metronidazole has been researched along with Lupus Erythematosus, Discoid in 2 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Lupus Erythematosus, Discoid: A chronic form of cutaneous lupus erythematosus (LUPUS ERYTHEMATOSUS, CUTANEOUS) in which the skin lesions mimic those of the systemic form but in which systemic signs are rare. It is characterized by the presence of discoid skin plaques showing varying degrees of edema, erythema, scaliness, follicular plugging, and skin atrophy. Lesions are surrounded by an elevated erythematous border. The condition typically involves the face and scalp, but widespread dissemination may occur.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected." | 5.26 | [Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)]. ( Betous, F; Herreman, G; Krainik, F; Mundler, B; Nicolas, MO, 1981) |
| "Generalised convulsive seizures occurred on four occasions, associated with paresthesia of the four limbs, but without loss of motor or reflex activity, though some distal hypoesthesia was detected." | 1.26 | [Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)]. ( Betous, F; Herreman, G; Krainik, F; Mundler, B; Nicolas, MO, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Herreman, G | 1 |
| Krainik, F | 1 |
| Betous, F | 1 |
| Nicolas, MO | 1 |
| Mundler, B | 1 |
| Roth, W | 1 |
2 other studies available for metronidazole and Lupus Erythematosus, Discoid
| Article | Year |
|---|---|
[Convulsive seizures and polyneuritis in a patient with lupus treated with metronidazole (author's transl)].
Topics: Abscess; Adult; Biopsy; Female; Humans; Lupus Erythematosus, Discoid; Male; Metronidazole; Middle Ag | 1981 |
[Proceedings: Chronic discoid lupus erythematosus].
Topics: Adult; Diagnostic Errors; Female; Humans; Lupus Erythematosus, Discoid; Metronidazole | 1975 |