metronidazole has been researched along with Leukorrhea in 27 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Leukorrhea: A clear or white discharge from the VAGINA, consisting mainly of MUCUS.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metronidazole was used only for resistant cases of trichomoniasis, with a cure rate of over 80% when both partners were treated simultaneously." | 1.24 | CLINICAL TRIALS WITH AGENTS CURRENTLY USED IN THE MANAGEMENT OF VAGINITIS. ( O'BRIEN, JR, 1964) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 24 (88.89) | 18.7374 |
| 1990's | 3 (11.11) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| O'BRIEN, JR | 1 |
| Ronnike, F | 1 |
| NENNSTIEL, HJ | 1 |
| WALTHER, H | 1 |
| BARENTS, JW | 1 |
| Adler, MW | 1 |
| Balsdon, MJ | 1 |
| Sprott, MS | 1 |
| Ingham, HR | 1 |
| Pattman, RS | 1 |
| Eisenstadt, RL | 1 |
| Short, GR | 1 |
| Narang, HK | 1 |
| Sisson, PR | 1 |
| Selkon, JB | 1 |
| van Gelderen, CJ | 1 |
| Von Schubert, W | 1 |
| Ross, SM | 1 |
| Hoosen, AA | 1 |
| Sheik, AI | 1 |
| Chandeying, V | 1 |
| Skov, S | 1 |
| Kemapunmanus, M | 1 |
| Law, M | 1 |
| Geater, A | 1 |
| Rowe, P | 1 |
| Lanta, S | 1 |
| Mention, JE | 1 |
| Skotnica, M | 1 |
| Kuncar, S | 1 |
| Fort, J | 1 |
| Kawaciuková, J | 1 |
| Larsson, PG | 1 |
| Bergman, B | 1 |
| Forsum, U | 1 |
| Påhlson, C | 1 |
| Fonte, CE | 1 |
| Carlile, J | 1 |
| Lazerson, J | 1 |
| Blackwell, A | 1 |
| Hansen, JG | 1 |
| Schmidt, H | 1 |
| Liechti, R | 1 |
| Pohunek, M | 1 |
| Suk, K | 1 |
| Gruber, W | 1 |
| Ganju, D | 1 |
| Anjaneyulu, R | 1 |
| Götz, HG | 1 |
| de Watteville, H | 1 |
| Girotti, M | 1 |
| Hauser, GA | 1 |
| Breinl, H | 1 |
| Gerteis, W | 1 |
1 review available for metronidazole and Leukorrhea
| Article | Year |
|---|---|
Gardnerella vaginalis and its clinical syndrome.
Topics: Amoxicillin; Ampicillin; Culture Media; Female; Gardnerella vaginalis; Gentian Violet; Haemophilus; | 1982 |
6 trials available for metronidazole and Leukorrhea
| Article | Year |
|---|---|
'One-visit' therapy for pelvic inflammatory disease.
Topics: Acute Disease; Blood Sedimentation; Drug Therapy, Combination; Escherichia coli; Female; Fever; Huma | 1980 |
Evaluation of two clinical protocols for the management of women with vaginal discharge in southern Thailand.
Topics: Adult; Anti-Infective Agents; Candidiasis, Vulvovaginal; Clinical Protocols; Doxycycline; Female; Go | 1998 |
Treatment of bacterial vaginosis in women with vaginal bleeding complications or discharge and harboring Mobiluncus.
Topics: Adult; Bacteria, Anaerobic; Bacterial Infections; Double-Blind Method; Drug Administration Schedule; | 1990 |
Treatment of the Gardnerella vaginalis syndrome. A controlled, double-blind study comparing pivampicillin and metronidazole.
Topics: Ampicillin; Bacteriological Techniques; Clinical Trials as Topic; Double-Blind Method; Female; Gardn | 1985 |
[MK-915, a newreparation for the oral treatment of trichomonas colpitis].
Topics: Adult; Alkaline Phosphatase; Antifungal Agents; Aspartate Aminotransferases; Bilirubin; Blood Cell C | 1970 |
Leucorrhoea due to Trichomonas vaginalis--clinical trial with hamycin.
Topics: Adolescent; Adult; Antifungal Agents; Arsenicals; Clinical Trials as Topic; Female; Humans; Leukorrh | 1966 |
20 other studies available for metronidazole and Leukorrhea
| Article | Year |
|---|---|
CLINICAL TRIALS WITH AGENTS CURRENTLY USED IN THE MANAGEMENT OF VAGINITIS.
Topics: Anti-Bacterial Agents; Antibiotics, Antitubercular; Antifungal Agents; Atrophic Vaginitis; Bacterial | 1964 |
DISCHARGE SYMPTOMATOLOGY IN 1000 GYNAECOLOGICAL CASES EXAMINED WITH A VIEW TO TRICHOMONAS VAGINALIS. RESULTS OF METROHIDAZOL (FLAGYL) TREATMENT.
Topics: Antiprotozoal Agents; Denmark; Diagnosis; Female; Gynecology; Humans; Imidazoles; Leukorrhea; Metron | 1964 |
[ON THE SYMPTOMATOLOGY AND THERAPY OF TRICHOMONIASIS].
Topics: Arthritis; Female; Humans; Imidazoles; Leukorrhea; Metronidazole; Trichomonas Infections; Trichomona | 1964 |
[ON THE USE OF METRONIDAZOLE (FLAGYL) IN TRICHOMONAS LEUKORRHEA].
Topics: Drug Therapy; Female; Humans; Intraabdominal Infections; Leukorrhea; Metronidazole; Trichomonas; Tri | 1964 |
ABC of sexually transmitted diseases. Vaginal discharge--management.
Topics: Antifungal Agents; Candidiasis, Vulvovaginal; Female; Humans; Leukorrhea; Male; Metronidazole; Pessa | 1983 |
Characteristics of motile curved rods in vaginal secretions.
Topics: Anti-Bacterial Agents; Bacteria; Bacterial Physiological Phenomena; Female; Humans; Leukorrhea; Metr | 1983 |
[Metronidazole as the therapeutic choice in bacterial leukorrhea. Report from a gynecologic practice on the diagnosis and therapy of non-physiologic bacterial discharge].
Topics: Bacterial Infections; Female; Humans; Leukorrhea; Metronidazole | 1981 |
Diagnosis and treatment of vaginal discharge in pregnancy.
Topics: Candidiasis; Female; Humans; Leukorrhea; Metronidazole; Pregnancy; Pregnancy Complications, Infectio | 1980 |
[Leukorrhea: diagnostic trends].
Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Antifungal Agents; Antitricho | 1999 |
[Contemporary possibilities of the health community gynaecologist with the treatment of discharge (author's transl)].
Topics: Adult; Antifungal Agents; Female; Humans; Lactates; Leukorrhea; Metronidazole | 1975 |
[The treatment of the vaginal discharge as a prevention of maternal and new-born diseases (author's transl)].
Topics: Female; Humans; Leukorrhea; Metronidazole; Neomycin; Pregnancy; Pregnancy Complications; Sulfisoxazo | 1976 |
Vaginal discharge in a two-month-old infant.
Topics: Animals; Diagnosis, Differential; Female; Humans; Infant; Infant, Newborn; Leukorrhea; Metronidazole | 1987 |
Vaginal discharge.
Topics: Adult; Female; Humans; Leukorrhea; Metronidazole; Nystatin; Sexually Transmitted Diseases | 1985 |
Management of patients with vaginal infections. An invitational symposium.
Topics: Adult; Candidiasis, Vulvovaginal; Child; Chronic Disease; Clioquinol; Estrogens, Conjugated (USP); F | 1972 |
[Problem of Vibriofluor].
Topics: Female; Humans; Leukorrhea; Metronidazole; Vibrio Infections | 1972 |
[Vaginal discharge, diagnosis and therapeutic consequences].
Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria; Candidiasis, Vulvovaginal; Estrogens; Female; Humans; | 1971 |
[Drugs for treatment of fluor albus. 18].
Topics: Adrenal Cortex Hormones; Androgens; Anti-Bacterial Agents; Estrogens; Female; Humans; Hydrocortisone | 1967 |
[Diagnosis and treatment of leukorrhea].
Topics: Antifungal Agents; Arsenicals; Female; Furazolidone; Humans; Leukorrhea; Metronidazole; Trichomonas | 1968 |
[Clinical features of vaginal discharge].
Topics: Antifungal Agents; Female; Humans; Leukorrhea; Metronidazole; Mycoses; Trichomonas Vaginitis; Vagini | 1968 |
[Results of microscopic germ diagnosis of vaginal smears of a non-selective gynecologic collective (A contribution to the problem of leukorrhea)].
Topics: Colposcopy; Female; Humans; Leukorrhea; Metronidazole; Microscopy; Mycoses; Trichomonas Vaginitis; V | 1966 |