metronidazole has been researched along with Rectal Diseases in 42 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Rectal Diseases: Pathological developments in the RECTUM region of the large intestine (INTESTINE, LARGE).
| Excerpt | Relevance | Reference |
|---|---|---|
| " sordellii ischio-rectal abscess with rapidly fatal septicaemia is described which complicated ultrasound-guided transrectal biopsy of the prostate, despite ciprofloxacin prophylaxis." | 3.70 | Fatal Clostridium sordellii ischio-rectal abscess with septicaemia complicating ultrasound-guided transrectal prostate biopsy. ( Borer, A; Buskila, D; Gilad, J; Riesenberg, K; Schlaeffer, F; Sikuler, E, 1999) |
| " It is concluded that the intravenous chemoprophylaxis should be preferred because of the lowest dosage and therefore the fewest side-effects." | 2.66 | [Antimicrobial chemoprevention in colorectal interventions: a single parenteral dose at the start of surgery is adequate]. ( Berker-von-Schlichting, C; Hancke, E; Jensen, JC; Marklein, G; Stute, H; Voigt, U, 1986) |
| "The rate of postoperative wound infections was not significantly different in the groups (p = 0,09)." | 2.66 | [Perioperative antibiotic prevention in colon and rectum surgery. A randomized study on the value of single dose prevention]. ( Athanasiadis, S; Hahnel, E; Kuhlgatz, C, 1985) |
| "The effect of 1-day mechanical bowel preparation with 10% mannitol combined with oral neomycin and short-term perioperative intravenous Flagyl (group I) was studied in a prospective, randomized, double-blind study and was compared with oral neomycin and an intravenous placebo (Group II)." | 2.66 | A prospective, randomized, double-blind study of 10% mannitol mechanical bowel preparation combined with oral neomycin and short-term, perioperative, intravenous Flagyl as prophylaxis in elective colorectal resections. ( Fazio, VW; Jagelman, DG; Lavery, IC; Weakley, FL, 1985) |
| "Anaerobic sepsis was not seen at all and the surgical infection rate was 34." | 2.65 | Comparison of systemic prophylaxis with metronidazole/placebo and metronidazole/fosfomycin in colorectal surgery. A clinical study demonstrating the need for additional anti-aerobic prophylactic cover. ( Andåker, L; Höjer, H; Lindhagen, J, 1984) |
| "Patients with symptomatic anorectal Crohn's disease were studied in a prospective, nonblinded, nonrandomized study to evaluate the efficacy of topical 10 percent metronidazole." | 1.33 | Efficacy of topical metronidazole (10 percent) in the treatment of anorectal Crohn's disease. ( Armstrong, D; Nicholson, TJ; Stringer, EE, 2005) |
| "The rates of postoperative wound infection were 47." | 1.28 | [Preoperative oral antimicrobial bowel preparations in elective colorectal surgery]. ( Abe, O; Ishibiki, K; Kato, S; Kodaira, S; Ono, S; Tanaka, T, 1990) |
| " Oral administration of poorly absorbed antibiotics was for a long time a common practice in preparing patients for elective clo-rectal operations." | 1.28 | [Preoperative topical antibiotics in patients subjected to short term prophylaxis for colorectal surgery]. ( Castoldi, R; Di Carlo, V; Di Palo, S; Ferrari, G, 1989) |
| "In the case reported, rectal ameboma was responsible for the patient's rectal pain, hematochezia and weight loss." | 1.27 | Rectal ameboma. ( Ossowski, EM, 1984) |
| "OH-tinidazole was not detected in patient specimens (assay standards ensured that it could be assayed)." | 1.27 | Comparative pharmacokinetics of metronidazole and tinidazole and their tissue penetration. ( Bergan, T; Leinebø, O; Solhaug, JH; Søreide, O, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 26 (61.90) | 18.7374 |
| 1990's | 9 (21.43) | 18.2507 |
| 2000's | 4 (9.52) | 29.6817 |
| 2010's | 3 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kiyak, G | 1 |
| Ergul, E | 1 |
| Celik, A | 1 |
| Kurt, M | 1 |
| Ibis, M | 1 |
| Karaman, K | 1 |
| Bostanci, EB | 1 |
| Temucin, T | 1 |
| Businger, A | 1 |
| Grunder, G | 1 |
| Guenin, MO | 1 |
| Ackermann, C | 1 |
| Peterli, R | 1 |
| von Flüe, M | 1 |
| Norhafizah, M | 1 |
| Malina, O | 1 |
| Rukman, AH | 1 |
| Lee, BR | 1 |
| Ngah, ZY | 1 |
| Wan, OA | 1 |
| Jamal, F | 1 |
| Martinez, MW | 1 |
| Petre, S | 1 |
| Wisinger, D | 1 |
| Temesgen, Z | 1 |
| Stringer, EE | 1 |
| Nicholson, TJ | 1 |
| Armstrong, D | 1 |
| Ventura Cerdá, JM | 1 |
| Nomdedeu Guinot, J | 1 |
| Alós Almiñana, M | 1 |
| Yepes, VA | 1 |
| Pérez Salinas, I | 1 |
| Salvador Sanchís, JL | 1 |
| Aberg, C | 1 |
| Olin, B | 1 |
| Oresland, T | 1 |
| Lundholm, C | 1 |
| Bernander, S | 1 |
| Strömberg, A | 1 |
| Nordström, K | 1 |
| Cederberg, A | 1 |
| Lindhagen, J | 2 |
| Andåker, L | 1 |
| Höjer, H | 1 |
| Mittermayer, H | 1 |
| Gross, C | 1 |
| Brücke, P | 1 |
| Ossowski, EM | 1 |
| Douglas, JG | 1 |
| Crucioli, V | 1 |
| Hagen, TB | 1 |
| Bergan, T | 2 |
| Liavåg, I | 1 |
| Hadziomerović, A | 1 |
| Nordlung, S | 1 |
| Zbornik, J | 1 |
| Nowak, W | 1 |
| Erbe, HJ | 1 |
| Szabó, LE | 1 |
| Csikós, F | 1 |
| Helembai, L | 1 |
| Karádi, J | 1 |
| Csiba, A | 1 |
| Lo, TC | 1 |
| Heading, RC | 1 |
| Gilmour, HM | 1 |
| Chaussade, S | 1 |
| Jan, IA | 1 |
| Hazir, T | 1 |
| Qazi, A | 1 |
| Khan, MA | 1 |
| Khan, NA | 1 |
| Kovachev, L | 1 |
| Presolski, I | 1 |
| Tsvetkov, I | 1 |
| Borer, A | 1 |
| Gilad, J | 1 |
| Sikuler, E | 1 |
| Riesenberg, K | 1 |
| Schlaeffer, F | 1 |
| Buskila, D | 1 |
| Gülek, B | 1 |
| Onel, S | 1 |
| Watt-Boolsen, S | 1 |
| Justesen, T | 1 |
| Blichert-Toft, M | 1 |
| Hansen, JB | 1 |
| Adekunle, OO | 1 |
| Abioye, A | 1 |
| Pritchard, TJ | 1 |
| Schoetz, DJ | 1 |
| Roberts, PL | 1 |
| Murray, JJ | 1 |
| Coller, JA | 1 |
| Veidenheimer, MC | 1 |
| Ono, S | 1 |
| Kato, S | 1 |
| Tanaka, T | 1 |
| Ishibiki, K | 1 |
| Kodaira, S | 1 |
| Abe, O | 1 |
| Kling, PA | 2 |
| Nord, CE | 1 |
| Burman, LG | 2 |
| Di Palo, S | 1 |
| Ferrari, G | 1 |
| Castoldi, R | 1 |
| Di Carlo, V | 1 |
| Kingston, RD | 1 |
| Kiff, RS | 1 |
| Duthie, JS | 1 |
| Walsh, S | 1 |
| Spicer, A | 1 |
| Jeacock, J | 1 |
| Reynolds, JR | 1 |
| Graham, TR | 1 |
| Foster, GE | 1 |
| Bourke, JB | 1 |
| Hardcastle, JD | 1 |
| Diamond, T | 1 |
| Mulholland, CK | 1 |
| Hanna, WA | 1 |
| Parks, TG | 1 |
| Greig, J | 1 |
| Morran, C | 1 |
| Gunn, R | 1 |
| Mason, B | 1 |
| Sleigh, D | 1 |
| McArdle, C | 1 |
| Hobbiss, JH | 1 |
| Carr, ND | 1 |
| Schofield, PF | 1 |
| Wenzel, M | 1 |
| Esch, B | 1 |
| Hancke, E | 1 |
| Marklein, G | 1 |
| Jensen, JC | 1 |
| Voigt, U | 1 |
| Stute, H | 1 |
| Berker-von-Schlichting, C | 1 |
| Ribbans, WJ | 1 |
| Radcliffe, AG | 1 |
| Holmlund, D | 1 |
| Athanasiadis, S | 1 |
| Kuhlgatz, C | 1 |
| Hahnel, E | 1 |
| Jagelman, DG | 1 |
| Fazio, VW | 1 |
| Lavery, IC | 1 |
| Weakley, FL | 1 |
| Sweeney, JL | 1 |
| Hewett, P | 1 |
| Riddell, P | 1 |
| Hoffmann, DC | 1 |
| Burns, DG | 1 |
| Hayes, MM | 1 |
| Solhaug, JH | 1 |
| Søreide, O | 1 |
| Leinebø, O | 1 |
1 review available for metronidazole and Rectal Diseases
| Article | Year |
|---|---|
[Ileoanal anastomosis with pouch: a rigorous surgical technique is necessary, but the most frequent long-term postoperative complication remains inflammation of the pouch].
Topics: Adenomatous Polyposis Coli; Adrenal Cortex Hormones; Colitis, Ulcerative; Diarrhea; Female; Humans; | 1993 |
16 trials available for metronidazole and Rectal Diseases
| Article | Year |
|---|---|
Comparison of metronidazole with doxycycline prophylaxis in elective colorectal surgery. A prospective, randomized multicentre study.
Topics: Adult; Aged; Clinical Trials as Topic; Doxycycline; Female; Humans; Male; Metronidazole; Middle Aged | 1984 |
Comparison of systemic prophylaxis with metronidazole/placebo and metronidazole/fosfomycin in colorectal surgery. A clinical study demonstrating the need for additional anti-aerobic prophylactic cover.
Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria, Aerobic; Bacteriological Techniques; Clinical Trials a | 1984 |
Single dose cefuroxime/metronidazole versus metronidazole alone in elective colorectal surgery.
Topics: Adult; Aged; Cefuroxime; Cephalosporins; Clinical Trials as Topic; Colonic Diseases; Double-Blind Me | 1984 |
Prophylactic metronidazole in electrive colo-rectal surgery.
Topics: Aged; Clinical Trials as Topic; Colon; Colonic Diseases; Double-Blind Method; Escherichia coli; Fema | 1980 |
Comparison of systemic prophylaxis with metronidazole-fosfomycin and metronidazole-cephalothin in elective colorectal surgery.
Topics: Anti-Bacterial Agents; Bacterial Infections; Bacteroides; Cephalothin; Clinical Trials as Topic; Col | 1981 |
[Wound infection prophylaxis in colonic and rectal surgery with metronidazole and neomycin--a prospective study].
Topics: Colectomy; Colonic Diseases; Colostomy; Humans; Metronidazole; Middle Aged; Neomycin; Prospective St | 1982 |
The prophylaxis of septic complications in colo-rectal surgery. A controlled trial of metronidazole and oxytetracycline.
Topics: Administration, Oral; Aged; Clinical Trials as Topic; Colectomy; Colonic Diseases; Colostomy; Female | 1979 |
Comparison of two prophylactic single-dose intravenous antibiotic regimes in the treatment of patients undergoing elective colorectal surgery in a district general hospital.
Topics: Aged; Colonic Diseases; Drug Therapy, Combination; England; Female; Hospitals, General; Humans; Inje | 1989 |
Piperacillin in colorectal surgery.
Topics: Abscess; Colonic Diseases; Humans; Metronidazole; Piperacillin; Random Allocation; Rectal Diseases; | 1985 |
A prospective randomized trial to compare triple dose mezlocillin with triple dose cefuroxime plus metronidazole as prophylaxis in colorectal surgery.
Topics: Adult; Aged; Aged, 80 and over; Cefuroxime; Cephalosporins; Clinical Trials as Topic; Colonic Diseas | 1988 |
Wound sepsis after colorectal surgery: the effect of cefotetan lavage.
Topics: Bacteria, Aerobic; Bacteria, Anaerobic; Cefotetan; Clinical Trials as Topic; Colonic Diseases; Drug | 1987 |
Are we using the correct dose of metronidazole in colorectal surgery?
Topics: Colon; Colonic Diseases; Humans; Infusions, Intravenous; Metronidazole; Premedication; Random Alloca | 1988 |
[Antimicrobial chemoprevention in colorectal interventions: a single parenteral dose at the start of surgery is adequate].
Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Bacterial Infections; Bacteriological Techniques; | 1986 |
Single-dose intravenous metronidazole v. doxycycline prophylaxis in colorectal surgery. An open prospective, randomized trial.
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Diseases; Doxycycline; Female; Humans; Injections, In | 1985 |
[Perioperative antibiotic prevention in colon and rectum surgery. A randomized study on the value of single dose prevention].
Topics: Adult; Aged; Clinical Trials as Topic; Colonic Diseases; Colonic Neoplasms; Dose-Response Relationsh | 1985 |
A prospective, randomized, double-blind study of 10% mannitol mechanical bowel preparation combined with oral neomycin and short-term, perioperative, intravenous Flagyl as prophylaxis in elective colorectal resections.
Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Colonic Diseases; Double-Blind Method; Drug Admin | 1985 |
25 other studies available for metronidazole and Rectal Diseases
| Article | Year |
|---|---|
Spontaneous rupture of the rectum with evisceration of small intestine through the anus.
Topics: Aged; Anal Canal; Anti-Bacterial Agents; Anti-Infective Agents; Anus Diseases; Ceftriaxone; Female; | 2008 |
Rectal endometriosis and prolactinoma.
Topics: Adult; Anti-Infective Agents; Bromocriptine; Ciprofloxacin; Endometriosis; Female; Hormone Antagonis | 2010 |
Mechanical bowel preparation and antimicrobial prophylaxis in elective colorectal surgery in Switzerland--a survey.
Topics: Adult; Aged; Antibiotic Prophylaxis; Attitude of Health Personnel; Cathartics; Cephalosporins; Colon | 2011 |
Oh dear ... it's amoebic colitis.
Topics: Adult; Antiprotozoal Agents; Dysentery, Amebic; Female; Hemorrhage; Humans; Metronidazole; Middle Ag | 2011 |
Intestinal spirochetosis and diarrhea, commensal or causal.
Topics: Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Biopsy; Colitis, Microscopic; D | 2004 |
Efficacy of topical metronidazole (10 percent) in the treatment of anorectal Crohn's disease.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Anus Diseases; Crohn Disease; Female; H | 2005 |
[Single preoperative dose of metronidazole plus gentamicin for antimicrobial prophylaxis in colorectal surgery].
Topics: Anti-Infective Agents; Antibiotic Prophylaxis; Cohort Studies; Colonic Diseases; Gentamicins; Humans | 2007 |
Rectal ameboma.
Topics: Adult; Amebiasis; Female; Humans; Iodoquinol; Metronidazole; Rectal Diseases | 1984 |
Spirochaetosis: a remediable cause of diarrhoea and rectal bleeding?
Topics: Diarrhea; Gastrointestinal Hemorrhage; Humans; Male; Metronidazole; Middle Aged; Rectal Diseases; Sp | 1981 |
Metronidazole in the chemoprophylaxis of colon and rectum operations.
Topics: Adult; Aged; Colon; Colonic Diseases; Female; Humans; Male; Metronidazole; Middle Aged; Premedicatio | 1982 |
Intestinal spirochaetosis.
Topics: Adolescent; Adult; Colon; Colonic Diseases; Female; Humans; Male; Metronidazole; Rectal Diseases; Re | 1994 |
Fulminant pseudomembranous colitis leading to total colonic stricture.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Child; Colectomy; Colonic Diseases; Constriction, Path | 1997 |
[Decontamination in colorectal surgery].
Topics: Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Cause of Death; Cephalosporins; Colorectal Surg | 1998 |
Fatal Clostridium sordellii ischio-rectal abscess with septicaemia complicating ultrasound-guided transrectal prostate biopsy.
Topics: Abscess; Adenocarcinoma; Aged; Ampicillin; Anti-Infective Agents; Bacteremia; Biopsy; Ciprofloxacin; | 1999 |
US and CT findings of rectal amebian abscess.
Topics: Abscess; Adult; Animals; Anti-Infective Agents; Diagnosis, Differential; Dysentery, Amebic; Endosono | 1999 |
Synchronous leiomyosarcoma and ameboma of the rectum: report of a case.
Topics: Aged; Dysentery, Amebic; Female; Humans; Leiomyosarcoma; Metronidazole; Rectal Diseases; Rectal Neop | 1978 |
Perirectal abscess in Crohn's disease. Drainage and outcome.
Topics: Abscess; Adolescent; Adult; Catheters, Indwelling; Crohn Disease; Drainage; Female; Humans; Male; Me | 1990 |
[Preoperative oral antimicrobial bowel preparations in elective colorectal surgery].
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Bacteria; Colon; Colonic Diseases; | 1990 |
The significance of timing of metronidazole prophylaxis and addition of fosfomycin in colorectal surgery. An experimental study in rats.
Topics: Animals; Colon; Colonic Diseases; Colony Count, Microbial; Disease Models, Animal; Injections, Intra | 1990 |
[Preoperative topical antibiotics in patients subjected to short term prophylaxis for colorectal surgery].
Topics: Administration, Topical; Aged; Colonic Diseases; Female; Humans; Male; Metronidazole; Middle Aged; N | 1989 |
Open study of different perioperative prophylactic regimens with mezlocillin/metronidazole in proctectomy.
Topics: Aged; Drug Therapy, Combination; Female; Humans; Male; Metronidazole; Mezlocillin; Postoperative Com | 1987 |
Retroperitoneal abscess following sclerotherapy for hemorrhoids.
Topics: Abscess; Adult; Erythromycin; Gentamicins; Hemorrhoids; Humans; Intestinal Perforation; Male; Metron | 1985 |
Rectal gangrene: a complication of phosphate enema.
Topics: Aged; Constipation; Debridement; Drug Therapy, Combination; Enema; Female; Gangrene; Gentamicins; He | 1986 |
Rectal spirochaetosis--symptomatic response to metronidazole and mebendazole. A case report.
Topics: Benzimidazoles; Homosexuality; Humans; Male; Mebendazole; Metronidazole; Middle Aged; Rectal Disease | 1985 |
Comparative pharmacokinetics of metronidazole and tinidazole and their tissue penetration.
Topics: Adult; Aged; Colonic Diseases; Humans; Infusions, Parenteral; Metronidazole; Middle Aged; Nitroimida | 1985 |