metronidazole has been researched along with Gingival Hemorrhage in 57 studies
Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS.
metronidazole : A member of the class of imidazoles substituted at C-1, -2 and -5 with 2-hydroxyethyl, nitro and methyl groups respectively. It has activity against anaerobic bacteria and protozoa, and has a radiosensitising effect on hypoxic tumour cells. It may be given by mouth in tablets, or as the benzoate in an oral suspension. The hydrochloride salt can be used in intravenous infusions. Metronidazole is a prodrug and is selective for anaerobic bacteria due to their ability to intracellularly reduce the nitro group of metronidazole to give nitroso-containing intermediates. These can covalently bind to DNA, disrupting its helical structure, inducing DNA strand breaks and inhibiting bacterial nucleic acid synthesis, ultimately resulting in bacterial cell death.
Gingival Hemorrhage: The flowing of blood from the marginal gingival area, particularly the sulcus, seen in such conditions as GINGIVITIS, marginal PERIODONTITIS, injury, and ASCORBIC ACID DEFICIENCY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 9.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 9.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO." | 9.10 | Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients. ( Montebugnoli, L; Prati, C; Servidio, D, 2002) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 9.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 9.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 9.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "A newly developed metronidazole 25% dental gel was compared with subgingival scaling in the treatment of adult periodontitis." | 9.07 | Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. ( Ainamo, J; Ellingsen, BH; Hansen, BF; Johansson, LA; Karring, T; Kisch, J; Lie, T; Paunio, K; Stoltze, K, 1992) |
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 9.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 7.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 7.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 7.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 7.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 7.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| "Sites affected with adult periodontitis were observed for 3 months to compare their clinical and microbiologic responses to a single 2 g dose of metronidazole, scaling and root planing, or no treatment." | 7.67 | Clinical and microbiologic effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis. ( Armitage, GC; Buchanan, SA; Hoover, CI; Newbrun, E; Robertson, PB; Taggart, EJ; Walsh, MM, 1986) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 6.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| "A total of 184 patients with moderate-to-severe periodontitis were randomly allocated to one of four treatment groups: 1) FDIS+metronidazole; 2) FDIS+placebo; 3) SRP+metronidazole; or 4) SRP+placebo." | 5.17 | A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results. ( Baelum, V; Gjermo, P; Gunleiksrud, TM; Preus, HR; Sandvik, L, 2013) |
| "The aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (AM) when performing full-mouth ultrasonic debridement (FMUD) in generalized aggressive periodontitis (GAgP) treatment." | 5.16 | The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. ( Casarin, RC; Casati, MZ; Gonçalves, RB; Nociti, FH; Peloso Ribeiro, ED; Sallum, EA, 2012) |
| "To evaluate and compare the effects of adjunctive metronidazole plus amoxicillin, doxycycline and metronidazole on clinical and microbiological parameters in patients with generalized aggressive periodontitis." | 5.12 | Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis. ( Baka, A; Konstantinidis, A; Sakellari, D; Slini, T; Xajigeorgiou, C, 2006) |
| "To determine the effect of metronidazole plus amoxicillin (M+A) as the sole therapy, on the subgingival microbiota of chronic periodontitis." | 5.12 | Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis. ( Da Silva, I; Haffajee, AD; Japlit, MR; López, NJ; Socransky, SS, 2006) |
| "The present controlled, single-blind study was performed to assess and compare the clinical healing and the microbiological findings following repeated intrasulcular applications of 1% metronidazole or 1% chlorhexidine gels in persistent periodontal pockets previously treated by scaling and root planing (SRP)." | 5.11 | Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients. ( Cordella, C; D'Ercole, S; Paolantonio, M; Perinetti, G; Piccolomini, R; Serra, E, 2004) |
| "Several studies have reported adjunctive benefits to scaling and root planing (SRP) of systemic amoxycillin and metronidazole in the treatment of periodontal diseases." | 5.10 | Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study. ( Addy, M; Newcombe, RG; Rooney, J; Sprague, SV; Wade, WG, 2002) |
| "To evaluate the efficacy of metronidazole on cyclosporine-induced gingival overgrowth (GO), a prospective intra-subject double-blind longitudinal study was performed on six heart transplant patients with GO." | 5.10 | Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients. ( Montebugnoli, L; Prati, C; Servidio, D, 2002) |
| "The aim of this study was to examine the effect of doxycycline, metronidazole, and clindamycin used adjunctively in a 2-step nonsurgical procedure in patients with rapidly progressive periodontitis (RPP)." | 5.09 | A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis. ( Beier, M; Glockmann, E; Klinger, G; Pfister, W; Sigusch, B, 2001) |
| "The aim of the present study was to evaluate the clinical and microbiological effects of subgingival application of 25% metronidazole dental gel as an adjunct to scaling and root planing (SRP) in the treatment of adult periodontitis." | 5.09 | Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results. ( Bilgiç, A; Buduneli, E; Evrenosoglu, E; Tünger, A, 2001) |
| "The effect of topical application of a metronidazole gel (ELYZOL DENTAL GEL), and adjunctive therapy in the treatment of adult periodontitis was assessed clinically." | 5.09 | Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy. ( Al-Mubarak, SA; Ho, A; Karring, T, 2000) |
| "The aim of this study was to examine the effect of periodontal surgery on PGE2 levels in patients treated for advanced adult periodontitis, with and without application of a 25% metronidazole gel over 12 months follow-up." | 5.09 | Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival crevicular fluid PGE2. ( Collins, AM; Moles, DR; Needleman, IG, 2000) |
| "The aim of this double-blind, parallel study was to evaluate the adjunctive effects of systemically administered amoxicillin and metronidazole in a group of adult periodontitis patients who also received supra- and subgingival debridement." | 5.09 | Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study. ( Timmerman, MF; Van der Velden, U; Van der Weijden, GA; Van Winkelhoff, AJ; Winkel, EG, 2001) |
| "The aim of the study was to compare the clinical and microbiological effects of topical application of a metronidazole gel and a single session of subgingival scaling in the treatment of adult periodontitis." | 5.07 | Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis. ( Karring, T; Kilian, M; Pedrazzoli, V, 1992) |
| "This report presents the findings from an open randomized multicentre clinical trial designed to compare the clinical efficacy of scaling with application of 3 different preparations/dose frequencies of topical metronidazole in the treatment of adult periodontitis." | 5.07 | 3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults. ( Attström, R; Karring, T; Kisch, J; Klinge, B; Lewin, B; Stoltze, K, 1992) |
| "A newly developed metronidazole 25% dental gel was compared with subgingival scaling in the treatment of adult periodontitis." | 5.07 | Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis. ( Ainamo, J; Ellingsen, BH; Hansen, BF; Johansson, LA; Karring, T; Kisch, J; Lie, T; Paunio, K; Stoltze, K, 1992) |
| "The effect of metronidazole was assessed in 20 subjects with untreated periodontitis, in a double-blind trial." | 5.06 | Metronidazole: a double-blind trial in untreated human periodontal disease. ( Floyd, P; Palmer, R; Watts, T, 1986) |
| "The effect of adjunctive systemic metronidazole was studied in patients with moderate and advanced periodontitis recalcitrant to comprehensive non-surgical treatment." | 5.06 | The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults. ( Engström, PE; Frithiof, L; Nedlich, U; Rubin, B; Söder, B; Söder, PO; Wikner, S; Wouters, F, 1990) |
| "The aim of the present study is to evaluate the clinical and microbiologic changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole in individuals with aggressive periodontitis." | 3.78 | Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. ( De Micheli, G; Hirata, MH; Hirata, RD; Lima Neto, LG; Lotufo, RF; Lourenção, DS; Pannuti, CM; Rodrigues, AS, 2012) |
| "After baseline clinical and microbiological monitoring, 17 adult periodontitis subjects received full mouth SRP and 14 days systemic administration of either metronidazole (250 mg, TID, n=8) or amoxicillin (500 mg, TID, n=9)." | 3.71 | Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole. ( Allard, K; Feres, M; Haffajee, AD; Socransky, SS; Som, S, 2001) |
| "The aim of the present study was to monitor the microbiological and clinical effects of renewed supra- and subgingival debridement in conjunction with systemic metronidazole therapy (500 mg TID for 7 days) in 27 "refractory" periodontitis patients, culture positive for Bacteroides forsythus and negative for Actinobacillus actinomycetemcomitans." | 3.69 | Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus. ( Timmerman, MF; Van der Velden, U; Van Winkelhoff, AJ; Vangsted, T; Winkel, EG, 1997) |
| "The present study was performed to assess the effect of topical metronidazole therapy on ligature-induced periodontitis in beagle dogs." | 3.68 | The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog. ( Attström, R; Edwardsson, S; Kalfas, S; Klinge, B; Kuvatanasuhati, J, 1992) |
| "We report on the microbiological and clinical effects of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with Actinobacillus actinomycetemcomitans-associated periodontitis." | 3.68 | Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis. ( de Graaff, J; Tijhof, CJ; van Winkelhoff, AJ, 1992) |
| "Sites affected with adult periodontitis were observed for 3 months to compare their clinical and microbiologic responses to a single 2 g dose of metronidazole, scaling and root planing, or no treatment." | 3.67 | Clinical and microbiologic effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis. ( Armitage, GC; Buchanan, SA; Hoover, CI; Newbrun, E; Robertson, PB; Taggart, EJ; Walsh, MM, 1986) |
| "Metronidazole is an agent with reported success in the treatment of anaerobic periodontal infections." | 2.67 | Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters. ( Giordano, J; Grossman, N; Loesche, WJ, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (7.02) | 18.7374 |
| 1990's | 22 (38.60) | 18.2507 |
| 2000's | 22 (38.60) | 29.6817 |
| 2010's | 9 (15.79) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Neering, SH | 1 |
| Adyani-Fard, S | 1 |
| Klocke, A | 1 |
| Rüttermann, S | 1 |
| Flemmig, TF | 1 |
| Beikler, T | 1 |
| Jepsen, K | 1 |
| Jepsen, S | 1 |
| Laine, ML | 1 |
| Anssari Moin, D | 1 |
| Pilloni, A | 1 |
| Zeza, B | 1 |
| Sanz, M | 1 |
| Ortiz-Vigon, A | 1 |
| Roos-Jansåker, AM | 1 |
| Renvert, S | 1 |
| Emrani, J | 1 |
| Chee, W | 1 |
| Slots, J | 1 |
| Cionca, N | 2 |
| Giannopoulou, C | 2 |
| Ugolotti, G | 1 |
| Mombelli, A | 3 |
| Romeo, E | 1 |
| Lops, D | 1 |
| Storelli, S | 1 |
| Ghisolfi, M | 1 |
| Ribeiro, Edel P | 1 |
| Bittencourt, S | 1 |
| Zanin, IC | 1 |
| Bovi Ambrosano, GM | 1 |
| Sallum, EA | 2 |
| Nociti, FH | 2 |
| Gonçalves, RB | 2 |
| Casati, MZ | 2 |
| Ardila, CM | 1 |
| Granada, MI | 1 |
| Guzmán, IC | 1 |
| Kaner, D | 1 |
| Bernimoulin, JP | 3 |
| Dietrich, T | 1 |
| Kleber, BM | 1 |
| Friedmann, A | 1 |
| Bono, A | 1 |
| Brunotto, M | 1 |
| Rodrigues, AS | 1 |
| Lourenção, DS | 1 |
| Lima Neto, LG | 1 |
| Pannuti, CM | 1 |
| Hirata, RD | 1 |
| Hirata, MH | 1 |
| Lotufo, RF | 1 |
| De Micheli, G | 1 |
| Casarin, RC | 1 |
| Peloso Ribeiro, ED | 1 |
| Almaghlouth, A | 1 |
| Décaillet, F | 1 |
| Courvoisier, DS | 1 |
| Preus, HR | 1 |
| Gunleiksrud, TM | 1 |
| Sandvik, L | 1 |
| Gjermo, P | 1 |
| Baelum, V | 1 |
| Salvi, GE | 1 |
| Mayfield, L | 1 |
| Rutar, A | 1 |
| Suvan, J | 1 |
| Garrett, S | 1 |
| Lang, NP | 1 |
| Buduneli, E | 1 |
| Tünger, A | 1 |
| Evrenosoglu, E | 1 |
| Bilgiç, A | 1 |
| Al-Mubarak, SA | 1 |
| Karring, T | 5 |
| Ho, A | 1 |
| Jansson, H | 1 |
| Bratthall, G | 1 |
| Söderholm, G | 1 |
| Perinetti, G | 1 |
| Paolantonio, M | 2 |
| Cordella, C | 1 |
| D'Ercole, S | 2 |
| Serra, E | 1 |
| Piccolomini, R | 2 |
| Xajigeorgiou, C | 1 |
| Sakellari, D | 1 |
| Slini, T | 1 |
| Baka, A | 1 |
| Konstantinidis, A | 1 |
| Gaggl, AJ | 1 |
| Rainer, H | 1 |
| Grund, E | 1 |
| Chiari, FM | 1 |
| López, NJ | 2 |
| Socransky, SS | 2 |
| Da Silva, I | 1 |
| Japlit, MR | 1 |
| Haffajee, AD | 2 |
| Leiknes, T | 1 |
| Leknes, KN | 1 |
| Böe, OE | 1 |
| Skavland, RJ | 1 |
| Lie, T | 2 |
| Sander, L | 1 |
| Frandsen, EV | 1 |
| Arnbjerg, D | 1 |
| Warrer, K | 1 |
| Loesche, WJ | 2 |
| Grossman, N | 1 |
| Giordano, J | 1 |
| Saxén, L | 2 |
| Asikainen, S | 3 |
| Stelzel, M | 2 |
| Florès-de-Jacoby, L | 2 |
| Nieminen, A | 1 |
| Torkko, H | 1 |
| Kari, K | 1 |
| Uitto, VJ | 1 |
| Winkel, EG | 2 |
| Van Winkelhoff, AJ | 3 |
| Timmerman, MF | 2 |
| Vangsted, T | 1 |
| Van der Velden, U | 2 |
| von Troil-Lindén, B | 1 |
| Alaluusua, S | 1 |
| Wolf, J | 1 |
| Jousimies-Somer, H | 1 |
| Torppa, J | 1 |
| Berglundh, T | 1 |
| Krok, L | 1 |
| Liljenberg, B | 1 |
| Westfelt, E | 1 |
| Serino, G | 1 |
| Lindhe, J | 1 |
| Rudhart, A | 1 |
| Purucker, P | 2 |
| Kage, A | 1 |
| Hopfenmüller, W | 1 |
| Sculean, A | 2 |
| Donos, N | 2 |
| Blaes, A | 2 |
| Lauermann, M | 1 |
| Reich, E | 2 |
| Brecx, M | 2 |
| Catamo, G | 1 |
| Di Placido, G | 1 |
| Tumini, V | 1 |
| Picciani, C | 1 |
| Riep, B | 1 |
| Gamonal, JA | 1 |
| Martinez, B | 1 |
| Needleman, IG | 3 |
| Moles, DR | 2 |
| Collins, AM | 2 |
| Arweiler, N | 1 |
| Van der Weijden, GA | 1 |
| Sigusch, B | 1 |
| Beier, M | 1 |
| Klinger, G | 1 |
| Pfister, W | 1 |
| Glockmann, E | 1 |
| Feres, M | 1 |
| Allard, K | 1 |
| Som, S | 1 |
| Rooney, J | 1 |
| Wade, WG | 1 |
| Sprague, SV | 1 |
| Newcombe, RG | 1 |
| Addy, M | 1 |
| Montebugnoli, L | 1 |
| Servidio, D | 1 |
| Prati, C | 1 |
| Tijhof, CJ | 1 |
| de Graaff, J | 1 |
| Pedrazzoli, V | 1 |
| Kilian, M | 1 |
| Klinge, B | 2 |
| Kuvatanasuhati, J | 1 |
| Attström, R | 2 |
| Kalfas, S | 1 |
| Edwardsson, S | 1 |
| Kisch, J | 2 |
| Lewin, B | 1 |
| Stoltze, K | 2 |
| Ainamo, J | 1 |
| Ellingsen, BH | 1 |
| Hansen, BF | 1 |
| Johansson, LA | 1 |
| Paunio, K | 1 |
| Huynh, C | 1 |
| Roch-Arveiller, M | 1 |
| Meyer, J | 1 |
| Giroud, JP | 1 |
| Giordano, JR | 1 |
| Hujoel, P | 1 |
| Schwarcz, J | 1 |
| Smith, BA | 1 |
| Eisenberg, L | 1 |
| Suchow, R | 1 |
| Coles, RS | 1 |
| Deasy, MJ | 1 |
| Söder, PO | 1 |
| Frithiof, L | 1 |
| Wikner, S | 1 |
| Wouters, F | 1 |
| Engström, PE | 1 |
| Rubin, B | 1 |
| Nedlich, U | 1 |
| Söder, B | 1 |
| Watts, TL | 1 |
| Walsh, MM | 1 |
| Buchanan, SA | 1 |
| Hoover, CI | 1 |
| Newbrun, E | 1 |
| Taggart, EJ | 1 |
| Armitage, GC | 1 |
| Robertson, PB | 1 |
| Watts, T | 1 |
| Palmer, R | 1 |
| Floyd, P | 1 |
| Joyston-Bechal, S | 1 |
| Smales, FC | 1 |
| Duckworth, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reconstructive Surgical Therapy of Peri-implantitis-related Osseous Defects. A Multicenter Randomized Controlled Clinical Trial[NCT03077061] | 140 participants (Actual) | Interventional | 2017-04-01 | Active, not recruiting | |||
| Reconstructive Surgical Treatment of Peri-implant Intra-osseous Defects - A MULTICENTER RANDOMIZED PROSPECTIVE CLINICAL STUDY[NCT02406001] | 70 participants (Actual) | Interventional | 2010-06-30 | Completed | |||
| Impact of Different Dosages and Time of Administration of Metronidazole and Amoxicillin in the Treatment of Generalized Chronic Periodontitis: A Randomized Clinical Trial[NCT02735395] | Phase 4 | 110 participants (Actual) | Interventional | 2011-07-31 | Active, not recruiting | ||
| Metronidazole and Amoxicillin as Adjuncts to Scaling and Root Planing for the Treatment of Type 2 Diabetic Subjects With Periodontitis: a Randomized Placebo-controlled Clinical Trial[NCT02135952] | Phase 4 | 58 participants (Actual) | Interventional | 2011-09-30 | Active, not recruiting | ||
| Effect of Non Surgical Therapy on Calprotectin and Periostin Levels in Patients With Periodontitis and Cardiovascular Diseases - An Interventional Study[NCT05618743] | 45 participants (Anticipated) | Interventional | 2021-06-30 | Recruiting | |||
| Clarithromycin as Adjuvant to Periodontal Debridement in the Treatment of Generalized Aggressive Periodontitis: Randomized Clinical Trial[NCT02829983] | 40 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
| EFFECT OF LOCALLY DELIVERED ALOE VERA GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN THE TREATMENT OF CHRONIC PERIODONTITIS: A SPLIT-MOUTH CLINICAL AND MICROBIOLOGICAL STUDY[NCT02462993] | Phase 2/Phase 3 | 12 participants (Actual) | Interventional | 2014-02-28 | Completed | ||
| Clinical Effects of Doxycycline in the Treatment of Aggressive Periodontitis: Comparative Clinical Study[NCT03727620] | Phase 1/Phase 2 | 24 participants (Actual) | Interventional | 2014-01-06 | Completed | ||
| Clinical Evaluation of Systemic Moxifloxacin Compared to Amoxicillin Plus Metronidazole Adjunct to Non-surgical Treatment in Generalized Aggressive Periodontitis: A Randomized Clinical Trial[NCT02223702] | Phase 4 | 39 participants (Actual) | Interventional | 2011-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Distance from bottom of pocket to the cement-enamel junction (CEJ). (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.71 |
| Placebo Group | 3.03 |
Distance from the bottom of sulcus/pocket to gingival margin (NCT02829983)
Timeframe: 6 months
| Intervention | milimeter (Mean) |
|---|---|
| Clarithromycin Group | 2.53 |
| Placebo Group | 2.86 |
Attachment loss were recorded at baseline, 1st, 3rd and 6th months as millimeters. The data were compared among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 5.03 | 4.37 | 4.41 | 4.33 |
| Moxifloxacin | 4.94 | 4.14 | 3.98 | 4.30 |
We measured the probing depth at baseline, 1st, 3rd and 6th months. The changes were evaluated among and between groups. (NCT02223702)
Timeframe: 6-months
| Intervention | mm (Mean) | |||
|---|---|---|---|---|
| Baseline | 1st month | 3rd month | 6th month | |
| Amoxicillin+Metronidazole | 4.57 | 3.12 | 3.11 | 3.15 |
| Moxifloxacin | 4.18 | 2.91 | 2.79 | 3.01 |
1 review available for metronidazole and Gingival Hemorrhage
| Article | Year |
|---|---|
Amoxicillin/metronidazole or scaling and root planing in the treatment of chronic periodontitis.
Topics: Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Chronic Periodontitis; Dental Plaque Inde | 2010 |
44 trials available for metronidazole and Gingival Hemorrhage
| Article | Year |
|---|---|
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Reconstruction of Peri-implant Osseous Defects: A Multicenter Randomized Trial.
Topics: Adult; Aged; Aged, 80 and over; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents, Local; Bi | 2016 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Amoxicillin and metronidazole as an adjunct to full-mouth scaling and root planing of chronic periodontitis.
Topics: Adult; Aged; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Inf | 2009 |
Full-mouth ultrasonic debridement associated with amoxicillin and metronidazole in the treatment of severe chronic periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Bacteroides; | 2009 |
Calprotectin levels in gingival crevicular fluid predict disease activity in patients treated for generalized aggressive periodontitis.
Topics: Administration, Topical; Adult; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial Agents; Anti-I | 2011 |
The combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Are there specific benefits of amoxicillin plus metronidazole in Aggregatibacter actinomycetemcomitans-associated periodontitis? Double-masked, randomized clinical trial of efficacy and safety.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infecti | 2013 |
A randomized, double-masked clinical trial comparing four periodontitis treatment strategies: 1-year clinical results.
Topics: Adult; Aged; Anti-Infective Agents; Anti-Infective Agents, Local; Chlorhexidine; Combined Modality T | 2013 |
Local antimicrobial therapy after initial periodontal treatment.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Analysis of Variance; Anti-Bacterial Agents; Ant | 2002 |
Comparative clinical and microbiological effects of subgingival metronidazole application in adult periodontitis; 12-months results.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Bacterial Agents; Colony Count, Microbial | 2001 |
Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Dental Plaqu | 2000 |
Clinical outcome observed in subjects with recurrent periodontal disease following local treatment with 25% metronidazole gel.
Topics: Adult; Anti-Infective Agents; Dental Plaque Index; Dental Scaling; Follow-Up Studies; Gels; Gingival | 2003 |
Clinical and microbiological effects of subgingival administration of two active gels on persistent pockets of chronic periodontitis patients.
Topics: Adult; Anti-Infective Agents, Local; Case-Control Studies; Chlorhexidine; Chronic Disease; Colony Co | 2004 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Clinical and microbiological effects of different antimicrobials on generalized aggressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Age | 2006 |
Local oxygen therapy for treating acute necrotizing periodontal disease in smokers.
Topics: Acute Disease; Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin-Po | 2006 |
Effects of metronidazole plus amoxicillin as the only therapy on the microbiological and clinical parameters of untreated chronic periodontitis.
Topics: Adult; Aged; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bacteria; Case-Control Studi | 2006 |
Topical use of a metronidazole gel in the treatment of sites with symptoms of recurring chronic inflammation.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Chronic Disease; Delayed-Action Prepara | 2007 |
Effect of local metronidazole application on periodontal healing following guided tissue regeneration. Clinical findings.
Topics: Administration, Topical; Adult; Alveolar Bone Loss; Dental Plaque; Female; Gels; Gingival Hemorrhage | 1994 |
Metronidazole in periodontitis (IV). The effect of patient compliance on treatment parameters.
Topics: Alveolar Bone Loss; Colony Count, Microbial; Dental Plaque; Dental Scaling; Double-Blind Method; Fem | 1993 |
Metronidazole in the treatment of localized juvenile periodontitis.
Topics: Adolescent; Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Alveolar Bone Lo | 1993 |
Topical metronidazole application compared with subgingival scaling. A clinical and microbiological study on recall patients.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents, Local; Bacteria; Colony Count, Microbia | 1996 |
Value of some laboratory and clinical measurements in the treatment plan for advanced periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Anti-Bacterial Agents; Denta | 1996 |
Topical metronidazole application in recall patients. Long-term results.
Topics: Administration, Topical; Adult; Aged; Anti-Bacterial Agents; Bacteria; Dental Plaque; Dental Scaling | 1997 |
The use of metronidazole and amoxicillin in the treatment of advanced periodontal disease. A prospective, controlled clinical trial.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Amoxicillin; Anti-Bacterial Agents; Biopsy; Combined M | 1998 |
Local metronidazole application in maintenance patients. Clinical and microbiological evaluation.
Topics: Administration, Topical; Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony | 1998 |
Comparison of enamel matrix proteins and bioabsorbable membranes in the treatment of intrabony periodontal defects. A split-mouth study.
Topics: Absorbable Implants; Alveolar Bone Loss; Amoxicillin; Anti-Infective Agents; Dental Enamel Proteins; | 1999 |
Bacteriological and clinical follow-up of periodontal pockets during a topically applied 1% metronidazole-gel therapy in patients with adult periodontitis.
Topics: Administration, Topical; Adult; Dental Plaque; Female; Follow-Up Studies; Gels; Gingival Hemorrhage; | 1999 |
Repeated local metronidazole-therapy as adjunct to scaling and root planing in maintenance patients.
Topics: Administration, Topical; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Colony Count, | 1999 |
Repeated metronidazole and amoxicillin treatment of periodontitis. A follow-up study.
Topics: Adult; Aged; Amoxicillin; Analysis of Variance; Anti-Infective Agents; Chronic Disease; Disease Prog | 2000 |
Periodontal flap surgery with 25% metronidazole gel. (2). Effect on gingival crevicular fluid PGE2.
Topics: Administration, Topical; Adult; Analysis of Variance; Anti-Infective Agents; Combined Modality Thera | 2000 |
Periodontal flap surgery with 25% metronidazole gel. (1). Clinical outcomes.
Topics: Administration, Topical; Adult; Aged; Anti-Infective Agents; Combined Modality Therapy; Confidence I | 2000 |
The effect of postsurgical antibiotics on the healing of intrabony defects following treatment with enamel matrix proteins.
Topics: Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Anti-Infective Agents; Bone Substitutes; Den | 2001 |
Amoxicillin plus metronidazole in the treatment of adult periodontitis patients. A double-blind placebo-controlled study.
Topics: Adult; Amoxicillin; Anti-Bacterial Agents; Bacteroides; Dental Plaque; Double-Blind Method; Drug Com | 2001 |
A 2-step non-surgical procedure and systemic antibiotics in the treatment of rapidly progressive periodontitis.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Clindamycin; Clinical Protocols | 2001 |
Adjunctive effects to non-surgical periodontal therapy of systemic metronidazole and amoxycillin alone and combined. A placebo controlled study.
Topics: Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Capsules; Chronic Disease; Colony C | 2002 |
Effectiveness of metronidazole gel on cyclosporine-induced gingival overgrowth in heart transplant patients.
Topics: Analysis of Variance; Anti-Infective Agents; Chi-Square Distribution; Cyclosporine; Dental Plaque In | 2002 |
Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Bacteria; Bacteroides; Delayed-Action Preparatio | 1992 |
3 regimens of topical metronidazole compared with subgingival scaling on periodontal pathology in adults.
Topics: Adult; Aged; Delayed-Action Preparations; Dental Scaling; Drug Implants; Female; Follow-Up Studies; | 1992 |
Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis.
Topics: Adult; Aged; Delayed-Action Preparations; Dental Scaling; Drug Implants; Female; Follow-Up Studies; | 1992 |
Metronidazole in periodontitis: reduced need for surgery.
Topics: Adult; Alveolar Bone Loss; Bacteria; Bacteroidaceae; Bacteroides; Colony Count, Microbial; Combined | 1992 |
The effects of metronidazole administration on clinical and microbiologic parameters of periodontal disease.
Topics: Analysis of Variance; Biological Assay; Chi-Square Distribution; Dental Plaque; Dental Plaque Index; | 1991 |
The effect of systemic metronidazole after non-surgical treatment in moderate and advanced periodontitis in young adults.
Topics: Adult; Bone Resorption; Clinical Trials as Topic; Dental Prophylaxis; Dental Scaling; Double-Blind M | 1990 |
The effect of 1% metronidazole gel in routine maintenance of persistent furcation involvement in human beings.
Topics: Adult; Aged; Bacteria; Combined Modality Therapy; Confidence Intervals; Delayed-Action Preparations; | 1989 |
Metronidazole: a double-blind trial in untreated human periodontal disease.
Topics: Adult; Bacteria; Cell Movement; Clinical Trials as Topic; Dental Plaque; Double-Blind Method; Female | 1986 |
A follow-up study 3 years after metronidazole therapy for chronic periodontal disease.
Topics: Chronic Disease; Dental Plaque; Dental Scaling; Follow-Up Studies; Gingival Hemorrhage; Humans; Metr | 1986 |
12 other studies available for metronidazole and Gingival Hemorrhage
| Article | Year |
|---|---|
Periodontitis associated with plasminogen deficiency: a case report.
Topics: Adolescent; Alveolar Bone Loss; Amoxicillin; Anti-Bacterial Agents; Combined Modality Therapy; Conju | 2015 |
Bacterial colonization of oral implants from nondental sources.
Topics: Aggressive Periodontitis; Anti-Infective Agents; Bacteria; Bacteroides; Campylobacter rectus; Ciprof | 2009 |
Clinical peri-implant sounding accuracy in the presence of chronic inflammation of peri-implant tissues. Clinical observation study.
Topics: Alveolar Bone Loss; Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Debride | 2009 |
Antibiotic resistance of subgingival species in chronic periodontitis patients.
Topics: Adult; Aged; Aggregatibacter actinomycetemcomitans; Amoxicillin; Amoxicillin-Potassium Clavulanate C | 2010 |
Clinical and microbiologic evaluation, by real-time polymerase chain reaction, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Aggressive Periodontitis; Amoxicillin; Anti-Bacterial | 2012 |
Effects of metronidazole in patients with "refractory" periodontitis associated with Bacteroides forsythus.
Topics: Adult; Aggregatibacter actinomycetemcomitans; Anaerobiosis; Anti-Bacterial Agents; Bacteroidaceae In | 1997 |
Periodontitis patient and the spouse: periodontal bacteria before and after treatment.
Topics: Aggregatibacter actinomycetemcomitans; Anti-Bacterial Agents; Bacteria; Campylobacter; Dental Calcul | 1997 |
Change in subgingival microbial profiles in adult periodontitis subjects receiving either systemically-administered amoxicillin or metronidazole.
Topics: Actinomyces; Adult; Amoxicillin; Analysis of Variance; Anti-Bacterial Agents; Bacteria; Bacteroides; | 2001 |
Microbiological and clinical results of metronidazole plus amoxicillin therapy in Actinobacillus actinomycetemcomitans-associated periodontitis.
Topics: Adult; Age Factors; Aggregatibacter actinomycetemcomitans; Alveolar Bone Loss; Amoxicillin; Bacteroi | 1992 |
The effect of topical metronidazole therapy on experimentally-induced periodontitis in the beagle dog.
Topics: Animals; Bacteria, Aerobic; Bacteria, Anaerobic; Colony Count, Microbial; Delayed-Action Preparation | 1992 |
Gingival crevicular fluid of patients with gingivitis or periodontal disease: evaluation of elastase-alpha 1 proteinase inhibitor complex.
Topics: Adult; Aged; alpha 1-Antitrypsin; Anti-Infective Agents; Dental Scaling; Drug Combinations; Female; | 1992 |
Clinical and microbiologic effects of single-dose metronidazole or scaling and root planing in treatment of adult periodontitis.
Topics: Adult; Bacteria; Dental Plaque Index; Dental Prophylaxis; Dental Scaling; Drug Administration Schedu | 1986 |