7-hydroxy-6,4'-dimethoxyisoflavone profile

afromosin: structure given in first source; isolated from Wistaria brachybotrys [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

afrormosin : A 4'-methoxyisoflavone that is isoflavone substituted by methoxy groups at positions 6 and 4' and a hydroxy group at position 7. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

ID Source	ID
PubMed CID	5281704
CHEMBL ID	464404
CHEBI ID	2506
SCHEMBL ID	572274
MeSH ID	M000611489

Synonym
7-hydroxy-6-methoxy-3-(4-methoxyphenyl)chromen-4-one
4h-1-benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)-6-methoxy-
afrormosin
550-79-8
7-hydroxy-6-methoxy-3-(4-methoxyphenyl)-chromen-4-one
afromosin
bdbm50241529
cid_5281704
7-hydroxy-6-methoxy-3-(4-methoxyphenyl)-4h-chromen-4-one ,
MLS002473149
smr001397241
CHEMBL464404 ,
chebi:2506 ,
LMPK12050100
NCGC00247474-01
HMS2198K16
6,4'-dimethoxy-7-hydroxyisoflavone
89p1sb9fyw ,
unii-89p1sb9fyw
isoflavone, 7-hydroxy-4',6-dimethoxy-
4h-1-benzopyran-4-one, 7-hydroxy-6-methoxy-3-(4-methoxyphenyl)-
SCHEMBL572274
7-hydroxy-6-methoxy-3-(4-methoxyphenyl)-4h-1-benzopyran-4-one
AKOS024286653
KJGPBYUQZLUKLL-UHFFFAOYSA-N
6-methoxyformonetin
afrormosine
DTXSID90203543
7-hydroxy-4',6-dimethoxyisoflavone
7-hydroxy-6,4'-dimethoxyisoflavone
afromorsin
Q27105693
FT-0777979
FS-7688

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
7-hydroxyisoflavones	A hydroxyisoflavone compound having a hydroxy group at the 7-position.
4'-methoxyisoflavones	Any methoxyisoflavone which has a methoxy group at the 4-position of the phenyl substituent.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
afrormosin conjugates interconversion	0	7
afrormosin conjugates interconversion	0	9

Protein	Taxonomy	Measurement	Average (µ)	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Luciferase	Photinus pyralis (common eastern firefly)	Potency	11.2202	0.0072	15.7588	89.3584	AID588342
acid sphingomyelinase	Homo sapiens (human)	Potency	25.1189	14.1254	24.0613	39.8107	AID504937
thioredoxin reductase	Rattus norvegicus (Norway rat)	Potency	89.1251	0.1000	20.8793	79.4328	AID588456
BRCA1	Homo sapiens (human)	Potency	35.4813	0.8913	7.7225	25.1189	AID624202
ATAD5 protein, partial	Homo sapiens (human)	Potency	14.5750	0.0041	10.8903	31.5287	AID504466; AID504467
P53	Homo sapiens (human)	Potency	11.2202	0.0731	9.6858	31.6228	AID504706
IDH1	Homo sapiens (human)	Potency	32.6427	0.0052	10.8652	35.4813	AID686970
ras-related protein Rab-9A	Homo sapiens (human)	Potency	5.6234	0.0002	2.6215	31.4954	AID485297
urokinase-type plasminogen activator precursor	Mus musculus (house mouse)	Potency	3.5481	0.1585	5.2879	12.5893	AID540303
plasminogen precursor	Mus musculus (house mouse)	Potency	3.5481	0.1585	5.2879	12.5893	AID540303
urokinase plasminogen activator surface receptor precursor	Mus musculus (house mouse)	Potency	3.5481	0.1585	5.2879	12.5893	AID540303
geminin	Homo sapiens (human)	Potency	4.1095	0.0046	11.3741	33.4983	AID624296
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
kallikrein-7 isoform 1 preproprotein	Homo sapiens (human)	EC50 (µMol)	8.9980	2.5750	7.1878	9.4550	AID720500
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (47)

Assay ID	Title	Year	Journal	Article
AID504812	Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845	Primary qHTS for Inhibitors of ATXN expression
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635	Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Current protocols in cytometry, Oct, Volume: Chapter 13	Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2006	Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5	Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497	High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set	2010	Assay and drug development technologies, Feb, Volume: 8, Issue:1	High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810	Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign	2010	Endocrinology, Jul, Volume: 151, Issue:7	A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID334932	Cytotoxicity in human HeLa cells assessed as effect on cell viability at 50 uM after 1 hr
AID658416	Inhibition of human HCT116 clonogenicity after 7 days by crystal violet staining by densitometric analysis	2012	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 22, Issue:8	Isoflavones inhibit the clonogenicity of human colon cancer cells.
AID1276547	Antifungal activity against Candida albicans CAF2-1 after 24 hrs by spectrophotometry based broth dilution assay	2015	Journal of natural products, Dec-24, Volume: 78, Issue:12	Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex.
AID359664	Inhibition of 4NQO-induced carcinogenesis in mouse assessed as reduction of mouse with tumor at 1.25 mg after 25 weeks by two stage carcinogenesis test	1992	Journal of natural products, Dec, Volume: 55, Issue:12	Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
AID1276548	Antibiofilm activity against Candida albicans CAF2-1 after 48 hrs by XTT assay	2015	Journal of natural products, Dec-24, Volume: 78, Issue:12	Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex.
AID338533	Cytotoxicity against human RPMI7951 cells at 10 ug/ml	1993	Journal of natural products, May, Volume: 56, Issue:5	Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.
AID338537	Cytotoxicity against human KB cells at 10 ug/ml	1993	Journal of natural products, May, Volume: 56, Issue:5	Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.
AID359663	Inhibition of 4NQO-induced carcinogenesis in mouse assessed as number of tumors per mouse at 1.25 mg after 25 weeks by two stage carcinogenesis test	1992	Journal of natural products, Dec, Volume: 55, Issue:12	Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
AID775570	Inhibition of PTP1B (unknown origin) using p-nitrophenyl phosphate as substrate at 100 uM	2013	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 23, Issue:21	Evaluation of licorice flavonoids as protein tyrosine phosphatase 1B inhibitors.
AID540140	Antioxidant activity assessed as DPPH radical scavenging activity	2010	European journal of medicinal chemistry, Nov, Volume: 45, Issue:11	Chemometric modeling of free radical scavenging activity of flavone derivatives.
AID334924	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 10 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID334921	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 10000 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID334930	Cytotoxicity in human HeLa cells assessed as decrease in cell number at 50 uM after 1 hr
AID338539	Cytotoxicity against mouse P388 cells at 10 ug/ml	1993	Journal of natural products, May, Volume: 56, Issue:5	Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.
AID334923	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 100 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID338531	Cytotoxicity against human HCT8 cells at 10 ug/ml	1993	Journal of natural products, May, Volume: 56, Issue:5	Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.
AID359661	Inhibition of DMBA-induced/TPA-promoted carcinogenesis in mouse assessed as number of skin papillomas per mouse at 85 nmol administered twice weekly after 1 week of initiation measured after 20 weeks by two stage carcinogenesis test	1992	Journal of natural products, Dec, Volume: 55, Issue:12	Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
AID334926	Cytotoxicity against human Raji cells assessed as cell viability at 1000 molar ratio
AID1276546	Antifungal activity against Candida albicans CAF2-1 after overnight incubation by MTT based bioautography method	2015	Journal of natural products, Dec-24, Volume: 78, Issue:12	Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex.
AID334922	Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced EBV-early antigen activation in human Raji cells assessed as early antigen induction at 1000 molar ratio after 48 hrs by indirect immunofluorescence technique relative to TPA
AID1276545	Antifungal activity against hypersusceptible Candida albicans DSY2621 mutant after overnight incubation by MTT based bioautography method	2015	Journal of natural products, Dec-24, Volume: 78, Issue:12	Anti-Candida Cassane-Type Diterpenoids from the Root Bark of Swartzia simplex.
AID334929	Inhibition of EBV-early antigen activation in human Raji cells assessed as early antigen activation at 320 nM
AID334931	Displacement of [3H]TPA from TPA receptor in ICR mouse epidermal particulate fraction by Me2CO filter method
AID395316	Inhibition of Trypanosoma cruzi recombinant glycosomal GAPDH expressed in Escherichia coli by spectrophotometry	2009	Bioorganic & medicinal chemistry, Mar-15, Volume: 17, Issue:6	Discovery of novel Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase inhibitors.
AID334925	Cytotoxicity against human Raji cells assessed as cell viability at 10000 molar ratio
AID334920	Inhibition of TPA-stimulated [32P] incorporation into phospholipids in human HeLa cells at 50 uM after 1 hr
AID334928	Cytotoxicity against human Raji cells assessed as cell viability at 10 molar ratio
AID334927	Cytotoxicity against human Raji cells assessed as cell viability at 100 molar ratio
AID359662	Inhibition of 4NQO-induced carcinogenesis in mouse assessed as total number of tumors at 1.25 mg after 25 weeks by two stage carcinogenesis test	1992	Journal of natural products, Dec, Volume: 55, Issue:12	Anti-tumor-promoting activities of afromosin and soyasaponin I isolated from Wistaria brachybotrys.
AID525745	Inhibition of TNF-alpha-induced Nuclear factor-kappa-B dependent transcriptional activity in human HCT116 cells assessed normalized inhibitory ratio of at 10 uM for 12 hrs by NF-kappaB cis-acting luciferase reporter gene assay relative to untreated contro	2010	Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21	Isoflavone derivatives inhibit NF-κB-dependent transcriptional activity.
AID338535	Cytotoxicity against human TE671 cells at 10 ug/ml	1993	Journal of natural products, May, Volume: 56, Issue:5	Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.
AID338529	Cytotoxicity against human A549 cells at 10 ug/ml	1993	Journal of natural products, May, Volume: 56, Issue:5	Antitumor agents, 138. Rotenoids and isoflavones as cytotoxic constitutents from Amorpha fruticosa.
AID377875	Antifungal activity against Giardia intestinalis ATCC 30888 after 48 hrs by XTT assay	2000	Journal of natural products, Oct, Volume: 63, Issue:10	Antigiardial activity of isoflavones from Dalbergia frutescens bark.
AID1159550	Human Phosphogluconate dehydrogenase (6PGD) Inhibitor Screening	2015	Nature cell biology, Nov, Volume: 17, Issue:11	6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (10.53)	18.2507
2000's	4 (21.05)	29.6817
2010's	12 (63.16)	24.3611
2020's	1 (5.26)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (5.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (95.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
coumarin 2H-chromen-2-one: coumarin derivative	2.05	1	coumarins	fluorescent dye; human metabolite; plant metabolite
metronidazole Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.. metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.	2	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic
miconazole Miconazole: An imidazole antifungal agent that is used topically and by intravenous infusion.. 1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]imidazole : A member of the class of imidazoles that is 1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanol in which the hydroxyl hydrogen is replaced by a 2,4-dichlorobenzyl group.. miconazole : A racemate composed of equimolar amounts of (R)- and (S)-miconazole. Used (as its nitrate salt) to treat skin infections such as athlete's foot, jock itch, ringworm and other fungal skin infections. It inhibits the synthesis of ergosterol, a critical component of fungal cell membranes.	2.11	1	dichlorobenzene; ether; imidazoles
9,10-dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.	1.98	1	ortho-fused polycyclic arene; tetraphenes	carcinogenic agent
rotenone Derris: A plant genus of the family FABACEAE. The root is a source of rotenoids (ROTENONE) and flavonoids. Some species of Pongamia have been reclassified to this genus and some to MILLETTIA. Some species of Deguelia have been reclassified to this genus.. rotenoid : Members of the class of tetrahydrochromenochromene that consists of a cis-fused tetrahydrochromeno[3,4-b]chromene skeleton and its substituted derivatives. The term was originally restricted to natural products, but is now also used to describe semi-synthetic and fully synthetic compounds.	1.98	1	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin
oleanolic acid [no description available]	1.98	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	plant metabolite
tetradecanoylphorbol acetate Tetradecanoylphorbol Acetate: A phorbol ester found in CROTON OIL with very effective tumor promoting activity. It stimulates the synthesis of both DNA and RNA.. phorbol ester : Esters of phorbol, originally found in croton oil (from Croton tiglium, of the family Euphorbiaceae). A number of phorbol esters possess activity as tumour promoters and activate the mechanisms associated with cell growth. Some of these are used in experiments as activators of protein kinase C.. phorbol 13-acetate 12-myristate : A phorbol ester that is phorbol in which the hydroxy groups at the cyclopropane ring juction (position 13) and the adjacent carbon (position 12) have been converted into the corresponding acetate and myristate esters. It is a major active constituent of the seed oil of Croton tiglium. It has been used as a tumour promoting agent for skin carcinogenesis in rodents and is associated with increased cell proliferation of malignant cells. However its function is controversial since a decrease in cell proliferation has also been observed in several cancer cell types.	1.98	1	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator
ursolic acid [no description available]	2.05	1	hydroxy monocarboxylic acid; pentacyclic triterpenoid	geroprotector; plant metabolite
epicatechin (-)-epicatechin : A catechin with (2R,3R)-configuration.	2	1	catechin; polyphenol	antioxidant
betulin betulin: isolated from various white birch bark (BETULA). betulin : A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-hydroxymethyl substituents.	2.05	1	diol; pentacyclic triterpenoid	analgesic; anti-inflammatory agent; antineoplastic agent; antiviral agent; metabolite
lupenone lupenone: structure in first source	2.05	1	triterpenoid	metabolite
amorphigenin amorphigenin: RN given refers to (2R-(2alpha,6aalpha,12aalpha))-isomer; structure given in first source	1.98	1	rotenones
pisatin pisatin: phytoalexin produced in plants after injection with fungi; RN given refers to (6aS-cis)-isomer; structure	2.06	1
liquiritigenin liquiritigenin: structure given in first source; isolated from Pterocarpus marsupium. 4',7-dihydroxyflavanone : A dihydroxyflavanone in which the two hydroxy substituents are located at positions 4' and 7.. liquiritigenin : A dihydroxyflavanone compound having the two hydroxy substituents at the 4'- and 7-positions. Isolated from the root of Glycyrrhizae uralensis, it is a selective agonist for oestrogen receptor beta.	2.48	2	4',7-dihydroxyflavanone	hormone agonist; plant metabolite
tephrosin tephrosin: RN given for (7aR-cis)-isomer; has insecticidal activity; structure in first source. tephrosin : A member of the class of rotenones that is 13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one substituted with geminal methyl groups at position 3, hydroxy group at position 7a and methoxy groups at positions 9 and 10 (the 7aR,13aR stereoisomer). It is isolated from the leaves and twigs of Antheroporum pierrei and exhibits antineoplastic and pesticidal activities.	1.98	1	aromatic ether; cyclic ketone; organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; pesticide
soyasaponin bb soyasaponin Bb: has activity against polycystic kidney disease; isolated from soybean; structure in first source. soyasaponin I : A triterpenoid saponin that is composed of soyasapogenol B having an alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucopyranosiduronic acid moiety attached at the 3-position via a glycosidic linkage.	1.98	1	carbohydrate acid derivative; pentacyclic triterpenoid; trisaccharide derivative; triterpenoid saponin	sialyltransferase inhibitor
glabridin [no description available]	2.08	1	hydroxyisoflavans	antiplasmodial drug
lupeol [no description available]	2.05	1	pentacyclic triterpenoid; secondary alcohol	anti-inflammatory drug; plant metabolite
medicarpin (-)-medicarpin : The (-)-enantiomer of medicarpin.	2.06	1	medicarpin	plant metabolite
naringenin (S)-naringenin : The (S)-enantiomer of naringenin.	2.06	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite
naringin [no description available]	2.06	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; dihydroxyflavanone; disaccharide derivative; neohesperidoside	anti-inflammatory agent; antineoplastic agent; metabolite
vicenin ii vicenin: isolated from the leaves of the Indian plant Ocimum sanctum were tested for their radioprotective effect in mice. isovitexin 8-C-beta-glucoside : A C-glycosyl compound that is isovitexin in which the hydrogen at position 8 is replaced by a beta-D-glucosyl residue.	2.08	1	C-glycosyl compound; trihydroxyflavone	metabolite
Euchrestaflavanone A [no description available]	2.08	1	flavanones
likviriton liquiritin: isoalted from Glycyrrhizae radix. liquiritin : A flavanone glycoside that is liquiritigenin attached to a beta-D-glucopyranosyl residue at position 4' via a glycosidic linkage.	2.08	1	beta-D-glucoside; flavanone glycoside; monohydroxyflavanone; monosaccharide derivative	anti-inflammatory agent; anticoronaviral agent; plant metabolite
cabreuvin cabreuvin: structure in first source	2.47	2	methoxyisoflavone
7-methoxyisoflavone 7-methoxyisoflavone : A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 7.	2.47	2	7-methoxyisoflavones
sesquiterpenes [no description available]	2.06	1
isoschaftoside isoschaftoside: structure in first source. isoschaftoside : A C-glycosyl compound that is apigenin substituted at positions 6 and 8 by alpha-L-arabinopyranosyl and beta-D-glucosyl residues respectively.	2.08	1	C-glycosyl compound; trihydroxyflavone	metabolite
quercetin [no description available]	2.05	1	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger
biochanin a [no description available]	2.72	3	4'-methoxyisoflavones; 7-hydroxyisoflavones	antineoplastic agent; EC 3.5.1.99 (fatty acid amide hydrolase) inhibitor; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
formononetin [no description available]	2.43	2	4'-methoxyisoflavones; 7-hydroxyisoflavones	phytoestrogen; plant metabolite
quercetin 3-o-glucopyranoside quercetin 3-O-glucopyranoside: structure in first source. quercetin 3-O-beta-D-glucopyranoside : A quercetin O-glucoside that is quercetin with a beta-D-glucosyl residue attached at position 3. Isolated from Lepisorus contortus, it exhibits antineoplastic activityand has been found to decrease the rate of polymerization and sickling of red blood cells	2.08	1	beta-D-glucoside; monosaccharide derivative; quercetin O-glucoside; tetrahydroxyflavone	antineoplastic agent; antioxidant; antipruritic drug; bone density conservation agent; geroprotector; histamine antagonist; osteogenesis regulator; plant metabolite
genistein [no description available]	2.72	3	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor
isobavachalcone isobavachalcone: RN given for (E)-isomer; structure in first source. isobavachalcone : A member of the class of chalcones that is trans-chalcone substituted by hydroxy groups at positions 4, 2' and 4' and a prenyl group at position 3'.	2.08	1	chalcones; polyphenol	antibacterial agent; metabolite; platelet aggregation inhibitor
7-hydroxycoumarin 7-oxycoumarin: derivatives have anti-oxidant properties. umbelliferone : A hydroxycoumarin that is coumarin substituted by a hydroxy group ay position 7.	2.05	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite
mangiferin shamimin: isolated from the leaves of Bombax ceiba; structure in first source	2.05	1	C-glycosyl compound; xanthones	anti-inflammatory agent; antioxidant; hypoglycemic agent; plant metabolite
daidzein [no description available]	2.43	2	7-hydroxyisoflavones	antineoplastic agent; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; EC 3.2.1.20 (alpha-glucosidase) inhibitor; phytoestrogen; plant metabolite
prunetin prunetin: reduces herpes virus-1 plaque formation. prunetin : A hydroxyisoflavone that is genistein in which the hydroxy group at position 7 is replaced by a methoxy group.	2.47	2	7-methoxyisoflavones; hydroxyisoflavone	anti-inflammatory agent; EC 1.2.1.3 [aldehyde dehydrogenase (NAD(+))] inhibitor; EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor; metabolite
psi-baptigenin pseudobaptigenin : A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone and in which the phenyl group at position 3 is replaced by a 1,3-benzodioxol-5-yl group.	2.43	2	7-hydroxyisoflavones; benzodioxoles	antiprotozoal drug; plant metabolite
4',7-dihydroxyflavone 4',7-dihydroxyflavone: inducer of nod gene. 4',7-dihydroxyflavone : A dihydroxyflavone in which the two hydroxy substituents are located at positions 4' and 7.	2.08	1	dihydroxyflavone	metabolite
astragalin kaempferol-3-O-glucoside: isolated from the pit of Mahkota dewa; structure in first source. kaempferol 3-O-beta-D-glucoside : A kaempferol O-glucoside in which a glucosyl residue is attached at position 3 of kaempferol via a beta-glycosidic linkage.	2.08	1	beta-D-glucoside; kaempferol O-glucoside; monosaccharide derivative; trihydroxyflavone	plant metabolite; trypanocidal drug
3',4',7-trihydroxyisoflavone 3',4',7-trihydroxyisoflavone: from Streptomyces sp OH-1049; structure given in first source. 3',4',7-trihydroxyisoflavone : A 7-hydroxyisoflavone that is daidzein substituted by a hydroxy group at position 3'.	2.05	1	7-hydroxyisoflavones	antineoplastic agent; EC 1.3.1.22 [3-oxo-5alpha-steroid 4-dehydrogenase (NADP(+))] inhibitor; metabolite
6,7,4'-trihydroxyisoflavone 6,7,4'-trihydroxyisoflavone: structure in first source. 4',6,7-trihydroxyisoflavone : A hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 6.	2.05	1	7-hydroxyisoflavones	anti-inflammatory agent; antimutagen; EC 1.14.18.1 (tyrosinase) inhibitor; metabolite; PPARalpha agonist; PPARgamma agonist
eurycarpin b eurycarpin B: from the roots of Glycyrrhiza eurycarpa; structure in first source	2.08	1	isoflavonoid
glycitein glycitein : A methoxyisoflavone that is isoflavone substituted by a methoxy group at position 6 and hydroxy groups at positions 7 and 4'. It has been isolated from the mycelia of the fungus Cordyceps sinensis.	2	1	7-hydroxyisoflavone; methoxyisoflavone	fungal metabolite; phytoestrogen; plant metabolite
licochalcone b licochalcone B: isolated from Glycyrrhiza inflata; inhibits phosphorylation of NF-kappaB p65 in LPS signaling pathway; structure in first source	2.08	1	chalcones
7,4'-dihydroxy-3'-methoxyisoflavone 7,4'-dihydroxy-3'-methoxyisoflavone : A member of the class of 7-hydroxyisoflavones that is 7,4'-dihydroxyisoflavone substituted by a methoxy group at position 3'. It is isolated from the heart woods of Maackia amurensis subsp buergeri and Dalbergia louveli and exhibits antiplasmodial ativity.	2.05	1	7-hydroxyisoflavones; methoxyisoflavone	antiplasmodial drug; metabolite
tiliroside tiliroside: isolated from seeds of Eremocarpus setigerus	2.05	1	cinnamate ester; glycosyloxyflavone; monosaccharide derivative; trihydroxyflavone	plant metabolite
4',7,8-trihydroxyisoflavone 4',7,8-trihydroxyisoflavone: from Streptomyces sp OH-1049; structure given in first source	2.75	3	isoflavones
guajavarin guajavarin: from leaves of Psidium guajava	2.05	1
cladrin cladrin: isolated from Butea monosperma; structure in first source	2.05	1
4-hydroxylonchocarpin 4-hydroxylonchocarpin: structure in first source	2.08	1
beta-escin [no description available]	1.98	1
Retusin 7-Methyl Ether [no description available]	2.05	1	methoxyisoflavone
licochalcone c licochalcone C: has cardioprotective, antioxidant, anti-inflammatory and anti-apoptotic activities; isolated from licorice; structure in first source	2.08	1
mocetinostat mocetinostat: undergoing phase II clinical trials for treatment of cancer. mocetinostat : A benzamide obtained by formal condensation of the carboxy group of 4-({[4-(pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid with one of the amino groups of benzene-1,2-diamine. It is an orally active and isotype-selective HDAC inhibitor which exhibits antitumour activity (IC50 = 0.15, 0.29, 1.66 and 0.59 muM for HDAC1, HDAC2, HDAC3 and HDAC11).	2.08	1	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent
Kanzonol B [no description available]	2.08	1	chalcones
glabrol glabrol: from Glycyrrhiza glabra hairy root; structure in first source	2.08	1	flavanones
odoratin odoratin: structure; RN given refers to cpd without isomeric designation	2.44	2
rk 682 [no description available]	2.08	1

Condition	Relationship Strength	Studies
Cancer of Lung [description not available]	1.98	1
Cancer of Skin [description not available]	1.98	1
Cocarcinogenesis The combination of two or more different factors in the production of cancer.	1.98	1
Lung Neoplasms Tumors or cancer of the LUNG.	1.98	1
Skin Neoplasms Tumors or cancer of the SKIN.	1.98	1
Carcinoma, Epidermoid [description not available]	1.98	1
Cancer of Larynx [description not available]	1.98	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.98	1
Laryngeal Neoplasms Cancers or tumors of the LARYNX or any of its parts: the GLOTTIS; EPIGLOTTIS; LARYNGEAL CARTILAGES; LARYNGEAL MUSCLES; and VOCAL CORDS.	1.98	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2	1
Innate Inflammatory Response [description not available]	2.47	2
Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.	2.47	2
Cancer of Colon [description not available]	2.07	1
Colonic Neoplasms Tumors or cancer of the COLON.	2.07	1
Benign Neoplasms [description not available]	3.03	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	3.03	1
Neuromuscular Blockade The intentional interruption of transmission at the NEUROMUSCULAR JUNCTION by external agents, usually neuromuscular blocking agents. It is distinguished from NERVE BLOCK in which nerve conduction (NEURAL CONDUCTION) is interrupted rather than neuromuscular transmission. Neuromuscular blockade is commonly used to produce MUSCLE RELAXATION as an adjunct to anesthesia during surgery and other medical procedures. It is also often used as an experimental manipulation in basic research. It is not strictly speaking anesthesia but is grouped here with anesthetic techniques. The failure of neuromuscular transmission as a result of pathological processes is not included here.	2.05	1

7-hydroxy-6,4'-dimethoxyisoflavone

Description

Cross-References

Synonyms (34)

Roles (1)

Drug Classes (2)

Pathways (1)

Protein Targets (14)

Potency Measurements

Inhibition Measurements

Activation Measurements

Bioassays (47)

Research

Studies (19)

Market Indicators

Research Demand Index: 11.69

Study Types

7-hydroxy-6,4'-dimethoxyisoflavone

Description

Cross-References

Synonyms (34)

Roles (1)

Drug Classes (2)

Pathways (1)

Protein Targets (14)

Potency Measurements

Inhibition Measurements

Activation Measurements

Bioassays (47)

Research

Studies (19)

Market Indicators

Research Demand Index: 11.69

Study Types

Related Drugs (60)

Related Conditions (17)