Page last updated: 2024-09-28

Acute Infectious Thyroiditis

Acute inflammatory disease of the THYROID GLAND due to infections by BACTERIA; FUNGI; or other microorganisms. Symptoms include tender swelling, FEVER, and often with LEUKOCYTOSIS.

Synonyms(5)

Synonym
Acute Infectious Thyroiditis
Thyroiditis, Infectious
Acute Suppurative Thyroiditis
Thyroiditis, Suppurative
Infectious Thyroiditis

Research Excerpts

Overview

ExcerptReference
"Acute suppurative thyroiditis is a rarely encountered infection."( Caroff, RJ; Schenfeld, LA; Smeal, WE, 1986)
"Acute suppurative thyroiditis is an uncommon condition."( Chan, JC; Fan, WC; Loke, TK; Yung, BC, 2000)
"Acute suppurative thyroiditis is an uncommon disease in children."( Chang, P; Hsiao, PH; Huang, LM; Lee, JS; Lee, PI; Li, YW; Peng, SF; Tsai, WY, 2002)
"Acute infectious thyroiditis is a rare condition of the thyroid gland, most often arising in children with congenital conditions connecting the thyroid directly to the oropharynx, such as a piriform fistula or thyroglossal duct."( Bulzico, DA; Cabizuca, CA; Conceição, FL; de Almeida, MH; Vaisman, M, 2008)
"Acute suppurative thyroiditis is an uncommon disorder caused by a bacterial infection, usually presenting with normal thyroid function."( Costa, MM; Damásio, I; Maciel, J; Raimundo, L, 2023)

Treatment

ExcerptReference
"To present a rare case of actinomycotic suppurative thyroiditis in an infant with provision of the etiology, pathogenesis, clinical findings and treatment of this rare disease."( Atay, Z; Ceran, O; Erol, N; Goksugur, SB; Karatoprak, N, 2005)

Research

Studies (51)

TimeframeStudies, This Condition (%)All Conditions %
pre-19904 (7.84)23.3326
1990's13 (25.49)12.5806
2000's13 (25.49)18.1394
2010's18 (35.29)28.8240
2020's3 (5.88)9.53
DrugIndicatedRelationship StrengthStudiesTrials
iodine0low20
pyrazinamide0low10
amiodarone0low10
azathioprine0low10
ciprofloxacin0low10
gentamicin0low10
metronidazole0low20
prednisolone0low10
thyroxine0low20
prednisone0low10
penicillin g0low10
methylene blue0low10
oxacillin0low10
ampicillin0low20
trichloroacetic acid0low10
diatrizoate meglumine0low10
ethambutol0low10
vancomycin0low10
barium sulfate0low130
silver nitrate0low10
amoxicillin0low10
amikacin0low10
itraconazole0low10
fluorodeoxyglucose f180low20
voriconazole0low20
sulbactam0low10
levofloxacin0low10
cortisone0low10
meropenem0low10
clindamycin0low20
l 743,8720low10
thiouracil0low20
methimazole0low20
amphotericin b0low20
clavulanic acid0low10
amoxicillin-potassium clavulanate combination0low20
ro13-99040low30
sodium pertechnetate tc 99m0low30
rifampin0low10

Protein Targets (508)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
estrogen nuclear receptor alpha190019
peripheral myelin protein 224004
histone acetyltransferase KAT2A isoform 12002
lamin isoform A-delta108008
ATP-binding cassette sub-family C member 3015015
Multidrug resistance-associated protein 4015015
Bile salt export pump018018
Canalicular multispecific organic anion transporter 1015015
Aminoglycoside 3'-phosphotransferase 0001
ATP-dependent phosphofructokinase5005
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
acetylcholinesterase6006
phosphopantetheinyl transferase6006
hypoxia-inducible factor 1 alpha subunit7007
RAR-related orphan receptor gamma9009
SMAD family member 23003
ATAD5 protein, partial4004
Fumarate hydratase4004
USP1 protein, partial3003
NFKB1 protein, partial1001
PPM1D protein3003
SMAD family member 33003
TDP1 protein110011
Thrombopoietin1001
AR protein130013
caspase 7, apoptosis-related cysteine protease3003
aldehyde dehydrogenase 1 family, member A18008
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)3003
thyroid stimulating hormone receptor5005
estrogen receptor 2 (ER beta)7007
nuclear receptor subfamily 1, group I, member 3100010
progesterone receptor9009
EWS/FLI fusion protein8008
glucocorticoid receptor [Homo sapiens]110011
retinoic acid nuclear receptor alpha variant 1110011
retinoid X nuclear receptor alpha120012
estrogen-related nuclear receptor alpha120012
farnesoid X nuclear receptor8008
pregnane X nuclear receptor150015
G9009
cytochrome P450 2D63003
polyprotein4004
peroxisome proliferator-activated receptor delta100010
peroxisome proliferator activated receptor gamma8008
caspase-33003
euchromatic histone-lysine N-methyltransferase 2110011
thyroid stimulating hormone receptor3003
v-jun sarcoma virus 17 oncogene homolog (avian)100010
Histone H2A.x5005
cytochrome P450 2D6 isoform 11001
cellular tumor antigen p53 isoform a4004
cytochrome P450 2C9 precursor2002
D(1A) dopamine receptor1001
chromobox protein homolog 16006
thyroid hormone receptor beta isoform a5005
potassium voltage-gated channel subfamily H member 2 isoform d1001
thyroid hormone receptor beta isoform 27007
heat shock protein beta-16006
huntingtin isoform 22002
mitogen-activated protein kinase 14004
flap endonuclease 13003
serine/threonine-protein kinase mTOR isoform 11001
nuclear factor erythroid 2-related factor 2 isoform 1140014
peptidyl-prolyl cis-trans isomerase NIMA-interacting 14004
urokinase-type plasminogen activator precursor3003
plasminogen precursor3003
urokinase plasminogen activator surface receptor precursor3003
nuclear receptor ROR-gamma isoform 13003
geminin9009
survival motor neuron protein isoform d6006
cytochrome P450 3A4 isoform 13003
muscarinic acetylcholine receptor M13003
lethal factor (plasmid)2002
Gamma-aminobutyric acid receptor subunit pi3104
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Voltage-dependent L-type calcium channel subunit alpha-1C0101
Solute carrier organic anion transporter family member 1A40203
Voltage-dependent L-type calcium channel subunit alpha-1F0303
5-hydroxytryptamine receptor 40202
Lysine-specific demethylase PHF20101
Interferon beta100010
HLA class I histocompatibility antigen, B alpha chain 9009
Thyroid hormone receptor alpha0101
Receptor tyrosine-protein kinase erbB-20101
Cellular tumor antigen p539009
Integrin beta-32002
Tyrosine-protein kinase Fyn0101
ATP-dependent translocase ABCB10101
Aldo-keto reductase family 1 member B10202
Muscarinic acetylcholine receptor M20202
Muscarinic acetylcholine receptor M40202
ATP-dependent translocase ABCB10214
Integrin alpha-IIb2002
Beta-1 adrenergic receptor0202
Muscarinic acetylcholine receptor M50202
Alpha-2A adrenergic receptor0303
Adenosine receptor A30202
Cytochrome P450 2C80101
Thyroid hormone receptor alpha0112
Thyroid hormone receptor beta0112
Muscarinic acetylcholine receptor M10202
Beta-3 adrenergic receptor0202
D(2) dopamine receptor0202
Androgen receptor0505
Gamma-aminobutyric acid receptor subunit beta-13104
Alpha-1B adrenergic receptor0404
Lethal factor0101
Alpha-2B adrenergic receptor0202
Thyroid hormone receptor beta0101
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Muscarinic acetylcholine receptor M30202
ATP-dependent translocase ABCB10101
Substance-K receptor0202
D(1A) dopamine receptor0202
D(4) dopamine receptor0202
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Carnitine O-palmitoyltransferase 2, mitochondrial0101
Sodium-dependent noradrenaline transporter 0213
Histamine H2 receptor0202
Endothelin-1 receptor0202
5-hydroxytryptamine receptor 2A0202
5-hydroxytryptamine receptor 2C0202
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Lysine-specific demethylase 5A0101
Gamma-aminobutyric acid receptor subunit alpha-63104
B2 bradykinin receptor0202
Sodium-dependent serotonin transporter0202
Melanocortin receptor 40202
C-8 sterol isomerase0101
Melanocortin receptor 50202
Mu-type opioid receptor0202
D(3) dopamine receptor0202
Sodium channel protein type 1 subunit alpha0101
Sodium channel protein type 4 subunit alpha0101
Squalene synthase0101
Delta-type opioid receptor0202
Kappa-type opioid receptor0202
5-hydroxytryptamine receptor 2B0202
C-C chemokine receptor type 20202
Melanocortin receptor 30202
Alpha-1A adrenergic receptor0404
Histamine H2 receptor3003
D(1A) dopamine receptor1001
5-hydroxytryptamine receptor 60202
Carnitine O-palmitoyltransferase 1, liver isoform0101
C-C chemokine receptor type 40202
Spike glycoprotein5005
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Sodium channel protein type 7 subunit alpha0101
Voltage-dependent L-type calcium channel subunit alpha-1D 0303
Sodium-dependent dopamine transporter 0202
Potassium voltage-gated channel subfamily H member 20708
Voltage-dependent L-type calcium channel subunit alpha-1S0303
Voltage-dependent L-type calcium channel subunit alpha-1C0303
Sodium channel protein type 5 subunit alpha0101
Squalene monooxygenase0101
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase0101
Sodium channel protein type 9 subunit alpha0101
Lysine-specific demethylase 7A0101
GABA theta subunit3104
Carnitine O-palmitoyltransferase 1, muscle isoform0101
Inositol hexakisphosphate kinase 19009
Sodium channel protein type 2 subunit alpha0101
Ataxin-25005
Sigma non-opioid intracellular receptor 10202
Gamma-aminobutyric acid receptor subunit epsilon3104
NAD-dependent protein deacetylase sirtuin-3, mitochondrial0011
Sodium channel protein type 3 subunit alpha0101
Sodium channel protein type 11 subunit alpha0101
Histone lysine demethylase PHF80101
Sodium channel protein type 8 subunit alpha0101
Sodium channel protein type 10 subunit alpha0101
cytochrome P450 2C9, partial9009
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE6006
Chain A, Beta-lactamase2002
Chain A, 2-oxoglutarate Oxygenase5005
Beta-lactamase 0103
Beta-lactamase 0104
Beta-lactamase 0004
Beta-lactamase 0205
apical membrane antigen 1, AMA13003
Beta-lactamase 0003
DNA polymerase eta isoform 14004
DNA polymerase iota isoform a (long)4004
DNA polymerase kappa isoform 13003
Bile salt export pump0707
Beta-lactamase SHV-10104
Beta-lactamase SHV-10307
Cytochrome P450 2C9 0505
Beta-lactamase0206
Kappa-type opioid receptor0003
Solute carrier family 15 member 10606
Solute carrier family 15 member 10202
Cytochrome P450 2J20202
B2 metallo-beta-lactamase 0004
Solute carrier family 15 member 20505
Beta-lactamase 0104
Beta-lactamase 0104
Solute carrier family 15 member 20505
Beta-lactamase 0104
Beta-lactamase 0003
Chain A, HADH2 protein4004
Chain B, HADH2 protein4004
Chain A, Cruzipain4004
interleukin 83003
GLS protein3003
vitamin D (1,25- dihydroxyvitamin D3) receptor6006
tumor necrosis factor1001
vitamin D3 receptor isoform VDRA3003
Cytochrome P450 1A20202
Cytochrome P450 3A40303
Cytochrome P450 2D60202
Cytochrome P450 2C190303
Nuclear receptor ROR-gamma3003
Aurora kinase B0101
Broad substrate specificity ATP-binding cassette transporter ABCG20202
Chain A, Mutant Al2 6e7p9g0011
Chain A, ATP-DEPENDENT DNA HELICASE Q12002
Beta-lactamase 0003
acid sphingomyelinase1001
GLI family zinc finger 3110011
Beta-lactamase 0204
Beta-lactamase 0004
Metallo-beta-lactamase type 20015
Metallo-beta-lactamase VIM-11 0004
Metallo-beta-lactamase VIM-20004
Beta-lactamase 0105
Metallo-beta-lactamase0004
Beta-lactamase 0204
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 12002
DNA polymerase beta3003
Carbonic anhydrase 10101
Carbonic anhydrase 20101
60 kDa heat shock protein, mitochondrial0303
Beta-lactamase OXA-70002
10 kDa heat shock protein, mitochondrial0303
Angiopoietin-1 receptor0011
Beta-lactamase 0204
Beta-lactamase 0204
Beta-lactamase 0204
Thiosulfate sulfurtransferase0303
Metallo-beta-lactamase VIM-130004
Efflux transporter 0002
Beta-lactamase 0003
Beta-lactamase Toho-10003
Beta-lactamase 0002
Class D beta-lactamase0205
60 kDa chaperonin 0303
Metallo-beta-lactamase0003
Beta-lactamase 0205
Beta-lactamase 0014
10 kDa chaperonin 0303
Metallo-b-lactamase 0006
Carbapenem-hydrolyzing beta-lactamase KPC0307
Histamine H3 receptor0003
Beta-lactamase class B VIM-2 0017
Beta-lactamase VIM-1 0004
Chain A, Ferritin light chain2002
thioredoxin reductase6006
Microtubule-associated protein tau3003
thioredoxin glutathione reductase4004
P531001
arylsulfatase A2002
IDH13003
aryl hydrocarbon receptor7007
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a7007
activating transcription factor 65005
Bloom syndrome protein isoform 12002
peripheral myelin protein 22 isoform 12002
hemoglobin subunit beta1001
M-phase phosphoprotein 82002
muscleblind-like protein 1 isoform 14004
Voltage-dependent calcium channel gamma-2 subunit6006
Glutamate receptor 26006
ATPase family AAA domain-containing protein 54004
Protein-arginine deiminase type-40202
Beta-lactamase 0204
Beta-lactamase 0204
Metallo-beta-lactamase VIM-19 0003
Beta-lactamase 0204
Solute carrier family 22 member 60202
Albumin0033
Beta-lactamase 0002
Beta-lactamase 0204
Metallo-beta-lactamase VIM-20003
Solute carrier family 22 member 60101
Solute carrier family 22 member 70101
BlaVIM-1 0003
Beta-lactamase 0002
Solute carrier family 22 member 80202
Beta-lactamase 0104
Solute carrier family 22 member 110101
Solute carrier family 22 member 80203
Solute carrier family 22 member 70101
DNA gyrase subunit B0101
DNA gyrase subunit A0101
DNA gyrase subunit B0102
DNA gyrase subunit A0103
DNA gyrase subunit B0103
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0102
DNA topoisomerase 4 subunit A0102
DNA topoisomerase 2-alpha0104
DNA gyrase subunit A0102
Multidrug resistance protein MdtK0011
DNA gyrase subunit B0202
DNA gyrase subunit A0303
Enoyl-[acyl-carrier-protein] reductase [NADH]0104
DNA topoisomerase 4 subunit A0101
DNA topoisomerase 4 subunit B0101
Integrase 0101
Beta-lactamase 0202
Beta-lactamase0203
Beta-lactamase0202
Beta-lactamase0204
Neutrophil elastase0101
Beta-lactamase OXA-10202
Cytochrome P450 2B60213
Beta-lactamase TEM0508
Beta-lactamase0101
Beta-lactamase 0101
Beta-lactamase 0101
endonuclease IV1001
dopamine D1 receptor2002
pregnane X receptor2002
regulator of G-protein signaling 41001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a3003
atrial natriuretic peptide receptor 1 precursor1001
Glucocorticoid receptor08215
Sex hormone-binding globulin0011
Glycine receptor subunit alpha-10808
Corticosteroid-binding globulin0202
Glycine receptor subunit beta0808
Glycine receptor subunit alpha-20808
Glycine receptor subunit alpha-30808
Potassium voltage-gated channel subfamily A member 10011
TAR DNA-binding protein 433003
Multidrug and toxin extrusion protein 10202
Hsf1 protein0011
cytochrome P450 family 3 subfamily A polypeptide 47007
Pantothenate synthetase0101
Luciferase3003
histone deacetylase 9 isoform 32002
GALC protein1001
Cytochrome P450 1440022
Steroid C26-monooxygenase0022
Steroid C26-monooxygenase0022
Chain A, JmjC domain-containing histone demethylation protein 3A4004
Replicase polyprotein 1ab0101
CAAX prenyl protease 2 isoform 20001
streptokinase A precursor0033
Tubulin beta-4A chain0101
Tubulin beta chain0101
Tubulin alpha-3C chain0101
Tubulin alpha-1B chain0101
Tubulin alpha-4A chain0101
Tubulin beta-4B chain0101
Fatty-acid amide hydrolase 10101
DNA primase0101
Tubulin beta-3 chain0101
Tubulin beta-2A chain0101
Tubulin beta-8 chain0101
Tubulin alpha-3E chain0101
Tubulin alpha-1A chain0101
Tubulin alpha-1C chain0101
Tubulin beta-6 chain0101
Tubulin beta-2B chain0101
Tubulin beta-1 chain0101
Beta-lactamase 0002
Beta-lactamase 0002
Beta-lactamase IMP-1 0002
Beta-lactamase 0002
Polyphenol oxidase 20203
Dopamine beta-hydroxylase 0202
Lactoperoxidase0101
Lanosterol 14-alpha demethylase0303
Chain E, Fibrin beta chain0101
Chain A, Putative fructose-1,6-bisphosphate aldolase2002
T cell receptor, partial1001
luteinizing hormone receptor1001
glp-1 receptor, partial2002
integrase, partial0101
chaperonin-containing TCP-1 beta subunit homolog1001
lens epithelium-derived growth factor p750101
Caspase 6, apoptosis-related cysteine peptidase0001
TSHR protein1001
Apoptotic peptidase activating factor 10101
Smad31001
hypothetical protein, conserved1001
isocitrate dehydrogenase 1, partial1001
luciferase1001
bromodomain adjacent to zinc finger domain 2B2002
serine-protein kinase ATM isoform a1001
neutrophil cytosol factor 10101
nuclear factor erythroid 2-related factor 2 isoform 24004
parathyroid hormone/parathyroid hormone-related peptide receptor precursor1001
caspase-9 isoform alpha precursor0101
pyruvate kinase PKM isoform a1001
caspase-3 isoform a preproprotein0101
protein AF-9 isoform a0001
histone-lysine N-methyltransferase 2A isoform 2 precursor1001
Vpr1001
replicative DNA helicase0001
recombinase A0011
POsterior Segregation0011
DNA repair protein RAD52 homolog isoform a0001
neuropeptide S receptor isoform A1001
Glutathione reductase0101
Glutathione reductase, mitochondrial0102
Glycoprotein hormones alpha chain1001
Albumin0001
Amyloid-beta precursor protein0101
Dihydrolipoyl dehydrogenase, mitochondrial0102
Microtubule-associated protein tau0112
Amine oxidase [flavin-containing] A0101
Alpha-1D adrenergic receptor0202
Cruzipain0101
Alpha-synuclein1102
Guanine nucleotide-binding protein G2002
Inositol monophosphatase 11001
Thioredoxin reductase 1, cytoplasmic0102
Dihydrolipoyl dehydrogenase 0102
Zinc finger protein mex-50011
phosphoglycerate kinase1001
nonstructural protein 11001
nuclear receptor subfamily 1, group I, member 22002
Nuclear receptor subfamily 1 group I member 20033
Nuclear receptor subfamily 1 group I member 20011
Thioredoxin reductase 0101
Flavodoxin0001
Solute carrier family 22 member 80203
MecA 0101
Beta-lactamase 0001
Beta-lactamase0001
Beta-lactamase 10001
Beta-lactamase OXA-100001
Beta-lactamase0001
Beta-lactamase0001
Beta-lactamase 0102
luciferase0001
Fatty acid-binding protein, liver0101
Estrogen receptor0202
Progesterone receptor0203
Glucocorticoid receptor0112
Glucocorticoid receptor0011
Mineralocorticoid receptor 0213
Androgen receptor0202
Glutamine synthetase0011
Histamine H1 receptor0011
Prostaglandin G/H synthase 20101
Nociceptin receptor0011
Estrogen receptor beta0202
NAD-dependent protein deacetylase sirtuin-60101
15-lipoxygenase, partial1001
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 2B1 0202
NH(3)-dependent NAD(+) synthetase0101
Polyunsaturated fatty acid lipoxygenase ALOX150101
Arylacetamide deacetylase0102
Caspase-10101
Solute carrier organic anion transporter family member 1A10101
Solute carrier organic anion transporter family member 1A20102
Glutathione S-transferase omega-10101
DNA-directed RNA polymerase subunit beta0101
Solute carrier organic anion transporter family member 1B30203
Solute carrier organic anion transporter family member 1B10204
Replicase polyprotein 1ab0101
5-hydroxytryptamine receptor 1A0101
Metallo-beta-lactamase type 20101
Angiotensin-converting enzyme0101
Taste receptor type 2 member 380012
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
serine/threonine-protein kinase PLK11001
Solute carrier organic anion transporter family member 1A50001
Rap guanine nucleotide exchange factor 31001
Transthyretin0102
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
UDP-glucuronosyltransferase 1A1 0101
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Alpha-2B adrenergic receptor0101
Alpha-2C adrenergic receptor0101
Alpha-2A adrenergic receptor0101
Sodium-dependent serotonin transporter0101
D-alanyl-D-alanine dipeptidase0101
Transporter0101
Sterol 14-alpha-demethylase0011
14-alpha sterol demethylase 0011
Cholesterol side-chain cleavage enzyme, mitochondrial 0011
Lanosterol 14-alpha demethylase0011
Sterol 14-alpha demethylase0011
14-alpha sterol demethylase 0011
14-alpha sterol demethylase 0011
Cholesterol 24-hydroxylase0213
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]