| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
pyrazinamide
pyrazinecarboxamide : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis. | 2.13 | 1 | 0 | monocarboxylic acid amide;
N-acylammonia;
pyrazines | antitubercular agent;
prodrug |
acridone
acridone : A member of the class of acridines that is 9,10-dihydroacridine substituted by an oxo group at position 9. | 2.17 | 1 | 0 | acridines;
cyclic ketone | |
ethacridine
Ethacridine: A topically applied anti-infective agent. | 2.17 | 1 | 0 | acridines | |
amiodarone
Amiodarone: An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.. amiodarone : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias. | 2.17 | 1 | 0 | 1-benzofurans;
aromatic ketone;
organoiodine compound;
tertiary amino compound | cardiovascular drug |
ym 58483
[no description available] | 2.17 | 1 | 0 | | |
camphor, (+-)-isomer
[no description available] | 2.17 | 1 | 0 | bornane monoterpenoid;
cyclic monoterpene ketone | plant metabolite |
carbonyl cyanide m-chlorophenyl hydrazone
Carbonyl Cyanide m-Chlorophenyl Hydrazone: A proton ionophore. It is commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes.. CCCP : A member of the class of monochlorobenzenes that is benzene substituted by 2-(1,3-dinitrilopropan-2-ylidene)hydrazinyl and chloro groups at positions 1 and 3, respectively. It is a mitochondrial depolarizing agent that induces reactive oxygen species mediated cell death. | 2.17 | 1 | 0 | hydrazone;
monochlorobenzenes;
nitrile | antibacterial agent;
geroprotector;
ionophore |
deferiprone
Deferiprone: A pyridone derivative and iron chelator that is used in the treatment of IRON OVERLOAD in patients with THALASSEMIA.. deferiprone : A member of the class of 4-pyridones that is pyridin-4(1H)-one substituted at positions 1 and 2 by methyl groups and at position 3 by a hydroxy group. A lipid-soluble iron-chelator used for treatment of thalassaemia. | 3.55 | 2 | 0 | 4-pyridones | iron chelator;
protective agent |
deferoxamine
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.. desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator. | 3.55 | 2 | 0 | acyclic desferrioxamine | bacterial metabolite;
ferroptosis inhibitor;
iron chelator;
siderophore |
carbonyl cyanide p-trifluoromethoxyphenylhydrazone
Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone: A proton ionophore that is commonly used as an uncoupling agent in biochemical studies.. carbonyl cyanide p-trifluoromethoxyphenylhydrazone : A hydrazone that is hydrazonomalononitrile in which one of the hydrazine hydrogens is substituted by a p-trifluoromethoxyphenyl group. | 2.17 | 1 | 0 | aromatic ether;
hydrazone;
nitrile;
organofluorine compound | ATP synthase inhibitor;
geroprotector;
ionophore |
isoniazid
Hydra: A genus of freshwater polyps in the family Hydridae, order Hydroida, class HYDROZOA. They are of special interest because of their complex organization and because their adult organization corresponds roughly to the gastrula of higher animals.. hydrazide : Compounds derived from oxoacids RkE(=O)l(OH)m (l =/= 0) by replacing -OH by -NRNR2 (R groups are commonly H). (IUPAC). | 2.13 | 1 | 0 | carbohydrazide | antitubercular agent;
drug allergen |
metronidazole
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death. | 2 | 1 | 0 | C-nitro compound;
imidazoles;
primary alcohol | antiamoebic agent;
antibacterial drug;
antimicrobial agent;
antiparasitic agent;
antitrichomonal drug;
environmental contaminant;
prodrug;
radiosensitizing agent;
xenobiotic |
papaverine
Papaverine: An alkaloid found in opium but not closely related to the other opium alkaloids in its structure or pharmacological actions. It is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.. papaverine : A benzylisoquinoline alkaloid that is isoquinoline substituted by methoxy groups at positions 6 and 7 and a 3,4-dimethoxybenzyl group at position 1. It has been isolated from Papaver somniferum. | 2.17 | 1 | 0 | benzylisoquinoline alkaloid;
dimethoxybenzene;
isoquinolines | antispasmodic drug;
vasodilator agent |
pimobendan
pimobendan: produces arterial & venous dilatation in dogs; structure given in first source | 2.17 | 1 | 0 | benzimidazoles;
pyridazinone | cardiotonic drug;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent |
terfenadine
Terfenadine: A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME. | 2.17 | 1 | 0 | diarylmethane | |
thenoyltrifluoroacetone
Thenoyltrifluoroacetone: Chelating agent and inhibitor of cellular respiration. | 2.13 | 1 | 0 | | |
floxuridine
Floxuridine: An antineoplastic antimetabolite that is metabolized to fluorouracil when administered by rapid injection; when administered by slow, continuous, intra-arterial infusion, it is converted to floxuridine monophosphate. It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.. floxuridine : A pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. | 1.98 | 1 | 0 | nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside | antimetabolite;
antineoplastic agent;
antiviral drug;
radiosensitizing agent |
kanamycin a
Kanamycin: Antibiotic complex produced by Streptomyces kanamyceticus from Japanese soil. Comprises 3 components: kanamycin A, the major component, and kanamycins B and C, the minor components.. kanamycin : Kanamycin is a naturally occurring antibiotic complex from Streptomyces kanamyceticus that consists of several components: kanamycin A, the major component (also usually designated as kanamycin), and kanamycins B, C, D and X the minor components. | 2.13 | 1 | 0 | kanamycins | bacterial metabolite |
cytidine diphosphate
Cytidine Diphosphate: Cytidine 5'-(trihydrogen diphosphate). A cytosine nucleotide containing two phosphate groups esterified to the sugar moiety. Synonyms: CRPP; cytidine pyrophosphate. | 1.96 | 1 | 0 | cytidine 5'-phosphate;
pyrimidine ribonucleoside 5'-diphosphate | Escherichia coli metabolite;
mouse metabolite |
cycloserine
Cycloserine: Antibiotic substance produced by Streptomyces garyphalus.. D-cycloserine : A 4-amino-1,2-oxazolidin-3-one that has R configuration. It is an antibiotic produced by Streptomyces garyphalus or S. orchidaceus and is used as part of a multi-drug regimen for the treatment of tuberculosis when resistance to, or toxicity from, primary drugs has developed. An analogue of D-alanine, it interferes with bacterial cell wall synthesis in the cytoplasm by competitive inhibition of L-alanine racemase (which forms D-alanine from L-alanine) and D-alanine--D-alanine ligase (which incorporates D-alanine into the pentapeptide required for peptidoglycan formation and bacterial cell wall synthesis). | 2.13 | 1 | 0 | 4-amino-1,2-oxazolidin-3-one;
organonitrogen heterocyclic antibiotic;
organooxygen heterocyclic antibiotic;
zwitterion | antiinfective agent;
antimetabolite;
antitubercular agent;
metabolite;
NMDA receptor agonist |
cytarabine
[no description available] | 1.97 | 1 | 0 | beta-D-arabinoside;
monosaccharide derivative;
pyrimidine nucleoside | antimetabolite;
antineoplastic agent;
antiviral agent;
immunosuppressive agent |
isosorbide dinitrate
Isosorbide Dinitrate: A vasodilator used in the treatment of ANGINA PECTORIS. Its actions are similar to NITROGLYCERIN but with a slower onset of action. | 2.13 | 1 | 0 | glucitol derivative;
nitrate ester | nitric oxide donor;
vasodilator agent |
n-isopropyl-n-phenyl-4-phenylenediamine
N-isopropyl-N'-phenyl-p-phenylenediamine : The N-substituted diamine that is 1,4-phenylenediamine substituted at one N with an isopropyl group and at the other with a phenyl group. | 2.17 | 1 | 0 | N-substituted diamine | allergen;
antioxidant |
1,3-butylene glycol
1,3-butylene glycol: RN given refers to cpd without isomeric designation. butane-1,3-diol : A butanediol compound having two hydroxy groups in the 1- and 3-positions. | 1.97 | 1 | 0 | butanediol;
glycol | |
3-amino-9-ethylcarbazole
3-amino-9-ethylcarbazole: RN given refers to parent cpd | 2.17 | 1 | 0 | carbazoles | |
cycloguanil
cycloguanil: the active metabolite of proguanil; antifolate drug; structure in first source. cycloguanil : A triazine in which a 1,6-dihydro-1,3,5-triazine ring is substituted at N-1 by a 4-chlorophenyl group, at C-2 and -4 by amino groups and at C-6 by gem-dimethyl groups. A dihydrofolate reductase inhibitor, it is a metabolite of the antimalarial drug proguanil. | 2.17 | 1 | 0 | triazines | antifolate;
antiinfective agent;
antimalarial;
antiparasitic agent;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor |
2,4,6-trichlorophenyl 4-nitrophenyl ether
2,4,6-trichlorophenyl 4-nitrophenyl ether: structure | 2.17 | 1 | 0 | aromatic ether;
C-nitro compound;
chlorobenzenes | EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor;
herbicide |
dithiothreitol
1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol. | 1.96 | 1 | 0 | 1,4-dimercaptobutane-2,3-diol;
butanediols;
dithiol;
glycol;
thiol | chelator;
human metabolite;
reducing agent |
vidarabine
adenine arabinoside : A purine nucleoside in which adenine is attached to arabinofuranose via a beta-N(9)-glycosidic bond. | 3.06 | 1 | 0 | beta-D-arabinoside;
purine nucleoside | antineoplastic agent;
bacterial metabolite;
nucleoside antibiotic |
palladium
Palladium: A chemical element having an atomic weight of 106.4, atomic number of 46, and the symbol Pd. It is a white, ductile metal resembling platinum, and following it in abundance and importance of applications. It is used in dentistry in the form of gold, silver, and copper alloys.. palladium : Chemical element (nickel group element atom) with atomic number 46. | 7 | 1 | 0 | metal allergen;
nickel group element atom;
platinum group metal atom | |
platinum
Platinum: A heavy, soft, whitish metal, resembling tin, with atomic number 78, atomic weight 195.084, symbol Pt. It is used in manufacturing equipment for laboratory and industrial use. It occurs as a black powder (platinum black) and as a spongy substance (spongy platinum) and may have been known in Pliny's time as alutiae. | 7 | 1 | 0 | elemental platinum;
nickel group element atom;
platinum group metal atom | |
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts. | 2.06 | 1 | 0 | copper group element atom;
elemental gold | |
benzonidazole
benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease. | 2.1 | 1 | 0 | C-nitro compound;
imidazoles;
monocarboxylic acid amide | antiprotozoal drug |
etoposide
[no description available] | 2.07 | 1 | 0 | beta-D-glucoside;
furonaphthodioxole;
organic heterotetracyclic compound | antineoplastic agent;
DNA synthesis inhibitor |
2-phenylthiazolidine-4-carboxylic acid
2-phenylthiazolidine-4-carboxylic acid: RN given refers to cpd without isomeric designation | 2.17 | 1 | 0 | | |
acarbose
[no description available] | 2.15 | 1 | 0 | tetrasaccharide derivative | EC 3.2.1.1 (alpha-amylase) inhibitor;
EC 3.2.1.20 (alpha-glucosidase) inhibitor;
geroprotector;
hypoglycemic agent |
cidofovir anhydrous
Cidofovir: An acyclic nucleoside phosphonate that acts as a competitive inhibitor of viral DNA polymerases. It is used in the treatment of RETINITIS caused by CYTOMEGALOVIRUS INFECTIONS and may also be useful for treating HERPESVIRUS INFECTIONS.. cidofovir anhydrous : Cytosine substituted at the 1 position by a 3-hydroxy-2-(phosphonomethoxy)propyl group (S configuration). A nucleoside analogue, it is an injectable antiviral used for the treatment of cytomegalovirus (CMV) retinitis in AIDS patients. | 2.06 | 1 | 0 | phosphonic acids;
pyrimidone | anti-HIV agent;
antineoplastic agent;
antiviral drug;
photosensitizing agent |
benz(cd)indol-2(1h)-one
benz(cd)indol-2(1H)-one: structure in first source | 2.17 | 1 | 0 | | |
4,4,4-trifluoro-1-phenyl-1,3-butanedione
4,4,4-trifluoro-1-phenyl-1,3-butanedione: can trap reactive metabolites of carcinogens | 2.13 | 1 | 0 | | |
tetraphenylcyclopentadienone
tetraphenylcyclopentadienone: singlet oxygen trapping agent | 2.17 | 1 | 0 | stilbenoid | |
3-(2-pyridyl)-5,6-diphenyl-1,2,4-triazine
[no description available] | 2.17 | 1 | 0 | 1,2,4-triazines | |
2-(2'-pyridyl)benzimidazole
2-(2'-pyridyl)benzimidazole: structure in first source | 2 | 1 | 0 | | |
9-(s)-(3-hydroxy-2-(phosphonomethoxy)propyl)adenine
[no description available] | 2.06 | 1 | 0 | | |
honokiol
[no description available] | 2.17 | 1 | 0 | biphenyls | |
bathophenanthroline
4,7-diphenyl-1,10-phenanthroline : A member of the class of phenanthrolines that is 1,10-phenanthroline bearing two phenyl substituents at positions 4 and 7. | 2.17 | 1 | 0 | benzenes;
phenanthrolines | chelator |
2-phenyl-4,5-dichloro-3-pyridazinone
[no description available] | 2.17 | 1 | 0 | | |
n-benzylmaleimide
[no description available] | 2.17 | 1 | 0 | | |
phenylglycine nitrile
phenylglycine nitrile: structure in first source | 2.17 | 1 | 0 | | |
4,5-dimethyl-1,2-phenylenediamine
4,5-dimethyl-1,2-phenylenediamine: RN given refers to parent cpd | 2.17 | 1 | 0 | | |
mmv665852
MMV665852: an antischistosomal agent | 2.17 | 1 | 0 | | |
n-(2-methoxyphenyl)maleimide
N-(2-methoxyphenyl)maleimide: structure given in first source | 2.17 | 1 | 0 | | |
cobalt
Cobalt: A trace element that is a component of vitamin B12. It has the atomic symbol Co, atomic number 27, and atomic weight 58.93. It is used in nuclear weapons, alloys, and pigments. Deficiency in animals leads to anemia; its excess in humans can lead to erythrocytosis.. cobalt(1+) : A monovalent inorganic cation obtained from cobalt.. cobalt atom : A cobalt group element atom that has atomic number 27. | 7.1 | 1 | 0 | cobalt group element atom;
metal allergen | micronutrient |
2-aminoperimidine
2-aminoperimidine: inhibits bacterial NhaA Na/H+ antiporters; structure in first source | 2.17 | 1 | 0 | | |
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine
cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine: prodrug for HPMPC; specific name and structure not given in first source | 2.06 | 1 | 0 | | |
1,3-bis(3-chlorophenyl)urea
[no description available] | 2.17 | 1 | 0 | ureas | |
2-phenyl-4-oxohydroquinoline
2-phenyl-4-oxohydroquinoline: structure given in first source | 2.17 | 1 | 0 | | |
cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine
cyclic-9-(3-hydroxy-2-phosphonylmethoxypropyl)adenine: specific name and structure not given in first source | 2.06 | 1 | 0 | | |
2-chloro-3-(4-methylanilino)naphthalene-1,4-dione
[no description available] | 2.17 | 1 | 0 | 1,4-naphthoquinones | |
mequindox
Mequindox: a synthetic quinoxaline 1,4-dioxide derivative which can effectively improve growth and feed efficiency in animals; structure in first source | 2.17 | 1 | 0 | | |
1,3-bis(3,5-dichlorophenyl)urea
1,3-bis(3,5-dichlorophenyl)urea: COH - City of Hope; has antineoplastic activity | 2.17 | 1 | 0 | | |
dienestrol
Dienestrol: A synthetic, non-steroidal estrogen structurally related to stilbestrol. It is used, usually as the cream, in the treatment of menopausal and postmenopausal symptoms.. dienestrol : An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively. | 2.17 | 1 | 0 | | |
cinnamoylglycine
cinnamoylglycine: structure given in first source. N-cinnamoylglycine : An N-acylglycine in which the acyl group is specified as (2E)-3-phenylprop-2-enoyl (cinnamoyl). | 2.17 | 1 | 0 | N-acylglycine | metabolite |
4-(4-ethoxyphenyl)-4-oxobutanoic acid
[no description available] | 2.17 | 1 | 0 | aromatic ketone | |
3-(4-chlorophenyl)-5-propyl-1H-pyrazolo[1,5-a]pyrimidin-7-one
[no description available] | 2.17 | 1 | 0 | pyrazoles;
ring assembly | |
N-[4-[methyl(phenyl)sulfamoyl]phenyl]-2-thiophenecarboxamide
[no description available] | 2.17 | 1 | 0 | aromatic amide | |
4-chloro-N-[3-cyano-4-(phenylthio)phenyl]benzamide
[no description available] | 2.17 | 1 | 0 | benzamides | |
3-(4-morpholinyl)-4-(2-pyridinyl)-N-[3-(trifluoromethyl)phenyl]-1-pyrazolecarboxamide
[no description available] | 2.17 | 1 | 0 | pyrazolopyridine | |
7-chloro-2-methyl-4-(4-methylphenyl)sulfonylthiazolo[5,4-b]indole
[no description available] | 2.17 | 1 | 0 | sulfonamide | |
4-[2-[(2,6-dimethoxyphenyl)-oxomethoxy]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester
[no description available] | 2.17 | 1 | 0 | methoxybenzoic acid | |
2-(1H-benzimidazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone
[no description available] | 2.17 | 1 | 0 | benzimidazoles | |
2,3-dihydro-1,4-dioxin-5-carboxylic acid [2-[4-[4-(2-methylbutan-2-yl)phenoxy]anilino]-2-oxoethyl] ester
[no description available] | 2.17 | 1 | 0 | aromatic ether | |
2-(1,3-benzoxazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone
[no description available] | 2.17 | 1 | 0 | benzoxazole | |
thiosemicarbazide
thiosemicarbazide: glutamate decarboxylase antagonist; structure given in first source. hydrazinecarbothioamide : A member of the class of thioureas that is thiourea in which a hydrogen of one of the amino groups is replaced by an amino group. | 1.96 | 1 | 0 | hydrazines;
thiocarboxamide;
thioureas | |
3-(4-chlorophenyl)-2-methyl-3,3a,4,5-tetrahydrobenzo[g]indazole
[no description available] | 2.17 | 1 | 0 | tetralins | |
6-hydroxy-4-methyl-2-phenyl-2,3-dihydropyridazin-3-one
[no description available] | 2.17 | 1 | 0 | pyridazinone | |
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea
1-(4-chlorophenyl)-3-[4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl]urea : An member of the class of phenylureas that is urea having 4-chlorophenyl and 4-methyl-2-(thiophen-2-yl)-1,3-thiazol-5-yl groups attached at positions 1 and 3 respectively. | 2.17 | 1 | 0 | 1,3-thiazoles;
monochlorobenzenes;
phenylureas;
thiophenes | |
N'-[(4-chlorophenyl)-oxomethyl]-2-methyl-4-thiazolecarbohydrazide
[no description available] | 2.17 | 1 | 0 | carbonyl compound;
organohalogen compound | |
bi-78d3
[no description available] | 2.17 | 1 | 0 | aryl sulfide | |
n-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide
N-(3-chloro-4-methylphenyl)-4-methyl-1,2,3-thiadiazole-5-carboxamide: activates the plant defense response; structure in first source. tiadinil : A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-methyl-1,2,3-thiadiazole-5-carboxylic acid with the amino group of 3-chloro-4-methylaniline. It is a fungicide used particularly for the control of fungal diseases in rice. | 2.17 | 1 | 0 | anilide fungicide;
monocarboxylic acid amide;
monochlorobenzenes;
organosulfur compound;
thiadiazoles | antifungal agrochemical |
N'2-[3-(trifluoromethyl)benzoyl]-3-aminopyrazine-2-carbohydrazide
[no description available] | 2.17 | 1 | 0 | (trifluoromethyl)benzenes | |
2-amino-4-(2-chlorophenyl)-6-[(4-chlorophenyl)thio]pyridine-3,5-dicarbonitrile
[no description available] | 2.17 | 1 | 0 | phenylpyridine | |
2-[5-[(3-chlorophenyl)thio]-2-thiophenyl]pyridine
[no description available] | 2.17 | 1 | 0 | aryl sulfide | |
8-methylsulfinyl-4,5-dihydrothieno[3,4-g][2,1]benzoxazole-6-carboxylic acid ethyl ester
[no description available] | 2.17 | 1 | 0 | thiophenecarboxylic acid | |
1-(5-tert-butyl-2-methyl-3-pyrazolyl)-3-(3,5-dichlorophenyl)urea
[no description available] | 2.17 | 1 | 0 | ureas | |
4-[[4-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-7-methyl-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]methyl]morpholine
[no description available] | 2.17 | 1 | 0 | isoquinolines | |
7-chloro-3-hydroxy-2-[3-(trifluoromethyl)phenyl]-4-quinazolinone
[no description available] | 2.17 | 1 | 0 | quinazolines | |
2-(1H-benzimidazol-2-ylthio)-1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]ethanone
[no description available] | 2.17 | 1 | 0 | benzimidazoles | |
ethyl 4-(3-oxo-2,3-dihydroisothiazol-2-yl)benzoate
[no description available] | 2.17 | 1 | 0 | organic molecular entity | |
7-chloro-N-(phenylmethyl)-4-quinolinamine
[no description available] | 2.17 | 1 | 0 | aminoquinoline | |
6-methoxy-2-methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-4-quinolinamine
[no description available] | 2.17 | 1 | 0 | aminoquinoline | |
indium
Indium: A metallic element, atomic number 49, atomic weight 114.818, symbol In. It is named from its blue line in the spectrum.. indium atom : A metallic element first identified and named from the brilliant indigo (Latin indicum) blue line in its flame spectrum. | 2.15 | 1 | 0 | boron group element atom | |
2-formylpyridine thiosemicarbazone
2-formylpyridine thiosemicarbazone: structure; RN given refers to parent cpd without isomeric designation | 7.43 | 2 | 0 | | |
thiosemicarbazone h
thiosemicarbazone H: antibacterial & antiparasitic properties; structure given in first source | 2.41 | 2 | 0 | | |
2-acetylpyridine-4-methyl-3-thiosemicarbazone
[no description available] | 3.13 | 5 | 0 | | |
sri 286
[no description available] | 2.15 | 1 | 0 | | |
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea
1-isoquinolin-5-yl-3-(4-trifluoromethyl-benzyl)-urea: structure in first source | 2.17 | 1 | 0 | | |
thioacetazone
Thioacetazone: A thiosemicarbazone that is used in association with other antimycobacterial agents in the initial and continuation phases of antituberculosis regimens. Thiacetazone containing regimens are less effective than the short-course regimen recommended by the International Union Against Tuberculosis and are used in some developing countries to reduce drug costs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p217). thiosemicarbazone : A hydrazone resulting from the formal condensation of an aldehyde or ketone with the non-thioacylated nitrogen of thiosemicarbazide or its substituted derivatives. | 1.96 | 1 | 0 | | |
3-aminopyridine-2-carboxaldehyde thiosemicarbazone
3-aminopyridine-2-carboxaldehyde thiosemicarbazone: a neuroprotective agent; structure given in first source | 3.58 | 2 | 0 | | |
2-acetylpyridine semicarbazone
[no description available] | 2.41 | 2 | 0 | | |
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime
4-(4-chlorophenyl)-3-methylbut-3-en-2-oxime: a TRPA1 antagonist | 2.17 | 1 | 0 | | |
di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone
[no description available] | 3.55 | 2 | 0 | | |
di-2-pyridyl ketone isonicotinoyl hydrazone
di-2-pyridyl ketone isonicotinoyl hydrazone: a chelating agent; structure in first source | 2.05 | 1 | 0 | | |
acyclovir
Acyclovir: A GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes.. acyclovir : An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. | 2.68 | 3 | 0 | 2-aminopurines;
oxopurine | antimetabolite;
antiviral drug |
rifampin
Rifampin: A semisynthetic antibiotic produced from Streptomyces mediterranei. It has a broad antibacterial spectrum, including activity against several forms of Mycobacterium. In susceptible organisms it inhibits DNA-dependent RNA polymerase activity by forming a stable complex with the enzyme. It thus suppresses the initiation of RNA synthesis. Rifampin is bactericidal, and acts on both intracellular and extracellular organisms. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1160) | 2.13 | 1 | 0 | cyclic ketal;
hydrazone;
N-iminopiperazine;
N-methylpiperazine;
rifamycins;
semisynthetic derivative;
zwitterion | angiogenesis inhibitor;
antiamoebic agent;
antineoplastic agent;
antitubercular agent;
DNA synthesis inhibitor;
EC 2.7.7.6 (RNA polymerase) inhibitor;
Escherichia coli metabolite;
geroprotector;
leprostatic drug;
neuroprotective agent;
pregnane X receptor agonist;
protein synthesis inhibitor |
ganciclovir
[no description available] | 2.06 | 1 | 0 | 2-aminopurines;
oxopurine | antiinfective agent;
antiviral drug |
salinazid
[no description available] | 2.13 | 1 | 0 | aromatic carboxylic acid;
pyridinemonocarboxylic acid | |
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone
2-hydroxy-1-naphthylaldehyde isonicotinoyl hydrazone: structure in first source | 3.55 | 2 | 0 | | |
pyridoxal isonicotinoyl hydrazone
pyridoxal isonicotinoyl hydrazone: acts as iron chelating agent | 3.55 | 2 | 0 | | |