Page last updated: 2024-10-31

metronidazole and Exophthalmos

metronidazole has been researched along with Exophthalmos in 6 studies

Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.

Exophthalmos: Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.

Research Excerpts

ExcerptRelevanceReference
"Whipple's disease can affect the periorbital tissues and the optic nerve, causing massive exophthalmos and serious transient visual loss."1.34Orbital manifestation of whipple's disease: an atypical case. ( Arnold, M; Clemetson, IA; Iizuka, T; Lieger, O; Otto, S, 2007)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19903 (50.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Pham Dang, N1
Bouchet, A1
Mondie, JM1
Barthelemy, I1
Lieger, O1
Otto, S1
Clemetson, IA1
Arnold, M1
Iizuka, T1
Feldman, DP1
Picerno, NA1
Porubsky, ES1
Jones, DI1
González-Bárcena, D1
Gómez-Leal, A1
Ocampo-Campos, R1
Portioli, I1
Rocchi, F1
Maraini, G1
Pescatori, A1

Trials

1 trial available for metronidazole and Exophthalmos

ArticleYear
The effect of metronidazole on exophthalmos in man.
    The Journal of endocrinology, 1968, Volume: 41, Issue:4

    Topics: Antithyroid Agents; Clinical Trials as Topic; Exophthalmos; Feeding and Eating Disorders; Humans; Hy

1968

Other Studies

5 other studies available for metronidazole and Exophthalmos

ArticleYear
[Frontal sinusitis, mucocele and subperiosteal superolateral orbit abscess].
    Revue de stomatologie et de chirurgie maxillo-faciale, 2011, Volume: 112, Issue:1

    Topics: Abscess; Anti-Bacterial Agents; Cefotaxime; Child; Drainage; Drug Combinations; Exophthalmos; Fronta

2011
Orbital manifestation of whipple's disease: an atypical case.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2007, Volume: 35, Issue:8

    Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Decompression, Surgical; Exophthalmos; Hu

2007
Cavernous sinus thrombosis complicating odontogenic parapharyngeal space neck abscess: a case report and discussion.
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery, 2000, Volume: 123, Issue:6

    Topics: Aged; Anti-Infective Agents; Cavernous Sinus Thrombosis; Ceftriaxone; Cephalosporins; Combined Modal

2000
[Treatment with metronidazole of endocrine exophthalmos].
    Archivos de investigacion medica, 1973, Volume: 4, Issue:1

    Topics: Evaluation Studies as Topic; Exophthalmos; Female; Humans; Hyperthyroidism; Male; Metronidazole; Thy

1973
[On the anti-exophthalmic and anti-thyroid action of an imidazole derivative with trichomonacidal action: metronidazole].
    Annali di ottalmologia e clinica oculistica, 1968, Volume: 94, Issue:12

    Topics: Adolescent; Adult; Exophthalmos; Female; Graves Disease; Humans; Hyperthyroidism; Male; Metronidazol

1968