metronidazole has been researched along with Pancreatic Insufficiency in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with exocrine pancreatic insufficiency have steatorrhoea as well as vitamin B12 malassimilation." | 1.28 | Short report: lipid and vitamin B12 malassimilation in pancreatic insufficiency. ( Bang Jørgensen, B; Thorsgaard Pedersen, N; Worning, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Walkowiak, J | 1 |
| Krawczynski, M | 1 |
| Herzig, KH | 1 |
| Carroccio, A | 1 |
| Montalto, G | 1 |
| Iacono, G | 1 |
| Ippolito, S | 1 |
| Soresi, M | 1 |
| Notarbartolo, A | 1 |
| Bang Jørgensen, B | 1 |
| Thorsgaard Pedersen, N | 1 |
| Worning, H | 1 |
3 other studies available for metronidazole and Pancreatic Insufficiency
| Article | Year |
|---|---|
Giardiasis aggravates malabsorption in cystic fibrosis.
Topics: Antiprotozoal Agents; Child, Preschool; Cystic Fibrosis; Exocrine Pancreatic Insufficiency; Female; | 2004 |
Secondary impairment of pancreatic function as a cause of severe malabsorption in intestinal giardiasis: a case report.
Topics: Animals; Antiprotozoal Agents; Antitrichomonal Agents; Exocrine Pancreatic Insufficiency; Giardia la | 1997 |
Short report: lipid and vitamin B12 malassimilation in pancreatic insufficiency.
Topics: Cephalexin; Cobalt Radioisotopes; Dietary Fats; Enzyme Therapy; Exocrine Pancreatic Insufficiency; F | 1991 |