metronidazole has been researched along with Brain Diseases, Metabolic, Familial in 3 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boyer, M | 1 |
| Sowa, M | 1 |
| Di Meo, I | 1 |
| Eftekharian, S | 1 |
| Steenari, MR | 1 |
| Tiranti, V | 3 |
| Abdenur, JE | 1 |
| Viscomi, C | 1 |
| Burlina, AB | 1 |
| Dweikat, I | 1 |
| Savoiardo, M | 1 |
| Lamperti, C | 1 |
| Hildebrandt, T | 1 |
| Zeviani, M | 2 |
1 review available for metronidazole and Brain Diseases, Metabolic, Familial
| Article | Year |
|---|---|
Altered sulfide (H(2)S) metabolism in ethylmalonic encephalopathy.
Topics: Anti-Infective Agents; Brain Diseases, Metabolic, Inborn; Humans; Hydrogen Sulfide; Metronidazole; M | 2013 |
2 other studies available for metronidazole and Brain Diseases, Metabolic, Familial
| Article | Year |
|---|---|
Response to medical and a novel dietary treatment in newborn screen identified patients with ethylmalonic encephalopathy.
Topics: Acetylcysteine; Amino Acids; Biomarkers; Brain Diseases, Metabolic, Inborn; Cysteine; Diet; Female; | 2018 |
Combined treatment with oral metronidazole and N-acetylcysteine is effective in ethylmalonic encephalopathy.
Topics: Acetylcysteine; Administration, Oral; Animals; Anti-Infective Agents; Brain Diseases, Metabolic, Inb | 2010 |