells; Hypoxia; Metronidazole; Nitrofurazone; N | 1976 |
Metronidazole (Flagyl): characterization as a cytotoxic drug specific for hypoxic tumour cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Survival; Dose-Response Relationship, Drug; Drug Evaluation, | 1976 |
Clinical testing of the radiosensitiser Ro-07-0582. II. Radiosensitisation of normal and hypoxic skin.
Topics: Constriction; Drug Evaluation; Humans; Hypoxia; Metronidazole; Nitroimidazoles; Oxygen; Radiation Do | 1976 |
Synthesis and biodistribution of 18F-labeled fluoronitroimidazoles: potential in vivo markers of hypoxic tissue.
Topics: Animals; Fluorine; Hypoxia; Metronidazole; Misonidazole; Nitroimidazoles; Radioisotopes; Radionuclid | 1986 |
Chloronitroimidazoles as radiosensitizers of hypoxic cells in vitro.
Topics: Aerobiosis; Animals; Cell Survival; Chlorine; Glutathione; Hypoxia; Metronidazole; Misonidazole; Nit | 1987 |
Tumor and normal tissue response to metronidazole and irradiation in mice.
Topics: Animals; Carcinoma; Cesium Isotopes; Dose-Response Relationship, Radiation; Epithelium; Female; Hypo | 1974 |
Radiosensitization of anoxic cells by metronidazole.
Topics: Hypoxia; Metronidazole; Oxygen Consumption; Plants; Radiation Effects; Radiation-Sensitizing Agents; | 1973 |
Demonstration of radiosensitization of hypoxic cells in solid tumours by metronidazole.
Topics: Animals; Dose-Response Relationship, Radiation; Hypoxia; Iodine Radioisotopes; Mammary Neoplasms, Ex | 1974 |