Cholesteatoma

A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.

Synonym
Cholesteatoma

Excerpt	Reference
"Although cholesteatomas are more commonly found in the middle ear and the mastoid, the disease can occur in the external ear canal."	( Holt, JJ, 1992)
"Since cholesteatomas are usually associated with inflammatory reactions in the middle ear cavity, we examined the effects of a granulation tissue conditioned medium on the terminal differentiation of basal keratinocytes in vitro."	( Chao, WY; Huang, CC; Yi, ZX, 1988)
"Although cholesteatomas are not malignant tumors, our working hypothesis was that their high lipid content might result in their exhibiting a remarkable affinity to HP, which is normally carried in the blood by lipoproteins."	( Iori, G; Meloni, F; Perria, C; Tanda, F; Teatini, GP, 1989)
"An attic cholesteatoma is defined as an epidermoid cyst found in the attic."	( Sadé, J, 1980)
"The formation of Cholesteatoma is often accompanied by infection, and is very likely to be influenced by inflammatory mediators."	( Grote, JJ; Hesseling, SC; Koopman, JP, 1995)
"Middle ear cholesteatoma is characterised by the presence of a stratified squamous epithelium with keratin depositions in the middle ear cavity."	( Bujia, J; Holly, A; Stammberger, M, 1993)
"Cholesteatoma is characterized by the presence of a squamous epithelium invading the middle ear altering its growth properties."	( Bujía, J; Holly, A; Kastenbauer, E; Schilling, V; Stammberger, M, 1993)
"Cholesteatoma is less common and can present a diagnostic challenge."	( Dort, JC; Garber, LZ, 1994)
"Secondary cholesteatoma are the most frequent pseudo-tumours of the middle ear: CT and MRI evaluate very well their extension particularly in the giant forms."	( Blonde, E; Moulin, G; Riehm, S; Roedlich, MN; Tongio, J; Veillon, F, 1999)
"Cholesteatoma is a disease of inflammatory bone resorption in the middle ear leading to hearing loss and vestibular dysfunction."	( Chole, RA; Faddis, BT; Jung, JY; Nishimoto, SY; Pashia, ME, 2004)
"Cholesteatoma is known as a proliferative disease in the middle ear which pathogenesis is not completely understood."	( Olszewska, E; Sudhoff, H, 2007)
"Cholesteatoma is the main lesion to distinguish from CG."	( Bartoszewicz, R; Januszek, G; Morawski, K; Niemczyk, K; Orkan-Lecka, E, 2007)
"Cholesteatoma is the growth of keratinizing squamous epithelium in the middle ear."	( Birkler, RI; Britze, A; Gregersen, N; Ovesen, T; Palmfeldt, J, 2014)
"Aetiology of cholesteatoma is thought to be multifactorial."	( Dziubdziela, W; Jura-Szołtys, E; Kostrząb-Zdebel, A; Likus, W; Markowski, J; Siemianowicz, K; Wiaderkiewicz, J; Wiaderkiewicz, R; Łos, MJ, 2016)
"Cholesteatomas are benign tumors mainly composed of cholesterol crystals that rarely arise within the orbit."	( Ángeles-Castellanos, M; Choreño-Parra, JA; García-Quintero, G; Guadarrama-Ortiz, P; Pacheco-Sánchez, FJ; Rodríguez-Muñoz, PE; Rodríguez-Nava, AI; Sánchez-Garibay, C, 2021)
"Cholesteatoma is a mass formed by the keratinizing squamous epithelium in the tympanic cavity and/or mastoid and subepithelial connective tissue and by the progressive accumulation of keratin debris with/without a surrounding inflammatory reaction."	( Akiyama, N; Hirabayashi, M; Kojima, H; Shimmura, H; Yamamoto-Fukuda, T, 2023)

Excerpt	Reference
"Cholesteatoma has attracted many studies seeking to uncover its nature and the pathogenesis of related diseases."	( Chen, HC; Chen, HK; Chen, YT; Kuo, CY; Lee, JT; Lin, YC; Lin, YY; Shih, CP; Wang, CH, 2018)

Excerpt	Reference
"To determine the efficacy in treatment of cholesteatoma the concentration of azlocillin in separate tissue fractions of cholesteatoma matrix, cholesteatoma debris and granulation tissue surrounding cholesteatoma was determined."	( Mertens, J; Ullmann, U; Wustrow, J, 1988)
"Cefoxitin should be considered for the treatment of cholesteatoma undergoing surgical procedures because it is well tolerated, has a broad spectrum of antibacterial activity against both Gram-positive and Gram-negative pathogens including anaerobes."	( Morikawa, K, 1982)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	189 (59.06)	23.3326
1990's	72 (22.50)	12.5806
2000's	31 (9.69)	18.1394
2010's	17 (5.31)	28.8240
2020's	11 (3.44)	9.53

Drug	Relationship Strength	Studies	Trials
gamma-aminobutyric acid	low	1	0
salicylic acid	low	3	0
lactic acid	low	2	0
formaldehyde	low	1	0
dalteparin	low	1	0
propylene glycol	low	1	0
putrescine	low	3	0
pyruvic acid	low	1	0
spermidine	low	1	0
spermine	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
3-methylcholanthrene	low	2	0
pimagedine	low	1	0
aspirin	low	1	0
chlorpromazine	low	1	0
ciprofloxacin	medium	4	2
diazepam	low	1	0
pentetic acid	low	4	0
enoxacin	medium	1	1
erythrosine	low	2	0
fluorouracil	low	4	0
gabapentin	low	1	0
gentamicin	low	3	0
guaifenesin	low	6	0
2-propanol	low	1	0
meperidine	low	1	0
metronidazole	low	1	0
metyrapone	low	1	0
activins	low	1	0
ofloxacin	low	1	0
phenobarbital	low	1	0
promethazine	low	1	0
sevoflurane	low	1	0
succinylcholine	low	1	0
sulfanilamide	low	1	0
tramazoline	low	1	0
thymidine	low	3	0
prednisone	low	2	0
carbon tetrachloride	low	1	0
chloramphenicol	low	3	0
edetic acid	low	1	0
leucine	low	2	0
ampicillin	low	1	0
histidine	low	1	0
phencyclidine	low	1	0
isoprene	low	2	0
4-butyrolactone	low	1	0
framycetin	low	1	0
aluminum acetate	low	1	0
hydrazine	low	1	0
betamethasone	low	1	0
reticulin	low	1	0
gentian violet	low	2	0
hematoporphyrin	low	1	0
congo red	low	1	0
acetylcysteine	low	2	0
clopamide	low	1	0
erythromycin	low	1	0
durapatite	low	10	0
e 111	low	1	0
streptomycin	low	5	0
carbenicillin	low	1	0
enbucrilate	low	1	0
platinum	low	1	0
technetium	low	4	0
titanium	low	5	0
gadolinium	low	4	0
gold	low	1	0
calcium phosphate, dibasic, anhydrous	low	3	0
calcium phosphate, monobasic, anhydrous	low	3	0
tricalcium phosphate	low	8	0
chlormerodrin	low	1	0
phenyl acetate	low	1	0
cefazolin	low	1	0
amoxicillin	medium	1	1
propiconazole	low	15	0
fomesafen	low	2	0
imiquimod	low	1	0
remifentanil	low	1	0
2',7'-dichlorofluorescein	low	1	0
metaperiodate	low	2	0
cephalosporin c	low	2	0
lathosterol	low	1	0
delphinidin	low	2	0
fibrinogen	low	1	0
cobalt	low	1	0
calcium pyrophosphate	low	3	0
cortisone	low	2	0
glycogen	low	1	0
elastin	low	1	0
inositol 3-phosphate	low	1	0
meropenem	low	1	0
cefoxitin	low	1	0
metrizamide	low	2	0
erythromycin ethylsuccinate	low	1	0
retinol	low	3	0
bromochloroacetic acid	low	53	0
mezlocillin	medium	1	1
sulindac	low	1	0
thiopental	low	1	0
cobaltous chloride	low	1	0
sodium dodecyl sulfate	low	1	0
homoserine lactone	low	1	0
alpha-chymotrypsin	low	3	0
17-ketosteroids	low	1	0
osteoprotegerin	low	2	0
dinoprostone	low	6	0
dinoprost	low	1	0
cholecalciferol	low	1	0
6-ketoprostaglandin f1 alpha	low	1	0
isotretinoin	low	1	0
thromboxane b2	low	1	0
phenylephrine hydrochloride	low	6	0
aluminum	low	3	0
bismuth	low	1	0
indium	low	1	0
cysteine	low	1	0
silicon	low	2	0
sulindac sulfone	low	1	0
cefotaxime	low	1	0
radium	low	1	0
oxalates	low	1	0
involucrin	low	2	0
azlocillin	low	1	0
gadolinium dtpa	low	4	0
aluminum oxide	low	2	0
scopolamine hydrobromide	low	1	0
acid phosphatase	low	5	0
jaw	low	1	0
nad	low	1	0
phosphatidylcholines	low	1	0
mesna	low	1	0
sodium hypochlorite	low	1	0
piperidines	low	1	0
interleukin-8	low	2	0
colistin	low	1	0
tetracycline	low	2	0
oxytetracycline, anhydrous	low	1	0
epidermal growth factor	low	3	0
transforming growth factor beta	low	2	0
hyaluronoglucosaminidase	low	1	0
transforming growth factor alpha	low	8	0
thromboplastin	low	2	0
exudates	low	1	0
lipoteichoic acid	low	1	0
eye	low	2	0

Protein Targets (987)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	4	0	0	4
Chain A, RNA-directed RNA polymerase NS5	0	1	0	1
acid sphingomyelinase	3	0	0	3
thioredoxin reductase	23	0	0	23
USP1 protein, partial	14	0	0	14
TDP1 protein	31	0	0	31
vitamin D3 receptor isoform VDRA	19	0	0	19
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	10	0	0	10
serine/threonine-protein kinase PLK1	5	0	0	5
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	7	0	0	7
GTP-binding nuclear protein Ran isoform 1	2	0	0	2
DNA polymerase eta isoform 1	5	0	0	5
DNA polymerase iota isoform a (long)	9	0	0	9
urokinase-type plasminogen activator precursor	8	0	0	8
plasminogen precursor	8	0	0	8
urokinase plasminogen activator surface receptor precursor	8	0	0	8
geminin	30	0	0	30
DNA polymerase kappa isoform 1	10	0	0	10
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	2	0	2
Transthyretin	0	0	1	1
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	1	0	1
Cannabinoid receptor 1	0	2	1	3
Cyclin-dependent kinase 2	0	1	1	2
Choline O-acetyltransferase	0	2	0	2
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	3	0	0	3
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	2	0	2
hypoxia-inducible factor 1 alpha subunit	11	0	0	11
RAR-related orphan receptor gamma	28	0	0	28
GLI family zinc finger 3	31	0	0	31
AR protein	40	0	0	40
aldehyde dehydrogenase 1 family, member A1	26	0	0	26
retinoic acid nuclear receptor alpha variant 1	29	0	0	29
retinoid X nuclear receptor alpha	20	0	0	20
estrogen nuclear receptor alpha	42	0	0	42
peroxisome proliferator-activated receptor delta	20	0	0	20
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	18	0	0	18
activating transcription factor 6	10	0	0	10
v-jun sarcoma virus 17 oncogene homolog (avian)	13	0	0	13
Histone H2A.x	11	0	0	11
thyroid hormone receptor beta isoform a	14	0	0	14
heat shock protein beta-1	10	0	0	10
nuclear factor erythroid 2-related factor 2 isoform 1	31	0	0	31
lamin isoform A-delta10	23	0	0	23
Voltage-dependent calcium channel gamma-2 subunit	13	0	0	13
Glutamate receptor 2	13	0	0	13
Luciferase	13	0	0	13
pregnane X receptor	11	0	0	11
phosphopantetheinyl transferase	14	0	0	14
SMAD family member 2	10	0	0	10
SMAD family member 3	10	0	0	10
Microtubule-associated protein tau	15	0	0	16
caspase 7, apoptosis-related cysteine protease	4	0	0	4
nuclear receptor subfamily 1, group I, member 3	23	0	0	23
estrogen-related nuclear receptor alpha	30	0	0	30
farnesoid X nuclear receptor	17	0	0	17
pregnane X nuclear receptor	24	0	0	24
peroxisome proliferator activated receptor gamma	18	0	0	18
caspase-3	4	0	0	4
euchromatic histone-lysine N-methyltransferase 2	31	0	0	31
aryl hydrocarbon receptor	14	0	0	14
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	7	0	0	7
Cellular tumor antigen p53	28	0	0	28
Cytochrome P450 1A2	0	4	2	6
Tyrosine-protein kinase Lck	0	1	0	1
Tyrosine-protein kinase Fyn	0	3	0	3
Aldo-keto reductase family 1 member B1	0	7	0	7
Adenosine receptor A3	0	8	0	8
Alpha-1B adrenergic receptor	0	11	0	11
Acetylcholinesterase	0	5	0	5
Sodium-dependent noradrenaline transporter	0	6	0	6
Aryl hydrocarbon receptor	0	0	1	1
Alpha-1A adrenergic receptor	0	12	0	12
Solute carrier organic anion transporter family member 2A1	0	1	0	5
Chain A, 2-oxoglutarate Oxygenase	15	0	0	15
Chain A, ATP-DEPENDENT DNA HELICASE Q1	8	0	0	8
acetylcholinesterase	9	0	0	9
dopamine D1 receptor	3	0	0	3
15-lipoxygenase, partial	7	0	0	7
NFKB1 protein, partial	5	0	0	5
Thrombopoietin	5	0	0	5
regulator of G-protein signaling 4	14	0	0	14
glucocorticoid receptor [Homo sapiens]	25	0	0	25
vitamin D (1,25- dihydroxyvitamin D3) receptor	18	0	0	18
arylsulfatase A	8	0	0	8
Bloom syndrome protein isoform 1	12	0	0	12
D(1A) dopamine receptor	5	0	0	5
thyroid hormone receptor beta isoform 2	24	0	0	24
peripheral myelin protein 22	14	0	0	14
survival motor neuron protein isoform d	9	0	0	9
muscarinic acetylcholine receptor M1	9	0	0	9
Histone deacetylase 3	0	2	0	2
Solute carrier family 22 member 6	0	6	0	6
Histone deacetylase 4	0	2	0	2
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	2	0	2
Histone deacetylase 2	0	2	0	2
Polyamine deacetylase HDAC10	0	2	0	2
Histone deacetylase 11	0	2	0	2
Ataxin-2	9	0	0	9
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	2	0	2
Histone deacetylase 5	0	2	0	2
ATP-dependent phosphofructokinase	15	0	0	15
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	13	0	0	13
Chain A, Beta-lactamase	9	0	0	9
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Beta-lactamase	0	0	0	5
Beta-lactamase	0	0	0	4
apical membrane antigen 1, AMA1	4	0	0	4
Beta-lactamase	0	0	0	2
ATP-binding cassette sub-family C member 3	0	22	0	22
Multidrug resistance-associated protein 4	0	22	0	24
Bile salt export pump	0	5	0	5
Bile salt export pump	0	34	0	34
Beta-lactamase SHV-1	0	0	0	2
Beta-lactamase SHV-1	0	0	0	4
Cytochrome P450 2C9	0	4	1	5
Beta-lactamase	0	0	0	5
Kappa-type opioid receptor	0	0	0	3
Solute carrier family 15 member 1	0	6	0	6
Solute carrier family 15 member 1	0	2	0	2
Cytochrome P450 2J2	0	3	0	3
B2 metallo-beta-lactamase	0	0	0	5
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Solute carrier family 15 member 2	0	3	0	3
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	4
Canalicular multispecific organic anion transporter 1	0	19	0	19
Chain A, Mutant Al2 6e7p9g	0	0	1	1
Chain A, Cruzipain	9	0	0	9
Beta-lactamase	0	2	0	4
GLS protein	12	0	0	12
Beta-lactamase	0	2	0	4
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase type 2	0	0	1	6
Metallo-beta-lactamase VIM-11	0	0	0	5
Metallo-beta-lactamase VIM-2	0	0	0	5
Beta-lactamase	0	0	0	4
Metallo-beta-lactamase	0	0	0	5
Beta-lactamase	0	2	0	4
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	11	0	0	11
chromobox protein homolog 1	18	0	0	18
DNA polymerase beta	3	0	0	3
Carbonic anhydrase 1	0	11	0	14
Carbonic anhydrase 2	0	11	1	15
60 kDa heat shock protein, mitochondrial	0	5	0	5
Beta-lactamase OXA-7	0	0	0	3
Spike glycoprotein	11	2	2	15
10 kDa heat shock protein, mitochondrial	0	5	0	5
Angiopoietin-1 receptor	0	0	1	1
Beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	4
Beta-lactamase	0	0	0	4
Thiosulfate sulfurtransferase	0	5	0	5
Metallo-beta-lactamase VIM-13	0	1	0	5
Efflux transporter	0	0	0	1
Beta-lactamase	0	0	0	5
Beta-lactamase Toho-1	0	0	0	2
Beta-lactamase	0	0	0	1
Class D beta-lactamase	0	0	0	2
60 kDa chaperonin	0	5	0	5
Metallo-beta-lactamase	0	0	0	5
Beta-lactamase	0	0	0	5
Beta-lactamase	0	0	1	4
10 kDa chaperonin	0	5	0	5
Metallo-b-lactamase	0	0	0	7
Carbapenem-hydrolyzing beta-lactamase KPC	0	0	0	5
Histamine H3 receptor	0	0	0	5
Beta-lactamase class B VIM-2	0	0	1	8
Beta-lactamase VIM-1	0	1	0	5
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	14	0	0	14
Chain A, Phospholipase A2 isoform 3	0	0	1	1
Chain A, HADH2 protein	10	0	0	10
Chain B, HADH2 protein	10	0	0	10
GTP-binding protein (rab7)	0	0	1	1
ras protein, partial	0	0	1	1
interleukin 8	8	0	0	8
thyroid stimulating hormone receptor	17	0	0	17
hypothetical protein, conserved	4	0	0	4
cytochrome P450 family 3 subfamily A polypeptide 4	16	0	0	16
EWS/FLI fusion protein	15	0	0	15
cytochrome P450 2D6	10	0	0	10
glucocerebrosidase	3	0	0	3
Rac1 protein	0	0	1	1
IDH1	7	0	0	7
cell division cycle 42 (GTP binding protein, 25kDa), partial	0	0	1	1
lethal factor (plasmid)	8	0	0	8
Prostaglandin-H2 D-isomerase	0	1	0	1
Prostaglandin G/H synthase 1	0	2	0	2
Prostaglandin G/H synthase 2	0	2	0	2
Epidermal growth factor receptor	0	6	0	6
Fatty acid-binding protein, liver	0	2	0	2
Integrin beta-3	4	1	0	5
Myeloperoxidase	0	2	0	2
Prostaglandin G/H synthase 1	0	2	0	2
Seed linoleate 13S-lipoxygenase-1	0	1	0	1
Integrin alpha-IIb	4	1	0	5
Glutathione hydrolase 1 proenzyme	0	1	0	1
Prostaglandin G/H synthase 1	0	4	0	4
Adenosine receptor A1	0	1	0	2
Adenosine receptor A2a	0	1	0	2
Substance-P receptor	0	1	0	1
Prostaglandin G/H synthase 2	0	5	0	5
Urotensin-2 receptor	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	1	0	1
Nuclear receptor ROR-gamma	9	1	2	12
Ras-related protein Rab-2A	0	0	1	1
Gamma-aminobutyric acid receptor subunit alpha-1	12	8	2	22
Prostaglandin G/H synthase 2	0	1	0	1
Rho-associated protein kinase 2	0	1	0	1
Nicotinate phosphoribosyltransferase	0	2	0	2
Solute carrier family 22 member 20	0	5	0	5
Solute carrier family 22 member 6	0	5	0	5
Sigma non-opioid intracellular receptor 1	0	5	1	6
Sigma non-opioid intracellular receptor 1	0	2	1	3
progesterone receptor	13	0	0	13
nuclear receptor subfamily 1, group I, member 2	2	0	0	2
nuclear factor erythroid 2-related factor 2 isoform 2	5	0	0	5
galanin receptor type 3	0	1	0	1
Glucocorticoid receptor	0	6	1	7
Glycine receptor subunit alpha-1	0	6	0	6
Glycine receptor subunit beta	0	6	0	6
Glycine receptor subunit alpha-2	0	6	0	6
Glycine receptor subunit alpha-3	0	6	0	6
ORF73	0	0	1	1
thyroid stimulating hormone receptor	14	0	0	14
Dihydroxyacetone phosphate acyltransferase	0	0	0	3
potassium voltage-gated channel subfamily H member 2 isoform d	8	0	0	8
Cytochrome P450 2E1	0	1	0	1
Chain A, Putative fructose-1,6-bisphosphate aldolase	5	0	0	5
Smad3	3	0	0	3
Solute carrier family 22 member 6	0	3	0	5
Solute carrier family 22 member 8	0	3	0	6
Solute carrier family 22 member 11	0	2	0	5
Solute carrier family 22 member 8	0	2	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	1	0	2
Metallo-beta-lactamase VIM-19	0	0	0	4
Beta-lactamase	0	0	0	1
Albumin	0	2	5	8
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase VIM-2	0	0	0	4
Solute carrier family 22 member 7	0	1	0	4
BlaVIM-1	0	0	0	4
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	3
Solute carrier family 22 member 7	0	1	0	4
Solute carrier family 22 member 8	0	1	0	2
G	9	0	0	9
streptokinase A precursor	0	0	5	5
Interferon beta	10	0	0	10
HLA class I histocompatibility antigen, B alpha chain	9	0	0	9
30S ribosomal protein S6	0	4	1	5
30S ribosomal protein S7	0	4	1	5
50S ribosomal protein L15	0	4	1	5
Cytochrome P450 3A4	0	7	2	9
50S ribosomal protein L10	0	4	1	5
50S ribosomal protein L11	0	4	1	5
50S ribosomal protein L7/L12	0	4	1	5
50S ribosomal protein L19	0	4	1	5
50S ribosomal protein L1	0	4	1	5
50S ribosomal protein L20	0	4	1	5
50S ribosomal protein L27	0	4	1	5
50S ribosomal protein L28	0	4	1	5
50S ribosomal protein L29	0	4	1	5
50S ribosomal protein L31	0	4	1	5
50S ribosomal protein L31 type B	0	4	1	5
50S ribosomal protein L32	0	4	1	5
50S ribosomal protein L33	0	4	1	5
50S ribosomal protein L34	0	4	1	5
50S ribosomal protein L35	0	4	1	5
50S ribosomal protein L36	0	4	1	5
30S ribosomal protein S10	0	4	1	5
30S ribosomal protein S11	0	4	1	5
30S ribosomal protein S12	0	4	1	5
30S ribosomal protein S13	0	4	1	5
30S ribosomal protein S16	0	4	1	5
30S ribosomal protein S18	0	4	1	5
30S ribosomal protein S19	0	4	1	5
30S ribosomal protein S20	0	4	1	5
30S ribosomal protein S2	0	4	1	5
30S ribosomal protein S3	0	4	1	5
30S ribosomal protein S4	0	4	1	5
30S ribosomal protein S5	0	4	1	5
30S ribosomal protein S8	0	4	1	5
30S ribosomal protein S9	0	4	1	5
50S ribosomal protein L13	0	4	1	5
50S ribosomal protein L14	0	4	1	5
50S ribosomal protein L16	0	4	1	5
50S ribosomal protein L23	0	4	1	5
30S ribosomal protein S15	0	4	1	5
50S ribosomal protein L17	0	4	1	5
50S ribosomal protein L21	0	4	1	5
50S ribosomal protein L30	0	4	1	5
50S ribosomal protein L6	0	4	1	5
30S ribosomal protein S14	0	4	1	5
30S ribosomal protein S17	0	4	1	5
30S ribosomal protein S1	0	4	1	5
50S ribosomal protein L18	0	4	1	5
50S ribosomal protein L2	0	4	1	5
50S ribosomal protein L3	0	4	1	5
50S ribosomal protein L24	0	4	1	5
50S ribosomal protein L4	0	4	1	5
50S ribosomal protein L22	0	4	1	5
50S ribosomal protein L5	0	4	1	5
30S ribosomal protein S21	0	4	1	5
50S ribosomal protein L25	0	4	1	5
50S ribosomal protein L36 2	0	4	1	5
Inositol hexakisphosphate kinase 1	9	0	0	9
Methionine--tRNA ligase, mitochondrial	0	0	1	1
cytochrome P450 2C9, partial	9	0	0	9
Proteasome subunit beta type-11	0	0	0	1
ATAD5 protein, partial	10	0	0	10
Fumarate hydratase	4	0	0	4
estrogen receptor 2 (ER beta)	13	0	0	13
NADPH oxidase 1	0	1	0	1
polyprotein	4	0	0	4
67.9K protein	4	0	0	4
Snq2p	0	0	0	2
Adenylate cyclase type 1	0	2	0	2
Caspase-7	4	0	0	4
Spike glycoprotein	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
cytochrome P450 2D6 isoform 1	2	0	0	2
cellular tumor antigen p53 isoform a	4	0	0	4
caspase-3	4	0	0	4
histone deacetylase 9 isoform 3	2	0	0	2
mitogen-activated protein kinase 1	9	0	0	9
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
ras-related protein Rab-9A	2	0	0	2
serine/threonine-protein kinase mTOR isoform 1	5	0	0	5
cytochrome P450 3A4 isoform 1	12	0	0	12
M-phase phosphoprotein 8	8	0	0	8
histone acetyltransferase KAT2A isoform 1	12	0	0	12
Gamma-aminobutyric acid receptor subunit pi	12	7	1	20
Proteasome subunit alpha type-7	0	0	0	1
Solute carrier family 22 member 1	0	3	0	6
Polyunsaturated fatty acid lipoxygenase ALOX15B	7	0	0	7
Transmembrane protease serine 2	0	2	2	4
Glutamate receptor ionotropic, NMDA 2D	0	2	0	2
Transient receptor potential cation channel subfamily V member 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	0	2
Voltage-dependent L-type calcium channel subunit alpha-1F	0	3	0	3
5-hydroxytryptamine receptor 4	0	4	0	4
Potassium channel subfamily K member 2	0	1	0	1
Albumin	0	0	2	2
Major prion protein	0	0	2	2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	0	1	0	1
Receptor tyrosine-protein kinase erbB-2	0	1	0	1
Major prion protein	0	0	1	1
Procathepsin L	0	2	2	4
Muscarinic acetylcholine receptor M2	0	8	0	8
Muscarinic acetylcholine receptor M4	0	8	0	8
ATP-dependent translocase ABCB1	0	3	0	5
Muscarinic acetylcholine receptor M1	0	3	1	4
Muscarinic acetylcholine receptor M3	0	2	1	3
Muscarinic acetylcholine receptor M4	0	2	1	3
5-hydroxytryptamine receptor 1A	0	1	0	1
5-hydroxytryptamine receptor 2C	0	2	0	2
Muscarinic acetylcholine receptor M5	0	2	1	3
Muscarinic acetylcholine receptor M5	0	7	0	7
Alpha-2A adrenergic receptor	0	6	0	6
Replicase polyprotein 1a	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
Replicase polyprotein 1ab	0	2	2	4
Cys-loop ligand-gated ion channel	0	1	0	1
Calmodulin-1	0	3	1	4
Replicase polyprotein 1ab	0	2	2	4
Cytochrome P450 2D6	0	5	2	7
Muscarinic acetylcholine receptor M2	0	3	2	5
Muscarinic acetylcholine receptor M1	0	8	0	8
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Angiotensin-converting enzyme	0	3	0	3
D(2) dopamine receptor	0	6	0	7
5-hydroxytryptamine receptor 2A	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	12	7	1	20
Sphingomyelin phosphodiesterase	0	1	0	1
Alpha-2B adrenergic receptor	0	8	0	8
Gamma-aminobutyric acid receptor subunit delta	12	7	1	20
Gamma-aminobutyric acid receptor subunit gamma-2	12	7	2	21
Alpha-2C adrenergic receptor	0	6	0	6
D	0	2	0	2
D(3) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 1A	0	8	1	9
Alpha-2B adrenergic receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-5	12	7	1	20
Gamma-aminobutyric acid receptor subunit alpha-3	12	7	1	20
D(2) dopamine receptor	0	1	0	1
Muscarinic acetylcholine receptor M3	0	7	0	7
Proteasome subunit beta type-1	0	0	0	1
Substance-K receptor	0	4	0	4
D(1A) dopamine receptor	0	6	0	7
D(4) dopamine receptor	0	2	0	3
D(1B) dopamine receptor	0	1	0	2
Adenylate cyclase type 3	0	2	0	2
Alpha-2C adrenergic receptor	0	3	0	3
UDP-glucuronosyltransferase 1A4	0	0	0	1
Alpha-2A adrenergic receptor	0	3	0	3
Gamma-aminobutyric acid receptor subunit gamma-1	12	7	1	20
Gamma-aminobutyric acid receptor subunit alpha-2	12	7	1	20
Alpha-1D adrenergic receptor	0	4	0	4
Sodium-dependent dopamine transporter	0	3	0	3
Histamine H2 receptor	0	8	0	8
Alpha-1D adrenergic receptor	0	8	0	8
D(1B) dopamine receptor	0	2	0	2
Proteasome subunit alpha type-1	0	0	0	1
Proteasome subunit alpha type-2	0	0	0	1
Proteasome subunit alpha type-3	0	0	0	1
Proteasome subunit alpha type-4	0	0	0	1
Adenylate cyclase type 2	0	2	0	2
Adenylate cyclase type 4	0	2	0	2
Proteasome subunit beta type-8	0	0	0	1
Proteasome subunit beta type-9	0	0	0	1
Proteasome subunit alpha type-5	0	0	0	1
Proteasome subunit beta type-4	0	0	0	1
Proteasome subunit beta type-6	0	0	0	1
Proteasome subunit beta type-5	0	0	0	1
5-hydroxytryptamine receptor 2A	0	6	0	6
5-hydroxytryptamine receptor 2C	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-4	12	7	1	20
Gamma-aminobutyric acid receptor subunit gamma-3	12	7	1	20
5-hydroxytryptamine receptor 1B	0	4	0	4
Trypanothione reductase	0	4	0	4
Gamma-aminobutyric acid receptor subunit alpha-6	12	7	1	20
D(4) dopamine receptor	0	2	0	2
5-hydroxytryptamine receptor 2B	0	2	0	2
Histamine H1 receptor	0	1	0	1
Sodium-dependent serotonin transporter	0	4	0	4
Melanocortin receptor 4	0	2	0	2
5-hydroxytryptamine receptor 7	0	1	0	1
Melanocortin receptor 5	0	2	0	2
Pleiotropic ABC efflux transporter of multiple drugs	0	2	0	4
5-hydroxytryptamine receptor 7	0	1	0	1
Histamine H1 receptor	0	4	0	4
Mu-type opioid receptor	0	5	1	6
Glutamate receptor ionotropic, NMDA 1	0	5	1	7
D(3) dopamine receptor	0	6	0	7
Sodium channel protein type 1 subunit alpha	0	2	0	2
Sodium channel protein type 4 subunit alpha	0	1	0	1
Adenylate cyclase type 8	0	2	0	2
Proteasome subunit beta type-10	0	0	0	1
Delta-type opioid receptor	0	3	0	3
Kappa-type opioid receptor	0	5	0	5
5-hydroxytryptamine receptor 2B	0	8	0	8
Melanocortin receptor 3	0	2	0	2
Histamine H2 receptor	11	0	0	11
Proteasome subunit beta type-3	0	0	0	1
Proteasome subunit beta type-2	0	0	0	1
D(1A) dopamine receptor	2	0	0	2
5-hydroxytryptamine receptor 6	0	4	0	4
5-hydroxytryptamine receptor 7	0	2	0	2
Gastrin/cholecystokinin type B receptor	0	1	0	1
Proteasome subunit alpha type-6	0	0	1	2
D(2) dopamine receptor	0	2	0	3
Calmodulin	0	1	2	3
Gamma-aminobutyric acid receptor subunit beta-3	12	7	1	20
Gamma-aminobutyric acid receptor subunit beta-2	12	7	2	21
Aldehyde oxidase 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	5	0	6
Glutamate receptor ionotropic, NMDA 2B	0	5	1	7
Glutamate receptor ionotropic, NMDA 2C	0	5	0	7
Sodium channel protein type 7 subunit alpha	0	1	0	1
Voltage-dependent L-type calcium channel subunit alpha-1D	0	3	0	3
Sodium-dependent dopamine transporter	0	4	0	4
Adenylate cyclase type 6	0	2	0	2
Adenylate cyclase type 5	0	2	0	2
Glutamate receptor ionotropic, NMDA 1	0	3	0	3
Aldehyde oxidase	0	2	0	2
Potassium voltage-gated channel subfamily H member 2	0	8	0	9
Glutamate receptor ionotropic, NMDA 2A	0	3	0	3
Glutamate receptor ionotropic, NMDA 2B	0	3	1	4
Voltage-dependent L-type calcium channel subunit alpha-1S	0	3	0	3
Voltage-dependent L-type calcium channel subunit alpha-1C	0	3	0	3
Sodium channel protein type 5 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2C	0	2	0	2
Sodium channel protein type 9 subunit alpha	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	5	0	6
Nuclear receptor subfamily 3 group C member 3	0	2	0	2
Adenylyl cyclase 7	0	2	0	2
Proteasome subunit alpha-type 8	0	0	0	1
Glutamate receptor ionotropic, NMDA 3A	0	2	0	2
Glutamate receptor ionotropic, NMDA 3B	0	5	0	6
GABA theta subunit	12	7	1	20
D	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	2	0	2
Proteasome subunit beta type-7	0	0	0	1
Angiotensin-converting enzyme 2	0	2	2	4
Gamma-aminobutyric acid receptor subunit epsilon	12	7	1	20
Sodium channel protein type 3 subunit alpha	0	2	0	2
Glutamate receptor ionotropic, NMDA 3A	0	5	0	6
Sodium channel protein type 11 subunit alpha	0	1	0	1
Sodium channel protein type 8 subunit alpha	0	1	0	1
Histamine H3 receptor	0	2	0	2
Sodium channel protein type 10 subunit alpha	0	1	0	1
Chain A, Ferritin light chain	8	0	0	8
nuclear receptor ROR-gamma isoform 1	7	0	0	7
60 kDa chaperonin	0	4	0	4
Vitamin D3 receptor	0	1	1	4
Glycine receptor subunit alpha-1	0	0	2	2
Vitamin D3 receptor	0	0	1	1
cytochrome P450 2C9 precursor	5	0	0	5
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	2
DNA gyrase subunit A	0	3	0	6
DNA gyrase subunit B	0	3	0	6
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	2
DNA topoisomerase 4 subunit A	0	1	0	2
DNA topoisomerase 2-alpha	0	3	0	6
DNA gyrase subunit A	0	1	0	2
Cytochrome P450 2C19	0	2	1	3
Multidrug resistance protein MdtK	0	0	1	1
DNA gyrase subunit B	0	3	0	4
DNA gyrase subunit A	0	3	0	4
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	0	0	2
DNA topoisomerase 4 subunit A	0	1	0	1
DNA topoisomerase 4 subunit B	0	1	0	1
Integrase	0	2	0	2
TAR DNA-binding protein 43	6	0	0	6
B2 bradykinin receptor	0	1	0	1
Dihydrofolate reductase	0	0	0	1
Dihydrofolate reductase	0	1	0	1
Chymotrypsinogen A	0	1	0	2
Amyloid-beta precursor protein	1	5	0	6
Beta-lactamase	0	0	0	3
Beta-galactosidase	0	1	0	2
Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	0	2	0	2
PH domain leucine-rich repeat-containing protein phosphatase 2	0	1	0	1
Chymotrypsin-C	0	1	0	1
endonuclease IV	4	0	0	4
peripheral myelin protein 22 isoform 1	8	0	0	8
atrial natriuretic peptide receptor 1 precursor	1	0	0	1
Sex hormone-binding globulin	0	0	1	1
Corticosteroid-binding globulin	0	1	0	1
Potassium voltage-gated channel subfamily A member 1	0	0	1	1
Multidrug and toxin extrusion protein 1	0	2	0	2
Vascular endothelial growth factor receptor 2	0	1	0	1
Alpha-synuclein	0	4	0	4
Lactoylglutathione lyase	0	2	0	2
Histone acetyltransferase p300	0	1	0	1
CREB-binding protein	0	1	0	1
Gamma-aminobutyric acid	0	1	1	2
glp-1 receptor, partial	4	0	0	4
Gamma-aminobutyric acid receptor subunit pi	0	3	0	3
Gamma-aminobutyric acid receptor subunit delta	0	3	0	3
Alpha-1-acid glycoprotein 1	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-1	0	2	0	3
Gamma-aminobutyric acid receptor subunit beta-1	0	2	0	3
Neuronal acetylcholine receptor subunit alpha-4	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit alpha-3	0	2	0	3
Neuronal acetylcholine receptor subunit beta-2	2	1	0	3
Gamma-aminobutyric acid receptor subunit alpha-1	0	3	3	6
Translocator protein	0	1	1	3
Gamma-aminobutyric acid receptor subunit alpha-6	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-1	0	3	1	4
Gamma-aminobutyric acid receptor subunit gamma-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	2	0	3
Gamma-aminobutyric acid receptor subunit gamma-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit delta	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-2	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	3	2	5
Translocator protein	0	1	0	1
Translocator protein	0	1	0	1
Cholecystokinin receptor type A	0	1	0	1
Gastrin/cholecystokinin type B receptor	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	0	3	3	6
Gamma-aminobutyric acid receptor subunit alpha-3	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit beta-2	0	3	2	5
Gamma-aminobutyric acid receptor subunit alpha-4	0	3	1	4
Gamma-aminobutyric acid receptor subunit beta-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit alpha-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit beta-3	0	1	1	2
Gamma-aminobutyric acid receptor subunit epsilon	0	3	0	3
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
Gamma-aminobutyric acid receptor subunit alpha-6	0	3	1	4
Gamma-aminobutyric acid receptor subunit alpha-5	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	3	0	3
Gamma-aminobutyric acid receptor subunit pi	0	1	1	2
Sphingosine-1-phosphate lyase 1	0	1	0	1
ATPase family AAA domain-containing protein 5	6	0	0	6
Gamma-aminobutyric acid receptor subunit gamma-3	0	3	0	3
Gamma-aminobutyric acid receptor subunit alpha-4	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	1	1	2
Gamma-aminobutyric acid receptor subunit gamma-1	0	1	1	2
Gamma-aminobutyric acid receptor subunit theta	0	3	0	3
Solute carrier family 22 member 2	0	0	0	2
Thromboxane A2 receptor	0	1	1	2
Prostaglandin E2 receptor EP1 subtype	0	3	2	5
Prostaglandin E2 receptor EP4 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	2	0	2
Prostaglandin F2-alpha receptor	0	2	2	4
Prostaglandin E2 receptor EP3 subtype	0	3	2	5
Prostaglandin E2 receptor EP2 subtype	0	3	1	4
Prostaglandin F2-alpha receptor	0	0	1	1
Prostacyclin receptor	0	3	1	4
Prostaglandin D2 receptor	0	1	0	1
Solute carrier organic anion transporter family member 2A1	0	2	0	5
Solute carrier organic anion transporter family member 2A1	0	1	0	1
Solute carrier organic anion transporter family member 2B1	0	1	0	1
prostaglandin E2 receptor EP2 subtype	1	0	0	1
Solute carrier organic anion transporter family member 1A5	0	0	0	1
Prostaglandin E2 receptor EP3 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	0	1
Prostaglandin E2 receptor EP1 subtype	0	1	0	1
Prostaglandin E2 receptor EP4 subtype	0	1	1	2
Prostaglandin E2 receptor EP2 subtype	0	1	0	1
Prostaglandin E2 receptor EP2 subtype	0	1	1	2
Solute carrier family 22 member 7	0	0	0	1
Solute carrier organic anion transporter family member 1B2	0	0	0	1
Eyes absent homolog 2	0	1	0	1
Angiotensin-converting enzyme	0	1	0	1
Beta-lactamase	0	1	0	2
Beta-lactamase	0	1	0	1
V-type proton ATPase subunit B, brain isoform	0	1	0	1
RISC-loading complex subunit TARBP2	0	0	1	1
Motilin receptor	0	0	1	1
low molecular weight phosphotyrosine protein phosphatase isoform c	0	1	0	1
Motilin receptor	0	1	1	2
Rap guanine nucleotide exchange factor 3	3	0	0	3
ATP-dependent translocase ABCB1	0	2	0	2
Chitinase B	0	1	0	1
ATP-dependent translocase ABCB1	0	2	0	2
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
Cytochrome P450 1B1	0	2	0	2
Lanosterol 14-alpha demethylase	0	2	0	2
exodeoxyribonuclease V subunit RecD	0	1	0	1
exodeoxyribonuclease V subunit RecB	0	1	0	1
exodeoxyribonuclease V subunit RecC	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	2	0	2
Solute carrier organic anion transporter family member 1B1	0	2	0	2
Genome polyprotein	0	1	1	2
chaperonin-containing TCP-1 beta subunit homolog	2	0	0	2
thioredoxin glutathione reductase	5	0	0	5
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
thyrotropin-releasing hormone receptor	3	0	0	3
ubiquitin carboxyl-terminal hydrolase 2 isoform a	6	0	0	6
eyes absent homolog 2 isoform a	1	0	0	1
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
relaxin receptor 1 isoform 1	1	0	0	1
Flavin reductase (NADPH)	0	0	1	1
large T antigen	0	1	0	1
Chain A, Uracil Phosphoribosyltransferase	0	1	0	1
Skn7p	0	0	0	1
nonstructural protein 1	4	0	0	4
hemoglobin subunit beta	1	0	0	1
huntingtin isoform 2	3	0	0	3
Vpr	2	0	0	2
muscleblind-like protein 1 isoform 1	5	0	0	5
Thymidylate synthase	0	1	0	2
Aromatase	0	3	0	3
HSP40, subfamily A [Plasmodium falciparum 3D7]	0	0	0	1
Menin	0	0	1	1
Lecithin retinol acyltransferase	0	1	0	1
Lethal factor	0	1	0	1
Protein Rev	0	0	1	1
Aminoglycoside 3'-phosphotransferase	0	0	0	1
Tyrosyl-DNA phosphodiesterase 1	0	1	0	1
Voltage-dependent calcium channel subunit alpha-2/delta-1	0	1	0	1
Gamma-aminobutyric acid receptor subunit rho-3	0	0	1	1
Hsf1 protein	0	0	1	1
transcriptional regulator ERG isoform 3	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	1	0	0	1
neuropeptide S receptor isoform A	4	0	0	4
Gamma-aminobutyric acid type B receptor subunit 2	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 1	0	2	0	2
Gamma-aminobutyric acid receptor subunit rho-1	0	0	2	2
Gamma-aminobutyric acid receptor subunit rho-2	0	0	1	1
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent taurine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	2	0	2
Sodium- and chloride-dependent GABA transporter 3	0	2	0	2
Sodium- and chloride-dependent GABA transporter 1	0	1	0	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Sodium- and chloride-dependent betaine transporter	0	2	0	2
Sodium- and chloride-dependent betaine transporter	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
4-aminobutyrate aminotransferase, mitochondrial	0	0	0	1
Sterol O-acyltransferase 1	0	0	1	1
Proton-coupled amino acid transporter 1	0	2	0	3
Platelet glycoprotein VI	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Gamma-aminobutyric acid type B receptor subunit 1	0	0	1	1
Gamma-aminobutyric acid type B receptor subunit 1	0	1	0	1
beta-amyloid peptide, A beta {N-terminal} [human, cerebrospinal fluid, conditioned medium of mixed-brain cell cultures, Peptide Partial, 33 aa]	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	6	0	0	6
alpha synuclein, partial	1	0	0	1
luciferase	1	0	0	1
tumor necrosis factor	1	0	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
nuclear factor NF-kappa-B p105 subunit isoform 1	1	0	0	1
Androgen receptor	0	2	0	2
Glutamate receptor ionotropic, kainate 1	1	0	0	1
Adenosine receptor A2a	0	4	0	4
Glutamate receptor ionotropic, kainate 2	1	0	0	1
Glutamate receptor ionotropic, kainate 3	1	0	0	1
Disintegrin and metalloproteinase domain-containing protein 17	3	0	0	3
Fatty-acid amide hydrolase 1	1	1	0	2
Inositol monophosphatase 1	2	0	0	2
Glutamate receptor ionotropic, kainate 4	1	0	0	1
Leukotriene B4 receptor 1	1	0	0	1
Glutamate receptor ionotropic, kainate 5	1	0	0	1
Leukotriene B4 receptor 2	1	0	0	1
Chain A, HISTIDINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Carbonic anhydrase 12	0	4	0	5
Plasma kallikrein	0	0	0	1
Carbonic anhydrase 3	0	4	0	5
Histidine-binding periplasmic protein	0	0	1	1
Carbonic anhydrase 4	0	6	0	7
Carbonic anhydrase 6	0	5	0	6
5-hydroxytryptamine receptor 1D	0	0	0	1
Carbonic anhydrase 5A, mitochondrial	0	6	0	8
Carbonic anhydrase	0	2	0	3
Carbonic anhydrase 7	0	4	0	5
Carbonic anhydrase	0	1	0	2
Large neutral amino acids transporter small subunit 1	0	2	0	2
Glutaminyl-peptide cyclotransferase	0	1	0	1
Carbonic anhydrase 9	0	6	0	7
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase-like protein, putative	0	0	0	1
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase	0	1	0	2
Carbonic anhydrase 13	0	1	0	2
Carbonic anhydrase 4	0	1	0	2
Carbonic anhydrase 15	0	5	0	6
Carbonic anhydrase 13	0	4	0	5
Carbonic anhydrase 14	0	4	0	5
Carbonic anhydrase 5B, mitochondrial	0	4	0	6
alpha-galactosidase	3	0	0	3
Uracil nucleotide/cysteinyl leukotriene receptor	0	1	0	1
Beta-lactamase	0	0	0	1
Metallo-beta-lactamase type 2	0	0	0	1
Beta-lactamase TEM	0	0	0	2
Beta-lactamase	0	0	0	1
Beta-lactamase	0	0	0	2
Beta-lactamase	0	0	0	2
Beta-lactamase IMP-1	0	0	0	2
Beta-lactamase	0	0	0	2
7,8-dihydro-8-oxoguanine triphosphatase	0	1	0	1
Toll-like receptor 8	0	0	1	1
Toll-like receptor 7	0	0	1	1
Chain A, meta-Cleavage product hydrolase	0	1	0	1
Free fatty acid receptor 3	0	0	1	1
Parkin	2	0	0	2
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
Ornithine decarboxylase	0	0	0	2
Retinoic acid receptor alpha	0	2	2	4
Retinoic acid receptor gamma	0	2	2	4
Retinoic acid receptor beta	0	2	2	4
Cellular retinoic acid-binding protein 2	0	0	2	2
Mitogen-activated protein kinase 1	0	3	0	3
Retinoic acid receptor RXR-alpha	0	2	2	4
Retinoic acid receptor RXR-beta	0	2	2	4
Retinoic acid receptor RXR-gamma	0	2	2	4
Cellular retinoic acid-binding protein 1	0	2	0	3
Cellular retinoic acid-binding protein 1	0	0	2	2
Rap guanine nucleotide exchange factor 4	1	0	0	1
Olfactory receptor 51E2	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, AMINOPEPTIDASE	0	1	0	1
Chain A, Leucine Aminopeptidase	0	1	0	1
Alkaline phosphatase, tissue-nonspecific isozyme	0	1	0	1
Intestinal-type alkaline phosphatase	0	1	0	1
Phospholipase A-2-activating protein	0	1	0	1
ClpP	1	0	0	1
Cytochrome P450 1A1	0	1	0	1
Cytochrome P450 1A2	0	1	0	1
Cholinesterase	0	2	0	2
Cytochrome P450 2C11	0	1	0	1
Ribosyldihydronicotinamide dehydrogenase [quinone]	0	2	0	2
Metabotropic glutamate receptor 1	0	1	0	1
Acetylcholinesterase	0	1	0	1
Mu-type opioid receptor	0	3	0	3
Nociceptin receptor	0	1	0	1
Melatonin receptor type 1A	0	2	1	3
Melatonin receptor type 1C	0	0	1	1
Melatonin receptor type 1A	0	1	1	2
Melatonin receptor type 1B	0	2	1	3
Melatonin receptor type 1C	0	1	1	2
Melatonin receptor type 1B	0	1	1	2
Nuclear factor erythroid 2-related factor 2	0	0	0	1
Palmitoleoyl-protein carboxylesterase NOTUM	0	1	0	1
Carboxylic ester hydrolase	0	1	0	1
Liver carboxylesterase 1	0	0	0	1
Sodium-dependent serotonin transporter	0	2	0	2
Delta-type opioid receptor	0	2	0	3
Kappa-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	1	0	2
Mu-type opioid receptor	0	2	0	2
Thioredoxin reductase	0	1	0	1
Flavodoxin	0	0	0	1
GALC protein	3	0	0	3
Steroid 17-alpha-hydroxylase/17,20 lyase	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Cytochrome P450 11B2, mitochondrial	0	1	0	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
Chain B, Exotoxin A	0	0	1	1
STE24	0	0	0	1
CAAX prenyl protease	0	0	0	1
Trypsin	0	0	0	1
WRN	1	0	0	1
Valosin-containing protein	0	1	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
microphthalmia-associated transcription factor isoform 9	0	1	0	1
eukaryotic translation initiation factor 4 gamma 1 isoform 4	0	1	0	1
eukaryotic translation initiation factor 4E isoform 1	0	1	0	1
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Serum paraoxonase/arylesterase 1	0	1	0	1
phosphoglycerate kinase	1	0	0	1
cytochrome P450 2C19 precursor	3	0	0	3
Chain A, Immunoglobulin	0	0	1	1
Chain B, Immunoglobulin	0	0	1	1
Muscarinic acetylcholine receptor M1	0	0	1	2
Cytochrome P450 2B6	0	1	0	1
Muscarinic acetylcholine receptor M4	0	0	1	2
Lysosomal Pro-X carboxypeptidase	0	1	0	1
Cholinesterase	0	1	0	1
Muscarinic acetylcholine receptor M5	0	0	1	2
Muscarinic acetylcholine receptor M3	0	0	1	2
Muscarinic acetylcholine receptor M2	0	0	1	2
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
5-hydroxytryptamine receptor 2A	0	0	1	1
Albumin	0	0	1	1
Neutrophil elastase	0	1	0	1
Complement C1s subcomponent	0	1	0	1
Nitric oxide synthase, endothelial	0	1	0	1
Nitric oxide synthase, brain	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Nitric oxide synthase, inducible	0	1	0	1
Collagenase 3	0	2	0	2
Nitric oxide synthase, inducible	0	1	0	1
Voltage-dependent N-type calcium channel subunit alpha-1B	0	1	0	1
Chloroquine resistance transporter	0	1	0	1
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	1	0	0	1
heat shock protein HSP 90-alpha isoform 2	0	1	0	2
heat shock protein 90, putative	0	0	0	1
Chain A, PUTRESCINE-BINDING PROTEIN	0	0	1	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Chain A, S-ADENOSYLMETHIONINE DECARBOXYLASE ALPHA CHAIN	0	1	0	1
Chain B, S-ADENOSYLMETHIONINE DECARBOXYLASE BETA CHAIN	0	1	0	1
Ornithine decarboxylase	0	1	0	2
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	0	3	0	3
S-adenosylmethionine decarboxylase proenzyme	0	0	0	1
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	0	3	0	3
Monocarboxylate transporter 4	0	0	0	1
Monocarboxylate transporter 2	0	0	0	1
Monocarboxylate transporter 1	0	0	0	1
C-terminal-binding protein 2	0	1	0	1
Monocarboxylate transporter 2	0	1	0	1
Prolyl 4-hydroxylase	0	1	0	1
Alpha-ketoglutarate-dependent dioxygenase FTO	0	1	0	1
Sigma non-opioid intracellular receptor 1	0	1	0	1
Chain A, PLASMA RETINOL-BINDING PROTEIN PRECURSOR	0	0	1	1
Retinol-binding protein 4	0	0	1	1
Beta-lactoglobulin	0	0	1	1
Estrogen receptor beta	0	0	0	1
Inhibitor of nuclear factor kappa-B kinase subunit beta	0	0	0	1
Polyphenol oxidase 2	0	1	0	2
5'-AMP-activated protein kinase subunit beta-2	0	0	0	1
Polymerase acidic protein	0	0	1	1
Stromelysin-1	0	1	1	2
Tyrosine-protein phosphatase YopH	0	1	0	1
High mobility group protein B1	0	0	1	1
Aldo-keto reductase family 1 member B1	0	2	0	2
Prolyl 4-hydroxylase subunit alpha-1	0	1	0	1
Tyrosine-protein phosphatase non-receptor type 1	0	1	0	3
Estrogen receptor	0	0	0	1
Cystathionine gamma-lyase	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-1	0	0	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-2	0	0	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
5'-AMP-activated protein kinase catalytic subunit alpha-1	0	0	0	1
Carbonic anhydrase	0	1	0	1
Ubiquitin-like domain-containing CTD phosphatase 1	0	1	0	1
5'-AMP-activated protein kinase subunit gamma-3	0	0	0	1
5'-AMP-activated protein kinase subunit gamma-2	0	0	0	1
5'-AMP-activated protein kinase subunit beta-1	0	0	0	1
Bifunctional epoxide hydrolase 2	0	1	0	1
Peroxisome proliferator-activated receptor alpha	1	0	0	1
PPM1D protein	1	0	0	1
Pyruvate kinase PKM	0	1	0	1
Sulfate anion transporter 1	0	0	0	1
Caspase-2	0	0	1	1
Protein-arginine deiminase type-4	0	3	0	3
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Chain A, Acetylcholinesterase	0	0	1	1
Acetylcholinesterase	0	1	0	1
Carbonic anhydrase	0	0	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase	0	1	0	1
Carbonic anhydrase 2	0	1	1	2
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Delta-type opioid receptor	0	1	0	1
Carbonic anhydrase	0	1	0	1
Beta-carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	1	0	1
Carbonic anhydrase, alpha family	0	1	0	1
Carbonic anhydrase	0	1	0	1
Delta carbonic anhydrase	0	1	0	1
Protein argonaute-2	0	0	1	1
Prostaglandin E synthase	0	1	0	1
Aldo-keto reductase family 1 member B10	0	1	0	1
Complement C5	0	0	1	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Aldo-keto reductase family 1 member B1	0	1	0	1
Retinoic acid receptor RXR-alpha	0	3	2	5
Peroxisome proliferator-activated receptor gamma	0	0	2	2
Endothelin-1 receptor	0	2	0	2
90-kda heat shock protein beta HSP90 beta, partial	0	1	0	1
estrogen receptor beta isoform 1	0	1	0	1
tyrosine-protein phosphatase non-receptor type 7 isoform 2	0	1	0	1
Tetracycline resistance protein, class B	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
Multidrug transporter MdfA	0	1	0	1
Neutrophil collagenase	0	1	0	1
Cannabinoid receptor 1	0	1	0	1
P2Y purinoceptor 12	0	1	0	1
Thymidine kinase	0	1	0	2
Thymidine kinase, cytosolic	0	2	0	4
Thymidine kinase	0	1	0	2
Thymidine phosphorylase	0	0	0	1
Polyunsaturated fatty acid 5-lipoxygenase	0	1	0	1
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Thymidine phosphorylase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase, cytosolic	0	0	0	2
Thymidine kinase	0	0	0	1
Thymidylate kinase	0	1	0	1
Thymidine kinase	0	1	0	2
Sterol O-acyltransferase 1	0	1	0	1
Thymidine kinase	0	0	0	1
Thymidine kinase	0	0	0	1
Chain A, Nuclear Receptor ROR-beta	0	1	0	1
Retinoic acid receptor alpha	0	2	2	7
Retinoic acid receptor beta	0	2	2	7
Retinoic acid receptor gamma	0	2	2	7
Alpha-1A adrenergic receptor	0	1	0	1
Retinoic acid receptor RXR-beta	0	2	2	4
Indoleamine 2,3-dioxygenase 1	0	1	0	1
Nuclear receptor ROR-alpha	0	1	0	1
Retinoic acid receptor RXR-gamma	0	2	2	4
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	0	2	1	3
Indoleamine 2,3-dioxygenase 2	0	1	0	1
Nuclear receptor ROR-beta	0	1	0	1
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (320)

Protein Targets (987)

Cholesteatoma

Synonyms(1)

Research Excerpts

Overview

Context

Treatment

Research

Studies (320)

Drugs Studied (168)

Protein Targets (987)