metronidazole has been researched along with Exophthalmos in 6 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Exophthalmos: Abnormal protrusion of both eyes; may be caused by endocrine gland malfunction, malignancy, injury, or paralysis of the extrinsic muscles of the eye.
Excerpt | Relevance | Reference |
---|---|---|
"Whipple's disease can affect the periorbital tissues and the optic nerve, causing massive exophthalmos and serious transient visual loss." | 1.34 | Orbital manifestation of whipple's disease: an atypical case. ( Arnold, M; Clemetson, IA; Iizuka, T; Lieger, O; Otto, S, 2007) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 3 (50.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 2 (33.33) | 29.6817 |
2010's | 1 (16.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Pham Dang, N | 1 |
Bouchet, A | 1 |
Mondie, JM | 1 |
Barthelemy, I | 1 |
Lieger, O | 1 |
Otto, S | 1 |
Clemetson, IA | 1 |
Arnold, M | 1 |
Iizuka, T | 1 |
Feldman, DP | 1 |
Picerno, NA | 1 |
Porubsky, ES | 1 |
Jones, DI | 1 |
González-Bárcena, D | 1 |
Gómez-Leal, A | 1 |
Ocampo-Campos, R | 1 |
Portioli, I | 1 |
Rocchi, F | 1 |
Maraini, G | 1 |
Pescatori, A | 1 |
1 trial available for metronidazole and Exophthalmos
Article | Year |
---|---|
The effect of metronidazole on exophthalmos in man.
Topics: Antithyroid Agents; Clinical Trials as Topic; Exophthalmos; Feeding and Eating Disorders; Humans; Hy | 1968 |
5 other studies available for metronidazole and Exophthalmos
Article | Year |
---|---|
[Frontal sinusitis, mucocele and subperiosteal superolateral orbit abscess].
Topics: Abscess; Anti-Bacterial Agents; Cefotaxime; Child; Drainage; Drug Combinations; Exophthalmos; Fronta | 2011 |
Orbital manifestation of whipple's disease: an atypical case.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Ceftriaxone; Decompression, Surgical; Exophthalmos; Hu | 2007 |
Cavernous sinus thrombosis complicating odontogenic parapharyngeal space neck abscess: a case report and discussion.
Topics: Aged; Anti-Infective Agents; Cavernous Sinus Thrombosis; Ceftriaxone; Cephalosporins; Combined Modal | 2000 |
[Treatment with metronidazole of endocrine exophthalmos].
Topics: Evaluation Studies as Topic; Exophthalmos; Female; Humans; Hyperthyroidism; Male; Metronidazole; Thy | 1973 |
[On the anti-exophthalmic and anti-thyroid action of an imidazole derivative with trichomonacidal action: metronidazole].
Topics: Adolescent; Adult; Exophthalmos; Female; Graves Disease; Humans; Hyperthyroidism; Male; Metronidazol | 1968 |