metronidazole has been researched along with Abscess, Peritonsillar in 13 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Search terms included all variations of peritonsillar abscess, penicillin and metronidazole." | 3.01 | A systematic review of the role of penicillin versus penicillin plus metronidazole in the management of peritonsillar abscess. ( Coleman, H; Douglas, CM; Lou, X; Moen, CM; Paramjothy, K; Smith, A; Williamson, A, 2023) |
| "Lemierre's syndrome is characterized by acute oropharyngeal infection complicated by internal jugular venous thrombosis secondary to septic thrombophlebitis, and metastatic abscesses." | 2.43 | Lemierre's syndrome presenting with peritonsillar abscess and VIth cranial nerve palsy. ( Jones, C; O'Reilly, BJ; Seymour, FK; Siva, TM, 2006) |
| "All patients with acute tonsillitis, peritonsillar abscess (PTA), and parapharyngeal abscess admitted to the Ear-Nose-Throat Department, Aarhus University Hospital, in the 2001-2014 period were included in the study." | 1.51 | Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections. ( Danstrup, CS; Klug, TE; Øhrstrøm, MT, 2019) |
| "Lemierre's syndrome is a condition characterised by suppurative thrombophlebitis of the internal jugular (IJ) vein following a recent oropharyngeal infection, with resulting septicaemia and metastatic lesions." | 1.48 | Lesson of the month 1: Lemierre's syndrome: a reminder of the 'forgotten disease'. ( Fattah, Z; Vijay, V, 2018) |
| "For cases of peritonsillar abscess, benzylpenicillin with metronidazole was the most common antibiotic combination chosen." | 1.36 | National UK survey of antibiotics prescribed for acute tonsillitis and peritonsillar abscess. ( Nix, P; Visvanathan, V, 2010) |
| "Acquired long QT syndrome is a rare condition whose diagnosis is of vital importance given the risk of torsade de pointes and sudden death." | 1.36 | [Perioperative acquired long QT syndrome: a case report]. ( Arizaga, A; Goitia, L; Pérez, P; Sebastián, P; Taibo, JM, 2010) |
| "In the routine management of peritonsillar abscess, bacteriologic studies are unnecessary on initial presentation." | 1.34 | [The microbiology of peritonsillar abscesses]. ( Gajda, M; Zagólski, O, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (7.69) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Moen, CM | 1 |
| Paramjothy, K | 1 |
| Williamson, A | 1 |
| Coleman, H | 1 |
| Lou, X | 1 |
| Smith, A | 1 |
| Douglas, CM | 1 |
| Vijay, V | 1 |
| Fattah, Z | 1 |
| Øhrstrøm, MT | 1 |
| Danstrup, CS | 1 |
| Klug, TE | 1 |
| Wikstén, JE | 1 |
| Pitkäranta, A | 1 |
| Blomgren, K | 1 |
| Feasson, T | 1 |
| Debeaupte, M | 1 |
| Bidet, C | 1 |
| Ader, F | 1 |
| Disant, F | 1 |
| Ferry, T | 1 |
| Chidiac, C | 1 |
| Valour, F | 1 |
| Zagólski, O | 1 |
| Gajda, M | 1 |
| Repanos, C | 1 |
| Mukherjee, P | 1 |
| Alwahab, Y | 1 |
| Visvanathan, V | 1 |
| Nix, P | 1 |
| Goitia, L | 1 |
| Pérez, P | 1 |
| Sebastián, P | 1 |
| Taibo, JM | 1 |
| Arizaga, A | 1 |
| Zätterstrøm, UK | 1 |
| Hokland, BM | 1 |
| Walberg, M | 1 |
| Stubhaug, A | 1 |
| Aaløkken, TM | 1 |
| Frøland, SS | 1 |
| Jones, C | 1 |
| Siva, TM | 1 |
| Seymour, FK | 1 |
| O'Reilly, BJ | 1 |
| Carlson, ER | 1 |
| Bergamo, DF | 1 |
| Coccia, CT | 1 |
| Maheshwar, AA | 1 |
| Jones, MB | 1 |
| Evans, RA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Penicillin and Metronidazole in Treatment of Peritonsillar Abscess - Prospective, Double-blind, Randomized, Placebo-controlled Study[NCT01255670] | 200 participants (Actual) | Interventional | 2010-02-28 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Number of participants recovering from peritonsillar abscess having metronidazole in addition to penicillin or penicillin and placebo. (NCT01255670)
Timeframe: 28 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Penicillin and Metronidazole | 74 |
| Penicillin and Placebo | 80 |
Number of participants with recurrence of peritonsillar abscess having metronidazole in addition to penicillin or penicillin and placebo. (NCT01255670)
Timeframe: 56 days
| Intervention | Participants (Count of Participants) |
|---|---|
| Penicillin and Metronidazole | 10 |
| Penicillin and Placebo | 10 |
2 reviews available for metronidazole and Abscess, Peritonsillar
| Article | Year |
|---|---|
A systematic review of the role of penicillin versus penicillin plus metronidazole in the management of peritonsillar abscess.
Topics: Anti-Bacterial Agents; Drainage; Humans; Metronidazole; Penicillin V; Penicillins; Peritonsillar Abs | 2023 |
Lemierre's syndrome presenting with peritonsillar abscess and VIth cranial nerve palsy.
Topics: Abducens Nerve Diseases; Adolescent; Anti-Bacterial Agents; Cefotaxime; Female; Follow-Up Studies; H | 2006 |
1 trial available for metronidazole and Abscess, Peritonsillar
| Article | Year |
|---|---|
Metronidazole in conjunction with penicillin neither prevents recurrence nor enhances recovery from peritonsillar abscess when compared with penicillin alone: a prospective, double-blind, randomized, placebo-controlled trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Double-Blind Method; Drainage; Dr | 2016 |
10 other studies available for metronidazole and Abscess, Peritonsillar
| Article | Year |
|---|---|
Lesson of the month 1: Lemierre's syndrome: a reminder of the 'forgotten disease'.
Topics: Anti-Bacterial Agents; Drainage; Early Diagnosis; Fusobacterium necrophorum; Humans; Jugular Veins; | 2018 |
Adherence to antibiotic guidelines in the treatment of acute pharyngeal infections.
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Denmark; Drug Prescriptions; Female; Guideline Adherenc | 2019 |
Impact of anti-inflammatory drug consumption in peritonsillar abscesses: a retrospective cohort study.
Topics: Adrenal Cortex Hormones; Adult; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents | 2016 |
[The microbiology of peritonsillar abscesses].
Topics: Acute Disease; Adult; Anti-Bacterial Agents; Drug Resistance, Bacterial; Female; Humans; Male; Metro | 2007 |
Role of microbiological studies in management of peritonsillar abscess.
Topics: Acute Disease; Anti-Infective Agents; Bacteria, Anaerobic; Cephalosporins; England; Humans; Metronid | 2009 |
National UK survey of antibiotics prescribed for acute tonsillitis and peritonsillar abscess.
Topics: Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Cefuroxime; Drug Therapy, Comb | 2010 |
[Perioperative acquired long QT syndrome: a case report].
Topics: Adjuvants, Anesthesia; Adrenergic beta-Antagonists; Amoxicillin-Potassium Clavulanate Combination; A | 2010 |
[A throat infection with rapid deterioration].
Topics: Abscess; Anti-Bacterial Agents; Diagnosis, Differential; Disease Progression; Drug Therapy, Combinat | 2002 |
Lemierre's syndrome: two cases of a forgotten disease.
Topics: Adolescent; Arthritis, Infectious; Bacteremia; Cefoxitin; Clindamycin; Fusobacterium Infections; Fus | 1994 |
Efficacy and safety of 'hot' tonsillectomy.
Topics: Acute Disease; Adolescent; Adult; Aged; Amoxicillin-Potassium Clavulanate Combination; Biopsy, Needl | 2001 |